Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT05832528Recruiting
Low FODMAP diet for indigestion after meals
This study tests whether a low FODMAP diet can reduce symptoms of functional indigestion or post-meal discomfort. It’s mainly for people whose symptoms are clearly linked to eating and who haven’t changed diets recently.
Leuven, Vlaams-BrabantAges 18–70 - NCT05833594Recruiting
Immunonutrition plus chemoradiation for unresectable esophageal cancer
This trial studies whether adding an “immunonutrition” nutrition plan to standard chemoradiation can improve outcomes for people with locally advanced, unresectable esophageal squamous cell cancer. It may help the treatment work better by supporting the immune system during therapy.
HefeiAges 18–85 - NCT05833815RecruitingPhase 2/Phase 3
Everolimus added to standard care for gallbladder cancer
This trial tests whether adding everolimus to the usual treatment helps people with advanced (stage III inoperable or stage IV) gallbladder cancer live longer and control the disease better. You may be eligible if you have not had prior treatment for the advanced cancer, and your blood tests and organ functions are in safe ranges.
Varanasi, Uttar PradeshAges 18–99 - NCT05835973Recruiting
Study of sleep changes in people with inflammatory bowel disease
This study looks at how sleep patterns change in adults with inflammatory bowel disease (IBD) who are currently in remission. It may help researchers understand sleep issues in IBD and identify ways to improve care during symptom-free periods.
Clermont-FerrandAges 18–65 - NCT05837897RecruitingPhase 3
Vedolizumab for adults with moderate-to-severe Crohn’s
This Phase 3 study tests whether vedolizumab can better control moderate-to-severe Crohn’s disease in adults whose symptoms haven’t improved enough with other treatments. You’d need to meet specific symptom scores, recent colonoscopy findings, and safety checks (including infections and vaccination status).
Hefei, AnhuiAges 18–80 - NCT05838391Recruiting
Targeted radiation approach for anal cancer
This trial tests an adaptive, image-guided radiation plan for anal canal squamous-type cancers. It may help deliver effective treatment while adjusting the radiation based on how your body and tumor respond.
New York, New YorkAges 18 years+ - NCT05841420RecruitingPhase 2
Lower-intensity chemo for fragile pancreatic cancer patients
This Phase 2 trial compares a standard gemcitabine approach versus a reduced-dose combination chemotherapy for people with pancreatic cancer that can’t be removed by surgery. It aims to find a treatment that works while being safer for “fragile” patients who can’t tolerate full-dose chemotherapy.
AalborgAges 18 years+ - NCT05842174RecruitingPhase 1/Phase 2
Checking a new treatment approach for liver cancer needing TACE
This early-stage trial studies a new strategy for hepatocellular carcinoma (a type of liver cancer) in people who are planned to receive TACE, a procedure that delivers treatment through the liver’s blood supply. It aims to test whether targeting a specific cell survival process can improve how well the treatment works and is tolerated.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05842512RecruitingPhase 2
Drug ADI-PEG 20 for NASH in people with mild cirrhosis
This trial tests ADI-PEG 20 against a placebo (inactive pill) to see if it improves liver disease in people with NASH and compensated cirrhosis. It may help by targeting liver fat and inflammation seen on scans and biopsy.
Chiayi City, TaiwanAges 18–80 - NCT05842850Recruiting
Study of fatty liver in people born with low birth weight
This trial focuses on people who have fatty liver disease (extra fat in the liver) and were born with low birth weight. It aims to test an approach in this specific group, which may help clarify what helps the liver in higher-risk people.
AarhusAges 35–40 - NCT05844046RecruitingPhase 2
Triple drug treatment for advanced liver cancer that can’t be removed
This Phase 2 trial tests three medicines together (durvalumab, tremelimumab, and bevacizumab) to treat non-surgical (non-resectable) liver cancer. It may help shrink tumors and slow disease progression by boosting the immune system and blocking tumor blood supply.
MunichAges 18 years+ - NCT05844514Recruiting
Breath test study for colorectal cancer detection and risk
This study tests a breath analysis (a sample you give by breathing into a device) to help detect or better understand colorectal cancer. It may help researchers see whether breath results can identify cancer sooner and in people who haven’t started treatment yet.
LondonAges 18 years+ - NCT05844865Recruiting
GI cancer study using a lab tumor model from your surgery
This study uses a special lab model made from tumor tissue taken during a planned standard cancer surgery. It tests how well the lab model can represent your cancer, which may help researchers improve future treatments.
Orange, CaliforniaAges 18 years+ - NCT05845450RecruitingPhase 2
Pre-surgery targeted drugs for selected colorectal cancer tumors
This trial tests targeted cancer drugs given before planned colon or rectal surgery. It may help by trying to shrink the tumor and treat specific tumor “targets” found in your stored pathology sample, depending on your tumor’s genetics and marker tests.
Milan, Lombardia/MIAges 18 years+ - NCT05846802Recruiting
Gastroparesis and stomach symptoms registry for adults
This registry is for adults with long-lasting stomach emptying problems or related symptoms, helping researchers better understand patterns of nausea, pain, and fullness. You may be able to join if you meet specific symptom and test results, and can complete a stomach-emptying scan.
Scottsdale, ArizonaAges 18–85 - NCT05847855Recruiting
Blood test to help detect certain early pancreatic tumors
This study looks at a special analysis of your blood (called cfDNA fragmentomics) to help find and tell apart certain early pancreatic tumors. If you’re having surgery for one of the listed solid pancreatic tumors, this trial may use your blood samples to improve diagnosis.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05848310Recruiting
Blood test before surgery to predict biliary atresia outcome
This study looks at a specific pre-surgery blood marker called FGF19 (and related liver blood tests) in children with biliary atresia. The goal is to see whether the blood results before surgery can help predict how well children recover after surgery.
Shanghai, Shanghai MunicipalityAges Any age - NCT05849480RecruitingPhase 1/Phase 2
Study of CD40 treatment with CAPOX and Keytruda for bile duct cancer
This trial studies a new immune “switch” treatment called CDX-1140 combined with standard chemo (CAPOX) and Keytruda, for biliary tract cancer that can’t be cured with surgery or transplant. It’s designed for people whose cancer has progressed after first-line treatment, with the goal of improving cancer control and outcomes.
Bethesda, MarylandAges 18–120 - NCT05849012Recruiting
Low-sulfur diet study for Crohn’s symptoms when disease is quiet
This pilot study tests whether a low-sulfur diet can improve ongoing belly pain and/or diarrhea symptoms in people with Crohn’s disease that looks “quiet” on tests. If you still feel symptoms even though inflammation is not active, this could help by targeting diet-related triggers.
Ann Arbor, MichiganAges 18 years+ - NCT05850130Recruiting
Acupuncture to treat nerve pain from oxaliplatin chemotherapy
This study tests whether acupuncture can reduce nerve pain caused by oxaliplatin chemotherapy in people with gastrointestinal cancers. It may help lessen symptoms like tingling, numbness, or burning that affect hands or feet.
CréteilAges 18 years+ - NCT05851534Recruiting
Pre-surgery risk reduction for pancreatic surgery
This study helps people going for planned pancreatic cancer surgery (with or without chemo beforehand) by focusing on controllable risk factors before the operation. The goal is to improve safety and outcomes after surgery.
's-HertogenboschAges 18 years+ - NCT05852457Recruiting
Testing a special endoscopy clip to close tissue openings
This study tests whether a new kind of endoscopy clip (a dual-action clip) works well to close openings or gaps seen during routine endoscopic procedures. It may help control bleeding, seal perforations or fistulas, or bring tissue edges together after certain stomach or throat procedures.
Orlando, FloridaAges 18 years+ - NCT05853718RecruitingPhase 4
Tenofovir treatment for hepatitis B during pregnancy
This study tests tenofovir alafenamide (TAF) to lower hepatitis B in pregnant people and reduce the chance of passing it to the baby. You may be able to join if you’re pregnant with active hepatitis B and meet safety lab and pregnancy ultrasound requirements.
Hangzhou, ZhejiangAges 20–40 - NCT05853094Recruiting
Testing different ways to create a stoma after rectal cancer surgery
This trial looks at how different stoma (opening in the belly) approaches affect recovery after curative rectal cancer surgery. It may help doctors choose the safest, most comfortable option for bowel function and healing after surgery.
ShanghaiAges 18–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.