Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,686
- Phase 21,188
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Hepatocellular Carcinoma (HCC)114
- Colon Cancer112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Chinese University of Hong Kong56
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona190
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,606 total
- NCT06280105RecruitingPhase 2
Testing cadonilimab and regorafenib for liver cancer after other treatments fail
This trial tests a combination of two drugs, cadonilimab and regorafenib, for people with liver cancer that has worsened after treatment with camrelizumab and apatinib. The goal is to see if this new combination can help control the cancer.
Fuzhou, FujianAges 18–75 - NCT06914648Recruiting
Liver preparation before surgery study for certain liver cancers
This study tests a procedure called portal vein embolization (PVE) to help grow the healthy part of the liver before surgery. It may be an option for people with certain liver cancers who need more healthy liver tissue before their operation.
New Haven, ConnecticutAges 18 years+ - NCT07090759RecruitingPhase 3
Test of new drug for hepatitis B not fully controlled by current treatment
This trial tests a new drug called GST-HG141 for people with chronic hepatitis B whose virus is still active despite taking standard antiviral pills. It aims to see if the new drug can better control the virus.
Hangzhou, ZhejiangAges 18–70 - NCT07094204RecruitingPhase 1
Study of ASP5834 for advanced solid tumors with KRAS changes
This study tests a new drug (ASP5834) for people with advanced solid tumors that have changes in the KRAS gene. The study looks for a safe and effective dose, and may help you if your standard treatments have stopped working.
Santa Monica, CaliforniaAges 18 years+ - NCT07094113RecruitingPhase 1
AMG 410 alone or with other drugs for KRAS-altered advanced cancers
This study tests a new drug called AMG 410 by itself or with other medicines in people whose cancer has a specific change in the KRAS gene. It is for advanced or metastatic solid tumors that have not responded to standard treatments or who have chosen not to take them.
Duarte, CaliforniaAges 18 years+ - NCT07089615Recruiting
Capsule vs colonoscopy for polyp detection
This trial tests a new capsule that you swallow to take pictures of your colon. It may help find polyps (growths that can turn into cancer) as well as a standard colonoscopy does.
Chula Vista, CaliforniaAges 45–75 - NCT07093463Recruiting
Colon-delivered Vitamin B2 for Gut Health
This trial tests whether a special form of vitamin B2 (riboflavin) delivered to the colon can improve gut health in people with mild to moderate bowel complaints. The study compares the effects of this supplement to a standard diet add-on (inulin) and looks at changes in gut bacteria and symptoms.
Berlin, State of BerlinAges 50–70 - NCT07090499RecruitingPhase 1
Study of PF-08046876 for advanced solid tumors
This trial tests a new medicine, PF-08046876, for people with advanced cancers of the bladder, lung, head and neck, esophagus, or pancreas. It aims to see if the drug is safe and works against these cancers.
Duarte, CaliforniaAges 18 years+ - NCT06453317RecruitingPhase 2
Comparing UC treatments: infliximab vs ustekinumab vs both
This study compares an existing UC medication (infliximab) with a newer one (ustekinumab) and a combination of both. The goal is to see which works best for moderate to severe UC when other treatments have failed.
LodzAges 18–64 - NCT06968221RecruitingPhase 3
Bovine reinforcement for stomach, colorectal, and lung surgery
This trial tests whether a bovine reinforcement material helps make staple lines in stomach, colorectal, and lung surgeries stronger and safer. It may reduce the risk of leaks or bleeding at the staple line.
ShanghaiAges 18–75 - NCT07090083Recruiting
Liver health and food support for children
This study tests whether providing fruit and vegetable vouchers to families with children who have fatty liver disease can improve liver health. Diet and lifestyle are key to managing this condition.
San Francisco, CaliforniaAges 6–17 - NCT07089277Recruiting
Validating a bleeding risk score for stomach bleeding
This study checks how well a risk score predicts the need for treatment in patients with upper gastrointestinal bleeding (bleeding in the stomach or esophagus). It may help doctors decide if you need urgent care.
SousseAges 18 years+ - NCT07088081Enrolling by invitation
Immunotherapy drugs for advanced liver cancer
This trial tests two types of immunotherapy (atezolizumab with bevacizumab or durvalumab with tremelimumab) for people with advanced liver cancer that hasn't been treated with systemic therapy before. It aims to see if these treatments are safe and effective.
Cairo, AbbasyaAges 18 years+ - NCT07088354Recruiting
AI model predicts treatment response in esophageal cancer
This trial tests whether an artificial intelligence (AI) model can accurately predict if esophageal cancer will completely disappear after chemotherapy combined with immunotherapy before surgery. If successful, it could help doctors decide the best treatment plan for patients.
Wuhan, HubeiAges 18 years+ - NCT07090291Recruiting
China colorectal cancer screening trial for adults 45–74
This trial is testing a new way to screen for colorectal cancer in adults aged 45 to 74. If you join, you will help researchers find better methods for early detection.
GuandongAges 45–74 - NCT07088757RecruitingPhase 4
Low-Dose vs Standard-Dose Indomethacin for Pancreatitis Prevention After ERCP
This study compares a low dose of indomethacin (a pain reliever) with the standard dose to see if it works just as well for preventing pancreatitis (inflammation of the pancreas) after an ERCP procedure. It may reduce side effects while still protecting your pancreas.
ShanghaiAges 18 years+ - NCT07091617Recruiting
Better genetic testing for young adults with cancer
This study tests a new way to offer genetic testing to young adults (ages 18-39) who have or had cancer. The goal is to make it easier for you to learn if you have inherited gene changes that could affect your cancer and your family's health.
Anchorage, AlaskaAges 18 years+ - NCT07091539Recruiting
Fruit and vegetable vouchers for kids with fatty liver disease
This trial tests whether providing fruit and vegetable vouchers can help children with fatty liver disease (MASLD) improve their liver health. Families living in California with a child who has elevated BMI and liver enzymes may be eligible.
San Francisco, CaliforniaAges 6–17 - NCT07088900Recruiting
Dexmedetomidine with bupivacaine for pain relief in children's appendix surgery
This trial tests if adding dexmedetomidine to bupivacaine (a numbing medicine given near the tailbone) provides better pain relief during and after appendix surgery in children. It may help reduce the need for other pain medicines.
CairoAges 2–7 - NCT07086469RecruitingPhase 2
Surufatinib plus chemo-immunotherapy before chemoradiation for advanced esophageal cancer
This trial tests a new combination of treatments for people with advanced esophageal cancer that can't be removed by surgery. It uses a targeted therapy called surufatinib along with chemo-immunotherapy and radiation to see if it can shrink the tumor before further treatment.
Guangzhou, GuangdongAges 18–80 - NCT07085806Recruiting
Pentoxifylline for liver growth after donor surgery
This study tests if a medicine called pentoxifylline can help your liver grow faster after donating a large part of it. You would take the medicine before and after your donor surgery.
New DelhiAges 18–55 - NCT07087418Recruiting
AI imaging study for digestive diseases (IBD, TB, Behçet's)
This trial uses artificial intelligence to combine CT/MR scans and colonoscopy images to better diagnose and predict outcomes for people with inflammatory bowel disease, intestinal tuberculosis, or Behçet's disease. It aims to see if AI can help doctors make more accurate decisions.
ShanghaiAges Any age - NCT07086989Recruiting
Heart health study for kids with chronic conditions
This study looks at heart disease risk in children and young adults (ages 6-25) with long-term health conditions like certain heart, kidney, or diabetes disorders. The goal is to better understand and manage heart risks early.
BudapestAges 6–25 - NCT07093346Recruiting
Pectin supplement for fatty liver disease
This study tests whether a pectin supplement (a fiber found in fruits) can reduce inflammation and improve liver and metabolic health in people with fatty liver disease (MASLD). You might be eligible if you have MASLD, a healthy weight range, and can avoid certain medications and foods.
Nottingham, United KingdomAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 12,023 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.