Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT06162650RecruitingPhase 2
Pre-surgery chemo-radiation therapy for rectal cancer
This trial tests a combination of chemotherapy and radiation therapy before surgery for people with mid or low rectal cancer that hasn't spread. The goal is to see if this approach works better than current treatments.
TainanAges 20 years+ - NCT06165341RecruitingPhase 3
Fazirsiran for mild liver scarring in alpha-1 antitrypsin deficiency
This study tests an investigational drug called fazirsiran, which is designed to treat alpha-1 antitrypsin deficiency-related liver disease with mild scarring. The goal is to see if fazirsiran is safe and can improve or slow liver damage in people with the PiZZ genetic type.
Phoenix, ArizonaAges 18–75 - NCT06164769Recruiting
Laparoscopic tumor removal for benign pancreatic tumors
This trial tests a surgical technique to remove benign or low-risk pancreatic tumors from the head or neck of the pancreas while temporarily blocking blood flow to reduce bleeding. It may help patients avoid more extensive surgery.
Hangzhou, ZhejiangAges 14–70 - NCT06165029Recruiting
Ultrasound score to predict anti-TNF success in IBD
This study tests whether an ultrasound score (called VAT) combined with another ultrasound score (IUS) can predict how well anti-TNF medications (like infliximab) work for people with inflammatory bowel disease. If you are starting a new anti-TNF treatment, this study may help doctors understand if the medication will be effective for you.
Changsha, HunanAges 18–80 - NCT06166147Recruiting
Blood test for early detection of pancreatic cancer
This study is testing a new blood test to find pancreatic cancer early. It looks for tiny bits of cancer DNA floating in your blood, which could help catch the disease before symptoms start.
Shanghai, Shanghai MunicipalityAges 40–75 - NCT06167967Recruiting
Blood test for chemotherapy guidance in stage 3 colorectal cancer
This study uses a blood test to check for tumor DNA after surgery, which may help doctors decide if you need additional chemotherapy. It is for people with stage 3 colorectal cancer that is removed by surgery.
Hanzhou, ZhejiangAges 18–75 - NCT06168786RecruitingPhase 2
New drug combo and radiation for advanced colorectal cancer
This trial tests a new combination of drugs (cadonilimab, fruquintinib) plus targeted radiation (SBRT) for people with advanced MSS colorectal cancer who have already tried several standard treatments. The goal is to see if this combination can help shrink tumors or slow disease progression.
Wuhan, HubeiAges 18–75 - NCT06169163Recruiting
Breath test for esophageal squamous cell cancer
This study looks at chemicals in your breath to see if they can help detect a type of esophageal cancer (squamous cell carcinoma) early. You may join if you have untreated squamous cell esophageal cancer, or if you are having a routine endoscopy for stomach issues and your results are normal or show a benign condition.
London, Greater LondonAges 18–90 - NCT06169592Recruiting
Bleeding and Clotting Risks After Living Donor Liver Transplant
This study is for people with severe liver cirrhosis who are getting a liver transplant from a living donor. It looks at the risk of bleeding or clotting problems after the transplant, to help doctors better manage these risks.
TashkentAges 18–70 - NCT06170736Recruiting
Radiofrequency vs. doppler-guided surgery for hemorrhoids
This study compares two minimally invasive procedures for treating symptomatic grade 2 or 3 hemorrhoids: radiofrequency ablation and doppler-guided hemorrhoidal artery ligation. The goal is to see which one works better and is safer.
AmiensAges 18–80 - NCT06173986RecruitingPhase 1/Phase 2
Immunotherapy plus chemoradiation for advanced esophageal cancer
This trial tests whether adding immunotherapy to standard chemoradiation can help people with unresectable locally advanced esophageal cancer. It aims to improve outcomes for those who cannot have surgery.
ShanghaiAges 18–75 - NCT06173947Recruiting
SSM Score for Liver Injury in Chronic Liver Disease
This study looks at how well a simple score (called SSM) can predict recovery in people with chronic liver disease who suddenly get a liver injury with jaundice. It may help your doctors understand how serious your condition is.
Guangzhou, GuangdongAges 18–80 - NCT06174272Recruiting
Better care after hospital for liver swelling
This trial tests a program to help people with cirrhosis and severe fluid swelling get better care after leaving the hospital. It focuses on guiding you through treatment with water pills and managing fluid buildup at home.
Hershey, PennsylvaniaAges 18 years+ - NCT06175325Recruiting
Embolization for hemorrhoids: a procedure without surgery
This trial tests a minimally invasive procedure called embolization (blocking the blood supply) to treat hemorrhoids that bleed or come back. It may be a good option if you want to avoid surgery.
Stoke-on-TrentAges 18 years+ - NCT06176885RecruitingPhase 2
Immunotherapy plus chemo and targeted therapy for MSS colorectal cancer
This trial tests adding immunotherapy to standard chemotherapy and targeted therapy for people with metastatic colorectal cancer that is MSS (microsatellite stable) and cannot be removed with surgery. It aims to see if this combination helps shrink tumors and improve outcomes.
Jinhua, ZhejiangAges 18–75 - NCT06177041RecruitingPhase 3
M108 plus chemo for CLDN18.2-positive stomach cancer
This trial tests a new drug (M108) combined with standard chemotherapy (CAPOX) as a first treatment for people with advanced stomach or gastroesophageal junction cancer that has a specific protein called Claudin 18.2. The goal is to see if adding M108 helps improve outcomes compared to chemotherapy alone.
Beijing, Beijing MunicipalityAges 18–75 - NCT06177418Recruiting
Appendix surgery through the belly button in children
This trial is testing a specific type of appendix removal surgery that uses a small incision in the belly button. It aims to see if this approach works well for children and teens.
IstanbulAges 5–18 - NCT06177938Recruiting
Using breath test to diagnose lactose intolerance
This study tests a new way to diagnose lactose intolerance by measuring certain markers in your breath. It may help people who have trouble digesting dairy foods get a faster, easier diagnosis.
Zurich, Canton of ZurichAges 18–65 - NCT06178198RecruitingPhase 2
Radiation and liver surgery for large liver tumors
This trial tests combining radiation therapy (radioembolization) with surgery to remove part of the liver for people with a single large liver tumor (over 8 cm) that hasn't spread. The goal is to see if this approach can treat the tumor effectively.
Seoul, SeoulAges 18 years+ - NCT06178315Recruiting
Nerve block for pain from chronic pancreatitis
This trial tests a treatment where medication is injected near nerves in the belly to block pain signals. It may help people with long-term pain from chronic pancreatitis by reducing pain without surgery.
Orlando, FloridaAges 18 years+ - NCT06179498Recruiting
Partner navigation for hepatitis C treatment in young people who inject drugs
This trial offers a partner navigation program to help young people who inject drugs and their main injecting partner work together to get treatment for hepatitis C (a liver infection).
San Francisco, CaliforniaAges 18 years+ - NCT06179602Recruiting
Study of thermal ablation for liver tumors
This study follows patients who are having a procedure called thermal ablation to treat liver tumors. It aims to learn more about how well the procedure works and how safe it is.
LeidenAges 18–110 - NCT06180382RecruitingPhase 4
Comparing vedolizumab to higher-dose adalimumab for Crohn's disease
This trial tests whether switching to vedolizumab works better than increasing your adalimumab dose if your Crohn's symptoms or inflammation are coming back despite treatment. It aims to find the best next step for people whose condition is no longer well-controlled.
Le Kremlin-Bicêtre, PARISAges 18 years+ - NCT06180590Recruiting
Vosevi for hepatitis C patients who didn't get better with past antiviral treatment
This trial tests if Vosevi (a combination of three antiviral drugs) can clear the hepatitis C virus in people who have already tried standard antiviral treatment but still have the virus. It also compares this to another treatment option.
Guangzhou, GuangdongAges 20–70
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.