Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,896 recruiting studies in this area right now.
By phase
- Not applicable4,922
- Phase 21,186
- Phase 1581
- Phase 3466
- Phase 1/Phase 2394
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer492
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California462
- Arizona177
- Texas149
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,896 total
- NCT06786169Recruiting
Stress and treatment results in stomach cancer
This study looks at how psychological stress affects treatment success and long-term outcomes in people with stomach cancer. It includes three different groups of patients at various stages of the disease.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06787014Recruiting
Surgery vs. no surgery for small intestinal NET with spread
This study looks at whether removing the main tumor in the small intestine (along with standard treatment) helps people with small intestinal neuroendocrine tumors that have spread and cannot be cured. It compares this approach to treatment without surgery.
BernAges Any age - NCT06787313Recruiting
Precision palliative care for advanced esophageal cancer
This trial studies a personalized approach to palliative care for people with advanced or recurrent esophageal cancer who are being treated with immunotherapy. It aims to improve quality of life and symptom management.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06787625Recruiting
Growing tumor models from colorectal cancer and liver metastases
This study takes samples from colorectal cancer that has spread to the liver and grows them in the lab. The goal is to create models that can help researchers understand the cancer better and find new treatments.
RomeAges 18 years+ - NCT06788548Recruiting
Fluorescence-Guided Surgery for Early Stomach Cancer
This trial tests a new technique that uses a special dye to highlight the first lymph nodes where stomach cancer might spread, allowing surgeons to remove only the necessary nodes during surgery. The goal is to reduce side effects while still effectively treating the cancer.
Beijing, Beijing MunicipalityAges 18–80 - NCT06789172RecruitingPhase 1
New drug OKN4395 with or without pembrolizumab for solid tumors
This trial tests a new oral drug called OKN4395, which targets a COX2-related immune pathway, alone or with the immunotherapy pembrolizumab, in people with advanced solid tumors. It may be an option if you have certain types of cancer that have stopped responding to other treatments.
Beverly Hills, CaliforniaAges 18 years+ - NCT06789757RecruitingPhase 2
Study of 3 drugs for liver cancer that can't be removed by surgery
This trial tests if combining two immunotherapy drugs (atezolizumab and bevacizumab) with a brain-health medicine (memantine) can help people with advanced liver cancer that isn't treatable with surgery. It aims to see if this triple therapy works better than standard options.
Fairfax, VirginiaAges 18 years+ - NCT06789848RecruitingPhase 2
Testing two immunotherapy drugs for advanced liver and bile duct cancers
This trial tests two investigational drugs, ligufalimab and cadonilimab, for people with advanced liver cancer (hepatocellular carcinoma, HCC) or bile duct cancer (biliary tract cancer, BTC) that has not responded to previous treatment with an immunotherapy drug. The goal is to see if this combination can shrink tumors or slow cancer growth.
Dallas, TexasAges 18 years+ - NCT06790134Recruiting
AI-assisted pancreas ultrasound training study
This study tests whether an AI tool can help doctors perform and learn pancreatic ultrasound exams better. If you need a pancreas ultrasound, you may be able to join.
ChangshaAges 18–80 - NCT06790797Recruiting
Predicting immunotherapy success in chest cancers
This study is for people with lung or esophageal cancer who will receive immunotherapy (drugs that help your immune system fight cancer). The researchers want to find markers in your blood and tumor that can predict how well the treatment will work.
Suzhou, JiangsuAges 18–80 - NCT06791083RecruitingPhase 2
Envafolimab, Fruquintinib, and chemo before gastric cancer surgery
This trial tests a combination of two targeted drugs (Envafolimab and Fruquintinib) plus chemotherapy given before surgery for certain types of stomach cancer. The goal is to see if this approach can shrink the tumor and improve outcomes.
Fuzhou, FujianAges 18–75 - NCT06791148RecruitingPhase 2
Low-dose radiation plus chemo and immunotherapy for advanced stomach cancer
This trial tests a combination of low-dose radiation, chemotherapy, and an immunotherapy drug (AK112) for people with advanced stomach or gastroesophageal junction cancer that has progressed after first-line treatment. The goal is to see if this combination can help shrink tumors or slow the cancer's growth.
Nanjing, JiangsuAges 18–75 - NCT06791512RecruitingPhase 3
Chemo Plus Targeted Therapy With or Without Immunotherapy for Colorectal Cancer
This trial compares a standard chemotherapy combination (mFOLFOX6) plus a targeted drug (bevacizumab) with or without an immunotherapy (PD-1 antibody) for locally advanced colorectal cancer. It aims to see if adding the immunotherapy improves outcomes for patients with a specific tumor type (pMMR/MSS).
Guangzhou, GuangdongAges 18–80 - NCT06791538Recruiting
Robotic vs. laparoscopic surgery for advanced stomach cancer
This trial compares robotic-assisted surgery to standard laparoscopic surgery for locally advanced stomach cancer. It aims to see which approach offers better outcomes and recovery for patients.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT06792149Recruiting
Guiding gastric cancer treatment with 3D bioprinting
This trial uses a 3D-printed model of your tumor to predict which drugs will work best for your gastric cancer. It aims to make treatment more personalized and effective.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06792162RecruitingPhase 2
Immunotherapy and targeted therapy trial for advanced gastric cancer
This trial tests a combination of two drugs: carilizumab (an immunotherapy) and apatinib (a targeted therapy) for patients with unresectable stage III or IV gastric cancer that has a specific DNA repair problem (dMMR). The goal is to see if this treatment can help shrink tumors and improve outcomes.
BeijingAges 18 years+ - NCT06792604Recruiting
Methylation test for anal cancer screening
This study is testing a new way to screen for anal cancer by looking at DNA methylation in cells collected from the anus. It may help people at higher risk for anal cancer find out earlier if they need further tests.
Paris, Île-de-France RegionAges 18 years+ - NCT06792786Recruiting
Study of Chemo-Immunotherapy and Radiation for Esophageal Cancer with Blood Monitoring
This study tests a combination of chemotherapy, immunotherapy, and radiation for esophageal cancer that cannot be surgically removed. It also uses a simple blood test (ctDNA) to monitor your cancer's response throughout treatment.
Jinhua, ZhejiangAges 18–75 - NCT06793124Recruiting
Comparing tests for CMV in bowel disease patients
This trial compares different diagnostic tests to find the best way to detect cytomegalovirus (CMV) organ disease in people with inflammatory bowel disease (IBD) whose symptoms get worse and need hospital care. The goal is to improve diagnosis and treatment for this complication.
Bologna, BolognaAges 18 years+ - NCT06793137RecruitingPhase 2
Antibiotics before surgery for advanced rectal cancer
This trial tests if taking antibiotics before standard treatment can improve outcomes for people with advanced rectal cancer that requires surgery.
São Paulo, São PauloAges 18 years+ - NCT06793709Recruiting
Study of Tasfygo for bile duct cancer with FGFR2 gene change
This study is watching people with a certain type of bile duct cancer that has a specific gene change (FGFR2 fusion). It looks at what happens when they take the drug Tasfygo after their cancer did not respond to chemotherapy.
TokyoAges Any age - NCT06793917RecruitingPhase 3
Immunotherapy plus chemo vs. chemo alone for advanced stomach cancer
This trial compares two types of chemotherapy with or without an immunotherapy drug (tislelizumab) for advanced stomach or gastroesophageal junction cancer. It aims to see which combination works better and has fewer side effects.
Fuzhou, FujianAges 18–70 - NCT06794073Recruiting
Combination therapy for advanced liver cancer
This trial is testing a combination of treatments for liver cancer that cannot be removed by surgery. It combines a targeted therapy pill (lenvatinib), an immunotherapy that boosts your immune system (PD-1 blocker), a procedure that destroys tumors with heat or cold (ablation), and a chemo procedure that delivers medicine directly to the liver (TACE). The goal is to see if this mix is safe and effective.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06796764Recruiting
Breathing tube safety during endoscopy in people with obesity
This trial tests a special breathing tube to see if it can prevent low oxygen levels during sedated endoscopy in people with obesity. If you are scheduled for both an upper endoscopy and colonoscopy, this study may help make the procedure safer.
Hangzhou, ZhejiangAges 18–70
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,896 recruiting gastroenterology studies from the U.S. registry right now, out of 12,425 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.