Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,896 recruiting studies in this area right now.
By phase
- Not applicable4,922
- Phase 21,186
- Phase 1581
- Phase 3466
- Phase 1/Phase 2394
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer492
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California462
- Arizona177
- Texas149
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,896 total
- NCT06833450Recruiting
Intestinal ultrasound for monitoring Crohn's disease
This study uses an intestinal ultrasound (a safe, painless scan) to check how well Crohn's disease is controlled. It may help doctors see inflammation without more invasive tests.
AmiensAges 18 years+ - NCT06833866RecruitingPhase 1
Testing a natural compound with chemo for advanced colorectal cancer
This trial combines a natural substance called hydroxytyrosol (HT) with standard chemotherapy (5-FU and possibly other drugs) for people with advanced or metastatic colorectal cancer that hasn't been treated yet. The goal is to see if adding HT makes the treatment work better.
Houston, TexasAges 18 years+ - NCT06834126RecruitingPhase 1
Papaverine with radiation for advanced rectal cancer
This trial tests if adding papaverine (a drug) to radiation therapy can help people with locally advanced rectal cancer avoid surgery and keep their rectum. It is for patients who have already had chemotherapy and want a non-surgical approach.
Duarte, CaliforniaAges 18 years+ - NCT06834178Recruiting
Counting undiagnosed hepatitis B, C and D in Austria
This study is looking for people in south-east Austria who have hepatitis B (HBV) or hepatitis C (HCV) that hasn't been fully treated or documented. It aims to find how many people also have hepatitis D (HDV) and are not yet aware of it.
Graz, StyraAges Any age - NCT06835023Recruiting
Dextran and Ringer's Lactate vs. Ringer's Lactate Alone for Pancreatitis
This trial compares standard fluids (Ringer's lactate) to a combination of dextran 40 and Ringer's lactate for treating mild or moderate acute pancreatitis. It aims to see which works better for rehydration and recovery.
Satu Mare, Satu Mare CountyAges 18 years+ - NCT06835374Recruiting
Comparing esophagitis in people with and without motility issues
This study looks at patients who have a swallowing disorder called achalasia and also show signs of acid reflux damage (esophagitis). It compares these patients to those without motility problems to better understand the link.
Hyderabad, TelanganaAges 18–75 - NCT06835569RecruitingPhase 1
ALTA3263 for advanced KRAS-mutated solid tumors
This trial tests an experimental pill called ALTA3263 for adults with advanced solid tumors that have a specific KRAS mutation. It's for people who have already tried other treatments or can't take them.
Orlando, FloridaAges 18 years+ - NCT06836453Recruiting
New sweat test for cystic fibrosis diagnosis
This trial tests a new device that measures how your sweat glands react to a common asthma medication. It aims to better classify people with cystic fibrosis or related diseases, and also includes healthy volunteers and carriers.
BrusselsAges Any age - NCT06836557RecruitingPhase 3
A safety study of tradipitant for stomach paralysis
This study is testing the safety of an investigational drug called tradipitant in people with stomach paralysis (gastroparesis) caused by unknown reasons or diabetes. It looks at how well the drug is tolerated over time.
LeuvenAges 18–70 - NCT06836739Recruiting
Genital nerve stimulation for bowel function after spinal cord injury
This trial tests whether gentle electrical stimulation of the genital nerve can help people with spinal cord injury improve bowel control. If it works, this at-home device could reduce constipation and make bowel care easier and more predictable.
Cleveland, OhioAges 18 years+ - NCT06837181Recruiting
Understanding diabetes complications in cystic fibrosis
This study looks at how long-term diabetes affects people with cystic fibrosis. It helps researchers understand complications and improve care.
Birmingham, AlabamaAges 12 years+ - NCT06837766Recruiting
Blood filtering for severe liver failure with organ damage
This study tests a blood-filtering system called CytoSorb in people with severe liver failure that also affects other organs. It aims to see if removing toxins from the blood can help reduce damage and improve recovery.
Ancona, AnconaAges 18 years+ - NCT06837831Recruiting
Mepilex Lite Dressing for radiation skin damage on anal area
This trial tests a special wound dressing (Mepilex Lite) to treat skin burns from radiation therapy in patients with rectal cancer. It may help heal the skin around the anal canal more comfortably.
Jinan, ShandongAges 18 years+ - NCT06838637Recruiting
Spinal cord stimulation at home for blood pressure issues
This trial tests using a gentle electrical device on your spine at home to help with dizziness from low blood pressure (orthostatic hypotension). It is for people with chronic spinal cord injury or multiple system atrophy who live in British Columbia.
Vancouver, British ColumbiaAges 19–70 - NCT06838845Recruiting
A study on upadacitinib for Chinese adults with moderate to severe ulcerative colitis
This study is looking at how well the drug upadacitinib works and how safe it is for Chinese adults with moderate to severe ulcerative colitis. It is not a treatment trial, but will observe patients who are already taking upadacitinib as decided by their doctor.
Guangzhou, GuangdongAges 18 years+ - NCT06839105RecruitingPhase 1
Testing AWT020 for advanced cancers
This study tests an experimental drug called AWT020 in people with advanced cancers that have either stopped responding to standard treatments or aren't candidates for them. The goal is to see if AWT020 is safe and tolerable across several cancer types such as lung cancer, melanoma, colorectal cancer, kidney cancer, and others.
Fuzhou, FujianAges 18 years+ - NCT06839248Recruiting
Fasting before procedures with GLP-1 meds
This study looks at whether people taking weekly GLP-1 medications (like Ozempic or Wegovy) should follow standard fasting rules or a 24-hour clear liquid diet before a procedure. The goal is to find the safest way to prepare.
Melbourne, VictoriaAges 18 years+ - NCT06839716Recruiting
Comparing a numbing gel with standard pain block after stomach cancer surgery
This study tests a gel made of ropivacaine (a numbing medicine) in a special hydrogel to see if it works as well as the standard pain block injection (TAP block) for controlling pain after minimally invasive stomach cancer surgery. The gel is applied directly near the surgical wound.
SeoulAges 20 years+ - NCT06840067Recruiting
Carbon ion radiotherapy for pancreatic cancer
This trial tests a new type of radiation called carbon ion therapy for people with advanced pancreatic cancer (stages III–IV) that has spread or can't be removed by surgery. It's combined with standard chemotherapy (gemcitabine plus nituzumab) to see if it can help shrink tumors and improve outcomes.
Wuwei, GansuAges 18–80 - NCT06840704RecruitingPhase 3
Can immunonutrition reduce esophagitis during lung cancer radiation?
This trial tests if a special nutritional supplement (immunonutrition) can lower the risk of severe throat and chest irritation (esophagitis) caused by radiation therapy for lung cancer. You may qualify if you are about to start chest radiation and can eat normally.
Changsha, HunanAges 18 years+ - NCT06841172RecruitingPhase 3
Radiation vs treatment switch for limited liver cancer growth
This trial tests whether giving radiation to a few growing cancer spots while continuing your current treatment works better than switching to a new treatment right away. It's for people whose advanced liver cancer has only barely started to progress on their first therapy.
Jinan, ShandongAges 18–75 - NCT06841406RecruitingPhase 4
Budesonide for chronic stomach discomfort after meals
This trial tests whether a medicine called budesonide can help people with a type of chronic stomach discomfort that gets worse after meals (functional dyspepsia). If you often feel full or bloated after eating and have had a normal stomach exam, this study may be a good fit for you.
LeuvenAges 18–70 - NCT06841484Recruiting
Robotic tools vs. human-assisted tools in stomach cancer surgery
This study tests two ways of using robotic tools during stomach cancer surgery: one where the surgeon controls all instruments from a console, and another where a human assistant operates some tools. It aims to see which method works better for patients having the lower part of the stomach removed.
SeoulAges 20 years+ - NCT06841705RecruitingPhase 2
Early vedolizumab as first treatment for colitis from immunotherapy
This trial tests if giving vedolizumab early can help control severe diarrhea and colon inflammation caused by immunotherapy (a type of cancer treatment). It may offer a new option for people who develop these side effects.
Boston, MassachusettsAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,896 recruiting gastroenterology studies from the U.S. registry right now, out of 12,425 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.