Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,903 recruiting studies in this area right now.
By phase
- Not applicable4,926
- Phase 21,187
- Phase 1582
- Phase 3466
- Phase 1/Phase 2395
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer101
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California462
- Arizona177
- Texas149
- Florida135
- Massachusetts127
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,903 total
- NCT07307703Recruiting
TENS for pain and anxiety after gallbladder surgery
This trial tests whether TENS, a mild electrical therapy, can reduce pain and anxiety after gallbladder removal. If you are having planned gallbladder surgery and are in good health, you may be able to participate.
Niğde, AdanaAges 18 years+ - NCT07308548RecruitingPhase 2
Testing HP515 for fatty liver disease (NASH/MASH)
This trial tests a new drug called HP515 for people with non-alcoholic fatty liver disease, including NASH or MASH. It aims to see if the drug can help reduce liver fat and improve liver health.
Beijing, Beijing MunicipalityAges 18–65 - NCT07308730Recruiting
Pain diary after gallbladder surgery
This study looks at whether using a pain diary can help people manage pain better after gallbladder removal surgery. If you are having this surgery for the first time and can read and write in Turkish, you may be able to join.
Muğla, MenteşeAges 18 years+ - NCT07309185RecruitingPhase 2
Adebrelimab, famitinib, and irinotecan for advanced stomach cancer
This trial tests a combination of three drugs (adebrelimab, famitinib, and irinotecan) for people with advanced stomach or gastroesophageal junction cancer that got worse after first-line treatment. It may offer a new option if you have already tried standard therapy.
Jinan, ShandongAges 18–75 - NCT07309289RecruitingPhase 3
Comparing two drug combos for first-line metastatic colorectal cancer
This trial tests whether a combination of chemotherapy drugs (NALIRIFOX) plus targeted therapy works better than another standard combination (FOLFOX) plus targeted therapy for people with metastatic colorectal cancer who haven't had treatment yet. It aims to find a more effective first treatment option.
ShanghaiAges 18 years+ - NCT07309601Recruiting
Sucrase-isomaltase genes and meal study for IBS
This study looks at how people with irritable bowel syndrome (IBS) handle meals based on their genes for an enzyme that breaks down sugar and starch. It may help explain why some people benefit from a starch- and sugar-reduced diet.
Malmö, Skåne CountyAges 18–70 - NCT07309991Recruiting
Oxygen Levels After Esophageal Cancer Surgery and Healing Complications
This study looks at whether low oxygen levels in the blood after esophageal cancer surgery increases the risk of problems with how the surgery heals. By understanding this connection, doctors may be able to better prevent or treat healing complications.
Guangzhou, GuangdongAges 18–80 - NCT07310173RecruitingPhase 2
Study of AST-3424 for advanced liver cancer with high AKR1C3
This trial tests a new drug called AST-3424 in people with advanced liver cancer that has gotten worse after prior treatment. It is for those whose tumor cells have high levels of a protein called AKR1C3, which the drug targets.
Nanjing, JiangsuAges 18–75 - NCT07310446Recruiting
Blood test study for colorectal cancer detection
This study is collecting blood samples to improve a test that looks for signs of colorectal cancer in the blood. It may help find cancer earlier or better understand how to detect it.
Lake Barrington, IllinoisAges 45–84 - NCT07310537Recruiting
Liquid biopsy trial for colorectal cancer liver metastases
This study tests whether a simple blood sample from your finger can detect tumor DNA as well as a standard blood draw. It is designed for people with colorectal cancer that has spread to the liver and hasn't responded to treatment.
Rotterdam, South HollandAges 21 years+ - NCT07310888Recruiting
Robotic stomach surgery using a 5th arm
This trial tests a new robotic technique for stomach cancer surgery using an extra robot arm. It may help you recover faster and with fewer complications.
Hong KongAges 18–75 - NCT07311408RecruitingPhase 2
New drug combo for stomach cancer after immunotherapy
This trial tests a combination of new drugs (SHR-1701, Rivoceranib, and possibly SHR-2554) for people with advanced stomach cancer whose disease has continued to grow after immunotherapy. It aims to find a better treatment option for those who have not had success with standard therapy.
Shenyang, LiaoningAges 18 years+ - NCT07312162Recruiting
Liver cancer health disparities study
This study looks at why some people with liver cancer are diagnosed at a later stage. Researchers want to understand differences in care and outcomes for patients in certain areas of Los Angeles County.
Los Angeles, CaliforniaAges 18 years+ - NCT07312292RecruitingPhase 2
Radioembolization with angiotensin II to boost tumor radiation dose
This trial tests whether adding a drug called angiotensin II (which tightens blood vessels in healthy tissue) during radioembolization can deliver more radiation directly to liver tumors. It is for people who have liver tumors (either primary or that have spread to the liver) and are scheduled for radioembolization.
Utrecht, UtrechtAges 18 years+ - NCT07312422RecruitingPhase 1/Phase 2
Low-dose radiation with immunotherapy and standard therapy for advanced pancreatic cancer
This trial combines low-dose radiation with an immunotherapy drug (pucotenlimab) and standard treatment for advanced pancreatic cancer. It aims to see if this triple therapy can help control the cancer without using a PD-1/PD-L1 inhibitor before.
Hangzhou, ZhejiangAges 18–75 - NCT07312760Recruiting
Talking therapy for existential distress in advanced cancer
This trial compares a short-term psychodynamic therapy (ORPHYS) with usual care for people with advanced cancer who are struggling with existential distress, such as loss of hope, fear of death, or loneliness. It aims to see if this therapy can help improve emotional well-being.
DüsseldorfAges 18 years+ - NCT07312864RecruitingPhase 1/Phase 2
New bioartificial liver for liver failure and small-for-size syndrome
This study tests a new bioartificial liver made from special cells to support people with severe liver problems, including liver failure or when the liver is too small after surgery. It aims to see if it is safe and can help the liver recover.
BeijingAges Any age - NCT07313579Recruiting
Heated chemotherapy for stomach cancer during surgery
This trial tests giving heated chemotherapy directly into the belly during surgery for stomach cancer. It might help people with cancer that has spread to the lining of the belly but not to other organs.
KyivAges 18–80 - NCT07314151Recruiting
TCM tools for inflammatory bowel disease
This study compares people with Crohn’s disease or ulcerative colitis to healthy volunteers to see if traditional Chinese medicine tools can help identify unique features of these conditions, like changes in tongue coating. It aims to improve how we diagnose and understand inflammatory bowel disease.
Taichung, NorthAges 18 years+ - NCT07314229Recruiting
Breathing limits during exercise in cystic fibrosis patients on ETI
This study measures how often people with cystic fibrosis who take elexacaftor-tezacaftor-ivacaftor (ETI) experience breathing limitations during exercise and what factors are linked to this.
LilleAges 18 years+ - NCT07314294RecruitingPhase 2
Study of EMB-01 for advanced left-sided colorectal cancer
This trial tests a new drug, EMB-01, in people with advanced left-sided colorectal cancer that has spread or cannot be removed. It may help if standard treatments have stopped working or caused side effects.
BeijingAges 18 years+ - NCT07314489RecruitingEarly Phase 1
Glucose and enzyme function in chronic pancreatitis
This study looks at how chronic pancreatitis affects blood sugar and digestion. It tests if your body makes enough enzymes and how your sugar control changes over time.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07314606Recruiting
Diet plus infliximab for kids with Crohn’s
This study tests if a special diet (called CDED) combined with infliximab (a biologic drug) is more effective than infliximab alone for children with newly diagnosed or relapsed moderate-to-severe Crohn’s disease. It aims to improve gut healing and reduce inflammation.
Vancouver, British ColumbiaAges 9–17 - NCT07314996Recruiting
Laparoscopic vs. open surgery for colon cancer with belly fat
This trial compares laparoscopy (minimally invasive) and open surgery for treating colon cancer in people with extra belly fat around internal organs (visceral obesity). The goal is to see which approach gives better recovery and outcomes.
Hangzhou, ZhejiangAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,903 recruiting gastroenterology studies from the U.S. registry right now, out of 12,451 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.