Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,916 recruiting studies in this area right now.
By phase
- Not applicable4,936
- Phase 21,188
- Phase 1583
- Phase 3465
- Phase 1/Phase 2396
- Phase 4237
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer148
- Crohn Disease144
- Ulcerative Colitis140
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)107
- Liver Cancer101
- Lung Cancer99
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma89
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona174
- Texas148
- Florida135
- Massachusetts127
- Alabama123
- New York123
- Maryland87
- Ohio80
- Pennsylvania72
Recruiting studies7,916 total
- NCT07673861Recruiting
Using ctDNA to find resistance and guide cancer treatment
This trial uses a simple blood test to look for changes in your cancer's DNA that might show why your current treatment stopped working. The results could help your doctor choose your next treatment more precisely.
LondonAges 18 years+ - NCT06714318Recruiting
Using blood samples to improve colorectal cancer screening
This study is looking at whether adding a blood test can make the current stool-based screening for colorectal cancer more accurate. It may help find cancers earlier or reduce the need for colonoscopy.
AabenraaAges 50–74 - NCT05777512Recruiting
Comparing feeding tube placement to improve breathing in preterm infants
This study tests whether placing a feeding tube past the stomach (postpyloric) can help very premature babies with ongoing lung problems breathe better. Infants born before 32 weeks who still need breathing support may join.
Boston, MassachusettsAges birth–1 year - NCT07486921RecruitingPhase 2
Etrasimod to prevent pouchitis after ulcerative colitis surgery
This trial tests if etrasimod can prevent pouchitis, which is inflammation of the surgically created internal pouch, in people who have had their colon removed due to ulcerative colitis. If you are at high risk for pouchitis or have had only one episode, this study may help keep your pouch healthy.
New York, New YorkAges 18–65 - NCT07487480Recruiting
Guselkumab for Crohn's after ustekinumab
This study looks at whether guselkumab, a different biologic medicine, can help people with Crohn's disease who have already tried ustekinumab but it didn't work well or caused side effects. It aims to see if switching to guselkumab is safe and effective.
Hangzhou, ZhejiangAges 18–75 - NCT07487623Recruiting
Nutritional supplement for liver protection in hepatitis C
This trial tests whether a special nutritional supplement can protect the liver in people with chronic hepatitis C. If you have mild to moderate liver damage and meet the criteria, you may be able to join.
Guadalajara, JaliscoAges 18–69 - NCT07488611RecruitingPhase 3
Progain nutrition program for stomach cancer surgery
This study tests a nutrition program (PROGAIN) for people having surgery for stomach cancer. The goal is to see if it helps with recovery.
Cheonan, Chungcheongnam-doAges 19 years+ - NCT07490132Recruiting
Observational study of past ERCP procedures
This trial looks back at past ERCP records to study the procedure better. You may qualify if you had an ERCP since 2000 and were at least 15 years old.
Dallas, TexasAges 15 years+ - NCT07490262RecruitingPhase 2/Phase 3
Immunotherapy combo for advanced liver cancer as first treatment
This trial tests a new combination of two immunotherapy drugs (IBI310 and sintilimab) as a first treatment for advanced liver cancer that cannot be removed by surgery. It aims to see if this combination is safe and works better than current options.
Hefei, AnhuiAges 18–75 - NCT07491848Recruiting
Mouth health study for hepatitis B and D patients
This study looks at mouth health in people with hepatitis B and D, including those taking a medicine called bulevirtide and those not taking it. It may help understand how these infections affect the mouth and gums.
CraiovaAges 18 years+ - NCT07492615RecruitingPhase 2
Sintilimab plus chemo vs. chemo alone for stomach cancer after surgery
This trial tests whether adding the immunotherapy drug Sintilimab to standard chemotherapy after surgery can help prevent stomach or gastroesophageal junction cancer from coming back. It's for people with high-risk or advanced stage cancer that has a specific genetic feature (dMMR or MSI-H).
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07492719Recruiting
Swallowing exercises with visual feedback after stroke
This study tests whether special swallowing exercises with a visual feedback tool can help people who have trouble swallowing after a recent stroke. If you've had a stroke in the last 6 months and have trouble swallowing, this may help you regain strength.
AnkaraAges 18 years+ - NCT07493044RecruitingPhase 1
Study of Super CAR-T for advanced liver cancer (GPC3-positive)
This trial tests a new cell therapy called Super CAR-T for people with advanced liver cancer that has GPC3 protein. It aims to see if the treatment is safe and effective. You may be eligible if your cancer has not responded to or stopped working on at least two standard treatments.
Guangzhou, GaungdongAges 18–75 - NCT07493421Recruiting
Surgery and heated chemotherapy for pancreatic cancer with spread to the abdomen
This trial tests if combining surgery to remove the tumor with a special heated chemotherapy bath for the abdomen (HIPEC) is safe and possible for people whose pancreatic cancer has spread only to the lining of the abdomen.
Shanghai, shangaiShanghai MunicipalityAges 18 years+ - NCT07493668RecruitingPhase 2
Fostrox plus Lenvatinib for advanced liver cancer after immunotherapy
This trial tests whether adding the drug Fostrox to the standard drug Lenvatinib works better than Lenvatinib alone for people with advanced liver cancer that has worsened after initial immunotherapy treatment. It is for those who cannot have surgery and have not had more than one prior cancer treatment.
Seongnam-si, Gyeonggi-doAges 19 years+ - NCT07493876Recruiting
Enhanced recovery after surgery for peritoneal cancer
This trial tests a special recovery program after surgery for cancer that has spread to the lining of the belly. The program aims to help you heal faster and feel better after the procedure.
Candiolo, TurinAges 18 years+ - NCT07494201Recruiting
MIMICC study for people with colorectal cancer
This trial is studying patients with colorectal cancer who are scheduled for surgery. Researchers want to learn more about the cancer to improve future treatments.
Candiolo, Torino (TO)Ages 18–75 - NCT07494318Recruiting
GI surgery training study for senior residents
This study looks at how advanced gastrointestinal surgery training is done for senior general surgery residents. It compares training for fourth- and fifth-year residents in accredited programs across the United States.
Dallas, TexasAges Any age - NCT07494968Recruiting
Finding ways to track diet compliance in IBS patients
This study looks for signs in your body—like breath and blood tests—that can show how well you are following a special diet for IBS. It aims to find better ways to track diet compliance, which could help make dietary treatments more effective.
Ann Arbor, MichiganAges 18–65 - NCT07495020Recruiting
Weight loss surgery study for type 2 diabetes
This study tests a new type of weight loss surgery for people with type 2 diabetes and a body mass index (BMI) between 25 and 35. The surgery uses a clip and a special stitch to help with weight loss and diabetes control.
AstanaAges 18–65 - NCT07495215RecruitingPhase 1/Phase 2
Personalized mRNA vaccine plus immunotherapy for liver cancer after surgery
This trial tests a personalized mRNA vaccine (iNeo-Vac-R01) combined with a PD-1 inhibitor to prevent liver cancer from coming back after surgery. It is for people with early-stage liver cancer who have a high risk of recurrence.
Hangzhou, ZhejiangAges 18–75 - NCT07495332Recruiting
Liver imaging study using new biomarkers
This study tests whether a new type of MRI scan can better detect and measure liver disease, including fatty liver and scarring, compared to standard CT scans. If you have chronic liver disease, this study may help improve how we diagnose and track it.
Durham, North CarolinaAges 18 years+ - NCT07496723Recruiting
Comparing diagnostic methods for appendicitis surgery
This trial looks at whether different ways of diagnosing appendicitis (like CT scans) are accurate. It's for people who already had surgery to remove their appendix and want to help doctors learn more.
Sanliurfa, ŞanlıurfaAges 18 years+ - NCT07496840Recruiting
Speedboat UltraSlim in POEM for swallowing disorders
This study is testing a new device called Speedboat UltraSlim™ during a procedure called POEM (per-oral endoscopic myotomy), which is used to treat achalasia and other swallowing disorders. The goal is to see if the device is safe and works well for people already scheduled for this surgery.
Houston, TexasAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,916 recruiting gastroenterology studies from the U.S. registry right now, out of 12,516 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.