Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT06421103Recruiting
ICG micro-dosing study for children having surgery
This study tests a tiny amount of a dye called Indocyanine Green (ICG) during surgery to see if it safely shows blood flow to the gut and urinary organs. It may help doctors check that these organs are getting enough blood during the operation.
LondonAges Up to 18 years - NCT05680246Recruiting
Study of long-term outcomes after special donor-liver preservation
This study looks at how well people do in the long run after liver transplant using donor livers that were preserved in a specific machine called DHOPE for more than 4 hours. It may help doctors understand whether this preservation method leads to better transplant outcomes over time.
GroningenAges 18 years+ - NCT03626194Recruiting
Tested an endoscopy method to close internal tissue openings
This study checks whether an endoscopy technique that brings tissue together safely closes several types of internal openings (like perforations or surgical leaks/defects). It also looks at whether the closures work well and have acceptable side effects.
Aurora, ColoradoAges 18–89 - NCT02920554Recruiting
Surgery comparison for T2–T3 gallbladder cancer
This study looks at whether a specific type of liver surgery (removing tissue in a wedge shape versus a different liver resection) improves outcomes for some patients with T2 or T3 gallbladder cancer. It may help decide the best surgical approach after the gallbladder has already been removed.
SuwonAges 19–80 - NCT06408584Recruiting
Short radiation plus two drugs for returning esophageal cancer
This trial tests a short course of radiation combined with two drugs (raltitrexed and tislelizumab) for people with esophageal cancer that has returned after standard treatment. The goal is to see if these combinations can shrink tumors and improve survival.
HefeiAges 18 years+ - NCT07851727Recruiting
Focused ultrasound for delayed stomach emptying
This study tests whether focused ultrasound (a non-invasive treatment using sound waves) can help improve symptoms of gastroparesis or delayed gastric emptying. It involves two visits where you will drink a nutritional shake and receive the ultrasound treatment, to see if it helps your stomach empty more normally.
Austin, TexasAges 18–70 - NCT07852273Recruiting
Sucralose sweetener study for Crohn's disease in remission
This study looks at whether the artificial sweetener sucralose (found in many diet products) affects people with Crohn's disease who are feeling well. You will consume sucralose or a placebo and track your symptoms and diet for a short period.
Chagrin Falls, OhioAges 18–75 - NCT07850791RecruitingPhase 2
Study of two drugs for advanced bile duct or gallbladder cancer
This trial tests a combination of two drugs, sacituzumab tirumotecan and pembrolizumab, for people with advanced bile duct or gallbladder cancer that has grown after previous treatment. The goal is to see if this combination can shrink tumors or slow the cancer's growth.
Beijing, Beijing MunicipalityAges 18–75 - NCT07851350Recruiting
Preparing for major surgery with a personalized fitness plan
This study offers a program to help you get physically and mentally ready for major surgery. It tests whether a personalized preparation plan improves recovery and reduces complications.
Varese, VAAges 18 years+ - NCT07850882Recruiting
Virus injection plus immunotherapy for advanced colorectal, stomach, or liver cancer
This study tests whether a special virus injected directly into tumors can help your body fight cancer when combined with an immunotherapy drug. It is for people with advanced colorectal, stomach, or liver cancer that has spread and who have tumors that can be reached for injection.
Guangdong, FoshanAges 18–75 - NCT07852091RecruitingPhase 2
Combination therapy aiming for a functional cure for chronic hepatitis B
This study tests a new combination of medicines to help your immune system control the hepatitis B virus, with the goal of stopping the need for long-term treatment. It may be an option for people who have taken or are currently taking hepatitis B medications.
Chongqing, Chongqing MunicipalityAges 18–60 - NCT05536089Recruiting
Testing blood methylation to predict colorectal cancer relapse
This trial checks a blood test for “ctDNA methylation” to see who may be at higher risk of colorectal cancer returning after surgery. It may help doctors better judge whether adjuvant chemotherapy is working or needed.
Hangzhou, ZhejiangAges 18 years+ - NCT06421818RecruitingPhase 2
Baitouweng Decoction for ulcerative colitis with damp-heat
This trial tests a traditional Chinese herbal formula called Baitouweng Decoction for people with mild to moderate ulcerative colitis who also have a specific pattern of symptoms called 'damp-heat' in the large intestine. It aims to see if the medicine can help reduce inflammation and improve symptoms.
Nanjing, JiangsuAges Any age - NCT06204835RecruitingPhase 1
ITGA6-targeted dye for liver cancer surgery guidance
This trial uses a special dye that lights up during surgery to help doctors see and remove liver cancer cells that have a specific protein (ITGA6). It aims to make surgery more precise and effective.
Guangzhou, GuangdongAges 18–80 - NCT06427460RecruitingPhase 2
Focused radiation therapy for solid tumors
This trial tests a special type of radiation that delivers a higher dose to the center of the tumor while limiting radiation to nearby healthy organs. It's for people with certain solid tumors that haven't spread widely or have only a few metastases.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06431100Recruiting
A study of TRT therapy for advanced solid tumors
This trial tests a new cell therapy called TRTs for people with advanced cancers like stomach, esophagus, cervical, breast, or lung cancer that no longer respond to standard treatments. The therapy uses your own tumor tissue or fluid to create a personalized treatment.
Zhengzhou, HenanAges 18–75 - NCT05911217RecruitingPhase 1
CT041 treatment after chemotherapy for resected pancreatic cancer
This Phase 1 study tests whether CT041 is safe and may help prevent pancreatic cancer from coming back after it’s been removed and you’ve completed standard chemotherapy. You may be eligible if your tumor is positive for CLDN18.2 and your recovery and blood tests meet key requirements.
Beijing, Beijing MunicipalityAges 18–79 - NCT06429839RecruitingPhase 2
Nimotuzumab with chemoradiation for esophageal cancer
This trial tests a drug called nimotuzumab combined with standard chemotherapy and radiation for patients with esophageal cancer. It may help improve treatment effectiveness for those whose cancer has not spread to other parts of the body.
BeijingAges 18–80 - NCT06415669RecruitingPhase 2
Combination therapy for advanced stomach cancer after immunotherapy
This study tests a combination of two drugs (paclitaxel, a chemotherapy, and apatinib, a targeted drug) with an immunotherapy (adebrelimab) for advanced stomach cancer. It may be an option if you've already tried immunotherapy and need a new approach.
Fuzhou, FujianAges 18–75 - NCT05630443Recruiting
Prone position after major abdominal cancer surgery
This study looks at whether placing you in a face-down (prone) position after major abdominal cancer surgery can improve recovery. You may be offered this positioning approach after your operation if it’s safe for you.
GothenburgAges Any age - NCT07848750Recruiting
Finger-press test for liver cancer detection
This study tests a new, non-invasive finger-press test that may help detect liver cancer (hepatocellular carcinoma). It compares results from people with liver cancer, people with benign liver disease, and healthy people to see if the test can tell them apart.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07845487RecruitingPhase 2
Study of PALI-2108 for moderate to severe ulcerative colitis
This trial tests an experimental drug called PALI-2108 against a placebo (a dummy treatment) for people with moderate to severe ulcerative colitis. It aims to see if PALI-2108 can help reduce symptoms and improve quality of life.
Sun City, ArizonaAges 18–75 - NCT03349762Recruiting
Huaier granules to help prevent colorectal cancer coming back
This study tests whether Huaier granules after surgery can lower the chance that colorectal cancer returns or spreads. It is for people who have recently had “radical” (complete) surgery for certain stages of colorectal cancer and are within about 2 months of that surgery.
Shijiazhuang, HebeiAges 18–75 - NCT05309863Recruiting
Compare home versus clinic weight programs for fatty liver
This study compares two weight-loss programs for children with fatty liver disease related to weight, to see which helps the liver and health better. You may be eligible if your child is already enrolled in a lifestyle program for childhood obesity and meets key safety checks.
Ghent, East-FlandersAges 8–18
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.