Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT06182319RecruitingPhase 3
Optimizing treatment for adhesive small bowel obstruction
This study tests the best way to treat a small bowel blockage caused by scar tissue (adhesions). It compares different care approaches to help you recover faster and avoid repeat blockages.
Los Angeles, CaliforniaAges 18 years+ - NCT06405776Recruiting
Lidocaine for pain and survival after bowel surgery in older adults
This study tests whether a drug called lidocaine, given during surgery, can help control pain after colon or rectal surgery and possibly improve long-term survival in older adults. The goal is to see if lidocaine offers better pain relief and recovery compared to standard care.
SichuanAges 60 years+ - NCT06403735RecruitingPhase 1
Study of QLC1101 for advanced solid tumors with KRAS G12D mutation
This trial tests a new drug, QLC1101, for people with advanced solid tumors that have a specific genetic change called KRAS G12D. It may be an option if you have tried other treatments or cannot take them.
Guangzhou, GuangdongAges 18 years+ - NCT06355206Recruiting
Recurrent acute pancreatitis study and treatment
This trial follows the natural course of recurrent acute pancreatitis and tests how well treatments work for it.
Shanghai, Shanghai MunicipalityAges Any age - NCT06406634RecruitingPhase 2
Cadonilimab, Lenvatinib, and HAIC for Unresectable Liver Cancer
This trial tests a combination of three treatments for advanced liver cancer that can't be removed by surgery. It uses an immunotherapy drug (cadonilimab), a targeted therapy pill (lenvatinib), and a direct chemotherapy infusion into the liver (HAIC). The goal is to see if this combo can shrink tumors and improve outcomes.
Changsha, HunanAges 18–75 - NCT06406244Recruiting
TEAS for chronic pain after liver surgery
This trial tests whether a gentle, needle-free electrical stimulation on certain points on the body (called TEAS) can help reduce chronic pain after liver surgery and improve long-term survival. It may be a good option if you are scheduled for a liver removal and want to explore non-drug pain relief.
ChengduAges 18–80 - NCT06124287Recruiting
Can MRI predict Crohn's relapse after stopping biologics?
This study looks at whether MRI scans can predict when Crohn's disease will come back after stopping biologic medications. If you are in remission and recently stopped a biologic, researchers want to see if your MRI results can help understand your risk of relapse.
LondonAges 16 years+ - NCT05786404RecruitingPhase 1
Fecal transplant study for people with active ulcerative colitis
This trial tests whether transplanting stool bacteria (called fecal microbiota transplantation, or FMT) can improve symptoms in people with active ulcerative colitis. You may be able to help test a new approach for restoring gut bacteria, while receiving standard ulcerative colitis care from your doctor.
Houston, TexasAges 18 years+ - NCT06023758RecruitingPhase 2
Study of two drugs with or without chemo for HER2-positive stomach cancer
This study tests two new immunotherapy drugs (KN026 and KN046) with or without chemotherapy (XELOX) for people with a specific type of advanced stomach cancer that makes too much HER2 protein. The goal is to see if this combination can shrink tumors or slow the cancer.
Beijing, Beijing MunicipalityAges 18–75 - NCT06338865Recruiting
Lower pressure vs. standard pressure for laparoscopic gynecologic surgery
This trial compares using lower gas pressure during minimally invasive gynecologic surgery to the standard pressure. The goal is to see if lower pressure reduces pain and speeds recovery after surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT05494086Recruiting
Laparoscopic stomach surgery for early gastric cancer
This study looks at a surgical technique (“dual-port laparoscopic distal gastrectomy”) for people with stomach adenocarcinoma at an early, specific stage. The goal is to remove the tumor with clean margins (called an “R0” result) and see how this approach works safely.
Guangzhou, GuangdongAges 18–75 - NCT04366999Recruiting
Bariatric surgery for fatty liver disease in people with obesity
This trial looks at whether weight-loss (bariatric) surgery helps people with fatty liver disease, including “NASH,” and related liver scarring. If you have obesity and a confirmed liver fat diagnosis (and for NASH, biopsy-proven NASH with some fibrosis), the study may follow your outcomes after surgery.
Beijing, Beijing MunicipalityAges 16–65 - NCT06410651RecruitingPhase 2
Nimotuzumab with chemoradiation for advanced esophageal cancer
This trial tests adding the targeted drug nimotuzumab to standard chemotherapy and radiation for people with esophageal cancer that cannot be removed by surgery. It may help shrink the tumor or stop it from growing further.
BeijingAges 18–80 - NCT06051253RecruitingPhase 4
Personalized infliximab dosing for active Crohn's fistulas
This study tests whether adjusting the dose of infliximab (a biologic medicine given by IV) based on drug levels in your blood works better for treating draining fistulas caused by Crohn's disease. It is for people who have not tried other biologics and whose fistulas have not healed with usual treatments.
SeoulAges 19–80 - NCT05927584Recruiting
Local removal for early rectal cancer without extra treatment
This trial studies removing an early rectal cancer tumor locally (through the rectum/anal area) with no additional therapy afterward. The goal is to preserve organs and maintain quality of life while still trying to cure the cancer.
MadridAges 18 years+ - NCT06064864Recruiting
Switching Infliximab from IV to Subcutaneous for Crohn's
This study tests whether switching from an IV infliximab to a subcutaneous (under-the-skin) version is safe and works well for people with moderate to severe Crohn's disease. It's for people who have never used a biologic and need a new treatment option.
SeoulAges 18–100 - NCT05866783Recruiting
Blood test to predict cancer coming back after liver transplant
This study uses a blood test (looking at sugars in the blood) to help predict whether liver cancer will come back after a liver transplant. It may help doctors monitor you more accurately and earlier if cancer returns.
GhentAges 18 years+ - NCT06347120Recruiting
Nasogastric tube for bowel obstruction
This trial compares the effectiveness of placing a nasogastric tube versus not placing one for treating small bowel obstructions caused by adhesions. It aims to see if the tube is really needed for patients who do not have complications.
AmiensAges 18–85 - NCT06413459Recruiting
New markers for lung disease in cystic fibrosis
This study looks for biological markers (substances in your body) that can show if a lung infection with Mycobacterium abscessus is getting worse. It may help researchers develop better ways to track and treat the infection in people with cystic fibrosis.
Milan, MIAges 18 years+ - NCT06417567Recruiting
Preventing nausea and vomiting after GI cancer surgery
This study tests whether the medication NEPA (Netupitant and Palonosetron) can prevent nausea and vomiting in people who have had surgery for liver, gallbladder, or pancreatic cancer. It may help those who want to avoid post-surgery sickness.
Tianjin, Tianjin MunicipalityAges 18–65 - NCT06167967Recruiting
Blood test for chemotherapy guidance in stage 3 colorectal cancer
This study uses a blood test to check for tumor DNA after surgery, which may help doctors decide if you need additional chemotherapy. It is for people with stage 3 colorectal cancer that is removed by surgery.
Hanzhou, ZhejiangAges 18–75 - NCT06068114Recruiting
Stomach function study in people with diabetes
This study looks at how diabetes affects stomach function by measuring stomach activity with special tests. It may help doctors better understand and treat stomach problems in people with diabetes.
OstravaAges 18–70 - NCT05954078RecruitingPhase 3
ctDNA-guided chemotherapy after colon cancer surgery
This trial checks whether a special blood test (ctDNA methylation) can help decide the best chemotherapy after surgery for people at higher risk of colon cancer coming back. It may help spare some patients unnecessary treatment while aiming to improve outcomes for those likely to relapse.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06418165Recruiting
Cooled oxygenated machine perfusion for liver transplant
This study tests a new way to preserve donated livers using a machine that keeps the organ cool and oxygenated before transplant. It may help improve how well the liver works after the surgery.
ViennaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.