Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT03808584Recruiting
Core muscle training after abdominal surgery to reduce hernia and pain
This study tests whether guided “core” muscle training after abdominal surgery can lower the chance of developing an incisional hernia and reduce pain. You may be eligible if you’re having abdominal surgery and can safely do the study exercise plan.
KoblenzAges 18 years+ - NCT04490031RecruitingPhase 4
Ketamine sedation for ERCP procedure
This trial tests whether using ketamine as a sleep/sedation medicine during ERCP (a scope procedure to check/clear bile or pancreatic ducts) is safe and effective. If you’re scheduled for ERCP and can consent, this study may help doctors improve sedation options for patients like you.
Bandar Tun Razak, Kuala LumpurAges 16 years+ - NCT04236128Recruiting
Mobile app support after colorectal surgery at home
This trial studies a home mobile app to help people after elective colorectal surgery transition safely back home. It may help you feel more supported with recovery and instructions once you’re discharged.
Toronto, OntarioAges 18 years+ - NCT04282473Recruiting
Mesh or no mesh after a colostomy hernia
This study looks at how often a hernia happens 5 years after a terminal colostomy. It compares using a mesh patch to reinforce the area versus not using mesh, to see which approach may work better.
BesançonAges 18 years+ - NCT04524871RecruitingPhase 1/Phase 2
Immunotherapy combinations for advanced liver cancer
This Phase 1/2 study tests new combinations of immune system medicines in people with advanced liver cancer that cannot be cured by surgery. It looks for safer treatment and signs that the medicines can shrink or control the cancer.
Costa Mesa, CaliforniaAges 18 years+ - NCT04358159Recruiting
Compare Ventralex and onlay mesh for small hernias
This study compares two types of surgical mesh used to repair small incisional hernias (or hernias that came back after a previous repair). It may help determine which mesh works better and with fewer problems.
KarlskogaAges 18–100 - NCT04037956Recruiting
No-tube surgery versus usual laparoscopy for rectosigmoid cancer
This trial compares two surgical approaches to remove rectosigmoid cancer: a “tubeless” method versus standard laparoscopic surgery. It aims to see which approach works better and is easier or safer for recovery.
Guangzhou, GuangdongAges 18–75 - NCT04248569RecruitingPhase 1
Vaccine plus immunotherapy for a specific liver cancer gene change
This Phase 1 trial tests a personalized peptide vaccine (targeting the DNAJB1-PRKACA fusion) combined with immunotherapy drugs to treat fibrolamellar hepatocellular carcinoma (FLC) or other eligible non-FLC cancers with the same gene fusion. It aims to see whether this immune-based treatment can shrink tumors and improve outcomes safely.
Baltimore, MarylandAges 12 years+ - NCT04143516RecruitingPhase 2/Phase 3
Test tissue testing right after liver tumor ablation
This study looks at liver metastases treated with a procedure that destroys tumors (ablation) and then checks tumor tissue right away. The team wants to see whether the tissue results can guide immediate retreatment to better control cancer in the liver.
New York, New YorkAges 18 years+ - NCT04195425Recruiting
Breastfeeding study on newborn gut health
This study looks at how breastfeeding may affect a baby’s gut (digestive) health. It enrolls parents during pregnancy and follows the family after birth to collect information and samples, to better understand what supports healthy development.
LilleAges 18 years+ - NCT04623424Recruiting
Study gut bacteria during stem cell transplant
This study looks at changes in your gut bacteria (microbiome) around the time of stem cell transplant. The goal is to understand how these bacteria relate to transplant outcomes, which may help doctors improve care in the future.
Detroit, MichiganAges 18–80 - NCT04150614RecruitingPhase 4
Granisetron skin patch versus ondansetron for transplant nausea
This study compares a granisetron skin patch to ondansetron tablets/medicine to see which works better to prevent nausea and vomiting around stem cell transplant. It may help your care team choose the most effective anti-nausea option for transplant patients.
Chicago, IllinoisAges 18–75 - NCT04295473Recruiting
Test of smaller-incision stomach surgery for gastric cancer
This trial studies a stomach cancer surgery done with fewer/smaller incisions (laparoscopic with reduced ports). It may help people with certain early-to-mid stage stomach cancers by comparing whether this approach is safe and effective for them.
Nanchong, SichuanAges 18–90 - NCT04367987Recruiting
Heart Rate Changes After Colorectal Surgery
This study measures how your heart rate varies after planned colorectal surgery to see if these changes can predict complications. Researchers will monitor your heart rhythm before and after your operation to understand whether certain patterns might warn of problems early.
NîmesAges 18 years+ - NCT04523701RecruitingPhase 3
Testing a “white test” to find bile ducts during liver surgery
This trial studies whether a simple “white test” using a special lipid (fat-like) solution can help the surgical team spot open bile ducts early during liver removal. Finding them sooner may help prevent bile leakage after liver surgery.
AarauAges 18 years+ - NCT04527055Enrolling by invitationPhase 4
Bismuth treatment for H. pylori: 10 or 14 days
This trial compares two common stomach medicine plans that use bismuth for 10 days versus 14 days to clear an H. pylori infection. It may help you find a shorter or more effective treatment schedule if you have H. pylori confirmed by an endoscopy.
TainanAges 18–100 - NCT04678583Recruiting
Surgery plan for RAS-mutant colon cancer liver metastases
This trial studies an approach to surgically removing liver metastases from colon (or rectal) cancer that has an RAS gene mutation (KRAS or NRAS). If you qualify, you would be evaluated for whether a “complete” (R0) liver operation is planned and technically possible, aiming to improve cancer control by how the liver is cut.
Mannheim, Baden-WurttembergAges 18 years+ - NCT04408482Recruiting
Pancreatic stent to prevent pancreatitis after ERCP procedure
This study looks at whether placing a small tube (a pancreatic stent) during an ERCP procedure can lower the chance of getting pancreatitis afterward. If you need a difficult ERCP with bile duct access, the results may help improve prevention of post-procedure pancreatitis.
HelsinkiAges 18–100 - NCT04229043Recruiting
Test drink timing to study stomach emptying in late labor
This study measures how quickly a pregnant person’s stomach empties a water or sports drink during late labor. It may help improve safety and timing of what people can drink when labor is starting or being induced.
Boston, MassachusettsAges 18–50 - NCT04161768RecruitingPhase 3
Antibiotic pill study to prevent repeat belly infection in liver disease
This study tests whether taking norfloxacin plus itopride helps prevent another episode of spontaneous bacterial peritonitis (a serious belly infection) in people with cirrhosis and fluid buildup in the abdomen. It compares that combo to norfloxacin alone to see which approach better lowers repeat infections.
TantaAges Any age - NCT04306458Recruiting
Testing robot-assisted vs standard surgery for resectable esophageal cancer
This trial compares a robot-assisted approach to a standard minimally invasive approach for surgery in people with certain types of esophageal or gastroesophageal junction cancer that can be removed. It aims to see which surgery method works better and is safer for these patients.
MainzAges 18–90 - NCT04520737Recruiting
Exercise coaching during chemotherapy for liver metastases
This trial studies whether a “prehab” program—structured exercise and preparation—can help people keep up function while they are on chemotherapy for colorectal cancer that has spread to the liver. If you can safely exercise, the program may help you tolerate treatment and stay active.
TarragonaAges 18 years+ - NCT06472973Recruiting
Addiction support after liver transplant
This trial tests a special addiction support program for people who have had a liver transplant because of alcohol-related liver disease. The goal is to help them stay healthy and avoid drinking again.
BesançonAges 18 years+ - NCT04578340Recruiting
Follow-up after hernia repair with mesh
This study looks at long-term outcomes after abdominal hernia surgery where a mesh patch was used. It may help doctors understand what to expect long-term and how well mesh repair works over time.
Evanston, IllinoisAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.