Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT07482891RecruitingPhase 4
Preventing nausea and vomiting from multi-day chemo
This study tests if two medicines given together, fosaprepitant and palonosetron, can prevent nausea and vomiting caused by strong chemotherapy given over several days. It's for people who have never had chemo before and are about to start a multi-day treatment for a solid tumor.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07658222Recruiting
Understanding heart changes in advanced cirrhosis
This study is looking at how cirrhosis affects the heart (called cirrhotic cardiomyopathy). It aims to understand the connection between advanced liver disease and heart function, which may help improve care for people with cirrhosis.
Nashville, TennesseeAges 18 years+ - NCT06660550Recruiting
Needlescopic vs traditional laparoscopic hernia repair in children
This trial compares a newer, smaller-scope surgery (needlescopic) with the standard laparoscopic method for fixing inguinal hernias in kids. It aims to see if the needlescopic approach is safer or has better recovery.
SohagAges Up to 18 years - NCT06031584RecruitingPhase 1/Phase 2
Testing BL-M07D1 for HER2-positive or low solid tumors
This trial tests a new drug called BL-M07D1 for people with certain advanced solid tumors that have the HER2 protein (high or low amounts). The goal is to see if it can shrink or slow the growth of these cancers, especially in urinary and digestive system tumors.
Beijing, Beijing MunicipalityAges 18–75 - NCT06763432Recruiting
Colonoscopy readiness study
This study helps patients aged 45–75 at Codman Square Health Center get ready for a colonoscopy to screen for colon cancer. It aims to make the process easier and more comfortable.
Boston, MassachusettsAges 45–75 - NCT07043400RecruitingPhase 3
Study comparing two ways to give tislelizumab plus chemo for stomach cancer
This trial compares a shot under the skin versus an IV infusion of tislelizumab, given along with chemotherapy, for people with advanced stomach or gastroesophageal junction cancer that has not been treated before. The goal is to see if the shot works as well as the IV and may be more convenient.
Chandler, ArizonaAges 18 years+ - NCT07511764Recruiting
Comparing two airway devices for children's hernia surgery
This trial compares a laryngeal mask airway with a breathing tube in children having laparoscopic hernia repair. It aims to see which method works better.
Diyarbakır, Eyalet/YerleşkeAges 1–10 - NCT04611217Recruiting
Testing fiber to change gut bacteria and help with fullness
This study tests how eating different amounts of dietary fiber affects your gut bacteria and how full you feel. You may be able to help researchers understand whether fiber can support appetite and metabolic health.
Columbia, MissouriAges 20–55 - NCT07510347Recruiting
Pain relief study for sleeve gastrectomy patients
This study tests if giving pain medicine in a different area of the abdomen can reduce pain after weight-loss surgery. It may help you feel more comfortable after your sleeve gastrectomy.
Shibīn al Kawm, MenofiaAges 20–60 - NCT07464600Recruiting
CRP testing to predict leaks after colon surgery
This trial checks if a simple blood test for CRP (a marker of inflammation) after colorectal surgery can help predict if a patient might develop a leak where the bowel is reconnected. If you are having planned colon or rectal surgery, this study might be for you.
AmiensAges 18 years+ - NCT06123494RecruitingPhase 3
A trial of SHR-A1811 for HER2-positive gastric cancer
This trial tests a new drug, SHR-A1811, for people with HER2-positive stomach or gastroesophageal junction cancer that has worsened after initial treatment. It aims to see if this drug can help when standard anti-HER2 therapy stops working.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06769438Recruiting
Reducing unplanned hospital visits after emergency digestive surgery
This study tests a new care pathway (RAUC) to see if it can help reduce unplanned hospital visits after emergency digestive surgery. If you are having emergency surgery for a digestive issue, you may be able to join.
RouenAges 18 years+ - NCT06988852RecruitingPhase 2
Chemo infusion into liver for colorectal cancer spread
This trial tests a strong chemotherapy combination given directly into the liver's blood supply (called HAIC) for people whose colorectal cancer has spread only to the liver and cannot be removed with surgery yet. The goal is to shrink the liver tumors enough so they can be surgically removed.
Wuhan, HubeiAges 18–75 - NCT07493902Recruiting
Acupuncture for swallowing problems after a stroke
This study tests whether acupuncture can help people who have trouble swallowing after a stroke. It looks for volunteers who had a stroke within the past year and now have swallowing difficulty that is not too mild or too severe.
Tianjin, Tianjin MunicipalityAges 18–80 - NCT06459869RecruitingPhase 1
NG-350A plus chemoradiotherapy for advanced rectal cancer
This trial is testing a new virus-based therapy (NG-350A) combined with standard chemoradiotherapy for people with locally advanced rectal cancer. It aims to see if the combination is safe and can help shrink tumors before surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT06482788RecruitingPhase 2
Immunotherapy plus chemo before & after junction cancer surgery
This trial tests giving an immunotherapy drug (adebrelimab) along with two chemotherapy drugs (capecitabine and oxaliplatin) before and after surgery for a specific type of stomach-cancer junction tumor. It aims to see if this combination is safe and effective in shrinking the tumor and improving outcomes.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07487896RecruitingPhase 3
YL201 vs. chemo for advanced esophageal cancer after first treatment
This trial tests a new drug called YL201 against standard chemotherapy for people with advanced esophageal squamous cell carcinoma that has gotten worse after one prior treatment. The goal is to see if YL201 works better at controlling the cancer.
Anqing, AnhuiAges 18 years+ - NCT07124260Recruiting
Gut and tongue bacteria study for low ovarian reserve
This study looks at the bacteria in your gut and on your tongue to see if they are different in women with low ovarian reserve. It may help doctors find new ways to understand and treat this condition.
Hangzhou, ZhejiangAges 20 years+ - NCT07487311Recruiting
Study of guselkumab plus JAK inhibitors for tough-to-treat IBD
This trial tests a combination of two medications—guselkumab and a JAK inhibitor—for people with inflammatory bowel disease that hasn't responded to other treatments. The goal is to see if this combination is safe and effective for patients with hard-to-control Crohn's disease or ulcerative colitis.
Hangzhou, ZhejiangAges 14–80 - NCT07125001Recruiting
Mango study for Hispanic/Latino teens' health
This study looks at whether eating mango every day for 12 weeks can improve gut health and heart health in Hispanic/Latino teens who are overweight. Participants will be asked to eat a mango product and take daily photos.
Davis, CaliforniaAges 12–19 - NCT07483567RecruitingPhase 2
Combination treatment before and after stomach cancer surgery
This trial tests a combination of experimental drugs (IBI343, Sintilimab, and chemotherapy) before and after surgery for a specific type of stomach cancer that is CLDN18.2 positive. The goal is to see if this treatment shrinks the tumor and helps prevent the cancer from coming back.
Beijing, Beijing MunicipalityAges 18–75 - NCT06997419Recruiting
Dexamethasone for nausea after open surgery
This trial tests if a steroid called dexamethasone palmitate can prevent nausea and vomiting after open surgery. It is for people having planned spine, chest, or abdominal surgery under general anesthesia.
BeijingAges 18–65 - NCT07127471Recruiting
Comparing two colonoscopy methods for finding pre-cancerous polyps
This study tests two different colonoscopy techniques to see which one finds more pre-cancerous polyps called serrated lesions. It may help your doctor choose the best way to screen for colon cancer during your procedure.
Montreal, QuebecAges 40–80 - NCT07464756RecruitingPhase 2
Study of SHR-1701 and apatinib with chemo before stomach cancer surgery
This trial tests whether adding SHR-1701 (an immunotherapy) with or without apatinib (a targeted therapy) to standard chemotherapy before surgery can help treat gastric cancer. It is for people with stomach or gastroesophageal junction cancer that has spread to nearby lymph nodes but is still removable.
Nanjing, JiangsuAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.