Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,685
- Phase 21,189
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer90
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California442
- Arizona190
- Texas140
- Alabama129
- Florida127
- New York120
- Massachusetts119
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,606 total
- NCT07654751RecruitingPhase 4
Study of Tremfya in breast milk of breastfeeding women
This study measures how much Tremfya (guselkumab) gets into breast milk for women who are already taking it for conditions like psoriasis or arthritis and choose to breastfeed. It helps understand if the drug passes to the baby.
Chapel Hill, North CarolinaAges 18 years+ - NCT07654283RecruitingPhase 2
Study of AHB-137 for chronic hepatitis B
This trial tests a new drug, AHB-137, in people with chronic hepatitis B who are already on a stable antiviral treatment. It aims to see if AHB-137 can help lower the virus further or improve outcomes.
Palo Alto, CaliforniaAges 18–65 - NCT07650773Recruiting
Understanding liver cancer care patterns and outcomes
This study reviews medical records of people diagnosed with hepatocellular carcinoma (liver cancer) between 2015 and 2023 to better understand how the disease progresses and how different treatments work. Your information helps researchers learn what care approaches work best for future patients.
Al MansurahAges Any age - NCT07653776Recruiting
Study of wellness products for gut health
This study tests whether certain daily wellness products can improve gut-related quality of life. If you have room to feel better and are willing to take a product without knowing if it's active or a placebo, you may be able to join.
Del Mar, CaliforniaAges 21–105 - NCT07647172Recruiting
Flavonoid Treatment for Hemorrhoids After Minimally Invasive Surgery
This study tests whether a plant-based medicine called MPFF (a purified flavonoid fraction) helps reduce symptoms and improve healing after minimally invasive surgery for hemorrhoids. You would take this medicine before and after your scheduled procedure.
MoscowAges 18 years+ - NCT07653685RecruitingPhase 1/Phase 2
Study of a new drug with chemotherapy for advanced colorectal cancer
This trial tests a new drug (TQB2930) combined with chemotherapy, with or without another drug called bevacizumab, for people whose colorectal cancer has spread or cannot be removed by surgery and has a specific protein called HER2. The goal is to see if this combination can help shrink tumors or slow the cancer's growth.
Beijing, Beijing MunicipalityAges 18–75 - NCT07652632Recruiting
Regenerative endoscopy for hard-to-treat Crohn's fistulas
This trial tests a new, less invasive procedure called regenerative endoscopy to repair complex fistulas in people with Crohn's disease. It's for those who haven't gotten better with standard treatments like biologics or surgery.
Hyderabad, TelanganaAges 18–65 - NCT07649057Recruiting
Urine Test for Early Colorectal Cancer Detection
This study tests whether a simple urine sample can detect colorectal cancer or precancerous polyps. Researchers want to see if this non-invasive test could help identify people at risk before symptoms develop or catch cancer earlier.
New York, New YorkAges 18 years+ - NCT07651553Recruiting
Transanal vs. Robotic Surgery for Rectal Cancer
This trial compares two surgical approaches to remove rectal cancer while preserving bowel function. Researchers want to see which method—performed through the anus or with robotic assistance—leads to better outcomes and quality of life.
Guangzhou, GuangdongAges 18–75 - NCT07652892Recruiting
Fatty Liver, Memory, and Health in Men and Women
This study looks at how fatty liver disease (related to metabolism) affects memory, strength, and quality of life—especially comparing men and women. It helps understand why some people with fatty liver feel more tired or have trouble thinking clearly.
Barcelona, BarcelonaAges 20–80 - NCT07646574Enrolling by invitation
Non-surgical treatment after immunotherapy for specific gastric cancer
This trial tests whether patients with advanced gastric cancer (a specific type called dMMR/MSI-H) can be treated without surgery after receiving immunotherapy and chemotherapy. The goal is to see if this approach can control the cancer while avoiding the risks of surgery.
Chengdu, SichuanAges 18 years+ - NCT07646639RecruitingPhase 2
Radiation, chemotherapy, and immunotherapy for advanced rectal cancer
This study tests a combination of radiation therapy, chemotherapy drugs (capecitabine and oxaliplatin), and two types of immunotherapy (a PD-1 blocker and IL-2) for locally advanced rectal cancer. The goal is to see if this combination helps shrink tumors and improve outcomes before surgery.
Nanjing, JiangsuAges 18–70 - NCT07647640Recruiting
Tracking flare-ups with your smartwatch
This study tests whether data from your own smartwatch or smartphone can help detect when your Crohn's disease or ulcerative colitis flares up. If you join, you'll use your own device, and no extra equipment will be provided.
's-HertogenboschAges 18 years+ - NCT07646834Recruiting
Brain-Gut Study of IBS with Anxiety and Depression
This study explores how stress and mood changes affect irritable bowel syndrome (IBS) using brain imaging. Researchers will scan your brain and collect health information to understand the connection between your gut and mental health.
Xi'an, ShaanxiAges 18–60 - NCT07649928RecruitingEarly Phase 1
Testing ES502 for Advanced Pancreatic and Other Cancers
This early-stage trial tests a new drug called ES502 for patients with advanced cancers (including pancreatic cancer) that have a specific genetic mutation and certain immune markers. The study aims to find the right dose and see if it helps shrink tumors.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07651644Recruiting
AI tool to help doctors read gastric cancer imaging
This study tests whether an AI-assisted tool helps radiologists (doctors who read imaging scans) better interpret CT scans of gastric cancer patients. The research compares how accurately doctors read scans with and without AI help.
Shenyang, LiaoningAges Any age - NCT07651358Recruiting
Web Program to Help Pancreatic Cancer Patients Exercise and Eat Better
This study tests a personalized website program called COMPASS designed to help people with stage I-III pancreatic cancer improve their exercise and diet while receiving chemotherapy before surgery. The goal is to see if this program helps patients feel better and stay stronger during treatment.
Portland, OregonAges 18 years+ - NCT07649681Recruiting
AI nutrition help for taste changes from cancer treatment
This study tests whether an AI-powered nutrition program can help people with taste changes caused by cancer therapy. You'll get personalized recipe suggestions and nutrition advice through an online portal to help you eat better during treatment.
Augsburg, BavariaAges 18 years+ - NCT07648446Recruiting
Learning About Pulses and Gut Health in Children
This study teaches children ages 6–13 about pulses (beans, lentils, chickpeas) and how they affect gut health. Researchers want to understand whether eating pulses helps children's digestive systems work better.
Tallahassee, FloridaAges 6–13 - NCT03418350Recruiting
Study how acid reflux may affect lung scarring
This trial studies whether reflux (acid moving up toward the throat) plays a role in idiopathic pulmonary fibrosis (IPF), a condition where lung tissue becomes scarred. It may help doctors understand triggers that could worsen symptoms and guide more targeted care.
Denver, ColoradoAges 40–95 - NCT05072041Recruiting
Degradable chemo bead treatment for liver cancer
This trial studies a new type of “degradable” chemo bead delivered through a catheter to treat hepatocellular carcinoma (HCC). It aims to check safety and whether the treatment works when surgery or transplant is not an option.
Seoul, SeoulAges 19–79 - NCT05919030RecruitingPhase 3
Tislelizumab with chemoradiation for advanced esophagus cancer
This trial tests whether adding tislelizumab to chemoradiation as the first treatment helps people with advanced esophageal squamous cell cancer. It aims to improve how well the cancer responds when it cannot be cured with surgery or full-dose curative treatment.
Wuhan, HubeiAges 18 years+ - NCT06560307Recruiting
Enhanced stimulation for gastroparesis relief
This trial tests a new way to program an implanted device (Enterra®) to better treat severe nausea and vomiting caused by gastroparesis. If you have frequent nausea and vomiting despite other treatments, this study might help find a better setting for your device.
Tampa, FloridaAges 18–70 - NCT06296706RecruitingPhase 3
Study of a new docetaxel for advanced stomach cancer
This trial is testing a new form of the chemotherapy drug docetaxel (called albumin-bound docetaxel) for people with advanced stomach or gastroesophageal junction cancer that has worsened after initial treatment. It aims to see if this version of the drug works better or has fewer side effects.
Shijiazhuang, HebeiAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 11,952 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.