Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT06822816Recruiting
Video library for AI endoscopy training
This trial collects videos of endoscopy procedures to help train artificial intelligence to improve quality reporting and education. If you are having an upper endoscopy or colonoscopy, you may be able to participate.
Montreal, QuebecAges 18 years+ - NCT07081698Recruiting
Walnuts as a first solid food for healthy babies
This study tests whether adding walnuts (ground into a powder or paste) as a first solid food is safe and healthy for breastfed babies. It may help families understand how to introduce nuts early.
Fort Collins, ColoradoAges 5 months–5 months - NCT07081100Recruiting
Probiotics for stomach and bowel health improvement
This trial tests whether a probiotic supplement can help people with common stomach or bowel issues like indigestion or constipation that are not caused by another disease. You take the probiotic daily to see if it improves your symptoms.
Suzhou, JiangsuAges 18–65 - NCT06844318Recruiting
IBD treatment and frailty in patients over 60
This study looks at how inflammatory bowel disease (IBD) activity affects frailty in people over 60. It tests whether starting or changing medication for active IBD can help understand and manage frailty.
Vitoria-Gasteiz, AlavaAges 60 years+ - NCT07074379Recruiting
Treatments for painless chronic pancreatitis
This study tests whether a procedure using a scope (endotherapy) or shock waves to break up stones can help people with painless chronic pancreatitis who have not had these treatments before.
Shanghai, Shanghai MunicipalityAges 18–85 - NCT07609641Recruiting
Surgery for Bile Duct Cancer: Two Surgical Approaches
This trial compares two different surgical approaches for treating bile duct cancer (cholangiocarcinoma) to see which method works better and is safer. You would undergo surgery and have your recovery and outcomes closely monitored.
Tianjin, Tianjin MunicipalityAges 18–80 - NCT07063979Recruiting
Using a nerve-stimulation band to reduce nausea after weight-loss surgery
This trial tests if adding a small nerve-stimulation device (Reliefband) to standard recovery care can help prevent nausea and vomiting in the first 24 hours after robotic sleeve gastrectomy. If you are having this surgery and match the criteria, you may be able to join.
Plainsboro, New JerseyAges 18–75 - NCT06561529Recruiting
Stomach bypass stent for liver scarring in obese patients
This study tests a stomach bypass stent to treat liver scarring caused by fatty liver disease in people with obesity. If you have obesity and a confirmed liver condition called NASH with moderate scarring, this stent might help you achieve weight loss and improve your liver health.
Riga, RigaAges 18–65 - NCT07622797RecruitingPhase 2
Immunotherapy with chemotherapy and radiation for esophageal cancer
This trial tests a new immunotherapy drug (camrelizumab) combined with standard chemotherapy and radiation to treat advanced esophageal cancer while avoiding surgery if possible. The goal is to shrink the tumor and help you keep your esophagus working.
Luoyang, HenanAges 18 years+ - NCT07622732Enrolling by invitation
Biofeedback training for constipation caused by pelvic muscle tension
This study tests whether biofeedback—a technique that shows you real-time information about your pelvic muscles—can help women with constipation caused by muscles that don't relax properly during bowel movements. You'll learn to relax these muscles with visual feedback from a machine.
Giza, Cairo GovernorateAges 35–65 - NCT06861478RecruitingPhase 2
PPIs for bleeding varices in liver disease
This trial tests whether proton pump inhibitors (PPIs) can help people with cirrhosis who are hospitalized for variceal bleeding. It looks at whether PPIs reduce complications during the hospital stay.
Monterrey, Nuevo LeónAges 18 years+ - NCT06576700Recruiting
Can grape extract help repair leaky gut in ulcerative colitis?
This study tests if a substance called procyanidins (found in grape seeds and apples) can help repair leaky gut in people with ulcerative colitis (UC) that is in remission. It aims to see if improving gut barrier function can prevent future flares.
Padua, PaduaAges 18–80 - NCT07045857Recruiting
H. pylori recurrence: causes and patterns
This study looks at whether H. pylori infection comes back after treatment and what factors might cause it to come back. It is for people with confirmed H. pylori who have stomach symptoms.
SohagAges 18–75 - NCT07044908RecruitingPhase 1/Phase 2
New drug combo for advanced colorectal cancer
This trial tests a new drug called TQB2922 combined with TAS-102, with or without bevacizumab, for people whose advanced colorectal cancer has a normal RAS and BRAF gene and has not responded to standard chemotherapy. The goal is to see if this combination can slow or stop cancer growth.
Hefei, AnhuiAges 18–75 - NCT06578065Recruiting
Comparing powered vs. manual staplers for colon surgery
This trial tests if a new powered circular stapler reduces complications compared to a manual stapler when connecting the colon after left-sided colon or rectal surgery. It may help improve healing and outcomes.
Sabadell, BarcelonaAges 18 years+ - NCT07045688Recruiting
Vonoprazan for Helicobacter pylori infection
This trial tests vonoprazan-based treatments to see if they can effectively clear H. pylori infection. It may help if you have not been treated for H. pylori before.
SohagAges 19 years+ - NCT06817551Enrolling by invitationPhase 4
Comparing treatments for bowel obstruction
This trial compares different ways to manage a bowel blockage caused by scar tissue (adhesions) that doesn't need emergency surgery. It aims to find the best approach to help you recover without surgery.
Seattle, WashingtonAges 18 years+ - NCT07042308Recruiting
Study of advanced chronic liver disease over time
This study follows people with advanced chronic liver disease to understand how their condition changes over time. If you have cirrhosis or high liver stiffness, you may be able to join to help researchers track the disease and learn more about it.
Hong KongAges 18 years+ - NCT06816407RecruitingPhase 3
Prucalopride for bowel recovery after colorectal surgery
This trial tests if different doses of prucalopride, a medicine that helps the bowels move, can speed up gut function recovery after planned (not emergency) colorectal surgery.
CairoAges 18–75 - NCT07034664Recruiting
Ultrasound to predict Guselkumab response in Crohn's disease
This trial tests if a medication called Guselkumab can help people with moderate to severe Crohn's disease. It uses a special ultrasound to see how the bowel responds to treatment.
Changsha, HunanAges 18–80 - NCT06585540RecruitingPhase 3
Barhemsys for nausea and vomiting after weight loss surgery
This study tests if Barhemsys (a medicine to prevent nausea and vomiting) works for people who have had weight loss surgery (like gastric sleeve or gastric bypass). You would receive the medicine during surgery to see if it helps you avoid feeling sick afterwards.
Seattle, WashingtonAges 18–65 - NCT06857331Recruiting
Numbing block for pain after liver transplant
This trial tests a special numbing injection (erector spinae plane block) to help control pain after liver transplant surgery. It may be a good option if you have severe liver disease and need a transplant.
KyivAges Any age - NCT06849661Enrolling by invitation
Bilirubin and recovery after sedation for ERCP
This trial checks if your bilirubin level before sedation affects how quickly you recover and how long you stay in the hospital after an ERCP procedure. ERCP is a procedure to examine your bile ducts.
IstanbulAges 18 years+ - NCT03959878Recruiting
Test of a constant-pressure skin disk for feeding tubes
This study looks at whether a small constant-pressure skin device (a “skin disk”) is safe and practical when placed in people getting PEG or PEJ feeding tubes. If you qualify, it may help improve comfort and care around the tube site.
Rochester, MinnesotaAges 22 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.