Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT06860477RecruitingPhase 2
Freezing therapy plus targeted drugs vs. chemotherapy for advanced bile duct cancer
This trial tests whether a combination of cryoablation (freezing tumors) and two drugs (lenvatinib and tislelizumab) works better than a standard chemotherapy regimen (FOLFOX) for people with advanced intrahepatic cholangiocarcinoma (a type of bile duct cancer in the liver) that has not responded to or has stopped responding to one prior therapy.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07152912Recruiting
Comparing two anesthetics for gallbladder surgery
This trial compares two types of anesthetic gases, isoflurane and sevoflurane, to see which one causes less oxidative stress (a type of cell damage) during gallbladder removal surgery. It may help surgeons choose the safer option for patients.
CairoAges 20–60 - NCT06819280Recruiting
Immune cells for advanced colorectal cancer after first treatment
This trial tests whether your own immune cells, called tumor-infiltrating lymphocytes (TILs), can be grown in a lab and given back to you to fight advanced colorectal cancer. It is for people whose cancer has continued to grow after their first round of chemotherapy.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT06974123Enrolling by invitationPhase 1/Phase 2
Testing a new oral drug for radiation proctitis
This trial tests an oral drug called Teslanbaicin for people who have pelvic cancer and developed radiation proctitis (inflammation of the rectum from radiation therapy). The goal is to see if it is safe and helps heal the inflammation.
Xinxiang, HenanAges 18 years+ - NCT07138326Recruiting
Medication absorption in people with an ostomy
This trial looks at how well your body absorbs certain medications if you have an ileostomy or colostomy. It aims to help doctors better understand dosing for people with ostomies.
Vienna, State of ViennaAges 18 years+ - NCT06819748Recruiting
Numbing medicine mix for less pain after gallbladder surgery
This trial tests a mixture of numbing medicines (ropivacaine cocktail) injected into the surgery area to reduce pain after gallbladder removal. It's for people having same-day laparoscopic surgery and aims to help you recover with less pain.
Chengdu, SichuanAges 18–70 - NCT04656041RecruitingPhase 2
Test chemo with radiation for gastroesophageal cancer
This Phase 2 study tests a combination of chemotherapy (5-FU/leucovorin plus irinotecan and oxaliplatin) together with radiation for certain types of esophagus/stomach-junction cancer. It may help shrink tumors and control cancer that is locally advanced but not spread to distant organs.
Boston, MassachusettsAges 18 years+ - NCT06840665RecruitingPhase 2
Radiation plus immunotherapy and chemo for rectal cancer
This trial combines a special type of radiation (MRI-guided adaptive radiotherapy) with an immunotherapy drug (PD-1 antibody) and chemotherapy (CAPOX) for locally advanced rectal cancer. The goal is to see if this combination can improve treatment outcomes.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07247877Enrolling by invitation
Study of small liver grafts for portal hypertension treatment
This trial explores using smaller liver grafts in a partial transplant to treat portal hypertension, which may help patients avoid full transplant risks. It compares this approach to standard liver transplant.
Ages 14 years+ - NCT07115485RecruitingPhase 2
Study of HLX43 for advanced stomach or junction cancer
This trial tests a new drug called HLX43 (an antibody-drug conjugate targeting PD-L1) for people with advanced stomach or gastroesophageal junction cancer that has progressed after at least one prior treatment. It aims to see if it can shrink tumors and help patients live longer.
BeijingAges 3 weeks–2 months - NCT03687814Recruiting
Low FODMAP diet plus PEG for IBS with constipation
This study tests whether a low-FODMAP diet combined with PEG 3350 can reduce symptoms in adults with IBS-C (irritable bowel syndrome with constipation). It may help improve bowel habits and abdominal pain, and it checks which people can safely follow the diet and treatment plan.
Ann Arbor, MichiganAges 18 years+ - NCT07541924Recruiting
Image-Guided Colonoscopy: Patient Experience and Doctor Efficiency
This study tests whether using CT scan images to guide doctors during colonoscopy (a camera exam of your colon) improves how well the procedure goes and reduces doctor stress. You'll answer questions about your experience before and after the procedure.
Beijing, Beijing MunicipalityAges 18–80 - NCT06559085Recruiting
Comparing two laparoscopic fixes for rectal prolapse
This trial is testing two different ways of doing laparoscopic surgery (using small incisions and a camera) to fix a complete rectal prolapse. The goal is to see which approach works better.
AsyutAges 18–75 - NCT07117318Recruiting
NSAIDs with or without a pancreatic stent to prevent pancreatitis after ERCP
This trial tests whether using rectal NSAIDs (a type of painkiller) with or without a small tube (stent) in the pancreas can prevent pancreatitis after ERCP. It's for people who are at higher risk for this complication.
Beijing, Beijing MunicipalityAges 18–90 - NCT07108725Recruiting
Better MRI scan for bile duct blockage
This trial is testing if a special MRI technique called diffusion-weighted imaging (DWI) can better find bile duct blockages caused by tumors, compared with standard MRI. If you have symptoms like yellow skin or dark urine and need a detailed look at your bile ducts, this might help your doctor make a more accurate diagnosis.
CairoAges 18 years+ - NCT07276932Recruiting
Acupoint paste for constipation after chemo
This study tests whether applying a special paste to acupoints (specific points on your body) can help relieve constipation and boost energy (qi) in people with colorectal cancer who've had chemotherapy. It's for patients who feel weak and have trouble with constipation after treatment.
Hangzhou, ZhejiangAges 18 years+ - NCT07105865Recruiting
Nickel and LTPs in stomach and bowel issues
This study looks at whether being sensitive to nickel or certain proteins called LTPs is linked to ongoing stomach and bowel problems. It aims to find better ways to diagnose and help people with functional dyspepsia or irritable bowel syndrome.
NaplesAges 4–65 - NCT07102836RecruitingPhase 2
Zinc vs probiotics for jaundice in newborns on light therapy
This trial tests whether zinc or probiotics can help babies with jaundice recover faster while receiving phototherapy (light treatment). It aims to find a safe, easy way to lower bilirubin levels.
Bahawalpur, Punjab ProvinceAges birth–4 weeks - NCT07235930RecruitingPhase 3
New drug combo for advanced pancreatic cancer
This trial tests a combination of chemotherapy plus two targeted drugs (serplulimab and bevacizumab) against chemotherapy alone for pancreatic cancer that cannot be removed by surgery or has spread. This approach may help shrink or stabilize the tumor longer.
Hangzhou, ZhejiangAges 18–75 - NCT07093463Recruiting
Colon-delivered Vitamin B2 for Gut Health
This trial tests whether a special form of vitamin B2 (riboflavin) delivered to the colon can improve gut health in people with mild to moderate bowel complaints. The study compares the effects of this supplement to a standard diet add-on (inulin) and looks at changes in gut bacteria and symptoms.
Berlin, State of BerlinAges 50–70 - NCT06814249Enrolling by invitation
Pancreatic stump ligation after distal pancreatectomy study
This study looks at a specific surgical technique for closing the remaining part of the pancreas after a distal pancreatectomy (removal of the tail or body). It aims to see if a special ligation method can improve outcomes. You may be able to join if you are planning this surgery.
Wuhan, HubeiAges 18–75 - NCT07233486Recruiting
Digital health app for fatty liver disease
This trial tests a digital health app designed to help people with metabolic-associated fatty liver disease (MAFLD). The app provides diet and exercise guidance to improve liver health.
Hangzhou, ZhejiangAges 18–65 - NCT07626606Recruiting
Gut Health and Rotavirus Vaccine Response in Adults
This study examines how the health of your digestive system affects how well your body responds to an oral rotavirus vaccine (a vaccine given by mouth to protect against rotavirus infection). You'll have two endoscopy procedures—a camera test to look inside your digestive tract—and provide samples to help researchers understand this connection.
Lusaka, Lusaka ProvinceAges 18–50 - NCT07231705Recruiting
Plant-based formula for growth and tolerance in toddlers
This study tests how well toddlers (12-17 months old) tolerate and grow on a plant-based formula. It compares this new formula to standard ones for children who get most of their calories from formula.
Columbus, OhioAges 1 year–1.4 years
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.