Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,685
- Phase 21,189
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer90
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California442
- Arizona190
- Texas140
- Alabama129
- Florida127
- New York120
- Massachusetts119
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,606 total
- NCT06612281RecruitingPhase 2
Testing a new screening tool for colorectal cancer in people with negative FIT results
This trial tests a new device called Gixam to see if it can help find colorectal cancer in people who recently had a normal FIT test (a stool test for blood). You may be able to join if you are between 45 and 85 years old and are already scheduled for a routine screening colonoscopy.
Portland, OregonAges 45–85 - NCT06688383Recruiting
Leak after right colon cancer surgery: a study on outcomes
This study looks at how often a leak happens at the connection site after right colon cancer surgery. It includes both emergency and planned surgeries, and all types of surgical approaches. The goal is to learn more about this complication so doctors can prevent it better.
Orbassano, PiedmontAges 18 years+ - NCT07644117Recruiting
Personalized Anti-TNF Treatment for Inflammatory Bowel Disease
This trial tests a personalized approach to starting anti-TNF therapy—a common treatment for inflammatory bowel disease (IBD)—in patients who have never taken it before. The goal is to help doctors choose the right anti-TNF medication and dose based on each patient's individual characteristics.
Tel AvivAges 18 years+ - NCT07641036RecruitingPhase 1/Phase 2
CAR-NK Cell Therapy for Advanced Biliary Tract Cancer
This trial tests a new type of immune cell therapy (CAR-NK cells) designed to target cancer cells in advanced biliary tract cancers—including bile duct and gallbladder cancers. The cells are engineered to recognize and attack cancer cells that have specific markers (HER2 and CEA), and this approach may help patients whose cancer has progressed after standard chemotherapy.
Shenzhen, GuangdongAges 18 years+ - NCT07646106RecruitingPhase 1
Testing THE-0504 in Advanced Solid Tumors
This Phase 1 trial tests a new drug called THE-0504 in patients with advanced solid tumors (like lung, colon, pancreas, stomach, or breast cancer) that have not responded to standard treatments. The study aims to find the right dose and understand how well and safely the drug works.
Rome, LazioAges 18 years+ - NCT07643623RecruitingPhase 2/Phase 3
Immunotherapy for operable stomach cancer before and after surgery
This trial tests a combination of immunotherapy drugs (sintilimab, chemotherapy, and sometimes ipilimumab) given before surgery to shrink stomach or esophageal junction tumors, then continued after surgery. The goal is to improve survival in patients with resectable (removable) gastric or gastroesophageal junction cancer.
Guangzhou, GuangdongAges 18 years+ - NCT05346393Recruiting
TIPS procedure for kidney failure in people with cirrhosis
This trial studies whether a liver procedure called TIPS can help people with cirrhosis who develop sudden kidney failure (HRS-AKI). It aims to improve kidney function and overall outcomes, but participation depends on several safety checks.
AachenAges 18–80 - NCT04867408Recruiting
Using bowel scope images to improve inflammatory bowel disease training
This study uses pictures taken during routine bowel scope (endoscopy) to build and test a computer system for training and research in inflammatory bowel disease. It may help doctors and trainees interpret scope images more consistently over time.
Hull, East YorkshireAges 16–99 - NCT05272579RecruitingEarly Phase 1
Phage treatment to help gut development in very preterm babies
This early-phase trial tests whether giving a specific bacteria-fighting treatment (called bacteriophage) through the gut can help preterm babies’ intestinal development mature faster. It may help reduce early gut-related problems, but the study is mainly to check safety and early effects.
CopenhagenAges Any age - NCT05980455Recruiting
Nighttime cycling of Enterra pacemaker for gastroparesis
This study tests a new way to program the Enterra stomach pacemaker so it cycles at night, aiming to improve gastroparesis symptoms. It's for people who already have the device and have stable symptoms.
Louisville, KentuckyAges 18–70 - NCT06322862Recruiting
Fluorescence test for blood flow in emergency bowel surgery
This trial tests if a special imaging technique (fluorescence) can help doctors see how well blood is flowing to the bowel during emergency surgery for suspected mesenteric ischemia. This could help them decide which part of the bowel to remove, if any.
Copenhagen, Capital RegionAges 18 years+ - NCT06551961Recruiting
How two fibers affect your gut health
This study tests how two types of fiber (inulin and methylcellulose) affect your gut when eaten regularly. You'll eat provided meals and have your breath tested to see how your gut breaks down the fiber.
Nottingham, NottinghamshireAges 18–65 - NCT06348420Recruiting
New procedure vs. acid-reducing pills for GERD
This study compares a new procedure called anti-reflux mucosal valvuloplasty (ARMV) to acid-reducing medicines (PPIs) for treating GERD. It may help people who have had reflux for a long time and need daily PPIs.
Jinan, ShandongAges 18–60 - NCT07643285Recruiting
Faster Recovery After Laparoscopic Appendix Surgery in Kids
This study tests a new recovery plan designed to help children go home faster and feel better sooner after laparoscopic appendix surgery (a minimally invasive operation). The plan focuses on early movement, eating, and pain control without heavy pain medications.
Kayseri, KayseriAges 5–18 - NCT07643298Recruiting
Lidocaine through feeding tube to reduce nausea after weight-loss surgery
This study tests whether delivering lidocaine (a numbing medication) through a feeding tube during weight-loss surgery can reduce nausea and vomiting afterward. You would receive this medication as part of the surgery procedure to see if it helps you feel better in recovery.
Yinchuan, NingxiaAges 18–65 - NCT07639138RecruitingPhase 2
Lenalidomide with targeted therapy and immunotherapy for advanced liver cancer
This trial tests whether adding lenalidomide (a drug that boosts the immune system) to your current targeted therapy and immunotherapy can help advanced liver cancer that has progressed after previous treatments. You would be eligible if your cancer has already been treated with at least two prior drug combinations and initially responded before growing back.
Beijing, No. 1 Shuaifuyuan, Dongcheng District, Beijing, ChinaAges 18–75 - NCT07642076RecruitingPhase 4
L-carnitine supplement for critically ill liver disease patients
This study tests whether adding L-carnitine (a naturally occurring compound) to standard care helps people with serious liver disease who are in the intensive care unit. L-carnitine may help the body use energy better and reduce complications from liver failure.
Shibīn al KawmAges 18 years+ - NCT07644286RecruitingPhase 2
Pirfenidone and immunotherapy with optional radiation for advanced colorectal cancer
This study tests a combination of three treatments—pirfenidone (an anti-scarring drug), a PD-1 inhibitor (an immunotherapy that helps your immune system fight cancer), and sometimes radiation—for colorectal cancer that has stopped responding to standard treatments. The goal is to see if this combination can slow or shrink your cancer.
Wuhan, HubeiAges 18–75 - NCT07639281Enrolling by invitation
Opioid Education for Ventral Hernia Repair Surgery
This study teaches patients about opioid pain medication before hernia repair surgery. It aims to help patients make informed decisions about pain management and understand safer opioid use.
Lexington, KentuckyAges 18–85 - NCT07646197Recruiting
Peanut Consumption and Fatty Liver Disease in Adults
This study tests whether eating peanuts regularly can help improve fatty liver disease (a condition where fat builds up in the liver). You'll be asked to eat peanuts as part of your diet while researchers track changes in your liver health.
Detroit, MichiganAges 30–70 - NCT07642401Enrolling by invitation
Building models to understand esophageal cancer
This research study uses medical records and imaging from patients with various esophageal conditions—from inflammation to cancer—to develop better diagnostic and prediction tools. Researchers want to understand what changes in the esophagus lead to cancer and how to catch it earlier.
Anyang, HenanAges 18–90 - NCT07640243Recruiting
Sedation Methods for Bile Duct Drainage Procedures
This study compares different sedation (sleep) methods used during a procedure to drain blocked bile ducts. Researchers want to see which sedation approach gives patients the best experience and fastest recovery.
Ankara, AnkaraAges 18 years+ - NCT07640230Recruiting
Cartoons and games to ease surgery anxiety in children
This study tests whether watching cartoons or playing mobile games can help reduce anxiety and fear in children ages 7–12 who need surgery for appendicitis (an inflamed appendix). The goal is to find simple, non-medication ways to calm children before their operation.
AnkaraAges 7–12 - NCT07638527RecruitingPhase 4
Comparing nausea-prevention drugs after gallbladder surgery
This study tests two different medication combinations to prevent nausea and vomiting after laparoscopic gallbladder removal surgery. You'll receive either ondansetron plus metoclopramide, or dexamethasone plus metoclopramide, and researchers will track how quickly you need rescue medication if nausea occurs.
Faisalābad, Punjab ProvinceAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 11,952 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.