Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT07023471Enrolling by invitation
AI-assisted colonoscopy for cancer screening, tandem study
This study tests whether a smart computer program (artificial intelligence) can help doctors find more polyps during a standard colonoscopy for colorectal cancer screening. It may improve detection of early signs of cancer.
Bangkok, BangkokAges 40–85 - NCT05905926Enrolling by invitationPhase 3
Tenapanor safety study for teens with constipation-predominant IBS
This trial checks the safety of tenapanor in children and teens (ages 6 to under 18) with IBS-C. It is only for people who finished a previous related study and agreed to continue follow-up.
Foley, AlabamaAges 6–18 - NCT07016919Recruiting
Early feeding vs. standard diet after child appendix surgery
This trial compares starting feeding soon after surgery versus waiting longer in children who had simple appendix removal. It aims to see if early feeding helps recovery.
Lahore, Punjab ProvinceAges 6–14 - NCT07015723Enrolling by invitation
Liver fat study in living donors
This study looks at stored medical data from living liver donors to better understand fat in the liver (steatosis). It may help improve future transplant care.
Rotterdam, South HollandAges 18–60 - NCT07016269RecruitingPhase 4
Study of CnU Cap. 500 mg for Biliary Dyspepsia
This trial tests a medication called CnU Cap. 500 mg to see if it helps people with biliary dyspepsia, a type of upper belly pain caused by the gallbladder or bile ducts. It may help if you have episodes of steady pain in the upper right belly that last at least 30 minutes and disrupt your daily life.
Ansan, Gyeonggi-doAges 19 years+ - NCT07015424Recruiting
TORe procedure vs lifestyle changes for weight regain after bypass
This study compares a procedure called TORe (a way to reduce the size of your stomach opening) combined with lifestyle changes versus lifestyle changes alone to help people who have regained weight after gastric bypass surgery. The goal is to see which approach works better for long-term weight control.
Irvine, CaliforniaAges 18 years+ - NCT04096586Recruiting
Study tests how watermelon affects fullness and digestion
This study looks at whether eating watermelon changes how full you feel and how your digestion works. It’s for generally healthy people and skips those with certain health factors or who can’t eat watermelon safely.
San Diego, CaliforniaAges 10–55 - NCT05746884Recruiting
Gel to prevent bleeding after ampulla surgery
This trial tests whether a blood-clotting gel (PuraStat®) can help prevent bleeding after endoscopic removal of certain ampulla/duodenal growths. You might be offered the gel during the procedure to lower the risk of post-procedure bleeding.
LyonAges 18 years+ - NCT07072351RecruitingPhase 1/Phase 2
Radiation plus chemoimmunotherapy for gastroesophageal junction cancer
This trial tests a shorter course of radiation combined with chemotherapy and immunotherapy to shrink gastroesophageal junction cancer before surgery. It aims to make the tumor removable and improve outcomes.
Xiamen, FujianAges 18 years+ - NCT06756139Recruiting
Mobile app therapy for stubborn stomach upset
This study tests if a mobile app teaching cognitive behavioral therapy (a way to change thinking patterns) can help people with stubborn stomach pain or discomfort. It might benefit those whose symptoms haven't improved with usual medicines.
Haikou, HainanAges 18–80 - NCT07212907Recruiting
Probiotic and Ginger for Stomach Discomfort
This trial tests whether a combination of probiotics and ginger can improve symptoms and quality of life for people with functional dyspepsia (a condition causing ongoing stomach discomfort). Participants will take the supplement for several weeks and report how they feel.
IstresAges 18 years+ - NCT06748690Recruiting
Comparing biopsy methods for stomach tumors
This trial compares two ways to take a tissue sample from stomach tumors before surgery to see which works better. The results may help doctors choose the best method for patients.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07229950RecruitingPhase 2
Experimental tablet for moderate to severe Ulcerative Colitis
This trial tests an experimental tablet, HRS-7085, for people with moderate to severe Ulcerative Colitis who haven't gotten enough help from standard treatments. The goal is to see if the drug can reduce inflammation and improve symptoms.
Chengdu, SichuanAges 18–75 - NCT06501625RecruitingPhase 1/Phase 2
Targeted therapy plus immunotherapy for IDH1-mutated bile duct cancer
This trial tests a new combination of three drugs (ivosidenib, durvalumab, and gemcitabine/cisplatin) as a first treatment for people with advanced bile duct cancer that has a specific IDH1 gene mutation. The goal is to see if this combination can shrink tumors and help patients live longer.
Los Alamitos, CaliforniaAges 18 years+ - NCT06764355RecruitingPhase 2
Chemo, Immunotherapy, and Chemoradiation Before Surgery for Advanced Esophageal Cancer
This trial tests a combination of chemotherapy, immunotherapy, and chemoradiation before surgery for people with advanced esophageal squamous cell carcinoma. The goal is to see if this approach helps shrink the tumor and improve outcomes.
TaipeiAges 18–75 - NCT07008235RecruitingPhase 2/Phase 3
Testing two drugs for upset stomach relief
This trial tests whether a combination of two medications, amitriptyline and trifluoperazine, can help patients with ongoing discomfort in the upper stomach (functional dyspepsia). It may be an option if other treatments haven't worked.
DhakaAges 18–60 - NCT07007494Recruiting
Early outcomes and nutrition after weight loss surgery
This study looks at how well patients recover after laparoscopic sleeve gastrectomy and how nutritional scores relate to their early outcomes. It may help doctors improve care for people having this common weight loss surgery.
Istanbul, Merkez MahallesiAges 18–65 - NCT07450144Recruiting
Chatbot to Help Reduce Alcohol in Fatty Liver Disease
This study tests a chatbot that helps people with fatty liver disease reduce how much they drink. If you drink regularly and are ready to change, this tool could support you.
Hong KongAges 18 years+ - NCT07001943Recruiting
Blood flow in stomach and gut injury in ICU patients
This trial checks if changes in blood flow to the stomach and intestines can predict gut injury in critically ill patients who need feeding through a tube. It uses a safe ultrasound test at the bedside.
Beijing, Beijing MunicipalityAges 18–80 - NCT06946706Recruiting
Bacteria overgrowth in stomach condition study
This study looks at whether people with autoimmune gastritis (a stomach condition) are more likely to have small intestinal bacterial overgrowth (SIBO), which can cause bloating and other symptoms. It uses a simple breath test and questionnaires.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT06869564Recruiting
Blood test study for acute mesenteric ischemia diagnosis
This pilot study looks at markers in your blood that might help doctors tell if you have a serious bowel condition called acute mesenteric ischemia. You may be asked to participate if you have severe belly pain and need a special CT scan to check for this condition.
MarseilleAges 18 years+ - NCT07624409Enrolling by invitationEarly Phase 1
Occupational health study for high-altitude workers
This study examines how working at high altitudes (where there is less oxygen in the air) affects employees at an astronomical observatory in Chile. Researchers want to understand health impacts and develop better support for people working in these extreme conditions.
San Pedro de Atacama, AntofagastaAges 20–50 - NCT07744672Recruiting
Comparing two surgeries for high anal fistula
This trial compares two surgical techniques to treat a complex type of anal fistula (an abnormal tunnel between the anal canal and skin). It aims to find which approach offers better healing and fewer risks.
CairoAges 16 years+ - NCT06714279RecruitingPhase 1
Pain relief methods for gallbladder surgery
This trial compares two ways to reduce pain after laparoscopic gallbladder removal: one uses a nerve block during surgery and the other uses local anesthetic inside the abdomen. The goal is to find which approach provides better pain relief.
DublinAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.