Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,911
- Phase 21,185
- Phase 1581
- Phase 3465
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer289
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland85
- Ohio79
- Pennsylvania72
Recruiting studies7,879 total
- NCT06619990RecruitingPhase 1/Phase 2
Study of XmAb942 for active ulcerative colitis
This study tests a new drug called XmAb942 for people with moderate to severe ulcerative colitis. It aims to see if the drug can reduce inflammation and improve symptoms when other treatments haven't worked well enough or caused side effects.
Scottsdale, ArizonaAges 18–75 - NCT07606599RecruitingPhase 3
New drug BL-M07D1 for advanced biliary tract cancer
This trial tests a new drug called BL-M07D1 against standard chemotherapy for biliary tract cancer that has spread or is locally advanced and has stopped responding to platinum-based chemotherapy. The trial is looking for patients whose cancer has a specific genetic marker to see if this new treatment works better.
Hefei, AnhuiAges 18–75 - NCT05394714RecruitingPhase 1
Magicell-NK cell therapy after colon cancer surgery
This early-stage trial tests an individualized immune cell treatment (Magicell-NK) made from your own cells to help prevent colon cancer from coming back after surgery. It studies safety and how well the treatment works in people with early-stage colon cancer.
TaoyuanAges 20 years+ - NCT06910657RecruitingPhase 1
IDOV-Immune vaccine for advanced solid tumors
This trial tests an experimental virus-based treatment for people with advanced solid tumors that have stopped responding to standard therapies. The treatment is designed to infect and destroy cancer cells while boosting the immune system.
St Louis, MissouriAges 18 years+ - NCT07582315RecruitingPhase 3
BL-B01D1 for advanced biliary tract cancer after prior treatments
This study tests a new drug called BL-B01D1 against standard treatment options for patients with advanced biliary tract cancer (cancer of the bile ducts) that has stopped responding to platinum chemotherapy and immunotherapy. The drug is designed to target and destroy cancer cells more effectively.
Beijing, Beijing MunicipalityAges 18–75 - NCT07042243Recruiting
Florida ASCENT cancer study for patients and providers
This study looks at cancer care in Florida. If you have had cancer in the past and are not currently getting active treatment (like chemotherapy or radiation), this study may help researchers understand how to improve care.
Gainesville, FloridaAges 18–100 - NCT06478823Recruiting
Healthy stool donors for fecal transplant studies
This trial is looking for healthy stool donors to provide samples for fecal microbiota transplantation, a treatment that uses healthy bacteria from stool to help people with certain gut diseases. As a donor, you would give stool samples regularly to help others.
Paris, ParisAges 18–49 - NCT06545942RecruitingPhase 1
Studying MOMA-313 for advanced or metastatic solid tumors
This trial tests a new oral drug, MOMA-313, alone or with another drug (olaparib), in people whose cancer has a specific DNA repair problem (HR-deficient mutation). It aims to see if the drug can shrink tumors or slow their growth.
Goodyear, ArizonaAges 18 years+ - NCT05919264RecruitingPhase 1/Phase 2
FOG-001 for advanced solid tumors with certain gene changes
This trial tests a new drug, FOG-001, alone or with other treatments, for people with advanced solid tumors that have specific changes in the WNT pathway genes. It aims to see if the drug can shrink tumors or slow their growth.
Phoenix, ArizonaAges 18 years+ - NCT06967571Recruiting
Rebuilding the digestive tract after stomach removal
This trial tests a new way to rebuild the connection between the esophagus and small intestine after total stomach removal. It creates a pouch from the jejunum (part of the small intestine) to help with eating and digestion.
RomaAges 18–75 - NCT06910670Recruiting
Web tool for cancer treatment decisions
This trial tests a web-based tool to help people with certain cancers make treatment decisions. It is for patients already enrolled in a related study at Washington University.
St Louis, MissouriAges 18 years+ - NCT05957367RecruitingPhase 1/Phase 2
Study drug for advanced GIST tumors with specific gene mutations
This early-phase study tests inlexisertib (a targeted cancer drug) combined with other anticancer treatments in adults with advanced GIST. It is mainly looking for safety and the best way to dose, and it may help tumors that have certain KIT or PDGFRA gene changes.
Los Angeles, CaliforniaAges 18 years+ - NCT07721441Enrolling by invitation
Predicting Gut Healing in Ulcerative Colitis with a Stool Test
This study looks at whether a simple stool test can tell if treatment is healing the gut lining in people with moderate to severe ulcerative colitis who are starting their first biologic medicine. If it works, this test might help doctors adjust treatment earlier.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06755632Recruiting
Hepatic fibrosis or cirrhosis screening trial
This trial screens for liver scarring (fibrosis) or severe scarring (cirrhosis) caused by hepatitis B or C. It aims to find people who may benefit from further care or treatment.
BobignyAges 18 years+ - NCT07133750RecruitingPhase 2
PM8002 plus chemo for untreated metastatic colorectal cancer
This trial tests a new combination therapy (PM8002 plus chemotherapy) for people with metastatic colorectal cancer who have not had prior treatment. It may be an option if your cancer is not MSI-H/dMMR and you are in good overall health.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07456566Recruiting
Self-management help for inflammatory bowel disease
This trial tests a self-management program for people with active Crohn's disease or ulcerative colitis. It aims to improve quality of life by helping you better manage your condition.
Ann Arbor, MichiganAges 18 years+ - NCT06974110RecruitingPhase 1
Study of a new drug for advanced solid tumors with MSI-H or dMMR
This trial tests an oral medication called MOMA-341 in people with advanced solid tumors that have high microsatellite instability (MSI-H) or mismatch repair deficiency (dMMR). It aims to see if the drug can help when prior immunotherapy hasn't worked or isn't available.
Phoenix, ArizonaAges 18 years+ - NCT07521852RecruitingPhase 2
New drug combination with immunotherapy for liver cancer
This trial tests a new drug called CVM-1118 combined with an immunotherapy drug (sintilimab) and a procedure called TACE (a catheter-based treatment that delivers medicine directly to tumors) in people with hepatocellular carcinoma (liver cancer) that cannot be cured by surgery. The goal is to see if this combination is effective and safe.
Fuzhou, FujianAges 18 years+ - NCT05028725Recruiting
Testing an esophagus sponge test for early cancer detection
This study checks whether a special sponge you swallow (EsophaCap) can help detect early esophageal cancer—or help sort out concerning symptoms. You may be contacted again 1–2 weeks later for a short interview.
Dar es Salaam, MloganzilaAges 18 years+ - NCT06188793Recruiting
Virtual reality for IBD pain during hospital stay
This study tests if using virtual reality can help manage pain for people with inflammatory bowel disease (IBD) while they are in the hospital. It may offer a drug-free way to feel better.
Ann Arbor, MichiganAges 18 years+ - NCT07718490RecruitingPhase 2
Immunotherapy with simvastatin and chemo for advanced colorectal cancer
This trial tests a new combination of immunotherapy, simvastatin (a cholesterol drug), and standard chemotherapy for advanced colorectal cancer that has not been treated before. The goal is to see if adding simvastatin can help the immune system fight the cancer better.
Nanjing, JiangsuAges 18–75 - NCT07720245Recruiting
Self-health app study for adults in Hong Kong
This trial tests a mobile app that helps you check your own health. It is for adults in Hong Kong who want to use the app to learn about their health and get tips.
Hong KongAges 25–65 - NCT07718828Recruiting
Comparing two types of hernia surgery for hiatal hernia
This study compares two laparoscopic surgery methods (Nissen vs Toupet) for fixing a hiatal hernia. Both aim to stop stomach acid from flowing back into the esophagus and help relieve heartburn or reflux symptoms.
Sofia, Sofia-GradAges 18–90 - NCT07720323Recruiting
Can a wristband help with long-term nausea and vomiting?
This study tests if a special wristband (EmeTerm) can reduce nausea and vomiting symptoms in people who have had these problems for more than two months. You will use the band and report your symptoms through online surveys.
Columbus, OhioAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,372 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.