Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,366 recruiting studies in this area right now.
By phase
- Not applicable975
- Phase 2167
- Phase 398
- Phase 146
- Phase 434
- Phase 1/Phase 232
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma80
- Dysphagia72
- Hearing Loss61
- Tinnitus31
- Hearing Loss, Sensorineural25
- Allergic Rhinitis23
- Nasopharyngeal Carcinoma (NPC)23
- Head and Neck Cancer22
- Oropharynx Cancer21
- Stroke19
- Sensorineural Hearing Loss18
- Nasopharyngeal Cancinoma (NPC)16
- Chronic Rhinosinusitis With Nasal Polyps15
- Oropharyngeal Cancer15
- Nasopharyngeal Cancer14
- Vestibular Schwannoma14
- Head and Neck Squamous Cell Carcinoma13
- Chronic Rhinosinusitis (CRS)12
Leading sponsors
- Sun Yat-sen University58
- Eye & ENT Hospital of Fudan University17
- Cairo University15
- Assistance Publique - Hôpitaux de Paris14
- NYU Langone Health14
- Mayo Clinic12
- National Cancer Institute (NCI)12
- Johns Hopkins University11
- Ming-Yuan Chen10
- Cochlear9
Where studies are running
- California62
- Maryland37
- New York35
- Florida29
- Massachusetts21
- Illinois20
- Arizona17
- Texas17
- Colorado16
- Alabama15
Recruiting studies1,366 total
- NCT07041671Recruiting
Can a mouth spray reduce virus in breath?
This trial tests whether ColdZyme mouth spray can lower the amount of virus you breathe out when you have a cold or flu-like illness. It may help you recover faster and reduce spreading the virus to others.
LundAges 18 years+ - NCT06861751Recruiting
Smartphone overuse and jaw proprioception in teens
This trial looks at how heavy smartphone use affects neck posture, neck muscle endurance, and jaw awareness in teenagers aged 17-19. It aims to understand if long-term phone use is linked to these physical changes.
Al MansurahAges 17–19 - NCT06007092RecruitingPhase 1/Phase 2
HPV vaccine trial for oropharyngeal cancer patients
This trial tests a therapeutic vaccine for people with HPV16-positive oropharyngeal cancer who have finished curative treatment and are free of disease. The vaccine aims to help the immune system prevent the cancer from coming back.
VillejuifAges 18 years+ - NCT07297784Enrolling by invitation
Screen time and pain after tonsil removal in children
This study looks at whether children who use a lot of screens (like tablets, phones, or TV) feel more or less pain after tonsil surgery. It could help parents understand how media use affects recovery.
Tokat Province, Tokat ProvinceAges 4–11 - NCT07013955Enrolling by invitationPhase 3
Comparing nasal packing drugs for better sinus surgery view
This trial is testing whether packing the nose with one of three medications (dexmedetomidine, midazolam, or bupivacaine) during functional endoscopic sinus surgery (FESS) can improve the surgeon's view during the procedure. It may help patients by reducing bleeding and making the surgery smoother.
MinyaAges 16–60 - NCT07013461Recruiting
Nasopharyngeal cancer staging study
This study looks at how well the current cancer staging system works for nasopharyngeal cancer. If you have been diagnosed with this type of cancer between October 2025 and September 2026, you may be able to join.
Shenzhen, GuangdongAges 18 years+ - NCT07010003Recruiting
Ear acupressure for anxiety and pain during heart surgery
This trial tests whether small ear acupressure beads can help reduce anxiety and pain in adults having planned heart surgery. The beads are placed on specific ear points and are easy to use.
StuttgartAges 18 years+ - NCT06997094RecruitingPhase 1
Decitabine plus standard therapy for HPV-negative head and neck cancer
This trial tests whether adding the drug decitabine to standard treatment (surgery and possibly radiation) can help people with a type of head and neck cancer not caused by HPV. You would receive decitabine before surgery, and then continue with standard care after.
Jacksonville, FloridaAges 18 years+ - NCT07611604Enrolling by invitation
Walking and Balance Changes in Long-Term Dizziness
This study measures how dizziness and balance problems affect the way people walk and move. Researchers compare people with chronic vestibular disease (long-term inner ear or balance nerve problems) to healthy volunteers to understand these differences better.
Istanbul, KüçükçekmeceAges 18–65 - NCT06991049Recruiting
Early vs late stenting for benign esophageal narrowing
This study compares placing a stent early versus waiting longer in people with non-cancerous narrowing of the esophagus that makes swallowing difficult. The goal is to find out which timing works best to improve swallowing and quality of life.
Milwaukee, WisconsinAges 18 years+ - NCT06978829RecruitingPhase 2
Combination therapy for untreated advanced head and neck cancer
This trial tests a combination of three drugs (cetuximab, tislelizumab, and chemotherapy) in people with advanced head and neck cancer that hasn't been treated before. The goal is to see if this mix can shrink tumors and improve outcomes.
Chongqing, Chongqing MunicipalityAges 18 years+ - NCT06970977Recruiting
Chronic sinusitis questionnaire validation study
This study is testing a new questionnaire to better understand chronic sinusitis symptoms. It may help improve how doctors diagnose and treat the condition.
Santa Monica, CaliforniaAges 18 years+ - NCT06960772Recruiting
Flow ball phonation for voice professionals
This trial tests whether a device called a flow ball can help professional voice users with functional voice disorders improve their voice or prevent voice disorders. You blow into the ball to make it float while making sounds, which may strengthen your voice.
Ghent, East-FlandersAges 18–60 - NCT05938972Recruiting
Study of biologic medicines in severe CRSwNP patients
This study looks at how “biologic” medicines work in real-life care for people with severe chronic rhinosinusitis with nasal polyps (CRSwNP). It may help confirm which patients benefit and how treatment is used in everyday practice.
GhentAges 18–80 - NCT07436949RecruitingPhase 1/Phase 2
Study of BBT002 for chronic sinusitis with nasal polyps and asthma
This study tests a new drug called BBT002 in healthy people and in patients with chronic sinusitis and nasal polyps, with or without asthma. It aims to see if the drug is safe and effective for reducing symptoms.
Beijing, Beijing MunicipalityAges 18–75 - NCT05838690Recruiting
Improving breathing tube placement safety in NICU newborns
This trial focuses on newborns in the NICU who need a breathing tube placed through the mouth or airway. It aims to improve the success and safety of the first intubation while reducing risks.
Little Rock, ArkansasAges Up to 1 year - NCT06950957Recruiting
Comparing two airway devices for septoplasty
This trial compares a video laryngeal mask with a breathing tube during septoplasty (nose surgery) to see which works better. If you are having this surgery, you may be able to join.
Samsun, IlkadimAges 18–65 - NCT06932328RecruitingPhase 2
Granules for acute sore throat with wind-heat pattern
This trial tests whether Qinqiao Yan Shu Granules can help adults with acute pharyngitis (sore throat) that started within 48 hours. You must have a specific pattern called wind-heat invading the exterior, and at least moderate throat pain.
Harbin, HeilongjiangAges 18–65 - NCT06750302RecruitingPhase 1/Phase 2
Penthrox vs placebo for sinus surgery pain
This trial tests if a pain reliever called Penthrox (methoxyflurane) works better than a placebo for pain during minor sinus procedures. If you are having a simple sinus surgery or coblation procedure, you may be able to join.
Vancouver, British ColumbiaAges 19 years+ - NCT07745127Recruiting
Nasal stitch versus packing after nose surgery
This study compares two ways to stop bleeding after nasal surgery (septoplasty): using a special stitch inside the nose versus using nasal packing. It aims to see which method is more comfortable and effective for patients like you.
Islamabad, FedralAges 18–50 - NCT07604155Enrolling by invitation
Bone grafting for sinus lift in dental implants
This trial tests two ways to add bone in your upper jaw so dental implants can be placed. Researchers compare custom-made bone blocks to bone particles to see which works better for your bone growth.
TantaAges 20 years+ - NCT06914908Enrolling by invitationPhase 2
Long-term safety study of lunsekimig for nasal polyps
This study tests the long-term safety and effectiveness of a medication called lunsekimig for people with chronic sinusitis and nasal polyps. It is for those who already completed a previous study on this drug.
La Jolla, CaliforniaAges 18 years+ - NCT06912243Recruiting
Animation to calm kids before ear tube surgery
This study tests if showing children an educational animation before ear tube surgery can lower their fear and anxiety. It’s a simple, short video that explains what will happen, and the goal is to help your child feel calmer.
Merkez, BartınAges 6–10 - NCT05852730RecruitingPhase 2
Nasal scopolamine and sensory training to reduce motion sickness
This Phase 2 study tests whether a nasal scopolamine medicine plus sensory training can reduce motion sickness and improve movement control during demanding motion experiences (like astronaut training or flight simulations). It may help people who get sick in these settings, as long as they have no related medical problems and can safely take scopolamine.
Houston, TexasAges 18–65
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,366 recruiting otolaryngology studies from the U.S. registry right now, out of 2,207 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.