Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,269 recruiting studies in this area right now.
By phase
- Not applicable890
- Phase 2154
- Phase 3103
- Phase 147
- Phase 431
- Phase 1/Phase 230
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma73
- Dysphagia66
- Hearing Loss61
- Tinnitus29
- Hearing Loss, Sensorineural24
- Nasopharyngeal Carcinoma (NPC)24
- Head and Neck Cancer23
- Allergic Rhinitis22
- Oropharynx Cancer21
- Nasopharyngeal Cancinoma (NPC)18
- Sensorineural Hearing Loss18
- Stroke17
- Oropharyngeal Cancer14
- Vestibular Schwannoma14
- Chronic Rhinosinusitis With Nasal Polyps13
- Deafness13
- Head and Neck Squamous Cell Carcinoma13
- Nasopharyngeal Cancer13
Leading sponsors
- Sun Yat-sen University57
- Assistance Publique - Hôpitaux de Paris14
- Eye & ENT Hospital of Fudan University14
- National Cancer Institute (NCI)14
- Cairo University13
- NYU Langone Health13
- Mayo Clinic12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Massachusetts Eye and Ear Infirmary10
Where studies are running
- California61
- Maryland38
- Florida32
- New York32
- Massachusetts24
- Illinois20
- Texas20
- Alabama15
- Arizona15
- Colorado15
Recruiting studies1,269 total
- NCT06722170Recruiting
Gene therapy study for hearing loss caused by OTOF gene mutation
This trial tests a gene therapy called EH002 for people with severe or profound hearing loss due to changes in the OTOF gene. The treatment aims to help the ear hear better by replacing the faulty gene.
Zhengzhou, HenanAges 6 months+ - NCT06763640Enrolling by invitation
TILs as a predictor in nasopharyngeal cancer
This study looks at how immune cells called TILs (tumor-infiltrating lymphocytes) in your tumor tissue might predict outcomes for nasopharyngeal cancer. It may help doctors better understand your cancer and guide future treatment decisions.
Nanchang, JiangxiAges 18–70 - NCT06768125Enrolling by invitation
Shorter radiation therapy for head and neck cancer in older adults
This trial tests a shorter course of radiation therapy for patients aged 65 and older with head and neck cancer who cannot have surgery or standard radiation. The goal is to find an effective and more convenient treatment option.
Beijing, Beijing MunicipalityAges 65 years+ - NCT05894070Recruiting
Using your voice recordings to spot cancer coming back
This study looks at whether changes in your voice can help detect early return of laryngeal or hypopharyngeal cancer. If you’ve finished curative treatment and are disease-free for a certain period, your voice will be monitored to see if it can signal recurrence sooner.
BernAges 18 years+ - NCT04940000Recruiting
Remote video speech therapy check-ins for head and neck cancer
This trial tests whether video call speech therapy consultations can work well for people with head and neck (ORL) cancer who need speech/voice support during treatment. It may help you get care closer to home while still being guided by speech therapists.
ToulouseAges 18 years+ - NCT03649048Recruiting
Weekly low-dose or high-dose cisplatin with radiation for head and neck cancer
This trial compares two cisplatin dosing schedules (weekly low-dose vs higher dose less often) given alongside radiation for certain head and neck cancers. It’s testing which schedule works well while keeping side effects manageable during planned, curative-intent radiation.
Hamilton, OntarioAges 18 years+ - NCT06743490Recruiting
Tracking MG symptoms with smartphone recordings
This study uses your smartphone to record symptoms like slurred speech, hoarseness, arm fatigue, or droopy eyelids, making it easier for doctors to understand and monitor myasthenia gravis. Both people with MG and healthy volunteers can take part.
Leiden, South HollandAges 18 years+ - NCT06747390RecruitingPhase 1
Lidocaine injection before throat cancer surgery
This early-phase trial tests whether injecting lidocaine (a numbing medicine) into the tumor before surgery can help with pain or other outcomes in people with oropharyngeal cancer. It's for patients who are already scheduled for a scope procedure and surgery at the University of Pennsylvania.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06743295Recruiting
AI noise reduction in Phonak hearing aids
This study tests a new AI feature in Phonak hearing aids to reduce background noise. It may help people with hearing loss, whether or not they already use hearing aids, and even those with one cochlear implant.
Rochester, MinnesotaAges 18–110 - NCT06732414Recruiting
Long-term study of multiple allergic diseases
This study creates a biorepository to collect and store samples (blood, nasal fluid, skin swabs) from people with allergies, asthma, sinus disorders, or immune dysregulation. It aims to better understand these conditions over time, which may help develop better treatments.
Bethesda, MarylandAges 3–100 - NCT06737185Recruiting
Comparing two ways to set a cochlear implant
This trial tests if a new method for programming cochlear implants helps people understand speech better than the usual method. If you are an adult getting a cochlear implant, this study could help improve how you hear.
DijonAges 18 years+ - NCT06734039Enrolling by invitation
Early Performance with Anatomy-Based Cochlear Implant Programming
This study looks at how programming a cochlear implant based on your inner ear's shape may improve early hearing performance. It is for adults who already have or will get a MED-EL cochlear implant and have some hearing in the opposite ear.
Iowa City, IowaAges 18 years+ - NCT06729632Recruiting
Cooling device to protect ears from noise damage
This trial tests a non-invasive device that cools the ears to prevent hearing loss from loud noise. It is for adults aged 18-55 with normal hearing who are at risk for noise-induced hearing loss, such as firefighters.
Miami, FloridaAges 18–55 - NCT06731881Recruiting
Light therapy to prevent infections after sinus or nose surgery
This study tests if a special light therapy can help prevent infections after sinus or nose surgeries. The treatment is given in addition to standard care and might lower the chance of needing more antibiotics.
London, LondonAges 16 years+ - NCT06734975RecruitingPhase 2
Nerve block for better recovery after vocal cord surgery
This study tests if a nerve block can help reduce pain and improve recovery after surgery to remove a noncancerous growth on the vocal cords. Participants will be randomly assigned to receive either the nerve block or standard care.
Newark, New JerseyAges 18 years+ - NCT06732440Recruiting
Gentle motion therapy for balance problems
This study tests if mild, gentle head movements can help improve your balance and reduce dizziness. It is for people whose balance organs are not working well on one or both sides.
Omaha, NebraskaAges 19–89 - NCT06734897Recruiting
Music therapy for better hearing with cochlear implants
This study tests whether music therapy can help people with cochlear implants understand speech better in noisy environments. If you are getting a new cochlear implant and speak German, you may be able to join.
Lucerne, Canton of LucerneAges 18–85 - NCT06738030Recruiting
Brain stimulation and listening training for hearing in noise
This study tests whether a gentle brain stimulation technique (transcranial stimulation) combined with listening exercises can help people who have trouble hearing speech in noise. If you are 50 or older and struggle to follow conversations in crowded places, this trial may be a good fit.
Boston, MassachusettsAges 50 years+ - NCT06723262Recruiting
Testing a new sound tuning for cochlear implant users
This trial studies a new way to adjust a cochlear implant's sound settings based on how the ear naturally processes pitches. It may help improve speech understanding over 6 months compared to standard settings.
LimogesAges 18 years+ - NCT06726928Recruiting
Stent for pulsatile tinnitus from narrowed head vein
This trial tests a special stent (a small mesh tube) placed in a narrowed vein in the head to stop a bothersome whooshing sound in the ear (pulsatile tinnitus) that hasn't gone away.
ParisAges 18 years+ - NCT06712979Recruiting
Adding breathing exercises to voice therapy for professionals
This study tests if adding a special breathing exercise (lung volume recruitment) to the Lee Silverman voice therapy program helps voice professionals improve their voice. You may be able to join if you're a voice professional with a healthy voice and no smoking history.
Anápolis, GoiásAges 20–60 - NCT06706401RecruitingPhase 3
Lymphocyte-sparing radio-immunotherapy for head and neck cancer
This trial tests a new approach that combines radiation and immunotherapy, while trying to protect your immune cells. It is for people with head and neck cancer that has not spread across the midline of the body and has not been treated yet.
Lyon, FranceAges 18 years+ - NCT06696456Enrolling by invitation
Long-term follow-up of gene therapy for otoferlin hearing loss
This study follows up with people who received a gene therapy (AAVAnc80-hOTOF) in a previous clinical trial. It checks how well the treatment works over time and how safe it is.
Iowa City, IowaAges Any age - NCT06702033RecruitingPhase 2
Surgery for HPV-related oropharyngeal cancer
This trial is testing a surgical approach for people with HPV-related oropharyngeal cancer that is stage I or II (but not the very smallest). The goal is to see if removing the tumor through the mouth and taking out neck lymph nodes is effective and safe. It may be an option if you are healthy enough for surgery.
St Louis, MissouriAges 18 years+
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,269 recruiting otolaryngology studies from the U.S. registry right now, out of 2,074 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.