Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,269 recruiting studies in this area right now.
By phase
- Not applicable890
- Phase 2154
- Phase 3103
- Phase 147
- Phase 431
- Phase 1/Phase 230
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma73
- Dysphagia66
- Hearing Loss61
- Tinnitus29
- Hearing Loss, Sensorineural24
- Nasopharyngeal Carcinoma (NPC)24
- Head and Neck Cancer23
- Allergic Rhinitis22
- Oropharynx Cancer21
- Nasopharyngeal Cancinoma (NPC)18
- Sensorineural Hearing Loss18
- Stroke17
- Oropharyngeal Cancer14
- Vestibular Schwannoma14
- Chronic Rhinosinusitis With Nasal Polyps13
- Deafness13
- Head and Neck Squamous Cell Carcinoma13
- Nasopharyngeal Cancer13
Leading sponsors
- Sun Yat-sen University57
- Assistance Publique - Hôpitaux de Paris14
- Eye & ENT Hospital of Fudan University14
- National Cancer Institute (NCI)14
- Cairo University13
- NYU Langone Health13
- Mayo Clinic12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Massachusetts Eye and Ear Infirmary10
Where studies are running
- California61
- Maryland38
- Florida32
- New York32
- Massachusetts24
- Illinois20
- Texas20
- Alabama15
- Arizona15
- Colorado15
Recruiting studies1,269 total
- NCT05894083RecruitingPhase 2
PET-Scan Tailored De-escalation for p16+ throat cancer
This trial tests a treatment plan that may lower (de-escalate) therapy intensity for certain p16+ or HPV-positive throat cancers. It uses PET scan results and tumor features to try to keep cancer control while reducing side effects.
Ann Arbor, MichiganAges 18 years+ - NCT05905016Recruiting
Testing an endoscopy procedure for gut movement problems
This study looks at how useful the POEM procedure is for people with gut “motility” (trouble moving food through the digestive tract). If you’re already scheduled for POEM, your team will also track how well it helps and whether it’s practical in real care.
Orlando, FloridaAges 18 years+ - NCT05889013Recruiting
Nasal swab testing to guide care for kids with breathing issues
This study checks whether special nose tests help doctors choose the best treatments for children with long-term breathing and airway symptoms. It may help your child get more targeted care based on the test results.
Hartford, ConnecticutAges 2 years+ - NCT05880797Recruiting
Study of throat cancer profiles using multiple tests
This trial studies oropharyngeal (throat) cancer, including certain HPV-related cancers of unknown starting point, using several ways to measure tumor features. The goal is to better understand these cancers and possibly guide future care.
Palo Alto, CaliforniaAges 18 years+ - NCT05898659Recruiting
Tested new cochlear fitting with or without sound timing sync
This study compares two ways of setting up a cochlear implant to deliver sound, either with or without synchronized timing. It may help improve how well French-speaking adults with newer hearing loss can hear everyday sounds.
NiceAges 18 years+ - NCT03606200Recruiting
Join a registry for primary ciliary dyskinesia
This study is a registry that collects information from people diagnosed with primary ciliary dyskinesia. It may help researchers better understand the condition over time and improve future care.
BernAges Any age - NCT05859568Enrolling by invitation
Hearing device fit checks and baseline performance study
This study measures how well hearing devices work and how they are best fitted at the start. It helps the company collect baseline information so future testing and fitting can be improved.
Valencia, CaliforniaAges 8 years+ - NCT05867173Recruiting
Testing how cochlear implant wiring affects hearing perception
This study looks at how the connection between cochlear implant electrodes and nerve signals changes what you hear. It may help scientists improve how cochlear implants “map” sounds to your brain.
Boston, MassachusettsAges 3 months+ - NCT05865028RecruitingPhase 2
Test drug APG-157 for abnormal mouth tissue
This Phase 2 trial studies whether APG-157 can safely improve abnormal cells in the mouth (dysplasia) or early cancer-like changes (carcinoma in situ). You may be eligible if you have a visible, biopsy-proven lesion and can take oral medication while meeting blood and health requirements.
Miami, FloridaAges 18 years+ - NCT05870527Enrolling by invitation
Pupil changes during vagus nerve stimulation during ear surgery
This study looks at how your pupils (the black center of the eye) respond while a vagus nerve device is turned on during surgery for either a cochlear implant or a vagus nerve stimulator. It aims to better understand the eye/nerve effects of this stimulation, which may improve how such procedures are done safely.
New York, New YorkAges 18 years+ - NCT05815927RecruitingPhase 3
Pembrolizumab with targeted radiation for limited head and neck spread
This Phase 3 trial studies whether adding pembrolizumab (an immune medicine) to focused radiation (SABR) can better control head and neck cancer that has spread to only 1–5 spots. It may help some people live longer or delay cancer worsening by treating both the immune system and the specific metastases.
BrusselsAges 18 years+ - NCT05821959RecruitingPhase 3
Gene therapy for otoferlin-related hearing loss
This trial tests a gene therapy that aims to restore hearing in people with a specific genetic form of hearing loss. The therapy is given as a one-time injection into the inner ear and may help you hear without needing a cochlear implant.
San Francisco, CaliforniaAges Any age - NCT05838183Recruiting
Test treatment in people with lung disease and sleep apnea
This trial is studying how a treatment may work for adults who have interstitial lung disease or obstructive sleep apnea. It likely involves sleep testing so the team can measure breathing and sleep patterns.
TianjinAges 18–80 - NCT05837221Recruiting
Study of the mouth microbiome in oral cancer
This study looks at the types of bacteria in the mouth (the microbiome) in people with oral squamous cell cancer and compares them to people without this cancer. It may help researchers understand what’s different in oral cancer and what could be useful for diagnosis or treatment planning.
Aurora, ColoradoAges 18–100 - NCT05839756Recruiting
Predicting throat swelling after jaw surgery removal of a breathing tube
This trial studies how to predict who is most likely to develop a noisy, tight throat (stridor) after doctors remove the breathing tube following a jaw-stabilizing surgery. It may help clinicians spot higher-risk patients earlier so they can take preventive steps.
Al Mansurah, MansouraAges 18 years+ - NCT03042975Recruiting
Study brain and voice genetics in people with voice movement disorders
This study looks at how genetics and brain patterns are connected to laryngeal dystonia and voice tremor, including people with certain types of voice disorders. You may be asked to do imaging and voice-related assessments to help researchers understand what’s causing these symptoms.
Boston, MassachusettsAges Any age - NCT05150106Recruiting
Study brain and voice patterns in laryngeal dystonia
This study looks at how the brain and voice system work in people with laryngeal dystonia or voice tremor, and compares them with healthy volunteers. The goal is to better describe different “types” (phenotypes) so future care can be more targeted.
Boston, MassachusettsAges 18–80 - NCT04611516Recruiting
Study of ear, nose, and throat checks in PCD patients
This study follows people with primary ciliary dyskinesia (PCD) and looks at their regular ear, nose, and throat (ENT) checkups over time. Your participation may help doctors better understand how ENT care should be followed in PCD.
BernAges Any age - NCT04421365Recruiting
Brain–computer interface study for voice spasms from laryngeal dystonia
This study tests how a brain–computer interface reads brain signals to understand and possibly support people with a specific voice condition called adductor laryngeal dystonia. It also compares results with healthy people to help researchers see how brain activity differs during voice tasks.
Boston, MassachusettsAges 18–80 - NCT05805384Recruiting
Testing a noise-reduction program for cochlear implant users
This trial checks how well a computer “noise reduction” algorithm works for people who use cochlear implants. It may help make speech easier to understand in noisy settings.
New York, New YorkAges 12 years+ - NCT05810220Recruiting
Study how cochlear and auditory brain implants process sound
This study looks at how well sound signals are processed in people who use cochlear implants or auditory brainstem implants. Researchers may learn more about hearing and how the devices work, using lab-based listening tasks and brain/signal measurements.
New York, New YorkAges 2–90 - NCT05793151Recruiting
Guided care to start cancer treatment on time after surgery
This trial tests a navigation program (help from a care coordinator) versus usual care to help people start the recommended “next-step” treatments (like radiation, sometimes with chemo) on time after surgery. It’s for certain stages of squamous cell cancer in the head and neck area where late treatment could matter.
St Louis, MissouriAges 18 years+ - NCT05799144RecruitingPhase 2
Pembrolizumab plus investigational HPV drugs for throat cancer
This Phase 2 trial studies pembrolizumab (an immune therapy) combined with investigational treatment(s) pBI-11 and TA-HPV for advanced or recurrent oropharyngeal cancer that is HPV-positive and has certain immune marker levels (PD-L1 CPS ≥ 1). It may help your immune system better attack cancer.
Birmingham, AlabamaAges 18 years+ - NCT05808543Recruiting
BEARS training to improve hearing skills in teens with two implants
This study tests a structured training program (BEARS) designed to help children and teenagers who use cochlear implants in both ears hear better in everyday life. It aims to improve hearing abilities by building on your implant settings and usual care.
Birmingham, BirminghamAges 8–16
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,269 recruiting otolaryngology studies from the U.S. registry right now, out of 2,074 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.