Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,269 recruiting studies in this area right now.
By phase
- Not applicable890
- Phase 2154
- Phase 3103
- Phase 147
- Phase 431
- Phase 1/Phase 230
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma73
- Dysphagia66
- Hearing Loss61
- Tinnitus29
- Hearing Loss, Sensorineural24
- Nasopharyngeal Carcinoma (NPC)24
- Head and Neck Cancer23
- Allergic Rhinitis22
- Oropharynx Cancer21
- Nasopharyngeal Cancinoma (NPC)18
- Sensorineural Hearing Loss18
- Stroke17
- Oropharyngeal Cancer14
- Vestibular Schwannoma14
- Chronic Rhinosinusitis With Nasal Polyps13
- Deafness13
- Head and Neck Squamous Cell Carcinoma13
- Nasopharyngeal Cancer13
Leading sponsors
- Sun Yat-sen University57
- Assistance Publique - Hôpitaux de Paris14
- Eye & ENT Hospital of Fudan University14
- National Cancer Institute (NCI)14
- Cairo University13
- NYU Langone Health13
- Mayo Clinic12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Massachusetts Eye and Ear Infirmary10
Where studies are running
- California61
- Maryland38
- Florida32
- New York32
- Massachusetts24
- Illinois20
- Texas20
- Alabama15
- Arizona15
- Colorado15
Recruiting studies1,269 total
- NCT06077643Recruiting
Support groups for people after voice box removal
This trial tests whether joining workshops and exchange groups helps people who have had their voice box removed (a total laryngectomy) feel better supported. You would attend four sessions at Bichat Hospital to share experiences and learn from others.
ParisAges 18 years+ - NCT06072924Recruiting
Tongue exercise for swallowing after stroke
This study tests a tongue-strengthening exercise to help improve swallowing after a recent stroke. It may help patients who are having trouble swallowing safely.
Cincinnati, OhioAges 18 years+ - NCT06059261RecruitingPhase 2
Envafolimab plus chemoradiation and endostatin for advanced nasopharyngeal cancer
This trial tests a combination of a new immunotherapy (envafolimab) with standard chemoradiation and a drug that blocks blood vessel growth (endostatin) for people with advanced nasopharyngeal cancer that hasn't been treated before. The goal is to see if this combination works better than the usual treatment.
Chongqing, Chongqing MunicipalityAges 18–65 - NCT06076304RecruitingPhase 4
Comparing treatments for acute sinusitis
This trial tests whether nasal steroids, nasal irrigation, or oral antibiotics work best for acute sinusitis. It may help if you have ongoing sinus symptoms or a 'double-sickening' pattern after a cold.
Los Angeles, CaliforniaAges 18–75 - NCT06072495Recruiting
Understanding Why Some Cleft Palate Repair Patients Have Ongoing Speech Issues
This study uses special MRI scans to help doctors understand why some children who had cleft palate surgery still have difficulty with certain speech sounds. By looking at how the muscles in the back of the throat work, researchers hope to improve future surgical techniques and speech outcomes.
AmiensAges 7–12 - NCT06040892Recruiting
Hearing in noise for children with two cochlear implants
This study tests if wearing two cochlear implants helps children hear speech better in noisy places. The goal is to improve listening skills in everyday situations like classrooms or playgrounds.
LyonAges 7–17 - NCT06029270RecruitingPhase 2
Adding relatlimab to standard immunotherapy for nasopharyngeal cancer
This trial tests whether adding a new drug called relatlimab to the usual immunotherapy (nivolumab) helps people with nasopharyngeal cancer that has returned or spread. You will get standard chemotherapy plus nivolumab first, then if it works, you may be randomly assigned to get nivolumab alone or with relatlimab.
Dublin, CaliforniaAges 18 years+ - NCT06023550Recruiting
Complicated Ear, Nose, and Throat Infections Study
This study looks at patients with complicated infections of the ear, nose, throat, or neck that are treated at a specific hospital in Slovenia. The goal is to learn more about these infections and how they are managed.
Ljubljana, LjubljanaAges Any age - NCT06014710Recruiting
Studying swallowing function with new testing methods
This trial tests a new way to measure how well your throat and voice box work during swallowing. It may help doctors better understand swallowing problems and improve care.
BordeauxAges 18 years+ - NCT06017895Recruiting
Doxepin rinse for severe swallowing pain during throat radiation
This trial tests a medicated mouth rinse (doxepin) to ease severe pain when swallowing, caused by radiation therapy for nasopharyngeal cancer. It aims to help patients who are currently receiving radiation and have mouth or throat sores.
Guangzhou, GuangdongAges 18 years+ - NCT04591093Recruiting
Tested deep vs shallow sound settings in cochlear implants
This study looks at how changing the “stimulation depth” (how deep the sound signals are delivered in the implant) affects hearing performance in people with cochlear implants. It may help find the best settings for improving hearing outcomes for suitable adults.
ParisAges 18 years+ - NCT05983432RecruitingPhase 1
Study of BL-B01D1 for advanced lung and other solid tumors
This trial tests an experimental drug called BL-B01D1 for people with several types of advanced solid tumors, especially non-small cell lung cancer and breast cancer. It's designed for those whose cancer has continued to grow after standard treatments.
Beverly Hills, CaliforniaAges 18 years+ - NCT05951478Recruiting
Study for people with primary ciliary dyskinesia follow-up
This study (RaDiCo-DCP) follows people who have a confirmed diagnosis of primary ciliary dyskinesia, a condition that can affect how your lungs clear mucus. The trial looks at long-term symptoms over time, which may help improve care planning and understanding of the condition.
BesançonAges Any age - NCT05967507Recruiting
Testing oxygen flow during infant airway tube placement
This trial studies how different oxygen flow rates affect breathing during the process of placing a breathing tube in babies. It may help clinicians choose safer oxygen settings during routine and urgent (but not life-threatening) airway management.
Philadelphia, PennsylvaniaAges Up to 12 months - NCT05970562RecruitingEarly Phase 1
Voice therapy plus biofeedback for vocal overuse problems
This early-phase study tests a mix of voice therapy and “biofeedback” (real-time feedback to help you change how you use your voice) for people with vocal overuse symptoms. It may help improve voice quality by targeting muscle tension and strain that happen when the voice is overworked.
Boston, MassachusettsAges 18–65 - NCT05962359Recruiting
Personalized coaching for language in young children with hearing loss
This trial tests a language program designed for young children with hearing loss who are getting cochlear implants. It aims to improve how well children understand and use spoken language, by using a “prediction” approach to tailor support.
Chicago, IllinoisAges birth–5 years - NCT05946577Recruiting
Links tinnitus and hearing changes after head and neck cancer treatment
This study looks at how tinnitus (ringing in the ears) and hearing problems may develop after radiotherapy alone or with certain chemotherapy for high-risk head and neck cancer. The goal is to better understand who is more likely to experience these side effects.
ParisAges 18 years+ - NCT05955469Recruiting
Test two cochlear implant sound-fitting methods
This trial compares two ways of setting up a cochlear implant for adults who need one and speak French. It may help find a fitting approach that gives clearer sound by using a “tonotopy-based” method versus a standard method.
Saint-EtienneAges 18 years+ - NCT05920330Recruiting
Study of blocked noses and loss of smell
This study looks at people who have trouble smelling and also feel their nose is blocked. The researchers want to understand what causes these symptoms and how they might be related, which could guide better treatment.
Columbus, OhioAges 18–70 - NCT05922085Recruiting
Ultrasound check to spot swallowing trouble after ICU care
This trial tests whether bedside ultrasound can help identify people at risk for swallowing problems that can start after time in the ICU and on a breathing machine. If you’re at risk early, the goal is to guide the care team to take steps sooner to prevent complications.
DijonAges 18 years+ - NCT05936034Recruiting
Hearing aid vs no hearing aid during platinum chemotherapy
This study compares how patients’ quality of life changes when people who have hearing loss from platinum chemotherapy use a hearing aid versus not using one. It may help understand whether hearing aids improve daily life during treatment.
Vandœuvre-lès-NancyAges 18 years+ - NCT05941741RecruitingPhase 3
Tested low-dose radiation plus cadonilimab for nasopharyngeal cancer
This Phase 3 trial studies whether adding low-dose radiation to cadonilimab (an immune therapy) can improve outcomes for people newly diagnosed with a specific type and stage of nasopharyngeal cancer. If you’re eligible, it may offer a new treatment approach and helps researchers confirm whether it works best.
Guangzhou, GuangdongAges 18–70 - NCT05913882Recruiting
Breathing training for people with ALS to improve cough
This study tests a breathing and expiratory muscle training program to help people with ALS cough more effectively. It may help reduce breathing and airway trouble by strengthening the muscles used for cough in early-stage ALS.
Fort Lauderdale, FloridaAges 18–90 - NCT05768178RecruitingPhase 2/Phase 3
Vemurafenib plus cobimetinib for BRAF-mutant cancers
This trial tests whether combining two targeted cancer medicines—vemurafenib and cobimetinib—can treat adults whose tumors have a specific “BRAF V600” mutation. You may be screened with blood tests and a tissue biopsy before starting treatment.
BelfastAges 18 years+
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,269 recruiting otolaryngology studies from the U.S. registry right now, out of 2,074 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.