Endocrinology & metabolism
Hormones & metabolism clinical trials
Diabetes, obesity, thyroid, and other conditions of the body’s hormones and metabolism. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable5,335
- Phase 2607
- Phase 1557
- Phase 3417
- Phase 4318
- Phase 1/Phase 2288
- Phase 2/Phase 385
Top conditions
- Obesity619
- Ovarian Cancer336
- Pancreatic Cancer289
- Type 2 Diabetes276
- Diabetes192
- Diabetes Mellitus183
- Diabetes Mellitus, Type 2170
- Hypertension138
- Type 1 Diabetes130
- Metabolic Syndrome126
- Obesity & Overweight123
- Breast Cancer111
- Overweight106
- Cardiovascular Diseases105
- Amyotrophic Lateral Sclerosis102
- Colorectal Cancer92
- Pancreas Cancer90
- Endometrial Cancer87
Leading sponsors
- Mayo Clinic87
- Novo Nordisk A/S64
- University of Colorado, Denver53
- Assistance Publique - Hôpitaux de Paris52
- M.D. Anderson Cancer Center41
- Massachusetts General Hospital41
- Eli Lilly and Company40
- IRCCS Azienda Ospedaliero-Universitaria di Bologna40
- National Taiwan University Hospital40
- Cairo University38
Where studies are running
- California521
- Maryland180
- Alabama176
- Arizona170
- Florida166
- Texas158
- Massachusetts151
- New York142
- Colorado115
- Pennsylvania113
Recruiting studies7,607 total
- NCT07833592Recruiting
Liver-targeted treatment for genetic leptin-related obesity
This study is for people with a rare genetic condition that causes severe obesity and high appetite, called leptin receptor deficiency or related leptin problems. The trial tests a new approach that targets the liver to help with weight control, and it aims to see if this can improve their condition.
Novara, ItalyAges Any age - NCT07827625Recruiting
Comparing two physical therapies for ankle pain in type 2 diabetes
This study tests whether a specific hands-on therapy (Mulligan mobilization) improves ankle motion, pain, and quality of life better than standard physical therapy in people with type 2 diabetes who have ankle stiffness and pain.
Islamabad, FederalAges 50–70 - NCT07828626Recruiting
Retained insulin benefits for good health
This study looks at whether keeping some natural insulin production helps people with diabetes stay healthier. It may help researchers understand the benefits of having some of your own insulin.
Truro, CornwallAges 18 years+ - NCT07833930Recruiting
Breakthrough pain after arm numbing block in diabetic patients
This study looks at whether people with diabetes have more breakthrough pain (pain that breaks through despite the block) within 48 hours after an arm surgery with a specific type of nerve block. The goal is to understand and improve pain management for diabetic patients.
TaiyuanAges 18–80 - NCT07832994Recruiting
Exercise for teens with celiac disease, metabolic syndrome, and fatty liver
This trial tests whether a specific exercise program can improve metabolic syndrome and fatty liver in teenage girls with celiac disease. It may help reduce liver fat and improve overall health.
Giza, DokkiAges 13–17 - NCT05779917RecruitingPhase 1
CAR-T cells for cancers that have specific target proteins
This Phase 1 trial tests a customized immune therapy (CAR-T cells) for advanced cancers that have the proteins mesothelin, GPC3, and/or GUCY2C. It may help your body better recognize and kill cancer cells, but early-phase trials mainly focus on safety and learning how well the treatment works.
Guangzhou, GuangdongAges 18–75 - NCT03755739RecruitingPhase 2/Phase 3
Checkpoint cancer drug given into or near tumors
This trial studies whether giving immunotherapy “checkpoint inhibitor” medicine directly into the tumor area (and/or the artery feeding it), along with a chemotherapy-style drug, can work better for advanced solid tumors. It aims to boost the immune system’s ability to attack cancer while still being safe for people with measurable tumors.
Guanzhou, GuangdongAges 18 years+ - NCT05187338RecruitingPhase 1/Phase 2
Study drugs that target immune checkpoints for solid tumors
This early-phase study tests a combination of three immune “checkpoint” medicines in people with advanced solid cancers. It aims to see how well they work and what side effects occur, including when given through a specific liver-focused treatment in eligible patients.
Guangzhou, GuangdongAges 18–70 - NCT06359275RecruitingPhase 2
Combination therapy for locally advanced or recurrent pancreatic cancer
This trial tests a combination of immunotherapy (PD-1), chemotherapy, and a special type of radiation called PULSAR for patients with locally advanced pancreatic cancer or cancer that has come back only in the pancreas area. The goal is to see if this approach can shrink tumors or keep them from growing.
ShanhaiAges 18–75 - NCT05410717RecruitingPhase 1
CAR-NK cell therapy for certain solid tumors
This early-phase trial tests a lab-made immune cell treatment for advanced solid tumors that show specific targets (including Claudin 6, GPC3, Mesothelin, or AXL). It may help the immune system better recognize and kill tumor cells, but eligibility depends on test results and your overall health.
Guangzhou, GuangdongAges 18–75 - NCT06472388RecruitingPhase 2
Testing two doses of everolimus for neuroendocrine tumors
This trial compares two daily doses (5 mg vs 10 mg) of everolimus, a targeted therapy, to see which works better and is safer for people with advanced neuroendocrine tumors (NETs). You may qualify if your cancer has grown despite previous treatment and you are in relatively good health.
São Paulo, São PauloAges 16 years+ - NCT06196294RecruitingPhase 1
Engineered immune cells for cancers with GPC3 or mesothelin
This trial tests a new type of immune cell therapy made from your own cells (gamma-delta T cells) that are engineered to find and attack cancers that have GPC3 or mesothelin proteins. It may be an option for people with advanced cancer who have not had gene therapy before and are in generally good health.
Guangzhou, GuangdongAges 18–75 - NCT05197738Recruiting
Study using a sleep health app to improve sleep
This study tests a “sleep health” app (REFRESH) to see how it may help people track and improve sleep. You may be eligible if you’re an adult in the U.S. who can use the app on your own phone.
La Jolla, CaliforniaAges 18 years+ - NCT06478225Recruiting
Cell therapy for advanced pancreatic cancer
This trial tests a new cell therapy (BGT007H) for people with advanced pancreatic cancer that has not responded to earlier treatments. The goal is to see if it is safe and can help shrink or control the cancer.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07822061RecruitingPhase 3
Weight loss study for people with excess weight
This study tests an investigational medicine for weight loss in people with excess weight. It aims to see how effective the medicine is and may help you lose weight and improve health.
Sapporo, HokkaidoAges 18 years+ - NCT07823608RecruitingPhase 3
Monthly study medicine for adults with sleep apnea and overweight who use a breathing machine
This study tests an investigational medicine taken once a month for adults with moderate to severe sleep apnea who are overweight or have obesity and use a CPAP or similar breathing machine. It aims to see if the medicine improves sleep-related breathing.
Cullman, AlabamaAges 18 years+ - NCT07823049RecruitingPhase 3
Study of XNW28012 for advanced pancreatic cancer after prior treatments
This trial tests a new drug, XNW28012, for people with advanced pancreatic cancer that has worsened after two standard chemotherapy treatments. The drug targets a protein called tissue factor on cancer cells, which might help slow or stop the cancer's growth.
Shanghai, Shanghai MunicipalityAges Any age - NCT07824583Recruiting
New radiation treatment for chest and upper abdomen tumors
This trial tests a new radiation treatment workflow that guides the radiation beam more precisely when you hold your breath. It may help target tumors in the chest or upper belly while sparing healthy tissue.
St Louis, MissouriAges 21 years+ - NCT07820085RecruitingPhase 2/Phase 3
Oral treatment for light sensitivity in EPP and XLP
This study tests an oral medication, PORT-77, to reduce pain and sensitivity to sunlight in people with EPP or XLP. It may help those who experience symptoms shortly after sun exposure.
Huntington Beach, CaliforniaAges 12 years+ - NCT07817875RecruitingPhase 3
Tirzepatide for weight loss in children aged 6 to under 12
This study tests a once-weekly medication called tirzepatide to help children aged 6 to under 12 with obesity lose weight. It compares the medication to a placebo (inactive shot) to see if it safely helps with weight loss in this age group.
Tucson, ArizonaAges 6–11 - NCT07820371Recruiting
Perfusion index for diabetic ketoacidosis severity in the emergency department
This study looks at a simple, non-invasive measurement called the perfusion index, which shows how well blood is flowing to your tissues, to help doctors quickly determine how severe diabetic ketoacidosis (a serious diabetes complication) is. The goal is to see if this measurement can guide treatment and improve outcomes.
Ankara, AnkaraAges 18 years+ - NCT05546138Recruiting
Study for early diabetic nerve damage in people with diabetes
This trial looks for and studies early nerve problems in the feet or legs that can happen with diabetes, before nerve damage is clearly diagnosed. It may help doctors better predict who is at risk and understand early changes.
AalborgAges 18–60 - NCT06390189Recruiting
Inflammation resolution in heart and metabolic health
This study examines how your body naturally resolves inflammation, which is important for heart health and conditions like diabetes. It involves blood draws and tests to understand how inflammation works.
AarhusAges 18–75 - NCT06454448RecruitingPhase 1/Phase 2
Adebrelimab plus chemotherapy for advanced pancreatic cancer
This trial tests a combination of a targeted immune therapy (Adebrelimab) with three chemotherapy drugs for people with metastatic pancreatic cancer who haven't had any treatment yet. The goal is to see if this combination can shrink tumors and help people live longer.
Tianjin, Tianjin MunicipalityAges 18–75
Common questions
- How many hormones & metabolism clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting endocrinology & metabolism studies from the U.S. registry right now, out of 11,814 we cover in this area in total.
- What does “Hormones & metabolism” cover here?
- Diabetes, obesity, thyroid, and other conditions of the body’s hormones and metabolism. We group each study into hormones & metabolism based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a hormones & metabolism trial near me?
- Use the search to filter hormones & metabolism studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.