Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,230 recruiting studies in this area right now.
By phase
- Not applicable3,147
- Phase 21,063
- Phase 1819
- Phase 1/Phase 2442
- Phase 3425
- Phase 4238
- Phase 2/Phase 396
Top conditions
- Multiple Sclerosis343
- Multiple Myeloma332
- Asthma194
- Lymphoma182
- Rheumatoid Arthritis140
- Type 1 Diabetes133
- Atopic Dermatitis129
- Systemic Lupus Erythematosus125
- Acute Lymphoblastic Leukemia122
- HIV Infections116
- Chronic Lymphocytic Leukemia100
- Autoimmune Diseases81
- Follicular Lymphoma74
- Diabetes Mellitus, Type 169
- Hodgkin Lymphoma67
- Rheumatoid Arthritis (RA)66
- Leukemia64
- Type 1 Diabetes Mellitus63
Leading sponsors
- Institute of Hematology & Blood Diseases Hospital, China91
- National Institute of Allergy and Infectious Diseases (NIAID)90
- National Cancer Institute (NCI)73
- Assistance Publique - Hôpitaux de Paris70
- M.D. Anderson Cancer Center63
- Novartis Pharmaceuticals60
- AstraZeneca57
- City of Hope Medical Center47
- Mayo Clinic46
- Memorial Sloan Kettering Cancer Center44
Where studies are running
- California491
- Maryland195
- Alabama175
- Florida144
- Arizona142
- New York123
- Massachusetts119
- Texas118
- Illinois81
- Colorado77
Recruiting studies6,230 total
- NCT02898987Recruiting
Study quality of care for adults living with HIV
This trial looks at how care is being provided to adults with HIV who may be on treatment or not, and regardless of immune strength. It may help improve future care plans by identifying what works best in real-world settings.
BelfortAges 18 years+ - NCT02918188RecruitingPhase 2
Hydrogen therapy for steroid-resistant graft-versus-host disease
This Phase 2 study tests whether hydrogen therapy can improve symptoms in people with chronic graft-versus-host disease (cGVHD) who cannot tolerate steroid treatment. If steroids aren’t working or can’t be used, this trial may offer an alternative approach to help control the illness.
Beijing, Beijing MunicipalityAges Up to 65 years - NCT02521311RecruitingPhase 2
Clemastine to help restore nerve covering in optic neuritis
This Phase 2 trial tests whether clemastine can help regrow the protective covering around the optic nerve after acute optic neuritis (an inflammation-related vision problem). It may help improve vision recovery and signal how well “remyelination” happens.
San Francisco, CaliforniaAges 18–55 - NCT02508038RecruitingPhase 1
Test CD19+ depleted donor transplant for hard childhood cancers
This Phase 1 study tests a special type of half-matched (haploidentical) stem cell transplant plus medicines, aiming to reduce cancer relapse after transplant. It may help children and teens with certain leukemia/lymphoma or specific solid tumors who do not have a fully matched donor or whose best options are limited.
Madison, WisconsinAges 7 months–21 years - NCT02523118Recruiting
Measuring symptoms and test results in eosinophilic gut diseases
This study looks at how eosinophilic inflammation in the esophagus and intestines affects outcomes like symptoms and test findings. It may help clinicians better understand these conditions and track what changes over time.
Phoenix, ArizonaAges 3 years+ - NCT02869529Recruiting
Chronic lymphatic leukemia patient database study
This study collects information from people diagnosed with chronic lymphatic leukemia. It may help doctors better understand the disease, track patient needs, and improve future care.
Marseille, Bouches-du RhôneAges 18–95 - NCT02579967RecruitingPhase 2
Stem cell transplant for primary immune system disorders
This study tests whether an allogeneic stem cell (bone marrow) transplant can correct an inherited immune problem in people with severe primary immunodeficiencies. It may help reduce life-threatening infections and improve quality of life, depending on your overall health and donor match.
Bethesda, MarylandAges 4–75 - NCT02641145Recruiting
PET/MRI scans in light-chain amyloid heart disease
This study uses special PET and heart MRI scans to better understand light-chain amyloidosis affecting the heart. The scans may help researchers see how the disease behaves in different patient groups and treatment states.
Boston, MassachusettsAges 18–99 - NCT02714634RecruitingPhase 4
Methotrexate or leflunomide plus added therapy for rheumatoid arthritis
This study compares two combination treatments for rheumatoid arthritis in people whose current methotrexate or leflunomide isn’t working well enough. It aims to see whether adding a targeted therapy works better than the standard add-on of sulfasalazine plus hydroxychloroquine.
StrasbourgAges 18 years+ - NCT02883335Recruiting
MS registry for people living in Lorraine
This study is a registry that collects information from people who have multiple sclerosis (MS). It helps researchers better understand MS in the Lorraine region and may guide future care.
NancyAges Any age - NCT02869542Recruiting
Lymphoma registry to support future research
This trial is a lymphoma database (a way to collect and store health information). It helps researchers study people with Hodgkin or non-Hodgkin lymphoma to better understand outcomes and possibly improve future care.
Marseille, Bouches-du RhôneAges 18–95 - NCT02912897RecruitingPhase 1
EBV T-cell treatment for early multiple sclerosis-like symptoms
This early-phase study tests whether a patient’s own immune cells (made to target a common virus called EBV) are safe and practical for people who have their first episode that strongly suggests multiple sclerosis. If it works well, it could offer a new way to treat early disease—but the main goal now is safety and feasibility.
NantesAges 18–45 - NCT03004326Recruiting
Biopsy study to test skin inflammation gene signals
This study uses a skin biopsy to look at “gene signals” (transcriptomics) in patients with active vasculitis that shows up on the skin. It may help researchers understand what is happening in your disease and how different types of vasculitis differ.
Los Angeles, CaliforniaAges 5 years+ - NCT02954939Recruiting
Test medicines to change immune cells in lupus kidney flare
This study tests whether mycophenolate mofetil and cyclophosphamide can improve active lupus kidney inflammation by changing immune cell patterns in your blood. It may help patients whose lupus nephritis is currently active, shown by worsening urine protein and/or kidney blood tests.
Hong KongAges 18–80 - NCT03215836Recruiting
Study obesity and metabolism in adults with asthma
This study looks at how weight and blood-sugar/fat changes in the body may affect the airways in people with asthma. You may be asked to complete breathing tests and possibly an airway procedure (bronchoscopy) to help researchers compare groups.
Aurora, ColoradoAges 18–65 - NCT03207464RecruitingPhase 1/Phase 2
PET/MRI scan study for nerve inflammation in multiple sclerosis
This early-phase study uses a special PET scan and an MRI to look at nerve-related inflammation in people with multiple sclerosis (MS). The goal is to see whether this scan can detect MS-related changes, which could improve how MS is studied in the future.
Boston, MassachusettsAges 18–60 - NCT03352193Recruiting
Oral wheat tolerance treatment for children with wheat allergy
This trial tests a supervised “oral tolerance induction” approach, which means giving carefully controlled wheat exposure to try to train the immune system to tolerate wheat. It’s designed for children who have confirmed IgE-mediated wheat allergy, aiming to reduce allergic reactions over time.
AthensAges 2–16 - NCT03219450RecruitingPhase 1
Personalized vaccine for early-stage, treatment-free CLL
This Phase 1 study tests a personalized cancer vaccine made from each patient’s CLL (“neoantigens”) plus a medicine called poly-ICLC to help the immune system learn to recognize the cancer. It is designed for people who have CLL but are currently not needing treatment, to see if it’s safe and may help keep the disease under control.
Boston, MassachusettsAges 18 years+ - NCT03358693Recruiting
Study of inflammation patterns in chronic skin diseases
This study looks at molecular (body-level) signatures in people with chronic inflammatory skin conditions. You may help researchers understand what drives inflammation, while receiving standard (already approved) systemic treatment through routine care.
KielAges Any age - NCT03369821Recruiting
Study of immune changes in very early childhood type 1 diabetes
This study looks at immune system cells and gene activity in infants and young children to understand what causes type 1 diabetes to start so early. It may help researchers find earlier warning signs and better ways to support families right at diagnosis.
Seattle, WashingtonAges Up to 70 years - NCT03314974RecruitingPhase 2
Stem cell transplant study for blood cancers
This Phase 2 study tests a strong (myeloablative) stem cell transplant using donor stem cells (allogeneic transplant) for certain blood and bone marrow cancers. The goal is to see how well this approach works and whether it can improve outcomes for people who need transplant-level treatment.
Minneapolis, MinnesotaAges Up to 60 years - NCT03217396Recruiting
Study blood and MRI markers in people with multiple sclerosis
This study looks for signs of “synapse damage” in multiple sclerosis using blood tests and brain imaging (MRI). The goal is to find biomarkers that may help better understand MS and how it changes over time.
Pozzilli, IserniaAges 18–65 - NCT03146884Recruiting
Study of autoimmune hepatitis in people living in Switzerland
This study looks at people with autoimmune hepatitis (an immune system condition that attacks the liver). It aims to learn more about the disease by following patients who live in Switzerland.
Lugano, Canton TicinoAges Any age - NCT03375619Recruiting
Long-term follow-up after CAR-T treatment
This study checks in with people who already received CAR-T therapy to learn how they’re doing over time. It may help doctors understand the long-term benefits and side effects of CAR-T for future patients.
Milwaukee, WisconsinAges 18–80
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,230 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,763 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.