Pulmonology
Lungs & breathing clinical trials
Asthma, COPD, and other conditions that affect the lungs and breathing. We’re tracking 6,618 recruiting studies in this area right now.
By phase
- Not applicable4,293
- Phase 2848
- Phase 1470
- Phase 3423
- Phase 1/Phase 2310
- Phase 4207
- Phase 2/Phase 367
Top conditions
- Lung Cancer424
- Asthma194
- Non Small Cell Lung Cancer189
- Non-Small Cell Lung Cancer179
- Non-small Cell Lung Cancer171
- Obstructive Sleep Apnea156
- COPD143
- Breast Cancer109
- COVID-19107
- Pulmonary Hypertension100
- NSCLC95
- Chronic Obstructive Pulmonary Disease90
- Colorectal Cancer86
- Cystic Fibrosis78
- Interstitial Lung Disease78
- Pneumonia78
- Ovarian Cancer74
- Acute Respiratory Distress Syndrome72
Leading sponsors
- Assistance Publique - Hôpitaux de Paris79
- AstraZeneca65
- Mayo Clinic53
- M.D. Anderson Cancer Center46
- National Cancer Institute (NCI)40
- VA Office of Research and Development39
- Chinese University of Hong Kong36
- Shanghai Chest Hospital36
- University Health Network, Toronto36
- Riphah International University34
Where studies are running
- California389
- Alabama174
- Arizona154
- Massachusetts128
- Florida117
- New York113
- Maryland110
- Texas89
- Pennsylvania84
- Colorado71
Recruiting studies6,618 total
- NCT04604509RecruitingPhase 4
Smoking quit plan using counseling and nicotine-free medicines
This trial tests whether a quit program that combines counseling with medicines (nicotine replacement, varenicline, or bupropion) helps people stop or cut down smoking. It’s also delivered through telehealth, with repeated check-ins to see how well the plan works and whether it’s safe for you.
Houston, TexasAges 18 years+ - NCT04223466Recruiting
Surgery to remove the thymus using two different approaches
This trial compares two ways of surgically removing the thymus: a camera-assisted approach through the chest versus an approach through an opening under the breastbone. It may help people with thymus tumors or certain types of myasthenia gravis when medicines alone have not worked well.
Jinan, ShandongAges 20–80 - NCT04449458Recruiting
Online group program to help you quit smoking
This trial tests an online, group-based smoking-cessation program using nicotine replacement therapy (NRT) to help you quit smoking. It may help by combining stop-smoking support with internet-based group sessions you can join from home.
Tampa, FloridaAges 18 years+ - NCT04392401Recruiting
Study immune changes in adults during ICU stay for COVID-19
This study looks at how your immune system responds while you’re in the intensive care unit (ICU) for COVID-19. Researchers will collect samples early in the ICU stay to better understand immune changes during the illness.
BronAges 18 years+ - NCT04047784Enrolling by invitation
Using EBUS to help diagnose a blood clot in the lungs
This study looks at whether a procedure called EBUS (a camera passed through the airway) can help doctors diagnose an acute pulmonary embolism—a sudden blood clot in the lungs—in critically ill, intubated ICU patients. If you’re eligible, EBUS may be done during bronchoscopy as part of your usual care to help confirm or rule out the diagnosis.
Los Angeles, CaliforniaAges 18 years+ - NCT03999138Recruiting
MRI study of lung fluid changes in acute heart failure
This study uses MRI scans to measure lung fluid (pulmonary edema) in people hospitalized for acute heart failure. It aims to see how well the lung fluid responds to standard treatments like water pills (diuretics) given in the first couple of days.
Edmonton, AlbertaAges 18 years+ - NCT04395937Recruiting
Study of gentle aerobic exercise to improve severe asthma control
This trial studies whether a lower-intensity aerobic exercise program (not maximal effort) can improve asthma symptoms and control. It is meant for adults with asthma who are still not well controlled despite current inhaler treatments.
Liège, LiegeAges 18–65 - NCT04281979Recruiting
Testing a substance’s effects in adult cigarette and vape users
This study tests how a specific substance affects people who currently smoke cigarettes or e-cigarettes. You may be able to join if you’re within a certain age range and recently had specific smoking and drinking patterns, and if you meet health/safety requirements for study procedures like MRI.
Portland, OregonAges 21–40 - NCT04402788RecruitingPhase 2/Phase 3
Radiation added to immune therapy for extensive small cell lung cancer
This trial tests whether adding radiation therapy to standard immune therapy (atezolizumab) after initial chemo can help people with extensive-stage small cell lung cancer live longer and control the cancer better. You must have a good response (partial response) or stable disease after initial treatment, plus several lab/imaging checks to confirm safety.
Birmingham, AlabamaAges 18 years+ - NCT04538859Recruiting
Study of causes of flare-ups and death in bronchiectasis
This study looks at what factors are linked to flare-ups and serious outcomes in people with non–cystic fibrosis bronchiectasis. You may be followed because your lung scans and recent stability help researchers understand what predicts worsening.
Hong Kong, Please SelectAges 18 years+ - NCT06841822Recruiting
Nerve blocks for lung surgery: a study on heart function
This trial tests if a special ultrasound-guided nerve block can help keep your heart and blood pressure stable during the start of lung surgery. It may lead to a safer and more comfortable experience.
Nanjing, JiangsuAges 18 years+ - NCT04078412Enrolling by invitation
Registry for adults with nontuberculous lung infection
This is a research registry that collects information from adults diagnosed with nontuberculous mycobacterial (NTM) lung disease. It may help doctors better understand the disease and improve care over time.
SeoulAges 20 years+ - NCT04534296Recruiting
Early mobilization for breathing muscles in critically ill children
This study looks at whether starting movement early in the first day of breathing support can help keep the diaphragm (a key breathing muscle) working better in critically ill children. The researchers will check diaphragm thickness using ultrasound and compare it to usual care.
ShanghaiAges 6 months–12 years - NCT03851445RecruitingPhase 2/Phase 3
Lung cancer screening trial using tumor and blood test results
This trial helps sort people with previously treated lung cancer into the best next treatment options by using new tumor tissue (and sometimes blood) test results. It may help you get matched to therapies based on features like PD-L1 and other biomarkers.
Birmingham, AlabamaAges 18 years+ - NCT06945523RecruitingPhase 1
CAR-T cell therapy for CEA-positive advanced lung cancer
This trial tests a treatment using your own immune cells, modified to target a protein called CEA on lung cancer cells. It's for people with advanced lung cancer that has gotten worse after at least one prior treatment.
Wuhan, HubeiAges 18 years+ - NCT03546829RecruitingPhase 1
Testing targeted radiation plus short anti-microbial treatment
This early safety study tests a combination of focused radiation and a targeted anti-microbial (antibiotic/antifungal/antiviral/anti-parasite) plan for certain lung cancer that is starting to progress in a few spots. It aims to see whether this approach is safe and helps control the small areas of progressing cancer after prior treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT02924818Recruiting
Research study for adults with long-term breathing lung diseases
This study enrolls adults with chronic lung conditions like COPD, cystic fibrosis, bronchiectasis, or interstitial lung disease. It’s designed to learn more about these illnesses and to develop better ways to study or improve care.
ReimsAges 18 years+ - NCT05547698Recruiting
ECMO versus off-pump double lung transplant care
This study compares two ways of supporting the lungs and heart around the time of a double lung transplant: venoarterial ECMO versus an off-pump approach. It may help your team choose the safest support method based on your heart-lung pressures and surgical plan.
Louisville, KentuckyAges 18 years+ - NCT02812290Recruiting
Microarray testing during lung transplant biopsy
This study looks at using a special lab test (microarrays) on tissue taken during a lung transplant biopsy. It aims to learn how the test may help doctors better diagnose and guide care after transplant.
Phoenix, ArizonaAges 18 years+ - NCT05415761Recruiting
Mobile phone support to help you quit smoking in clinic
This study tests different texting/app-based ways to help people quit smoking, especially those who may have less access to care. You may be assigned to one approach and get support through your phone.
Gainesville, FloridaAges 21 years+ - NCT02493478Recruiting
Improve safety during placing breathing tubes in children
This trial looks at ways to improve the safety and quality of emergency breathing tube placement in pediatric critical care and emergency settings. It may help reduce complications and improve how clinicians do these urgent procedures.
Birmingham, AlabamaAges Any age - NCT05289063RecruitingPhase 1
Study new sleep apnea and blood vessel function
This Phase 1 study looks at how blood vessel function is affected by obstructive sleep apnea in adults who are newly diagnosed and have not used CPAP. It may help researchers understand the early effects of sleep apnea and guide future treatments.
New York, New YorkAges 18 years+ - NCT05761028RecruitingPhase 2/Phase 3
CM310 for moderate to severe asthma despite current inhalers
This study tests CM310 to see if it can improve asthma in people with moderate to severe asthma who are still having uncontrolled symptoms and severe flare-ups despite regular inhaler treatment. You may be eligible if your lung function and asthma control tests fit the study limits and you’ve had a recent severe exacerbation.
Beijing, BeijinAges 12–75 - NCT05689034RecruitingPhase 2/Phase 3
Azvudine for early COVID-19 in higher-risk adults
This trial studies azvudine in adults with early COVID-19 symptoms to see if it can prevent the illness from getting severe. You may qualify if you’re within about 5 days of symptom start and have risk factors for worsening disease.
Beijing, Beijing MunicipalityAges 18–120
Common questions
- How many lungs & breathing clinical trials are recruiting?
- Clin2 is tracking 6,618 recruiting pulmonology studies from the U.S. registry right now, out of 10,521 we cover in this area in total.
- What does “Lungs & breathing” cover here?
- Asthma, COPD, and other conditions that affect the lungs and breathing. We group each study into lungs & breathing based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a lungs & breathing trial near me?
- Use the search to filter lungs & breathing studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.