Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,764 recruiting studies in this area right now.
By phase
- Not applicable6,413
- Phase 2492
- Phase 1247
- Phase 3239
- Phase 4212
- Phase 1/Phase 294
- Phase 2/Phase 367
Top conditions
- Anxiety388
- Depression381
- Alzheimer Disease338
- Autism Spectrum Disorder240
- Dementia226
- Mild Cognitive Impairment195
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder142
- Opioid Use Disorder140
- Stress117
- PTSD105
- Mental Health98
- Autism94
- Mild Cognitive Impairment (MCI)88
- Suicidal Ideation87
Leading sponsors
- VA Office of Research and Development105
- Yale University86
- Massachusetts General Hospital77
- Stanford University68
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University61
- University of California, Los Angeles58
- The University of Hong Kong51
- University of Pennsylvania51
- Karolinska Institutet50
Where studies are running
- California517
- Massachusetts266
- New York254
- Texas209
- Maryland175
- Pennsylvania169
- Florida147
- Alabama118
- Arizona109
- Illinois103
Recruiting studies7,764 total
- NCT04637620RecruitingPhase 2
NMDA-based treatment study for major depression
This Phase 2 trial tests whether an NMDA-targeted treatment can improve symptoms of major depressive disorder (MDD). You may be able to join if your depression diagnosis and symptom score fit, and you meet several safety and study-following requirements.
TaichungAges 18–55 - NCT04959201RecruitingPhase 2
NMDA and antioxidant add-on to treat schizophrenia symptoms
This Phase 2 trial tests whether adding an “NMDA-enhancing” treatment plus an antioxidant can improve ongoing schizophrenia symptoms over 12 weeks. It’s meant for people who still have symptoms even though their usual antipsychotic dose has been stable for at least 3 months.
TaichungAges 18–65 - NCT04917302RecruitingPhase 2
NMDA and anti-inflammatory add-on for treatment-resistant schizophrenia
This trial tests whether combining an NMDA “signal-supporting” treatment with an anti-inflammatory medicine can reduce symptoms in people with schizophrenia who don’t respond well to usual antipsychotic drugs. If you’ve tried at least two antipsychotics and you’re still symptomatic, this study may be worth screening for.
TaichungAges 18–65 - NCT05136755RecruitingPhase 2
NMDA treatment for depression that did not improve
This trial studies an NMDA-based treatment for people with major depressive disorder who did not respond to at least one antidepressant. It may help by changing brain signaling linked to depression symptoms.
TaichungAges 18–65 - NCT06021197RecruitingPhase 2
NMDA-enhancing treatment for cognitive symptoms in schizophrenia
This study tests a new treatment that may help with thinking and memory problems in people with schizophrenia. It is for people whose schizophrenia symptoms are stable and who are already on a steady medication.
TaichungAges 18–65 - NCT05977023RecruitingPhase 2
NMDA-targeted medicine to treat bipolar I depression
This Phase 2 study tests a medication that works on NMDA receptors to improve depression symptoms in people with bipolar I disorder. It may help if you’re currently in a bipolar depression episode and other mood treatments haven’t fully controlled it.
TaichungAges 18–65 - NCT06234176Recruiting
Psychomotor therapy for quality of life in depression
This study tests whether a special type of therapy called psychomotor therapy (which focuses on the connection between your mind and body) can improve quality of life for people with severe depression. You’ll continue your usual care while also receiving this therapy, and the researchers will track how your mood and daily life change over time.
LimogesAges 20–60 - NCT06740188RecruitingPhase 4
Trazodone for depression and insomnia with poor sleep quality
This trial tests if trazodone, a medication, can improve deep sleep in people who have both depression and insomnia. It aims to find a treatment that helps with both conditions at once.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT07381374Recruiting
Fecal transplant for children with autism
This trial tests whether fecal microbiota transplantation can help children with moderate-to-severe autism. It involves giving healthy donor bacteria to improve gut health and possibly autism symptoms.
Shenzhen, GuangdongAges 3–16 - NCT07380412Recruiting
Supplement study for ADHD med side effects
This trial tests if a dietary supplement can help reduce common side effects of stimulant medications for ADHD, like trouble sleeping or feeling irritable. If you take a stable dose of ADHD medication and are dealing with these issues, you may be able to join.
Las Vegas, NevadaAges 18–55 - NCT07379827Recruiting
A study on switching to KarXT for schizophrenia
This trial looks at how well KarXT works and what side effects it might have when people with schizophrenia switch to it from their current antipsychotic medication. It may be an option for those who have started KarXT recently or who plan to switch from their current treatment.
Bryant, ArkansasAges 18 years+ - NCT06024473Recruiting
Brain stimulation and virtual reality for memory loss
This study uses a combination of brain stimulation (rTMS) and virtual reality exercises to help improve memory and thinking. It is for people aged 55 and older who have Mild Cognitive Impairment (MCI), a condition that can affect memory but is not dementia.
Little Rock, ArkansasAges 55 years+ - NCT06833645Recruiting
PET scans to spot early Alzheimer's changes
This trial uses special PET scans to see amyloid and tau proteins in the brain, which are linked to Alzheimer's. It aims to find these changes early, in people with mild memory problems or early-stage Alzheimer's.
Chengdu, SichuanAges 18 years+ - NCT06833710Recruiting
Ear acupressure for better sleep in nurses
This study tests if applying small acupressure stickers on specific ear points can improve sleep quality for nurses. It may help if you have poor sleep and want a simple, drug-free option.
TaipeiAges 18–65 - NCT06835907Recruiting
Baclofen for anxiety and alcohol use disorder
This trial tests if baclofen can help people with both anxiety and alcohol use disorder. It is an open-label study, meaning everyone knows they are taking the medication. Researchers want to see if it supports people in staying alcohol-free.
Jette, Brussels CapitalAges 18–65 - NCT05763966Recruiting
Uppsala study of psychosis risk and early psychosis
This study follows people with early psychosis, or a high risk of developing psychosis, to better understand brain and symptom changes over time. It may help future prevention or treatment by comparing brain/clinical measurements between people who are at risk, recently affected, and healthy controls.
UppsalaAges 18–40 - NCT07379853Enrolling by invitation
Online training for therapists in exposure therapy
This trial tests an online training program to help therapists learn exposure therapy for anxiety. It may improve your skills in treating anxiety disorders.
Riverside, Rhode IslandAges 21–99 - NCT07379736Recruiting
Online support for heavy cannabis users
This trial tests a brief online advice program to help people who use cannabis heavily reduce their use. You take part from home and get personalized tips and support.
London, Greater LondonAges 18 years+ - NCT07382596RecruitingPhase 4
Cervical injections for treatment-resistant PTSD
This study tests if injecting a sugar-water solution around neck nerves can help PTSD that hasn't improved with standard treatments. Half the participants get sugar-water, half get salt-water, and you'll be assigned to usual care for 3 months first.
Lexington, KentuckyAges 19–90 - NCT07387107Recruiting
Reducing stress with virtual reality and special sounds
This study tests if a short session of virtual reality and specially designed sounds (binaural beats) can help healthy adults feel less stressed. Volunteers attend a single 60-minute session.
Bad NauheimAges 18 years+ - NCT07383324Recruiting
Heat stress study for people with schizophrenia
This study looks at how people with and without schizophrenia respond to heat stress. It aims to understand how heat affects the body, which may help improve safety and care during hot weather.
Ottawa, OntarioAges 18–85 - NCT07379723Recruiting
Brief therapy for Functional Cognitive Disorder: a feasibility study
This study tests a brief psychological therapy for people with Functional Cognitive Disorder (difficulties with memory or thinking that aren't linked to a brain disease). The goal is to see if this approach can help manage symptoms and if it is possible to run a larger trial.
LondonAges 18–65 - NCT07385508Recruiting
Rehabilitation study for people with disorders of consciousness
This study looks at how different types of rehabilitation (alone or combined) affect recovery in people with disorders of consciousness after a brain injury. It aims to find the best approaches to help improve outcomes.
Messina, SicilyAges 18–90 - NCT07387627Recruiting
COPCA Therapy for Infants at Risk of Developmental Delays
This study is testing a new way of doing physical therapy (called COPCA) for babies who are at risk of developmental delays. The goal is to see if it helps them reach milestones better than standard care.
Seville, SevilleAges Up to 1 year
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,764 recruiting psychiatry studies from the U.S. registry right now, out of 12,350 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.