Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,780 recruiting studies in this area right now.
By phase
- Not applicable6,422
- Phase 2492
- Phase 1251
- Phase 3240
- Phase 4212
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety387
- Depression382
- Alzheimer Disease339
- Autism Spectrum Disorder240
- Dementia227
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder142
- Stress117
- PTSD105
- Mental Health99
- Autism94
- Suicidal Ideation89
- Mild Cognitive Impairment (MCI)88
Leading sponsors
- VA Office of Research and Development105
- Yale University87
- Massachusetts General Hospital77
- Stanford University68
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- The University of Hong Kong51
- Karolinska Institutet50
Where studies are running
- California520
- Massachusetts267
- New York256
- Texas209
- Maryland176
- Pennsylvania171
- Florida149
- Alabama118
- Arizona108
- Illinois104
Recruiting studies7,780 total
- NCT06508710RecruitingPhase 3
Ketamine plus venlafaxine for severe depression
This trial tests whether adding ketamine to the antidepressant venlafaxine helps relieve severe depression faster than venlafaxine alone. If you are hospitalized for a serious depression and you meet safety criteria, you may be eligible.
Le Kremlin-Bicêtre, FranceAges 18–65 - NCT06309251Recruiting
Ketogenic diet for children with epilepsy or other conditions
This trial studies how well a ketogenic diet works for children with hard-to-treat epilepsy or certain other diseases. It aims to see if the diet improves quality of life.
Milan, MIAges Up to 18 years - NCT06514495Recruiting
Virtual vs. real-life therapy for agoraphobia
This study compares facing fears in virtual reality versus real-life situations for people with agoraphobia. Researchers want to see which method works better to reduce anxiety.
MainzAges 18–75 - NCT06346119Recruiting
Touch relaxation in ICU patients on a breathing machine
This study tests whether gentle touch therapy (like a hand or foot massage) helps reduce stress in patients who are on a breathing machine and sedated in the ICU. The goal is to make the recovery process more comfortable.
NiortAges 18 years+ - NCT06538558RecruitingPhase 1
Study of tezampanel for opioid withdrawal
This trial tests if tezampanel can help relieve withdrawal symptoms in people with opioid use disorder who are seeking treatment. Participants must already be in an outpatient addiction program.
Indianapolis, IndianaAges 18–65 - NCT06534723RecruitingPhase 3
Wujia Yizhi granules for mild-to-moderate Alzheimer's
This trial tests if a Chinese herbal granule (Wujia Yizhi) can help people with mild-to-moderate Alzheimer's dementia. It is for patients who have memory problems for at least 6 months and meet specific Alzheimer's biomarker criteria.
Fuzhou, FujianAges 50–80 - NCT06540833RecruitingPhase 2
Study of a new drug for psychosis in people with Alzheimer's disease
This trial tests an experimental medication to reduce hallucinations and delusions in people who have Alzheimer's disease. It may help manage these symptoms and improve quality of life for patients and their caregivers.
Anaheim, CaliforniaAges 55 years+ - NCT06547489RecruitingPhase 2
Testing zelquistinel for major depression
This study tests whether zelquistinel, an investigational drug, can reduce symptoms of major depressive disorder (a type of clinical depression). It is for people who are currently experiencing a moderate to severe depressive episode and are not taking other antidepressants.
Birmingham, AlabamaAges 18–64 - NCT06541886Recruiting
Online therapy for teens with insomnia
This study tests a type of therapy called cognitive behavioral therapy for insomnia (CBT-I), adapted for teens. The therapy is done online in virtual sessions and aims to help you sleep better without medication.
Indianapolis, IndianaAges 13–18 - NCT06548490RecruitingPhase 2
Semaglutide for Opioid Use Disorder
This study tests whether a once-weekly injection of semaglutide (a GLP-1 receptor agonist) can reduce opioid use in people who are already on buprenorphine or methadone but still using opioids. It lasts about 19 weeks.
Baltimore, MarylandAges 18–75 - NCT06532734Recruiting
Barrett's Esophagus in people with purging eating disorders
This study checks if long-term purging (vomiting) in people with eating disorders can damage the tube that connects your mouth to your stomach (called the esophagus). The goal is to see how common Barrett's esophagus (a precancerous change) is in this group.
Denver, ColoradoAges 18–65 - NCT06538246Recruiting
Coping skills training for heart and lung failure survivors
This study tests a coping skills training program to help people who recently survived a serious heart or lung problem feel less anxious, depressed, or stressed. If you were in the ICU and now feel distressed at home, you may be able to join.
Durham, North CarolinaAges 18 years+ - NCT06547021Recruiting
Brain stimulation frequency study for people with dementia
This study tests different frequencies of gentle electrical brain stimulation to see which works best for memory and thinking. It is designed for people with mild to moderate dementia, not caused by Parkinson's or other brain conditions.
WinnipegAges 50–95 - NCT06534827Recruiting
Study on mental health and relationships for kids
This study looks at how mentoring affects the mental health of children aged 9 to 16 who are already in outpatient therapy. It aims to see if building supportive relationships can improve mental well-being.
Chicago, IllinoisAges 9–16 - NCT06534047RecruitingPhase 4
Brain stimulation or nicotine patch to help you quit smoking
This study tests whether a brain stimulation treatment called rTMS can help people with psychiatric conditions quit smoking. You will be randomly assigned to get either rTMS or a nicotine patch, and your progress will be tracked to see which treatment works better.
Toronto, OntarioAges 18–70 - NCT06535516Recruiting
Supporting youth and families after tough experiences
This study tests a program to help youth ages 10-15 who have faced child maltreatment, like abuse or neglect. It aims to build resilience in both the youth and their family.
Rochester, New YorkAges 10–15 - NCT06543407Recruiting
Safer smoking options for people with mental illness
This study offers a way to reduce harm from smoking for people with mental health conditions who are not ready to quit. It tests if switching to a less harmful product can help improve health without requiring you to stop smoking completely.
Louisville, KentuckyAges 21 years+ - NCT06547099Recruiting
Understanding new blood markers in memory loss and dementia
This study is looking for older adults (60+) to help researchers better understand how to detect and track memory changes and dementia. Participants will provide blood samples and other health information over time to identify new markers that might help with early diagnosis.
St Louis, MissouriAges 60 years+ - NCT06548191RecruitingPhase 1
Time-Restricted Eating for Alzheimer's Disease
This study tests whether a time-restricted eating schedule (eating all meals within a 10-hour window each day) can improve memory and thinking in people with early Alzheimer's disease or mild cognitive impairment. Healthy partners of people with memory problems can also join as a comparison group.
San Diego, CaliforniaAges 60 years+ - NCT06544408Recruiting
Brain stimulation for fast relief of PTSD
This study tests a rapid, non-invasive brain stimulation treatment to reduce PTSD symptoms. It aims to offer a faster way to help adults with PTSD feel better.
Tallahassee, FloridaAges 18–65 - NCT06547008RecruitingPhase 1
Suicide prevention training for army leaders
This study tests a suicide prevention training program for unit leaders and chaplains in the Connecticut Army National Guard. It aims to see if the training helps them better support soldiers in need.
Hartford, ConnecticutAges Any age - NCT06537921Recruiting
Testing minocycline for depression with obesity
This trial tests whether adding the antibiotic minocycline to your current antidepressant helps people with both depression and obesity. It aims to see if reducing inflammation can improve mood.
LondonAges 18–65 - NCT06549179Recruiting
Testing a tool to diagnose autism in adults
This study tests a new French questionnaire (AMSE) to see how well it can identify autism in adults who are seeking a first diagnosis. It may help you get a clearer answer about whether you have autism.
ParisAges 18 years+ - NCT06540703Recruiting
Ketogenic diet and brain health in anorexia recovery
This study tests whether a ketogenic (high-fat, low-carb) diet affects brain function in people who have recovered from anorexia nervosa. It aims to see if this diet could help improve eating disorder symptoms.
San Diego, CaliforniaAges 18–45
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,780 recruiting psychiatry studies from the U.S. registry right now, out of 12,430 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.