Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,779 recruiting studies in this area right now.
By phase
- Not applicable6,422
- Phase 2492
- Phase 1250
- Phase 3240
- Phase 4212
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety387
- Depression382
- Alzheimer Disease338
- Autism Spectrum Disorder239
- Dementia228
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder143
- Stress117
- PTSD105
- Mental Health99
- Autism94
- Mild Cognitive Impairment (MCI)89
- Suicidal Ideation89
Leading sponsors
- VA Office of Research and Development104
- Yale University87
- Massachusetts General Hospital77
- Stanford University68
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- Karolinska Institutet51
- The University of Hong Kong51
Where studies are running
- California520
- Massachusetts267
- New York255
- Texas209
- Maryland176
- Pennsylvania170
- Florida149
- Alabama118
- Arizona109
- Illinois104
Recruiting studies7,779 total
- NCT06109363Recruiting
Sleep improvement program for Chinese adults with insomnia
This study tests a step-by-step counseling program for insomnia (CBT-I) that starts with simple steps and adds more support if needed. It’s for Chinese adults who have trouble sleeping and may help you improve your sleep without medication.
Shatin, New TerritoriesAges 18–70 - NCT04781972RecruitingPhase 4
Brain scan study of ADHD effects from methylphenidate
This study uses brain imaging (MRI) to see how methylphenidate affects brain activity in people with ADHD. It may help doctors better understand how this medicine works and who benefits most.
Baltimore, MarylandAges 6–40 - NCT05700279Recruiting
PTSD treatment to help prevent future chronic pain
This study tests whether treating post-traumatic stress disorder (PTSD) right when you come to the emergency room for new, acute pain can lower the chance you develop long-term (chronic) pain. It may help people whose pain and trauma symptoms start around the same time.
Chicago, IllinoisAges 18–70 - NCT05711056Recruiting
Telehealth help to start and link treatment for opioid use disorder
This program offers telehealth support to help you start opioid use disorder treatment and get connected to ongoing care, using toxicology/medical specialists. It may help if you’re in a stable, sober condition and not already on similar treatment.
Atlanta, GeorgiaAges 18 years+ - NCT05630963Recruiting
Study sleep-like brain signaling in major depression
This trial looks at how a specific brain receptor related to pain signals (nociceptin/orphanin FQ receptor) may be involved in depression. It may help researchers understand depression better by comparing people with current versus past (remitted) major depression.
Belmont, MassachusettsAges 18–45 - NCT03202303RecruitingPhase 2
CBDV treatment study for children with autism irritability
This Phase 2 study tests CBDV, a form of cannabis-based medicine, compared with placebo (dummy medicine) in children with autism who have significant irritability and social challenges. It aims to see whether CBDV can improve behavior and overall symptom severity safely over the study period.
New York, New YorkAges 5–18 - NCT05877885Recruiting
Digital treatment for low motivation in older adults with depression
This study tests a digital therapy to improve apathy (feeling unmotivated or “checked out”) in people age 60+ who have depression. It also uses brain imaging (MRI) and questionnaires to see whether the treatment helps brain function linked to motivation.
Orlando, FloridaAges 60 years+ - NCT03047369Recruiting
Myelin brain disorder research biobank for samples and data
This study collects brain-related medical information and biological samples to help researchers better understand leukodystrophies and other white-matter brain disorders. It may help future diagnosis and treatments by building a valuable “biobank” of patient data and samples.
Los Angeles, CaliforniaAges Any age - NCT05793541Recruiting
Just-after-discharge support for people with suicidal thoughts
This study tests a “right when you need it” phone-based support program to help lower short-term suicide risk after you leave the hospital. If you recently had suicidal thoughts during your inpatient stay, you may be offered brief, timely interventions after discharge.
Boston, MassachusettsAges 18 years+ - NCT06094933Recruiting
Mobile anger reduction for veterans with PTSD
This study tests a mobile app that helps veterans with PTSD manage anger. If you often feel angry or irritable, this app might help you learn ways to feel calmer and more in control.
Durham, North CarolinaAges Any age - NCT06091566Recruiting
Nerve stimulation device for overactive bladder and bowel
This study tests a new kind of nerve stimulation device that is inserted into the vagina to help control bladder and bowel problems. It may reduce urgent trips to the bathroom, leaking, and other symptoms of overactive bladder or bowel dysfunction.
AarhusAges 18 years+ - NCT06088121Recruiting
TMS with cognitive training for mild Alzheimer's dementia
This study tests a combination of brain stimulation (TMS) and cognitive training to improve memory and thinking in people with mild Alzheimer's. It may help if you are already on a stable dose of a donepezil-type medication and have a confirmed Alzheimer's diagnosis.
Incheon, Bupyeong 6(yuk)-dong, Bupyeong-guAges 60–85 - NCT01246765Recruiting
Pregnancy medication registry for mental health medicines
This study helps track how psychiatric (mental health) medicines affect pregnancy outcomes by collecting phone interviews during pregnancy. If you are pregnant and take (or have taken) mental health medication, you may help doctors understand risks and benefits better.
Boston, MassachusettsAges 18–45 - NCT06085950Recruiting
Ultrasound brain stimulation for hard-to-treat depression
This trial tests whether a gentle ultrasound treatment aimed at the brain can help people with severe depression that hasn't improved with at least two prior medications. It's a first small study to see if the approach is safe and promising.
ParisAges 18–75 - NCT06093906Recruiting
Positive processes and transition to health (PATH) study
This study tests a new therapy that may help people recover after a stressful life event. Over about 6 weeks, you'll work with a coach to retrain your brain's patterns and feel more in control again, as well as reconnect with positive activities.
Newark, DelawareAges 18–65 - NCT06088589Recruiting
Speech-in-noise in autism and fragile x
This study measures how well people with autism or fragile X syndrome perceive speech in noisy settings, compared to typically developing individuals. It uses EEG to understand brain activity during listening tasks.
Cincinnati, OhioAges 15–35 - NCT06099379RecruitingPhase 1/Phase 2
How CBD changes THC's effects: a dose study
This study tests different ratios of CBD to THC to see how CBD can change the effects of THC. It may help people who use cannabis occasionally understand how CBD can reduce unwanted side effects.
Montreal, QuebecAges 21–49 - NCT06090422RecruitingPhase 1/Phase 2
Ketamine for depression and alcohol use disorder
This trial tests if ketamine can help people who have both depression and alcohol use disorder. You must be currently sober, have at least moderate depression, and be admitted to the hospital for addiction treatment.
TromsøAges 18–65 - NCT06092671Recruiting
Can FPCA prevent confusion in young kids after surgery?
This study tests whether a medicine called FPCA can prevent sudden confusion (delirium) in young children after surgery. If your child is having short surgery with mask anesthesia for the first time, this study may help them have a smoother recovery.
Wenzhou, ZhejiangAges 2–6 - NCT06084221Enrolling by invitation
Studying overdose review teams to improve surveillance
This study looks at how local overdose fatality review (OFR) teams work and how they can help track and prevent overdoses better. Researchers will also use anonymous administrative data to understand overdose patterns in Indiana. The goal is to make our surveillance systems stronger and save lives.
Indianapolis, IndianaAges Any age - NCT06081348RecruitingPhase 2
Sertraline vs. placebo for anxiety in kids with developmental disorders
This trial compares sertraline (a common antidepressant) to a placebo (a pill with no medicine) to see which better reduces anxiety in children and teens who also have a neurodevelopmental disorder like autism, ADHD, or Tourette's. The goal is to help you and your child understand if this treatment might offer relief from anxiety.
Calgary, AlbertaAges 8–17 - NCT06085937RecruitingPhase 1
Ketamine for suicidal patients in the ER
This trial tests if a single dose of ketamine can quickly reduce suicidal thoughts in people who come to the emergency department. If you are having active suicidal thoughts and need inpatient care, you may be able to join.
Kansas City, KansasAges 18–65 - NCT06102486Recruiting
Speech in noise study for mild cognitive impairment
This study looks at how well people with mild cognitive impairment (MCI) understand speech in noisy settings. It aims to find better ways to diagnose and help people with thinking and memory concerns.
Lebanon, New HampshireAges 55–80 - NCT06095297Recruiting
Cognitive rehab for brain fog from long COVID
This study tests a computer-based cognitive training program combined with a gentle nerve stimulation device to see if it can improve brain fog and daily functioning in people with long COVID. If you're struggling with thinking, memory, or concentration after COVID, this might help.
Birmingham, AlabamaAges 18 years+
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,779 recruiting psychiatry studies from the U.S. registry right now, out of 12,461 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Pain
- Injuries & trauma
- Mouth & dental
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.