Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,779 recruiting studies in this area right now.
By phase
- Not applicable6,422
- Phase 2492
- Phase 1250
- Phase 3240
- Phase 4212
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety387
- Depression382
- Alzheimer Disease338
- Autism Spectrum Disorder239
- Dementia228
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder143
- Stress117
- PTSD105
- Mental Health99
- Autism94
- Mild Cognitive Impairment (MCI)89
- Suicidal Ideation89
Leading sponsors
- VA Office of Research and Development104
- Yale University87
- Massachusetts General Hospital77
- Stanford University68
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- Karolinska Institutet51
- The University of Hong Kong51
Where studies are running
- California520
- Massachusetts267
- New York255
- Texas209
- Maryland176
- Pennsylvania170
- Florida149
- Alabama118
- Arizona109
- Illinois104
Recruiting studies7,779 total
- NCT05663034Recruiting
Compare CBT-I vs MBTI for sleep and trauma symptoms after TBI
This study compares two types of talk-based therapy to help veterans with long-lasting insomnia after a traumatic brain injury (TBI), and also looks at related post-trauma stress symptoms. It may help you improve sleep and reduce how much these symptoms affect daily life.
Eglin Air Force Base, FloridaAges 18 years+ - NCT05655195Recruiting
At-home light and sound therapy for mild Alzheimer’s
This study tests whether regular at-home “gamma” light and sound stimulation can help people with mild Alzheimer’s. Participants start with a month at home and are followed to see how they do during treatment.
Cambridge, MassachusettsAges 65–100 - NCT05664516RecruitingPhase 2
Oxytocin treatment study for binge eating disorder adults
This Phase 2 trial tests whether oxytocin (a hormone-like medication) can reduce binge-eating symptoms in adults with binge-eating disorder (including related conditions like bulimia or certain feeding/eating disorders). You may be eligible if your symptoms match the trial’s specific diagnosis rules and you can safely take the study medication.
Boston, MassachusettsAges 18–70 - NCT05664841RecruitingPhase 2
Virtual magic tricks training for teens with autism
This Phase 2 study tests whether learning magic tricks through a virtual training program can help teens with autism. The goal is to see if the program is beneficial and workable using online sessions.
Birmingham, AlabamaAges 11–18 - NCT05661084Recruiting
Non-surgery brain stimulation for dementia thinking and movement
This study tests whether a non-invasive brain stimulation device (tES) can improve thinking and movement problems in people with dementia. You (and your caregiver, if needed) will be asked to follow the study plan and attend visits so researchers can measure results and safety.
Boston, MassachusettsAges 55 years+ - NCT05641623RecruitingPhase 2
Add-on treatment for depression not improved by standard medication
This trial tests whether adding the study drug OSU6162 to your current antidepressant can help when standard medications haven't worked well enough. It aims to reduce depression symptoms over several weeks.
Lund, Skåne CountyAges 25–75 - NCT05655325Recruiting
Exercise program to improve thinking in older adults with mild memory trouble
This study tests whether a supervised exercise plan can improve executive thinking (like planning and task control) in older adults with mild cognitive impairment. Researchers also look for brain changes using an MRI.
Washington D.C., District of ColumbiaAges 55 years+ - NCT05662280Recruiting
Brain stimulation study for teens with ADHD and memory trouble
This study tests whether changing brain activity can improve working memory in teens who have ADHD and trouble remembering and holding information in mind. You and your parent will answer questionnaires, and brain imaging/brain-stimulation testing (MRI/TMS) may be used, with compensation for each session.
East Providence, Rhode IslandAges 12–18 - NCT05643144Recruiting
Shared decisions for dementia and diabetes care
This study tests a program that helps people with both memory problems (like dementia or mild cognitive impairment) and diabetes, along with their caregivers, make better care decisions together. It uses a special device to track blood sugar without fingersticks.
Indianapolis, IndianaAges 65 years+ - NCT05669534RecruitingPhase 4
HIV prevention support for people starting PrEP
This study tests how to better support HIV prevention for people who inject drugs and are newly starting PrEP (medicine to prevent HIV). It focuses on people taking medication for opioid use disorder and who have mild thinking and memory problems, to help them stay safe and adhere to prevention.
New Haven, ConnecticutAges 18 years+ - NCT05658796Recruiting
Program to reduce opioid use after hip or knee replacement
This trial tests a support program called RXWell to help people use less opioid pain medicine after elective hip or knee replacement surgery. It may help by addressing anxiety and depression symptoms that can affect pain and recovery.
Monroeville, PennsylvaniaAges 18–100 - NCT05668598Recruiting
Memory check study for older adults with and without dementia
This study creates a practical tool to measure “episodic memory,” which is your ability to recall events from daily life. It includes adults age 70+ with different memory levels, to see how well the tool works for people with dementia and for those without.
LensAges 70 years+ - NCT05658913Recruiting
Tau PET/CT scan study for people in an ongoing cohort
This study uses a special brain scan (tau PET/CT) to look for a protein called tau, and it ties the scan results to information collected in an existing research program. It may help researchers better understand brain changes over time.
Boston, MassachusettsAges 18–120 - NCT05656469Recruiting
Personalized psychiatry meds using gene test results
This study compares a personalized medication plan based on your genes versus standard dosing for people with depression, anxiety, or psychosis. It may help your clinician choose a safer or more effective dose or medicine by using pharmacogenomics (gene-informed prescribing).
Syracuse, New YorkAges 16–70 - NCT05640089Recruiting
Brain training with fMRI feedback for depression
This trial tests whether using real-time brain scan feedback (fMRI neurofeedback) can help reduce depressive symptoms. You may be eligible if you have depression that is still active despite being on antidepressant medicine.
MaastrichtAges 18 years+ - NCT05671133Recruiting
Decision support to help clinicians prevent suicide risk
This study looks at whether a computer tool helps clinicians respond in a way that reduces suicidal thoughts or behaviors. If you’re attending the APS and can consent, the study may involve your information being used to improve clinician decision-making.
Boston, MassachusettsAges 18 years+ - NCT05655390Recruiting
Study after a suicide attempt testing a new treatment link
This study looks at how well an approach helps people after a suicide attempt, and how certain measurements in the body and thinking relate to outcomes. You may be able to join if you’re an adult and can safely complete the study assessments.
Barcelona, BarcelonaAges 18 years+ - NCT05651295Recruiting
Smartphone precision study to improve emotion regulation
This trial tests a precision approach delivered through a smartphone to better track and target how you manage strong emotions. It may help if you have ongoing difficulty regulating emotions day to day.
Columbus, OhioAges 18 years+ - NCT05656001Recruiting
Brain training to reduce self-harm in teens
This study tests whether two brain-training methods (neurofeedback and biofeedback) can help reduce self-harm in teens. It is only open to youth aged 15–19 who are getting care in Linköping or Norrköping, Sweden, and who have hurt themselves on purpose recently.
LinköpingAges 15–19 - NCT05669742RecruitingPhase 3
Empagliflozin plus olanzapine to reduce metabolic side effects
This trial tests whether adding empagliflozin to standard olanzapine treatment can improve metabolic problems (like blood sugar and cholesterol changes) that can happen with olanzapine in people with schizophrenia. If you qualify, you would be closely monitored for benefits and side effects.
TantaAges 18–65 - NCT05659082Enrolling by invitationPhase 3
Brain capsulotomy surgery for severe OCD
This trial is testing whether a specific brain surgery step called a capsulotomy can help people with severe, hard-to-treat obsessive-compulsive disorder (OCD). You would be considered only if your case is approved by the hospital’s psychiatric neurosurgery committee.
Providence, Rhode IslandAges 18–90 - NCT05654207Recruiting
Care coaching for Black teens and their parents after the ER
This study offers a supportive care program to help Black youth (ages 12–19) and their parent/guardian after an emergency room visit. It’s meant to improve how care is coordinated and supported, with help from both the teen and caregiver.
New York, New YorkAges 12–19 - NCT05649059RecruitingPhase 4
Cannabidiol study for social anxiety symptoms
This trial studies whether cannabidiol (CBD) helps improve social anxiety symptoms. You may be able to join if you are an adult with significant social anxiety and meet medication and health safety requirements.
Cambridge, MassachusettsAges 18–55 - NCT05649852Recruiting
Testing how socio-aesthetic care may reduce anxiety during chemotherapy
This study looks at whether “socio-aesthetic” care (support that combines social and beauty/wellbeing elements) can lessen anxiety in people starting chemotherapy. It is designed for patients who are new to chemotherapy and can complete French questionnaires.
ValenceAges 18 years+
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,779 recruiting psychiatry studies from the U.S. registry right now, out of 12,461 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.