Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,779 recruiting studies in this area right now.
By phase
- Not applicable6,422
- Phase 2492
- Phase 1250
- Phase 3240
- Phase 4212
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety387
- Depression382
- Alzheimer Disease338
- Autism Spectrum Disorder239
- Dementia228
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder143
- Stress117
- PTSD105
- Mental Health99
- Autism94
- Mild Cognitive Impairment (MCI)89
- Suicidal Ideation89
Leading sponsors
- VA Office of Research and Development104
- Yale University87
- Massachusetts General Hospital77
- Stanford University68
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- Karolinska Institutet51
- The University of Hong Kong51
Where studies are running
- California520
- Massachusetts267
- New York255
- Texas209
- Maryland176
- Pennsylvania170
- Florida149
- Alabama118
- Arizona109
- Illinois104
Recruiting studies7,779 total
- NCT05699226Recruiting
Testing whether adjusting ECT treatment helps depression outcomes
This study tests a way of adjusting (titrating) ECT treatment to improve outcomes in people with major depression or bipolar II. It’s mainly for those who already need ECT with right-side electrode placement.
Albuquerque, New MexicoAges 50 years+ - NCT05703256Recruiting
Brain training with feedback to help depression
This trial tests a type of brain training called amygdala neurofeedback to reduce depression symptoms. It may help by teaching your brain patterns to become less “stuck” in depression-related activity.
Pittsburgh, PennsylvaniaAges 18–55 - NCT05680220Recruiting
40 Hz light therapy for adults with depression
This trial studies whether daily 40 Hz light stimulation can reduce symptoms of major depression. You’d use a light device for about an hour each day for 6 weeks, while researchers track changes in depression severity.
Copenhagen, DenmarkAges 18–75 - NCT05675735Recruiting
Methadone take-home program to help people stay in treatment
This trial studies whether changing how methadone is allowed to be taken home can improve how long people stay in opioid use disorder treatment. It focuses on clinics and on adults who have already been receiving take-home methadone.
Storrs, ConnecticutAges 18 years+ - NCT05685368RecruitingPhase 1/Phase 2
Therapy groups to help teens cope with sickle cell
This trial tests a structured talk-therapy program called Acceptance and Commitment Therapy (ACT) for teens and young adults with sickle cell disease. It aims to help you manage tough thoughts and feelings and cope with day-to-day challenges over 6 weekly group sessions.
Los Angeles, CaliforniaAges 14–21 - NCT05674409Recruiting
Telehealth family program for moderate to severe alcohol use
This study tests a brief treatment delivered by video that involves a Veteran and a concerned family member or friend. It’s meant for Veterans with ongoing alcohol problems, to see if family involvement helps them change drinking and stay safe during treatment.
Charleston, South CarolinaAges 21 years+ - NCT05683223Recruiting
Brain and body markers to improve treatment for social anxiety
This study uses brain recordings (EEG and MRI) to understand how treatments help people with social anxiety. It also looks for signals that may predict who is most likely to benefit from treatment.
Boston, MassachusettsAges 18–50 - NCT05681572RecruitingPhase 3
Sedation before surgery to help kids feel better after anesthesia
This study tests whether giving a calming medicine before general anesthesia improves how children feel and experience anesthesia afterward. The goal is to see which pre-surgery approach works best and is comfortable for kids.
Montpellier, MontpellierAges 7–18 - NCT05698589Recruiting
Therapy program to reduce self-stigma in mental health
This study looks at how a program may help people with long-term mental health conditions feel less shame about their diagnosis (self-stigma). It is meant for adults who are stable enough to participate and who speak French.
BordeauxAges 18 years+ - NCT05700474Recruiting
Wellness support program for people with HIV or prevention needs
This trial tests an education and support program to improve overall wellness for adults who have HIV or are seeking HIV prevention services. It also looks at people who have had alcohol or substance use recently.
Charlotte, North CarolinaAges 18 years+ - NCT05702021Recruiting
Using counseling incentives to reduce stimulant use in opioid clinics
This trial tests a counseling approach called “contingency management,” which uses structured incentives to reduce stimulant use. It’s meant for people receiving treatment in specialty addiction programs and/or newly starting opioid-use medication who also use stimulants.
Chicago, IllinoisAges 18 years+ - NCT05707923Recruiting
Simplified language study for comprehension in autistic toddlers
This study looks at whether using simpler language helps young children with autism understand and learn. It involves children ages 1 to 4 who mainly hear and respond to English.
East Lansing, MichiganAges 1–4 - NCT05703412Enrolling by invitation
Text or app check-ins after discharge for serious mental illness
This study tests an mHealth (phone-based) program that helps people with serious mental illness after leaving the hospital. It may help you stay connected to care and support in the community after discharge.
Providence, Rhode IslandAges 18 years+ - NCT05708716Recruiting
Diet and brain training for people after blood cancer
This study tests whether a combined diet plan and structured brain (cognitive) training can improve thinking and memory in people who have had blood cancer. It may help survivors who already have mild-to-moderate thinking problems.
Birmingham, AlabamaAges 21 years+ - NCT05681923Recruiting
Pregnancy study tracking how brain development risk may run in families
This study follows pregnant parents and their child to understand what factors influence early brain and development. It compares families with an autistic sibling (higher risk) to families without (lower risk) to spot patterns that may help future care.
MontpellierAges Any age - NCT05682248Enrolling by invitation
Testing a brain assessment and stimulation system for unconsciousness
This trial studies a device and plan to assess brain function and deliver an intervention in people who are in a coma, minimally conscious state, or unresponsive arousal state after brain injury, stroke, or lack of oxygen. If you qualify, it may help doctors understand and potentially improve brain function over time.
BeijingAges 14–80 - NCT05703347Recruiting
Mobile app coaching to improve sleep and prevent childhood obesity
This study tests a mobile health app that helps children get better sleep, aiming to support healthier weight over time. It is designed for children who are getting less sleep than recommended and are in the higher-but-not-highest weight range for their age.
Philadelphia, PennsylvaniaAges 8–12 - NCT05701969RecruitingEarly Phase 1
Melatonin for sleep during night shifts in residents
This early study tests whether melatonin can improve sleep patterns for doctors-in-training during overnight “night float” shifts. It may help you feel more rested and adjust to night work.
Charlottesville, VirginiaAges 18 years+ - NCT05684094Recruiting
Study links sleep, stress, and brain reward in risky drinking
This study looks at how sleep timing and stress affect brain responses related to reward and stress in young adults who drink heavily. It may help researchers understand why some people take bigger alcohol risks and how sleep and stress could be part of safer treatment.
Eugene, OregonAges 18–24 - NCT05570110RecruitingPhase 1/Phase 2
Enoxolone for depression, using body signals to track response
This study tests enoxolone, a medication related to licorice, in people with unipolar (non-bipolar) major depression. It also looks at your body “signals” (biomarkers) to see which ones match with whether treatment helps.
Marburg, HesseAges 18 years+ - NCT05669703Recruiting
Tracking mood and activity patterns in bipolar disorder families
This study watches how a person’s mood and movement change over time, and how those patterns relate to bipolar disorder. It may help researchers better understand the condition in families and potentially improve future care.
Bethesda, MarylandAges 8–70 - NCT05647044RecruitingPhase 1
Brain stimulation to reduce impulsivity and suicidal thoughts after mild TBI
This early-stage study tests whether a noninvasive brain stimulation treatment (called iTBS) can reduce impulsivity and suicidal thoughts in Veterans who have had a mild traumatic brain injury (mTBI) and recent suicidal thinking. If you qualify, you may be offered a monitored treatment plan and assessments for safety and symptom changes.
Hines, IllinoisAges 22–65 - NCT05648591RecruitingPhase 4
Iloperidone study for teens with schizophrenia or bipolar I
This Phase 4 study checks how safe and well-tolerated iloperidone is when used in a typical, open-label way for teenagers. It may help doctors better understand side effects and safety in teens with schizophrenia or bipolar I disorder.
Dothan, AlabamaAges 12–17 - NCT05660642RecruitingPhase 2
Safety and tolerability study for BPL-003 in hard-to-treat depression
This Phase 2 study tests BPL-003 in people with treatment-resistant depression to learn about its safety and how it affects the body and brain. Because it is open-label, everyone knows they are getting the study treatment, and you’ll also need to stop your current antidepressant during the study.
LiverpoolAges 18–75
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,779 recruiting psychiatry studies from the U.S. registry right now, out of 12,461 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.