Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,057 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 381
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University52
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California39
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,057 total
- NCT07522671Recruiting
3D-Printed Crowns and Bridges for Dental Implants
This trial compares two types of artificial tooth restorations (made from resin or zirconia) placed on dental implants that have already fused with your jawbone. The study tests how well these 3D-printed restorations work and last over time.
Shibīn al KawmAges 18–60 - NCT06447753Recruiting
Comparing two treatments for tooth pain in back molars
This study compares two ways to treat a deep cavity in a back molar that has a moderately inflamed nerve. If you have a painful deep cavity, this trial will test if a partial or complete nerve treatment works better to save your tooth.
Rohtak, HaryanaAges 18–60 - NCT07703007Enrolling by invitation
Clear aligners for growing kids with mild underbite
This study tests whether clear aligners can fix a mild underbite in growing children aged 8 to 11. It compares how well the aligners move teeth and jaws compared to other treatments.
Al Mansurah, Dakahlia GovernorateAges 8–11 - NCT07700095Recruiting
Comparing two ways to rebuild jawbone for dental implants
This trial tests two ways to rebuild bone in the back lower jaw using special barriers (custom 3D zirconia or titanium mesh) to support a dental implant. It may help if you have severe bone loss and want an implant.
Kafr ElsheikhAges 20–50 - NCT06455436Recruiting
Custom healing caps for immediate dental implants
This study tests whether using a custom-made healing cap right after placing a dental implant helps the gum and bone heal better around the implant. It may be a good option if you need a molar or premolar removed and want an implant placed immediately.
Barcelona, CataloniaAges 25 years+ - NCT06724783RecruitingPhase 4
Comparing two collagen membranes for bone growth around dental implants
This study compares two types of collagen membranes used to help rebuild bone around a dental implant. If you need a single implant in the front of your mouth and a bone graft at the same time, this trial may help determine which membrane works best.
Geneva, Canton of GenevaAges 18–90 - NCT06086873Recruiting
Comparing two dental implant surfaces for healing
This study compares two types of dental implant surfaces to see which helps the implant bond better with the jawbone after a tooth is pulled. It may help you if you need a single front tooth or first premolar replaced.
LondonAges 18 years+ - NCT07711132Recruiting
Remineralizing toothpaste for early cavities in teens
This trial tests three different treatments for repairing very early cavities on tooth enamel: a nano-eggshell paste, a special milk protein paste (CPP-ACP), and a standard fluoride paste. It is for teenagers and young adults who have a few small spots of early decay and a moderate to high risk of getting cavities.
Al MansurahAges 15–20 - NCT06961045Enrolling by invitation
Nerve repositioning study for dental implants in lower jaw
This study tests a computer-guided technique to move a nerve in the lower jaw so that dental implants can be placed in areas with thin bone. It looks at whether this procedure causes any numbness afterward.
Tanta, Gharbia GovernorateAges 30–75 - NCT07502651Enrolling by invitationEarly Phase 1
Comparing two sedatives for jaw fracture surgery
This trial tests two medications given as a nasal spray to help you relax during surgery for a broken jaw. The goal is to see which one works better and is safer.
Rohtak, HaryanaAges 18–50 - NCT06110611Enrolling by invitation
Zirconia crowns on titanium abutments: 5-year study
This study checks how well a type of ceramic crown (zirconia) attached to a titanium base works for replacing a single missing back tooth. It looks at results 5 years after treatment.
GroningenAges 18 years+ - NCT07524569Recruiting
Digital vs. manual anesthesia in children's dental care
This study compares two ways of numbing teeth (digital intraosseous and manual intraligamentary anesthesia) in children who need fillings on back molars. It aims to see which method works better and causes less discomfort.
Izmir, CigliAges 6–12 - NCT06695780Recruiting
Food habits and health in older adults
This study looks at the eating habits and overall health of older adults who live at home. You will do things like answer questions, take some samples (like blood) yourself, and use a video call — all from home.
Meylan, IsereAges 55–75 - NCT06875830Recruiting
Immediate tooth replacement with mesh vs. membrane for damaged front teeth
This trial compares two materials—titanium mesh and collagen membrane—used to support a new tooth implant placed right after removing a badly decayed tooth in the upper front area. It aims to see which material works better when the bone around the tooth is partially damaged.
Cairo, Heliopolis - CairoAges 21–50 - NCT06468111Recruiting
Can therapy dogs help kids during blood draws or dental work?
This study tests if having a gentle therapy dog nearby can help children ages 3 to 12 feel calmer and more comfortable during a blood draw or dental procedure. If your child likes dogs and needs one of these procedures, this might be a good fit.
LleidaAges 3–12 - NCT07600203Recruiting
Low-level laser therapy for chronic jaw pain
This study tests whether a special laser device called the Erchonia EVRL can reduce chronic jaw pain caused by TMJ (temporomandibular joint) disorders. You would receive laser treatment and rate your pain over time to see if the laser helps more than a placebo.
Acton, MassachusettsAges 22–75 - NCT06698276Recruiting
Testing Next-X for preserving bone after tooth removal
This trial tests a new method (Next-X) to help preserve the bone where a tooth is removed. It may be for you if you need a single-rooted tooth pulled and your mouth and health are in good condition.
São Paulo, São PauloAges 18–80 - NCT07517367RecruitingPhase 4
Cooling before numbing for tooth nerve pain
This study tests whether applying cold to your gum before a numbing injection helps the anesthetic work better for a severely painful lower front tooth. Researchers want to see if this simple cooling step reduces pain during the procedure.
Samsun, AtakumAges 18–60 - NCT07671794Enrolling by invitation
Jaw repositioning surgery for facial deformities
This trial tests a surgical procedure to reposition the upper jaw in adults with certain jaw or facial irregularities, such as an overbite, underbite, or asymmetry. It aims to improve facial balance as an alternative to braces or other non-surgical treatments.
CairoAges 18 years+ - NCT06955429Recruiting
Testing Biodentine XP for tooth fillings and root treatments
This study tests how well Biodentine XP works over time for fixing cavities or treating tooth roots in children and adults. It aims to see if this material is safe and lasts long in both baby teeth and permanent teeth.
KraainemAges 2 years+ - NCT06472453Recruiting
Vallomix Socket Preservation Study
This study tests a new material called Vallomix placed in the tooth socket after extraction to help preserve bone for a future dental implant. It may be an option if you need a back tooth removed and plan to get an implant later.
Baltimore, MarylandAges 18 years+ - NCT05795647RecruitingPhase 2
Testing pentoxifylline and vitamin E for jaw bone damage
This trial tests a combination of medicines (pentoxifylline and tocopherol, a form of vitamin E) to treat damage to the jaw bone caused by bone-strengthening drugs. If you have Stage 2 MRONJ and meet other criteria, this treatment may help heal the bone.
LimogesAges 18 years+ - NCT04693949Recruiting
A study on a new coating for dental bridges
This trial tests a special coating for dental bridges made from a strong white material (zirconia). It may help the bridge bond better to your tooth.
LjubljanaAges Any age - NCT07664046Recruiting
Peptide for remineralizing white spot lesions in teens
This trial tests a self-assembling peptide (P11-4) to help reverse early white spots on teeth caused by cavities in teenagers. If effective, it could rebuild enamel without drilling or fillings.
Warsaw, Masovian VoivodeshipAges 10–18
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,057 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,953 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.