Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,057 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 381
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University52
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California39
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,057 total
- NCT07749586RecruitingPhase 1/Phase 2
Study of ARV-6723 alone or with pembrolizumab for advanced solid tumors
This trial tests an experimental drug called ARV-6723, alone or with another drug called pembrolizumab, for people with advanced solid tumors that have not responded to other treatments. The goal is to see if these combinations can help shrink tumors or slow their growth.
Huntersville, North CarolinaAges 18 years+ - NCT06676748RecruitingEarly Phase 1
Benzydamine gargle for sore throat after surgery
This trial tests whether a medicated mouthwash or gargle with benzydamine can help prevent a sore throat after surgery. It's for women having surgery with a type of breathing tube called a laryngeal mask airway.
SingaporeAges 21–80 - NCT06627270RecruitingPhase 2
Antibiotics before surgery for oral cancer
This trial tests if taking antibiotics and using a mouth rinse before surgery can help treat oral cancer by targeting bacteria inside the tumor. It is for people with a new diagnosis of oral cancer who are scheduled for surgery.
Cleveland, OhioAges 18 years+ - NCT07750561Enrolling by invitation
Turkish questionnaire for facial synkinesis
This study tests a Turkish version of a questionnaire that measures abnormal facial movements (synkinesis) that can happen after facial palsy. It aims to see if the questionnaire works well for Turkish-speaking patients.
Istanbul, CevizlibağAges Up to 18 years - NCT04870762RecruitingTeam says not enrollingPhase 2
3D-printed tongue stents during head and neck radiation
This Phase 2 study tests whether customized 3D-printed stents can be used safely during head and neck radiotherapy. If you’re having radiation (with or without chemotherapy), the stent may help make treatment easier and more precise, potentially improving the experience and outcomes.
Phoenix, ArizonaAges 18 years+ - NCT07035236Recruiting
Titanium mesh for dental implant bone support
This trial tests a new method to help people who have lost bone in the upper jaw get dental implants. If your jawbone is too thin, they will use a small titanium mesh to support the sinus lining and make room for an implant.
IsmailiaAges 18–60 - NCT07024251Recruiting
Collecting biological samples for oral and maxillofacial research
This study collects leftover samples (like tissue, saliva, or blood) from routine dental visits or oral surgeries. The samples are used to learn more about mouth and jaw diseases, with no extra procedures needed.
Milan, ItalyAges 18 years+ - NCT07059481Recruiting
Root canal sealers and oxidative stress study
This study is looking at how different types of root canal filling materials (sealers) affect oxidative stress markers in the body. It is for people with a single tooth that has a chronic infection at the root tip and needs a root canal.
Ordu, Ordu- AltınorduAges 18–45 - NCT07041424Enrolling by invitation
Bonding methods for filling cavities to reduce tooth sensitivity
This trial tests two ways of bonding a tooth-colored filling to see which reduces tooth sensitivity after the procedure. It may help if you have a moderate cavity on a back tooth that causes brief pain or sensitivity.
Islamabad, FederalAges 18 years+ - NCT07056998Enrolling by invitation
AI detects root canal quality, then retreats if needed
This trial tests whether artificial intelligence can spot problems in root canal treatments seen on special X-rays (CBCT) compared to regular X-rays. If the AI finds an issue, a retreatment is done.
Cairo, Cairo GovernorateAges 18–50 - NCT07069881Recruiting
Comparing two dental cleaning methods for chronic root infection
This trial compares two ultrasonic cleaning methods (regular vs. passive) for treating a chronic tooth infection called chronic apical periodontitis. It aims to see which approach is more effective at clearing the infection and saving the tooth.
Guangzhou, GuangdongAges 18–59 - NCT07007572RecruitingPhase 2
Comparing new tooth implants with different materials
This trial compares two types of tooth implant materials for replacing a missing lower back tooth. It looks at bone health and biting strength to see which material works better.
Cairo, Cairo GovernorateAges 30–60 - NCT07017413Recruiting
Predicting complications in maxillary sinus lift for dental implants
This study looks at what factors might lead to problems during a sinus lift procedure for dental implants in the upper jaw. It aims to help dentists better plan for patients who have less than 6mm of bone height.
Baghdad, Bab AlmodaumAges 18–70 - NCT07079163Recruiting
Comparing standard and 3D-printed mouth pieces for jaw surgery
This trial compares two types of dental appliances (one made the traditional way, one made with a 3D printer) for people who need part of their upper jaw removed. It aims to see which one works better for you.
Al MansurahAges 36–68 - NCT07067164Recruiting
Filling cavities in back teeth: A clinical trial comparing two materials
This trial compares a new type of filling material (high-viscosity glass ionomer) with a standard composite filling for cavities between back teeth. It tests which material works better over one year.
Cairo, Cairo GovernorateAges 18–45 - NCT06956612Recruiting
Dietary nitrate supplements and your oral health
This trial tests whether taking dietary nitrate supplements can improve oral health in healthy adults. It may help you understand how simple diet changes could support your mouth's natural defenses.
NewcastleAges 18–65 - NCT06920485Enrolling by invitation
Mouthwash after wisdom tooth surgery
This trial tests whether a mouthwash with hypochlorous acid can help healing after impacted wisdom tooth removal. It may reduce discomfort and speed recovery.
AnkaraAges 18–45 - NCT06963242Recruiting
Testing a navigation tool for full-arch dental implants
This trial tests whether a dynamic navigation system helps place dental implants more accurately for people who need a full set of upper or lower teeth. If you are missing most or all of your teeth and are generally healthy, this study may be for you.
Ho Chi Minh CityAges 18 years+ - NCT06902454Enrolling by invitation
Sinus lift with special drill and same-day implant placement
This trial tests a new way to lift the sinus floor using a special drill and a surgical guide, placing a dental implant at the same time. It may help people who need an implant in the upper jaw but don't have enough bone height.
TantaAges 18 years+ - NCT06834087Enrolling by invitation
Laser and dye vs. nanoparticle therapy for dark gums
This trial compares two newer treatments for dark gums—laser plus a blue dye versus laser plus tiny particles that are activated by light. The goal is to see which works better and is safer.
Kafr ash Shaykh, Kafr Ash Shaikh/ ElhamrawyAges 18–50 - NCT06834139Enrolling by invitation
Testing a new cleaning device for people with braces
This trial tests a device called the Neo Pill to see if it helps keep teeth clean for people with braces. It compares the device to regular brushing and may help reduce plaque and gum problems during orthodontic treatment.
Kragujevac, SerbiaAges 18 years+ - NCT06803576Enrolling by invitation
Long-term study of dental implants after 10 to 22 years
This study looks at how well dental implants work and how healthy the mouth stays more than 10 years after implant placement. The goal is to learn about implant success and any gum or bone changes over time.
ThessalonikiAges 18 years+ - NCT06820840Recruiting
Resin vs ceramic onlays for back tooth cavities
This study compares two types of tooth-colored onlays (one made of layered resin and one of a ceramic-like material) for fixing cavities in back molars. If you need an onlay, this trial could help your dentist choose the best option for you.
CairoAges 18–50 - NCT06859866Recruiting
Light therapy for gum disease around dental implants
This trial tests whether a special light treatment (photodynamic therapy) you can use at home can help reduce inflammation around dental implants (peri-implant mucositis). It's designed for people with early gum problems around implants, before they get worse.
RomaAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,057 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,953 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.