Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,957 recruiting studies in this area right now.
By phase
- Not applicable1,542
- Phase 2142
- Phase 384
- Phase 181
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma73
- Periodontal Diseases50
- Dental Caries45
- Head and Neck Cancer35
- Gingivitis33
- Oral Cancer31
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,957 total
- NCT06241599RecruitingPhase 2/Phase 3
AK104 with chemo for advanced nasopharyngeal cancer
This study tests if adding a new immunotherapy drug (called AK104) to standard chemotherapy can help people whose nasopharyngeal cancer has come back or spread after previous treatment. The goal is to see if the combination works better than chemotherapy alone.
Guangzhou, GuangdongAges 18–75 - NCT04471493Recruiting
Study of children’s common infections in a clinic program
This trial is for children under 16 who have one of several common infections seen in outpatient or clinic visits. It aims to better study and manage these illnesses using a specific clinical documentation software.
CréteilAges 1 day–16 years - NCT06182657Recruiting
Nasopharyngeal cancer response to induction chemotherapy
This study looks at how well nasopharyngeal cancer (NPC) responds to the first round of chemotherapy before other treatments. It aims to see if the amount of tumor shrinkage can help predict outcomes and guide future care for people with advanced NPC.
Nanchang, JiangxiAges 18 years+ - NCT07853976Recruiting
UV-treated dental implants with or without melatonin
This study tests two types of dental implant treatments for replacing missing back teeth in the upper jaw. One uses special UV light to clean the implant surface, and the other adds melatonin to help healing. It aims to see which works better for long-term success.
Al Mansurah, Dakahlia GovernorateAges 18–60 - NCT07865780Enrolling by invitationPhase 1/Phase 2
Laser light with or without oxygen gel for mouth sores from radiation
This study tests two ways to treat painful mouth sores caused by radiation therapy for head and neck cancer. Half of the participants will receive laser light therapy alone, and the other half will receive laser light plus an oxygen gel applied to the sores. The goal is to see if adding the oxygen gel helps the sores heal faster and reduces pain.
AsyutAges 18 years+ - NCT07869407Recruiting
Painless cavity filling: new tools vs traditional drill
This trial compares two newer methods for removing tooth decay (smart burs and a dissolving gel called Carisolv) to the traditional drill, to see which causes less pain during the procedure. It may help find a more comfortable way to treat cavities.
Peshawar, Khyber PakhtunkhwaAges 18–45 - NCT03966131Recruiting
Study of tongue and palate effects on speech comfort
This study looks at how the tongue and roof of the mouth (palate) work together when wearing a new dental prosthesis. It may help improve comfort and how well people speak while using dentures.
LyonAges 18 years+ - NCT05339789Recruiting
Annual follow-up after surgery for implant gum disease
This trial follows people who had surgery for gum inflammation around a dental implant and checks their results over the long term. It may help by improving how clinicians monitor healing and prevent implant problems after surgery.
ViennaAges 18–130 - NCT04547673Recruiting
Test an endoscopy camera tool to help diagnose throat cancer
This study checks an “intelligent” camera used during a nose-and-throat exam to improve how nasopharyngeal cancer is diagnosed. If you are eligible, your care team will compare how well the tool identifies the condition.
Guangzhou, GuangdongAges 18 years+ - NCT07873697Recruiting
Gum disease and dry eye study
This study looks at whether people who have gum disease (periodontitis) are more likely to have dry eye disease. If you have both conditions, taking part could help doctors understand how they might be connected and improve care.
Sulaymaniyah, As Sulaymaniyah GovernorateAges 30–65 - NCT07864220Recruiting
Gum bacteria and pregnancy loss study
This study looks at whether bacteria in the mouth and related inflammation are linked to missed abortion, a type of early pregnancy loss. It may help find ways to prevent pregnancy loss in the future.
Konya, KonyaAges 18–40 - NCT07868315Recruiting
Single-visit root canal pain and success comparison
This study compares pain after a single-visit root canal treatment using different sealers (materials used to fill the root canal) in asymptomatic (pain-free) teeth. It aims to find which sealer causes less discomfort and has a better success rate.
Istanbul, EsenlerAges 18–65 - NCT07861906Recruiting
Wearable device for jaw muscle pain
This study tests a 24-hour wearable device that tracks jaw muscle activity to better understand and manage chronic jaw muscle pain. You would wear the device for a day to see how your muscles behave, which could help improve future treatments.
Downers Grove, IllinoisAges 18 years+ - NCT06084624RecruitingPhase 2
Mouth ulcer treatment with rebamipide vs. steroid cream
This study compares two mouth ulcer treatments: a newer medication called rebamipide and a standard steroid cream. It aims to see which one heals mouth ulcers faster and better.
CairoAges 18–70 - NCT07868705Enrolling by invitation
Comparing small screws for braces in the upper jaw
This study compares two sizes of tiny screws (called miniscrews) that are sometimes used with braces to help move teeth. The screws are placed in the upper jaw to help correct an overbite where the top teeth stick out too far. The study looks at how well the screws work, how stable they are, and how they feel to patients.
Kuala LumpurAges 13–50 - NCT07873268Recruiting
Resin infiltration for enamel spots on front teeth
This trial tests a dental treatment called resin infiltration, which is a liquid that is applied to the white or discolored spots on permanent front teeth caused by a condition called molar-incisor hypomineralization. The treatment aims to improve the appearance of these spots and strengthen the enamel without needing drilling or fillings.
Hanoi, NorthAges 7–11 - NCT07853872Recruiting
Cheek flap surgery for speech problems after cleft palate
This study looks at how using tissue from the cheek to help close the gap in the roof of the mouth affects the cheek and the muscle used for chewing. It aims to see if this surgery is safe and effective for improving speech.
SohagAges 18 years+ - NCT07857655RecruitingPhase 4
Intraoperative methadone for pain after head and neck cancer surgery
This trial tests whether giving methadone during your head and neck cancer surgery helps control pain right after the operation. Methadone is a long-acting painkiller that might reduce pain for up to a day or more, potentially improving your recovery experience.
Portland, OregonAges 18–89 - NCT07867951Recruiting
Pain after two root canal medicines
This study compares two medicines placed inside a tooth during root canal treatment to see which one reduces pain better afterward. It may help people with an infected tooth causing pain.
Swāt, KpkAges 16–50 - NCT06283095Recruiting
Expanding the palate to help sleep apnea
This surgery expands the palate to treat obstructive sleep apnea caused by a narrow upper airway. It may help people with mild to moderate sleep apnea who have a specific type of airway collapse seen on a sleep-endoscopy test.
AsyutAges 18–70 - NCT06287788Recruiting
Mouth soreness trial for nasopharyngeal cancer patients
This trial tests a new way to map mouth and throat sores caused by radiation therapy. It focuses on pain when swallowing to guide treatment, which may help reduce discomfort during cancer treatment.
Guangzhou, GuangdongAges 18 years+ - NCT06287346Recruiting
Comparing one-piece vs two-piece ceramic dental implants
This study tests two types of ceramic (metal-free) dental implants in people who are missing teeth and may have metal allergies. The implants are followed for 5 years to see how well they work and how safe they are.
Boulder, ColoradoAges 18 years+ - NCT06219980RecruitingPhase 2
Radiation and immunotherapy before surgery for oral cancer
This trial tests combining radiation therapy with immunotherapy and chemotherapy before surgery for advanced oral or throat cancer. The goal is to see if this approach can shrink the tumor and improve treatment outcomes.
Guangzhou, GuangdongAges 18–70 - NCT06307314Recruiting
Can SAA1 predict mouth sores from radiation therapy?
This study is looking at a blood marker called SAA1 to see if it can predict how severe mouth sores (oral mucositis) will be after radiation therapy. If you have head and neck cancer and are about to get radiation, this trial may help answer questions about side effects.
Guangzhou, GuangdongAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,957 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,729 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.