Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,957 recruiting studies in this area right now.
By phase
- Not applicable1,542
- Phase 2142
- Phase 384
- Phase 181
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma73
- Periodontal Diseases50
- Dental Caries45
- Head and Neck Cancer35
- Gingivitis33
- Oral Cancer31
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,957 total
- NCT05877872RecruitingPhase 3
Smaller surgery after chemotherapy for recurring nasopharyngeal cancer
This trial tests whether doing a smaller surgery (after chemotherapy works well) can control recurring nasopharyngeal cancer while reducing treatment burden. It is for people whose cancer can be removed by surgery and who respond to an initial course of chemotherapy plus immunotherapy (or another targeted regimen).
Guangzhou, GuangdongAges 18–75 - NCT05683405Recruiting
Non-surgical treatment study for peri-implantitis
This trial looks at a non-surgical dental treatment approach for people who have peri-implantitis, an inflammation around a dental implant. It may help improve the health of the gum and supporting tissue around the implant without surgery.
Tromsø, TromsAges 18–85 - NCT03919552RecruitingPhase 3
Chemoradiation with two cisplatin or carboplatin plans for nasopharyngeal cancer
This Phase 3 trial compares two chemotherapy-and-radiation combinations (cisplatin-based vs carboplatin-based) for locally advanced nasopharyngeal cancer that has not spread to distant organs. It may help researchers find which plan works best while balancing safety and effectiveness.
Guangzhou, GuangdongAges 18–64 - NCT05941338RecruitingPhase 2
Tirelizumab plus chemotherapy before head and neck surgery
This Phase 2 trial tests tirelizumab combined with two chemotherapy medicines before surgery for certain head and neck squamous cell cancers. It aims to shrink the tumor and improve outcomes after the operation.
Guangzhou, GuangdongAges 18–65 - NCT05973097Recruiting
Oral lichen planus treatment with herbal drug and light therapy
This trial tests whether an herbal medicine (paeoniflorin) combined with photodynamic therapy (a light-based treatment) can treat oral lichen planus. You may be considered if you’re an adult with oral lichen planus and can safely take part in the study.
BeijingAges 18 years+ - NCT05994170Recruiting
Lower radiation dose to tumor area for early nasopharyngeal cancer
This trial studies whether lowering the radiation dose to a smaller area around the tumor is safe and effective for people with newly diagnosed nasopharyngeal cancer that has not spread. It may reduce side effects while still curing the cancer.
Zhongshan, GuangdongAges 18–70 - NCT05980702RecruitingPhase 2
Comparing 2 vs 4 rounds of chemo-immunotherapy before surgery for head and neck cancer
This trial tests whether 2 or 4 cycles of pembrolizumab (immunotherapy) plus carboplatin and nab-paclitaxel (chemotherapy) before surgery works better for people with advanced head and neck cancer that can be removed. The goal is to see if fewer treatments are just as effective.
Guangzhou, GuangdongAges 18–75 - NCT06026878RecruitingPhase 3
GNT induction treatment for advanced nasopharyngeal cancer
This trial tests a new drug combination called GNT given before standard chemoradiation for people with locally advanced nasopharyngeal cancer. It aims to improve treatment outcomes.
Xi'an, ShaanxiAges 18–75 - NCT05296941Recruiting
Oral cancer screening for early mouth changes
This trial tests an oral (mouth) screening approach to catch early, possibly cancer-pre-cursor changes. It may help you find warning spots sooner if you have specific mouth lesions.
Falun, Dalarna CountyAges 18 years+ - NCT06039631RecruitingPhase 2
Immuno-chemo before surgery and organ-sparing treatment for throat cancer
This trial tests whether adding immunotherapy before surgery, followed by either radiation or organ-preserving surgery, can improve outcomes for people with locally advanced laryngeal or hypopharyngeal cancer. It may help avoid complete removal of the voice box.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06071637RecruitingPhase 3
Preventing mouth sores with laser therapy in stem cell transplant
This trial tests if a low-power laser can prevent painful mouth sores and throat pain in people getting a stem cell transplant from a donor. The laser is applied to the mouth before sores start, aiming to reduce pain and speed healing.
Rio de Janeiro, Rio de JaneiroAges 18–100 - NCT05918510Recruiting
Blood and tumor study for virus markers in throat cancer
This study looks at virus-related markers and tiny gene regulators (microRNAs) in tumor tissue from people with certain throat cancers caused by human papilloma virus (HPV). It’s observational, meaning it does not change your treatment, but results may help doctors better understand these cancers and how they behave.
RomeAges 18 years+ - NCT06105112Recruiting
Comparing hyaluronic acid to enamel matrix for gum regrowth
This trial tests whether a gel made from hyaluronic acid helps rebuild bone and gum tissue around teeth as well as a standard treatment (enamel matrix derivative). It's for people with advanced gum disease who have completed initial cleaning and still have deep pockets that need repair.
TurinAges 18 years+ - NCT06105489Recruiting
Comparing two sinus lift surgery techniques
This trial compares two surgical methods for lifting the sinus membrane to add bone for dental implants. It may help if you have very little bone left in your upper jaw back teeth area.
PadovaAges 18 years+ - NCT06123221Recruiting
Sinus lift study: comparing two dental implant techniques
This study compares two methods for lifting the sinus floor to place dental implants. It is for people who need an implant in the upper jaw but don't have enough bone height. The goal is to see which technique works better.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT06130332RecruitingPhase 2
Immunotherapy Plus Chemo Before Surgery for Early Oral Cancer
This trial tests a new immunotherapy drug (tirellizumab) combined with chemotherapy before surgery for early-stage oral cancer. It aims to see if this combination can help shrink the tumor and improve outcomes.
Guangzhou, GuangdongAges 18–75 - NCT05326880Recruiting
Long-term follow-up comparing zirconia and titanium dental implants
This study checks how well two kinds of dental implants (zirconia and titanium) work over 5 years in replacing a single tooth. You may be included if you already received the specific implant type and restoration the study requires and you can attend regular checkups.
DüsseldorfAges 18 years+ - NCT02290145RecruitingPhase 2
Study of Cyclin D1–targeted chemotherapy before oral cancer surgery
This Phase 2 trial tests a chemotherapy plan given first (before surgery) for people with oral squamous cell carcinoma that has specific cancer markers and lymph node involvement. It aims to shrink or control the cancer so treatment after may work better.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT04214366RecruitingPhase 2
Carbon ion radiation for head and neck adenoid cystic carcinoma
This trial studies carbon ion radiation (a specific type of high-energy radiation) for people with head and neck adenoid cystic carcinoma when surgery isn’t possible or was incomplete. It may help shrink or control the cancer while limiting side effects compared with other approaches.
HeidelbergAges 18–80 - NCT06092957RecruitingPhase 3
Reduced radiation after chemo-immunotherapy for high-risk nasopharyngeal cancer
This trial tests whether a lower dose of radiation, with or without additional chemo-immunotherapy, works as well as the standard full-dose chemoradiation for people with advanced nasopharyngeal cancer who had a complete response after initial chemo-immunotherapy.
Guangzhou, GuangdongAges 18–70 - NCT07859553Recruiting
Powered or manual toothbrushes for cavity risk in pre-teens
This study compares using a powered (electric) toothbrush versus a manual toothbrush in children aged 8 to 12 to see which is better at reducing the risk of cavities. Your child must already have some signs of tooth decay or a history of cavities in the past few years.
Ann Arbor, MichiganAges 8–12 - NCT07855887Recruiting
Calcium injection for jaw joint disc pain
This trial tests a calcium gluconate injection into the jaw joint for people with painful jaw joint disc displacement that hasn't improved with other treatments. The injection may help reduce pain and improve jaw function.
CairoAges 18–65 - NCT06143254Recruiting
Infant sign training for speech development
This trial tests whether teaching infants with cleft palate simple signs can help them communicate before they can speak. It may support their speech and language development.
Ghent, East FlandersAges 1–2 - NCT04741607Recruiting
Early versus delayed implant placement after tooth removal
This study compares placing a dental implant right away versus waiting after extracting a front upper tooth. It may help you and your dentist choose the best timing to support healing and implant stability.
Ghent, Oost-VlaanderenAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,957 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,729 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Mental health
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- Lungs & breathing
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- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.