Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,057 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 381
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University52
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California39
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,057 total
- NCT07041099RecruitingPhase 1
Study of CLN-978 for Sjögren's disease
This trial tests an experimental drug called CLN-978, given as a shot under the skin, that helps your immune system target and destroy disease-causing B cells. It's for people with moderate to severe Sjögren's disease who haven't had success with other treatments.
Orlando, FloridaAges 18 years+ - NCT07504614Enrolling by invitation
Comparing two types of tooth sealants for kids with MIH
This study tests whether a new pre-etched bioactive sealant works better than a standard resin-based one to protect permanent molars affected by molar incisor hypomineralization (MIH), a condition that makes teeth softer and more prone to cavities. It aims to find a more effective way to prevent decay in these vulnerable teeth.
IrbidAges 6–12 - NCT06731465Enrolling by invitation
Clear aligners vs braces for crowded lower front teeth
This study compares clear aligners (removable trays) to traditional braces for treating crowded lower front teeth. It aims to see which method works better and is more comfortable for patients.
Sharjah city, Emirate of SharjahAges 16–45 - NCT07321483Recruiting
Reflex therapy for jaw pain
This trial tests if a special reflex therapy can help people with jaw muscle pain that isn't caused by joint damage. It might be a new way to reduce discomfort and improve function.
OlomoucAges 18 years+ - NCT07397884Recruiting
Bone loss and stress markers in implant gum disease
This study looks at markers of bone damage and stress in people with gum disease around dental implants (peri-implantitis). It aims to understand how the body responds, which could help improve treatment.
Keçiören, AnkaraAges 18–65 - NCT07750392Recruiting
Dry needling and gentle laser therapy for recent neck pain
This trial tests two therapies—dry needling (thin needles into muscle knots) and low-level laser/microcurrent (gentle energy) treatment—alone or combined, to relieve acute neck pain from muscle knots (myofascial pain). It aims to reduce pain and improve function for people with recent onset symptoms.
Denpasar, BaliAges 20–45 - NCT06693297Recruiting
Early vs. standard tooth implant loading study
This trial compares putting a permanent crown on a dental implant soon after surgery versus waiting the usual time. It's for people who need to replace a single missing tooth and have healthy bone and gums.
AmmanAges 18 years+ - NCT03429036Recruiting
Collecting head and neck tissue samples for research
This study collects tissue and fluid samples from people with head and neck disorders to help researchers learn more about these conditions. By donating leftover samples from your regular medical care, you can help advance research without extra procedures.
Washington D.C., District of ColumbiaAges 3–120 - NCT07752849Recruiting
Platelet-rich fibrin gel for cleft palate repair
This study compares two types of gel made from the patient's own blood, with or without an antibiotic, applied during cleft palate surgery to see if they improve healing and reduce complications.
SanaaAges 3 months–18 years - NCT06017817Recruiting
Light therapy for implant gum disease
This study tests a special light-activated treatment (antibacterial photodynamic therapy) to fight infection around dental implants. It may be an option for people with moderate to severe implant-related gum disease who are not smokers and do not have diabetes.
StockholmAges 18–85 - NCT07752498Enrolling by invitation
Long-term results from twin block treatment
This study checks whether the results from an earlier treatment with the Twin Block appliance, which corrects bite problems, hold up over time. It looks at how stable the teeth and jaw remain years after treatment.
Jönköping, Jönköping CountyAges Any age - NCT06782165Recruiting
Long-term follow-up of jaw joint surgery
This study follows up on patients who had jaw joint (TMJ) surgery. It looks at how the joint is doing after 6 months to predict long-term results. It may help understand if earlier checkups can guide care.
HuddingeAges 18 years+ - NCT07732127Recruiting
Finding early cavities with fluorescent starch nanoparticles
This trial tests a new way to spot very early cavities using fluorescent starch nanoparticles, and compares it to saliva tests. It might help detect tooth decay before it needs a filling.
Shibīn al Kawm, MenoufiaAges 18–40 - NCT07664592RecruitingPhase 3
Comparing toothpastes for sensitive teeth
This trial tests whether a new toothpaste technology can block the tiny tubules in dentin that cause tooth sensitivity. It lasts 2 weeks and will help find better ways to treat sensitive teeth.
Porto Alegre, Rio Grande do SulAges 18–70 - NCT06628440Recruiting
Mouth check tool for ICU patients with breathing tubes
This study develops a new tool to check the health of the mouth in patients who have a breathing tube in their throat while in the intensive care unit (ICU). It aims to help nurses better assess and care for the mouth.
AngersAges 18 years+ - NCT06599112Recruiting
Dental implant stability with different bone drilling methods
This study compares three ways of preparing the jawbone for a dental implant in the upper back area. The goal is to see which technique makes the implant most stable right after placement and over time.
GizaAges 25–70 - NCT06558968Recruiting
Esthetic space maintainers for children's baby molars
This study tests two types of tooth-colored space maintainers (PEEK and BruxZir) in children who lose both lower first baby molars. The goal is to keep the space open for the permanent teeth to come in properly.
CairoAges 6–11 - NCT06507319Recruiting
Comparing two ways to move upper back teeth with anchors
This trial tests two different methods of using small bone anchors to move your upper back teeth further back to fix an overbite or overjet (Class II bite). It may be helpful if you've never had braces before and have good oral hygiene.
Al MansurahAges 12–16 - NCT06453304RecruitingPhase 2/Phase 3
Licorice root gel for root canal infection
This trial tests a natural anti-inflammatory medicine called glycyrrhizin (from licorice root) used inside the tooth during root canal treatment. It aims to see if it helps kill bacteria and reduce infection better than standard medications.
Al MansurahAges 20–60 - NCT06024395Recruiting
Helping people overcome fear of the dentist
This trial tests a step-by-step approach to help people who are afraid of the dentist. It uses a smartphone or tablet to guide you through relaxation and coping skills.
New York, New YorkAges 13–99 - NCT05772962Recruiting
Dental record study for children at risk
This study collects children’s dental records to learn about oral health in children who are considered at risk. Your participation could help researchers understand what dental problems happen more often and why.
Bergen, VestlandAges birth–18 years - NCT05492773Recruiting
Clear aligner treatment with tiny bone punctures to speed tooth movement
This trial tests whether a technique called tiny “micro-punctures” in the jaw bone can speed up orthodontic tooth movement in people with moderate front-lower tooth crowding. It uses clear aligners and may help teeth move faster, but only if you meet the dental and medical safety requirements.
HamaAges 18–26 - NCT05020158Recruiting
Family Talk support after a serious illness in the family
This trial tests a “Family Talk” support program for families dealing with a child’s life-threatening or life-limiting illness. It aims to help families talk and cope together during the early period after diagnosis or relapse.
StockholmAges 6 years+ - NCT07750171Recruiting
How smoking affects healing around dental implants
This study looks at how smoking affects the body's immune response around dental implants that are healthy or have mild gum disease. It may help us understand why some implants develop problems and could lead to better care for smokers with implants.
Ankara, AnkaraAges 21–75
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,057 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,953 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Immune system & allergy
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- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.