Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07110948Enrolling by invitation
Long-term follow-up of tongue-tie surgery in children
This study follows infants who had tongue-tie surgery (frenectomy) to see how they are doing as they grow up. Parents will bring their child to a clinic once a year and take photos of their child's tongue.
EdmontonAges 1 day–1 year - NCT07113873Recruiting
Comparing two types of ultra-white dental veneers for appearance and patient comfort
This trial tests two different materials for dental veneers—ultra-translucent zirconia and lithium disilicate—to see which one patients prefer and how well they work. If you are between 18 and 50, have good oral health, and need veneers to fix gaps, slight color issues, or tooth shape, this study may be a good fit.
CairoAges 18–50 - NCT07115212Recruiting
Bromelain for facial swelling after jaw surgery
This trial tests whether a natural enzyme called bromelain (found in pineapple) can reduce swelling after jaw surgery. You may be eligible if you're having orthognathic surgery and don't have certain health conditions or allergies.
Lexington, KentuckyAges 18–65 - NCT07107100Recruiting
Comparing two types of retainers after braces
This study compares two types of retainers (a wire that keeps teeth in place) after braces are removed: one that is directly bonded to the teeth and one that is made indirectly. It looks at which type keeps gums healthy, lasts longer, and how likely it is to break.
Karachi, SindhAges 13–40 - NCT07108738Recruiting
Pomegranate extract for treating deep cavities in baby molars
This trial tests a natural pomegranate peel extract as a new type of medicine to put inside a baby molar after the dentist removes the decayed part. It may help keep the tooth healthy without needing a more involved procedure.
TantaAges 4–7 - NCT07110142Recruiting
Tongue strength exercises after tongue cancer surgery
This study tests a tongue strengthening exercise program for people who have had partial tongue removal and reconstruction. The goal is to see if these exercises can help you regain better tongue function and speech after surgery.
Cleveland, OhioAges 18 years+ - NCT07108465RecruitingEarly Phase 1
Anesthetic comparison for wisdom tooth removal
This trial compares two numbing medicines, bupivacaine and ropivacaine, to see which works better for removing impacted lower wisdom teeth during general anesthesia. It may help determine which option provides better pain relief after surgery.
Porto Alegre, Rio Grande do SulAges 18–60 - NCT07111455Recruiting
Oral bacteria changes with chemoimmunotherapy for mouth cancer
This study is testing whether a combination of chemotherapy and immunotherapy before surgery can help treat advanced oral cancer. Researchers will also look at how the cancer changes the bacteria in your mouth.
Guangzhou, GuangdongAges 18–80 - NCT07109882RecruitingPhase 4
Comparing two muscle relaxants for bruxism pain
This study compares two muscle relaxant medications—chlorzoxazone and orphenadrine citrate—to see which works better for relieving pain caused by teeth grinding or jaw clenching (bruxism). If you have jaw or face pain and no other major health issues, you may be able to join.
BaghdadAges 15 years+ - NCT07114523Recruiting
Collagen membranes for healing after wisdom tooth surgery
This trial tests whether placing a collagen membrane after wisdom tooth removal helps the nearby second molar heal better. If you have impacted lower wisdom teeth on both sides, this study may compare healing with and without the membrane.
Ho Chi Minh CityAges 25 years+ - NCT07110220Enrolling by invitation
How well do ceramic dental restorations hold up over time?
This study looks at how well ceramic dental restorations (like crowns and bridges) have lasted over time. If you've had one placed at the University Hospital of Liège, your experience could help dentists understand how to improve future treatments.
LiègeAges Any age - NCT07108361Recruiting
New implant technique for back teeth (molars)
This study tests a new way of placing dental implants in the back of the mouth that may help the implant stay stronger. If you need a molar implant, this approach might lead to better outcomes.
CairoAges 18–50 - NCT04120688Recruiting
Transplanting a natural tooth using a 3D planned approach
This trial looks at a way to move a patient’s own tooth (or a prepared tooth) to replace a missing or damaged one, using a 3D plan to guide the procedure. It may help restore chewing ability and appearance by using a tooth-shaped replacement tailored for the patient.
Turku, TurkuAges 9–23 - NCT07095881Recruiting
Gum healing with a custom zirconia healing cap
This study tests how well the gum tissue heals around a special custom healing cap made from a strong white material (zirconia composite) placed on a dental implant. It may be a good option if you need a single tooth replaced and have healthy gums and bone.
Cairo, AbaseyaAges 20–50 - NCT07103941Recruiting
Study of whether MAD therapy prevents bite changes
This study tests how well a dental device called a Mandibular Advancement Device (MAD) prevents changes in your bite and jaw alignment. It is for adults with sleep-disordered breathing who already have healthy, well-restored teeth.
Lexington, KentuckyAges 18 years+ - NCT07102758Recruiting
Comparing gum grafts for immediate dental implants
This trial tests two ways to support the gum around a new dental implant placed right after a tooth is pulled. It compares a special blood-clot material (L-PRF) to a connective tissue graft to see which heals better.
Kafr ash Shaykh, KafrelsheikhAges 21–45 - NCT07104370Recruiting
Comparing freeze-dried donor bone vs. your own bone for jaw grafting
This trial compares two types of bone graft materials for rebuilding the jawbone so you can later get dental implants. One is a freeze-dried bone from a donor (allograft), and the other is a small piece of your own bone (autograft).
Budapest, HungaryAges 18 years+ - NCT07102121Enrolling by invitation
Comparing tooth sensitivity after cementing crowns with two dental materials
This study tests whether one type of dental cement causes less tooth sensitivity than another after placing a crown. The results could help your dentist choose the material that feels better for you.
Mingora, Khyber PakhtunkhwaAges 15–60 - NCT07101744RecruitingPhase 2
Drug combination study for advanced nasopharyngeal cancer
This trial tests a combination of three drugs for people with nasopharyngeal cancer that has come back or spread and stopped responding to first-line chemotherapy. It aims to see if this new combination can help when standard treatment no longer works.
GuangdongAges 18–70 - NCT07104656Recruiting
Study of a new saw for jaw surgery
This trial tests a new way to cut the jawbone during surgery to see if it helps the bone pieces fit together better. It might help patients needing jaw surgery.
Birmingham, AlabamaAges 12–75 - NCT07099846Recruiting
Hyaluronic acid and polynucleotides for tooth socket preservation
This trial tests a gel made of hyaluronic acid and polynucleotides to help preserve the bone and gum after a tooth is pulled. It may help you keep a healthy foundation for a future dental implant.
ParmaAges 25 years+ - NCT07098325Recruiting
3d printed retainers for braces after treatment
This trial tests how your mouth reacts to a 3d printed retainer after braces. It may help you keep your teeth straight.
AsyutAges Any age - NCT07097714Recruiting
Collagen scaffold with gum surgery to improve orthodontic results
This trial tests if a special collagen scaffold placed during gum surgery can improve orthodontic treatment for people with thin gums. It may help protect the gums and bone during teeth straightening.
Novosibirsk, Novosibirsk OblastAges 18–50 - NCT07100574Recruiting
Bacteria in dental plaque and artery plaque study
This study looks at bacteria found in dental plaque and in the fatty buildup inside your arteries. It might help researchers understand links between mouth health and blood vessel health after your endarterectomy surgery.
IstanbulAges 18–85
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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- Pain
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.