Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT06479811RecruitingPhase 1
Radioactive drug for advanced neuroendocrine and other cancers
This trial tests a new radioactive drug, [212Pb]VMT-Alpha-NET, that targets a protein on certain cancer cells. It is for people with specific types of advanced cancers that have gotten worse and are not responding to standard treatments.
Bethesda, MarylandAges 18–120 - NCT06480825Recruiting
Ultrasound study of gum tissue
This study uses a special high-frequency ultrasound to take detailed pictures of your gum tissue. It may help doctors understand gum disease better and find new ways to treat it.
Pisa, ItalyAges 18–70 - NCT07692880Recruiting
Digital vs. conventional brace bonding for teens
This trial compares a new digital method for putting braces on teeth to the usual manual method. If you need braces on both top and bottom and have all your adult teeth, this study may help improve how comfortable and fast your treatment is.
FlorenceAges 12–18 - NCT06420336Recruiting
Pain relief after cleft palate surgery
This study compares two ways to manage pain after cleft palate repair surgery that uses a bone graft from the hip. The goal is to see which method provides better pain control for children and teens.
Charleston, South CarolinaAges 6–18 - NCT07088679Recruiting
Natural gel for dental implant gum disease
This trial tests a natural gel to treat gum disease around dental implants. It may help reduce bleeding and bone loss around implants.
Pavia, LombardyAges 18–70 - NCT07692061Enrolling by invitation
Speech therapy study for Cantonese-speaking kids with cleft palate
This study tests a new speech therapy program for children and teens (ages 4–17) who had cleft palate repair before age 2 and have certain speech sound errors. It aims to improve their speech clarity and communication.
Shatin, New TerritoriesAges 4–17 - NCT04214561Enrolling by invitation
Studies how sleep measures relate to teeth grinding
This study looks at sleep testing results to understand what relates to sleep bruxism, which is teeth grinding or clenching during sleep. It may help researchers better understand the causes and patterns behind this condition.
WroclawAges 18–70 - NCT06486012Recruiting
Light therapy for gum disease in diabetic patients
This trial tests if regular use of antibacterial light therapy can help manage and prevent gum disease symptoms in people with diabetes. It may offer a simple, non-invasive way to improve oral health.
Tampere, PirkanmaaAges 18 years+ - NCT06490679Recruiting
Comparing a new air-polishing device to standard deep pocket cleaning
This trial tests if a special air-polishing device using erythritol powder is better than standard tools for cleaning deep gum pockets (7-10 mm). It aims to see which method works better without surgery, which could mean less discomfort and faster healing.
CairoAges 16–80 - NCT06494709Recruiting
Eye-tracking study of attention to faces after jaw surgery
This trial uses eye-tracking to measure how people look at faces after jaw surgery (orthognathic surgery). It is designed to help researchers understand changes in social attention following the procedure.
Amiens, PicardieAges 18 years+ - NCT06500390Recruiting
TMD and levonorgestrel IUD use study
This study looks at whether using a levonorgestrel intrauterine device (a hormone-releasing IUD) for at least 3 months is linked to jaw joint problems (temporomandibular disorder). It may help women understand potential side effects of this birth control method.
Istanbul, MaltepeAges 18–45 - NCT06505330Recruiting
Probiotics for kids with cleft palate
This study looks at whether giving probiotics (helpful bacteria) to children with cleft palate can improve the bacteria in their airways and possibly prevent infections. Researchers want to see if this simple treatment helps keep kids healthier.
Edegem, AntwerpAges 6 months–2 years - NCT06505759RecruitingPhase 1
Bromelain gel vs. chlorhexidine for gum disease treatment
This trial tests if a gel made from bromelain (a pineapple enzyme) works as well as a standard antibiotic gel to treat gum pockets caused by periodontitis. It may offer a gentler option for patients with moderate gum disease.
Bengaluru, KarnatakaAges 30–50 - NCT06506734Recruiting
Dental color changes and quality of life in early jaundice
This study looks at how early and long-lasting jaundice (high bilirubin levels) affects tooth color and quality of life in children with certain liver conditions. It aims to understand these effects to improve care.
BordeauxAges 12–18 - NCT06507202RecruitingPhase 4
Comparing Two Anesthetics for Recovery After Upper Airway Surgery
This trial compares two medications used during general anesthesia to see which one helps patients recover faster after surgery on the nose, mouth, throat, or voice box. Both drugs are commonly used, and the goal is to find which provides a smoother and quicker return to normal waking up.
Gyeonggi-do, Gwangmyeon-siAges 19 years+ - NCT06507280Recruiting
Gum treatment study for children with gingivitis
This study tests whether a gum treatment (periodontal therapy) can reduce inflammation in children with gingivitis. It measures certain proteins in the fluid around the gums to see if the treatment helps.
AydinAges 11–14 - NCT06509009RecruitingPhase 2
Nimotuzumab and TGP for first-line recurrent / metastatic nasopharyngeal cancer
This trial tests a combination of two drugs—nimotuzumab (a targeted therapy) and TGP (a chemotherapy)—as a first treatment for people whose nasopharyngeal cancer has returned or spread. The goal is to see if this combination can shrink tumors and help patients live longer.
Beijing, Beijing MunicipalityAges 18–75 - NCT06510244Recruiting
Measuring pain during dental treatment with brain waves
This trial uses EEG (a brain-wave test) and a pain scale to measure how much discomfort you feel during dental treatment on your upper front tooth. It may help dentists understand pain better and improve care.
Cleveland, OhioAges 20–60 - NCT06510881Recruiting
One surgery vs. multiple surgeries for cleft nose and gum repair
This trial compares doing a single surgery to fix both the nose and gum problems caused by a cleft lip and palate, versus doing multiple surgeries over time. It aims to find out which approach works better for children and teens.
AsyutAges 5–18 - NCT06511219Recruiting
Moving upper back teeth with a 3D-printed brace
This study tests a new 3D-printed dental device to move the upper back teeth backward in teenagers with an overjet (bucked teeth) and a class II bite. It may help correct the bite without removing teeth or using headgear.
Al MansurahAges 13–18 - NCT06511830Recruiting
Comparing plaque detection methods for better dental care
This study compares different ways of checking dental plaque (the sticky film on teeth) to see which method works best. It may help you understand how to better care for your teeth and gums.
Lincoln, NebraskaAges 19–85 - NCT06513039RecruitingPhase 4
Erythropoietin for preserving jawbone after tooth extraction
This trial tests whether a medicine called erythropoietin can help preserve the bone in your jaw after a tooth is pulled. It may help keep the area strong for future dental work.
CairoAges 18–40 - NCT06514677Recruiting
Nonsurgical treatment for implant infection with ultrasonic carbon tip
This study tests whether using a special ultrasonic carbon tip (a gentle cleaning tool) can treat infection around a dental implant without surgery. It is for people with a single problem implant who are otherwise healthy and have good oral hygiene.
KütahyaAges 18–99 - NCT06514885Recruiting
Silver diamine fluoride for root cavities in older adults
This trial studies a special liquid called silver diamine fluoride that is painted onto cavities on tooth roots. It may help stop the decay and keep the tooth healthy without drilling.
Hong KongAges 60 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.