Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT06515886Recruiting
Inflammation around dental implants: infection or allergy?
This study looks at why some dental implants get inflamed. It checks if the cause is a bacterial infection, an allergic reaction, or both. If you have a working dental implant that hasn't been treated for inflammation in the last three months, you might be able to join.
Montreal, QuebecAges 18 years+ - NCT06516133RecruitingPhase 3
Online adaptive radiotherapy for nasopharyngeal cancer
This trial tests a new type of radiation therapy that adjusts in real-time to treat nasopharyngeal cancer. It is for people who have not received prior radiation and have no distant spread of cancer.
Guangzhou, GuangdongAges 18–70 - NCT06516185Recruiting
Comparing two types of clear aligners for tooth movement
This trial tests two different clear aligner designs to see which works better for straightening teeth. It is for people who need braces and have not had orthodontic treatment before.
MadridAges Any age - NCT06517238Recruiting
Digital tool to improve dental care during braces treatment
This trial tests a new digital communication tool that helps your dentist and orthodontist work together better. The goal is to improve how your teeth are cared for while you have braces.
ReimsAges 8–18 - NCT06517927Recruiting
Long-term dental effects of childhood cancer chemo
This study looks at how chemotherapy given before age 10 affects teeth later in life. Researchers want to know if childhood cancer survivors have more dental problems than others.
BrusselsAges 12–36 - NCT06518421Recruiting
Emotions and Memory in Chronic Facial Nerve Pain
This study looks at how emotions and memory are affected in people with chronic trigeminal neuralgia (a type of facial nerve pain). Participants will have an MRI scan and fill out questionnaires to help researchers understand the link between chronic pain and cognitive changes.
Toronto, OntarioAges 35–60 - NCT06520137Recruiting
Wisdom tooth removal and gum disease study
This study looks at how removing an impacted upper wisdom tooth affects gum health. It may help people who need this tooth removed and do not have advanced gum disease.
Siena, Italy/SIAges 19–64 - NCT06522438Recruiting
Gel with Hyaluronic Acid for Gum Disease Treatment
This study tests whether a gel containing hyaluronic acid and octenidine can improve the results of standard deep cleaning for advanced gum disease. It may help reduce gum pocket depth and bleeding without the need for surgery.
LondonAges 18 years+ - NCT06522607Recruiting
3D Study of Palate Shape After Rapid Palatal Expansion
This trial studies how a rapid palatal expander (a device that widens the upper jaw) affects the shape of the roof of the mouth in growing children. It may help children with a posterior crossbite and a certain stage of dental development.
RomaAges 7–15 - NCT06525402Recruiting
Mouth rinse study for kids getting chemo
This trial tests three different mouth rinses—sodium bicarbonate, saline, and black mulberry syrup—to see which one best prevents or lessens mouth sores (oral mucositis) in children receiving chemotherapy.
IspartaAges 6–18 - NCT06525285Recruiting
Gum graft techniques for treating severe gum recession
This trial compares two different gum grafting methods to treat advanced gum recession in front teeth. It aims to see if adding a special connective tissue wall helps improve root coverage and gum health.
Bengaluru, KarnatakaAges 18–60 - NCT06529562Recruiting
Surgery plus reduced chemo and radiation vs standard for nasopharyngeal cancer
This trial compares two approaches for people with early-stage nasopharyngeal cancer that can be removed with surgery. It tests whether giving less intense chemotherapy and radiation after surgery works as well as a standard dose, with fewer side effects.
Zhuhai, GuangdongAges 18–70 - NCT06532526Recruiting
Tooth sensitivity treatment during teeth whitening
This study tests whether a special desensitizing gel can reduce tooth sensitivity caused by professional teeth whitening. If you are a smoker between 18 and 30 with dark anterior teeth wanting whiter teeth, this may help you experience less discomfort.
IrbidAges 18–35 - NCT06532279RecruitingPhase 2
Testing BMX-001 with chemoradiation for head and neck cancer
This trial tests whether adding BMX-001 (a drug that may protect healthy tissues) to standard chemoradiation can reduce side effects and improve outcomes for people with head and neck cancer. It's a randomized study, so you would have a 50/50 chance of getting BMX-001 or a placebo.
Gilbert, ArizonaAges 18 years+ - NCT06532903Recruiting
Recovery from facial paralysis study
This trial tests a physical therapy approach to help people recover from Bell's palsy or other types of facial paralysis that started recently (within the last 6 months). It aims to see if specific treatments can improve facial movement and function.
CorrientesAges Any age - NCT06533267Recruiting
Endoscopic surgery vs. radiation for early-stage nasal cancer
This trial compares two treatments for stage I nasopharyngeal cancer (a type of nasal cancer). It tests whether a minimally invasive surgery (endoscopic surgery) is as good as or better than radiation therapy. It may be an option for people whose cancer is small and hasn't spread to lymph nodes.
Zhuhai, GuangdongAges 18–75 - NCT06533215Recruiting
Nano gel for root canal retreatment in infected premolars
This study tests a new, nano-sized antimicrobial gel to fight stubborn infections during repeat root canal treatment. It's for people with a premolar that still hurts or shows signs of infection after a previous root canal.
TantaAges 19–60 - NCT06533397Recruiting
Testing a new bone graft for sinus lifts
This study tests a new bone graft material for sinus lifts, a procedure to add bone in the upper jaw so dental implants can be placed. It may help people who are missing bone in the back of their upper jaw due to enlarged sinuses.
Budapest, BudapestAges 18 years+ - NCT06536075Recruiting
Salivary gland function in Sjogren's syndrome
This study looks at how well your salivary glands work and if there is a connection with a special scan called sialoscintigraphy. It may help people with or without dry mouth symptoms and a Sjogren's diagnosis.
TaipeiAges 20–70 - NCT06536335Recruiting
Clear aligner treatment: Comparing two timing schedules
This study compares two different schedules for clear aligner treatment (invisible braces) to see which one feels better for patients. If you have a mild misalignment (Class I) and all your permanent teeth, you may be able to join.
RomaAges 18–40 - NCT06538870Recruiting
Dental implant healing and TNF-alpha blockers
This study looks at how dental implants heal in people who take TNF-alpha inhibitors (medicines that lower inflammation) compared to those who don't. It aims to see if the drug affects healing after implant surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06543667RecruitingPhase 1
Stem cell eye drops for dry eye treatment
This trial tests a new eye drop made from stem cells to see if it can help relieve dry eye symptoms. It is for people with moderate to severe dry eye who haven't had recent eye surgery or used other eye drops.
TehranAges 18–70 - NCT06545084Recruiting
Better healing after root-end surgery using a special blood clot
This study tests whether adding a concentrated blood clot (L-PRF) to standard root-end surgery helps tooth-related infections heal faster and better. You may be a good fit if you have a persistent infection at the tip of a tooth root and need this type of surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06548607RecruitingEarly Phase 1
CAR-T therapy for autoimmune diseases
This early-phase trial tests a new CAR-T cell therapy that targets CD19 or both CD19 and BCMA to treat several autoimmune diseases like lupus, scleroderma, and vasculitis. It aims to calm the overactive immune system with a single infusion of your own engineered cells.
Bengbu, AnhuiAges 18–70
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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- Genetic & congenital
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- Pain
- Injuries & trauma
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.