Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07136155Enrolling by invitation
Two ways to treat deep cavities in baby teeth
This study compares two ways to treat deep cavities in baby (primary) molars. One method places a special soothing medicine under a filling; the other uses a metal crown that covers the whole tooth. Both aim to keep the tooth healthy without needing a nerve treatment or extraction.
IrbidAges 4–9 - NCT07137052Recruiting
Precise adaptive radiotherapy for nasopharyngeal cancer
This trial tests a more precise form of radiation therapy (adaptive radiotherapy) for nasopharyngeal cancer. It is designed for patients who have not yet had any treatment and whose cancer is limited to the head and neck area.
XiamenAges 18–70 - NCT06961409Recruiting
Saliva markers test for gum health
This trial measures certain proteins in your saliva to understand how they relate to different stages of gum disease. If you're generally healthy and have not smoked or taken certain medications recently, you may be able to join and help researchers learn more about gum health.
Izmir, ÇiğliAges 18–70 - NCT07131358Recruiting
Comparing cavity prevention methods in schoolchildren
This trial tests three different methods to prevent cavities in children's back teeth (first permanent molars). It's for kids ages 6 to 8 who are at risk for cavities and attend public schools in Nezahualcóyotl, Mexico.
Nezahualcóyotl, State of MexicoAges 6–8 - NCT07133919Recruiting
AI communication to reduce dental anxiety in children
This trial tests whether a child-friendly, AI-assisted conversation method can help reduce anxiety in children who need a dental filling, pulpotomy, or similar treatment. It is for children ages 6-12 who are coming to the dentist for the first time and will receive local anesthesia.
Çanakkale, KepezAges 7–12 - NCT07133464Recruiting
CDH1 gene and BCDS syndrome registry
This registry studies people with changes in the CDH1 gene who may have blepharocheilodontic syndrome (BCDS). It collects information to better understand the condition and improve care.
Columbus, OhioAges Any age - NCT07125963Recruiting
Custom vs. standard jaw positioning for jaw surgery
This study compares two ways of positioning your jaw during surgery to correct jaw alignment. The goal is to see if using a custom-made guide based on your own CT scans leads to better results than the standard method.
Istanbul, BağcılarAges 18 years+ - NCT07129096Enrolling by invitation
Digital relaxation training for jaw pain
This study tests if a digital relaxation program can help reduce jaw pain caused by temporomandibular disorders (TMD). It may be a good option if you have jaw muscle or joint pain and want to try a non-drug approach.
OuluAges Any age - NCT07131813RecruitingPhase 4
Tofacitinib for oral lichen planus
This trial tests whether adding the drug tofacitinib to standard treatment helps reduce symptoms of oral lichen planus, a chronic inflammatory mouth condition. It is for people with moderate to severe disease who have not taken certain immune-suppressing medicines recently.
Bhubaneswar, OdishaAges 18 years+ - NCT07128589Recruiting
Testing a dental filling material for front teeth repair
This study tests a new flowable composite material that can be used to repair front teeth with class IV cavities or as veneers. The study looks at how well the material works and how satisfied patients are over time.
New York, New YorkAges 18–75 - NCT07134114Recruiting
How Hall Crowns Affect Your Child's Bite
This study tests the Hall Technique, a way to place stainless steel crowns on baby molars without numbing or drilling. It looks at how the crown affects your child's bite, and may help kids with cavities in back baby teeth who can cooperate for treatment.
Ankara, KeçiörenAges 7–10 - NCT07130760Recruiting
Testing two numbing methods for tooth pain in a back molar
This trial compares two ways to numb a painful lower back molar. If you have a tooth infection that needs a root canal, you may receive one of two injection techniques to see which works better.
Ferrol, A coruñaAges 18 years+ - NCT06252935Recruiting
Collagen membrane for gum and bone repair
This trial tests a new collagen membrane (FormaAid®) for repairing gum and bone damage from gum disease. It may help people with deep gum pockets and bone loss who are not smokers and have well-controlled health conditions.
Taipei, TaiwanAges 18–70 - NCT06833034Recruiting
New technique for impacted upper canine teeth
This trial tests a new method to expose an upper canine tooth that is stuck behind the other teeth (palatally impacted). If you have one impacted canine on one side and it's not too high or angled, this study may compare a newer, less invasive exposure technique to the standard approach.
Lund, Skåne CountyAges 10 months–1.5 years - NCT06963242Recruiting
Testing a navigation tool for full-arch dental implants
This trial tests whether a dynamic navigation system helps place dental implants more accurately for people who need a full set of upper or lower teeth. If you are missing most or all of your teeth and are generally healthy, this study may be for you.
Ho Chi Minh CityAges 18 years+ - NCT04276246Recruiting
Dental implant supports for removable dentures in back-tooth gaps
This trial tests whether small “supporting” implants can help hold a removable partial denture more securely. It’s for adults missing back teeth on both sides (a specific dental gap pattern) and may improve comfort and fit.
BaselAges 18 years+ - NCT07118241RecruitingPhase 2
Testing a new eye drop for Sjögren's dry eye
This trial tests a new eye drop made from a natural protein (rhPRG4) to see if it safely and effectively relieves dry eye symptoms in people with Sjögren's syndrome. You'll be randomly assigned to receive the study drop or a placebo (inactive) drop for several weeks.
Sydney, New South WalesAges 18–80 - NCT07124000Recruiting
T-DXd for advanced HER2-positive solid tumors
This trial is for people with advanced HER2-positive solid tumors (cancers that cannot be removed by surgery or have spread). It tests the drug T-DXd (also called Enhertu) when your doctor has already decided it's the right treatment for you and you have no other good options.
Birmingham, AlabamaAges 18–130 - NCT07124416Recruiting
Do gums around dental implants affect health and comfort?
This study looks at how the amount of firm, attached gum (called keratinized mucosa) around a dental implant affects gum health and how you feel about it. It may help you understand if your implant site needs more gum tissue for better long-term results.
Hangzhou, ZhejiangAges 18–90 - NCT07122128Recruiting
Saliva test for early oral cancer in people with OSMF
This trial studies whether a simple saliva test can help detect oral cancer early in people who have a condition called oral submucous fibrosis (OSMF), which raises the risk of oral cancer. Healthy volunteers and those with OSMF or proven oral cancer are needed.
Jāmshoro, SinchAges Any age - NCT07121595RecruitingPhase 2
Personalized neck radiation for mouth cancer with sentinel node biopsy
This study tests whether a personalized approach to radiation therapy after surgery, guided by a special lymph node biopsy (sentinel node biopsy), can effectively treat mouth cancer while reducing side effects. It is for people whose cancer is on one side of the mouth and has not spread to the other side of the neck or beyond.
Ann Arbor, MichiganAges 18 years+ - NCT07124520Recruiting
Lingual strength training after tongue cancer surgery
This study tests if using a device to exercise your tongue after partial tongue removal helps you recover tongue strength and function better than standard care. It is for people having their first surgery for oral tongue cancer.
Basking Ridge, New JerseyAges 18 years+ - NCT07123025Recruiting
Partial pulp treatment for painful tooth decay
This study tests if removing only the top part of the damaged tooth nerve can save a deeply decayed molar. It is for people with moderate to severe toothache that doesn't stop, especially when lying down.
Rohtak, HaryanaAges 15–40 - NCT05232604Recruiting
Exercise vs local pain exercises for jaw and neck pain
This study compares two types of treatment: aerobic exercise versus exercises aimed at the painful jaw/neck area. It may help people with long-term jaw and neck pain by testing which approach improves pain and function.
Osnabrück, Lower SaxonyAges 18–60
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.