Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT06445114RecruitingPhase 2
Blood-Guided Chemoradiation for HPV-Positive Throat Cancer
This study tests whether a blood test that looks for circulating HPV DNA (ctDNA) can help doctors decide if you need chemotherapy after surgery for HPV-positive throat cancer. After you have surgery to remove the cancer, you receive radiation (possibly with chemotherapy) — the results of the blood test guide whether or not to add chemo.
Beverly Hills, CaliforniaAges 18 years+ - NCT06446713RecruitingPhase 1
Higher-dose proton therapy for advanced throat cancer
This trial is testing a higher, more precise dose of proton beam radiation for people with advanced throat cancer that is not connected to HPV. It aims to improve tumor control while protecting healthy tissue.
GroningenAges 18 years+ - NCT06448026RecruitingPhase 2
Cemiplimab and cetuximab before surgery for mouth or throat cancer
This trial tests whether combining two targeted drugs (cemiplimab and cetuximab) before surgery can help people with recurrent mouth or throat cancer that has come back after initial treatment. It aims to see if this approach makes surgery more effective.
Houston, TexasAges 18 years+ - NCT06450535Recruiting
Comparing two bone grafting methods for the upper jaw
This trial tests two surgical methods to rebuild a narrow upper jaw so it can support dental implants. It compares using a solid block of your own bone versus a thin shell of bone to widen the ridge.
Cairo, Giza GovernorateAges 20–60 - NCT06451575Recruiting
Blood Clots and Behçet's Disease Study
This study looks at how Behçet's disease affects blood clotting. If you have Behçet's disease and are between 18–70, you may help doctors understand why some people with Behçet's develop dangerous blood clots.
Erzurum, Üniversite MahallesiAges 18–70 - NCT06451913RecruitingPhase 4
Probiotic for gut health during Lyme disease antibiotics
This trial tests if a probiotic (Saccharomyces boulardii) can help maintain healthy gut bacteria while you take antibiotics for the early skin rash of Lyme disease (erythema migrans). You'll take amoxicillin for 14 days, plus either the probiotic or a placebo.
LjubljanaAges 18 years+ - NCT06453005Recruiting
Comparison of two tooth cap methods for baby molars
This trial compares two ways to fix cavities in baby molars: the SMART Hall technique (a newer, less invasive method) and the traditional stainless steel crown. The goal is to see which works better for children aged 3 to 9.
Tirupati, AndhrapradeshAges 3–9 - NCT06454370Recruiting
New imaging vs standard biopsy for Sjögren's diagnosis
This trial compares a new, quick imaging method (called full-field optical coherence tomography) with the standard lab analysis of a saliva gland biopsy. It may help diagnose Sjögren's syndrome faster and with less discomfort.
Mâcon, Sâone-et-LoireAges 18–99 - NCT06455410RecruitingPhase 2
GP plus adebrelimab vs. chemo alone for nasopharyngeal cancer
This trial tests a new combination of chemotherapy drugs (GP) plus an immunotherapy drug (adebrelimab) before standard treatment for nasopharyngeal cancer. It aims to see if this combination works better than chemotherapy alone for shrinking tumors.
Foshan, GuangdongAges 18–65 - NCT06456060RecruitingPhase 1
Honey dressing vs. Alvogyl for dry socket healing
This trial tests whether a pure honey dressing works better than a standard treatment (Alvogyl) for healing dry socket, a painful condition after a tooth extraction. It may offer a natural alternative to help with pain and healing.
Multan Khurd, Punjab ProvinceAges 18–70 - NCT06457503RecruitingPhase 4
Toripalimab plus chemo for advanced nasopharyngeal cancer
This trial tests whether adding the immunotherapy drug toripalimab to standard chemotherapy (cisplatin and gemcitabine) can help people whose nasopharyngeal cancer has come back or spread. It is for those who haven't yet received other treatments for this advanced stage.
Little Rock, ArkansasAges 12 years+ - NCT06457737Recruiting
Comparing two bonding methods for back tooth crowns
This study compares two different ways of bonding tooth-colored crowns on back teeth to see which one lasts better. If you need a back tooth restored, you may be able to join.
IrbidAges 18 years+ - NCT06457828Recruiting
Root canal methods for painful molars: open tip vs steroid
This trial is testing two methods during a root canal on a painful molar: one that keeps the tip of the root open and one that uses a steroid medicine inside the tooth. The goal is to see which approach causes less pain afterward.
IsmailiaAges 21–60 - NCT06457776Recruiting
Jaw bone health in people taking bone-strengthening drugs
This study looks at how a specific jaw problem (osteonecrosis) may happen in people taking bone-strengthening medications. It aims to better understand and manage this side effect.
RomaAges 18 years+ - NCT06458478Recruiting
Gel to help healing after wisdom tooth removal
This trial tests a special gel applied after removing lower wisdom teeth to see if it helps healing. It is for healthy people who need both bottom wisdom teeth taken out.
PerugiaAges 18–35 - NCT06459830Recruiting
Facial exercises with or without nerve stretches for Bell's palsy
This study tests whether adding gentle nerve exercises (neural mobilization) to standard facial exercises (mime therapy) helps people with Bell's palsy recover more movement and expression. It is for people who have had one-sided facial weakness for 3 to 6 months.
Kasur, Punjab ProvinceAges 20–40 - NCT06461611Recruiting
Health diary study for teens with braces
This trial tests if keeping a health diary helps teenagers with braces take better care of their teeth and feel more in control. It is for first-time orthodontic patients aged 12 to 18.
Guangzhou, GuangdongAges 12–18 - NCT06463392Recruiting
Deep learning tool to diagnose post-radiation nasopharyngeal changes
This trial tests a new computer-based tool (deep learning) to help diagnose a condition called sbORN (suspected benign or recurrent nasopharyngeal carcinoma) after radiation therapy. It aims to see if the tool can accurately tell if a suspicious spot is a recurrence or something harmless.
Guangzhou, GuangdongAges 18 years+ - NCT06463574Recruiting
How aging affects a new tooth filling material
This study is looking at how a new kind of self-sticking tooth filling material holds up over time, especially in younger vs. older adults. You may be a good fit if you need a simple filling in a back tooth.
MinyaAges 25–45 - NCT06463938Recruiting
Laser vs. Laser plus paste for tooth sensitivity
This trial tests two treatments for tooth sensitivity: a laser device (Lasotronix) alone or combined with a special paste (CPP-ACP). The goal is to find which treatment works better to reduce pain from hot, cold, sweet, or touch.
Karachi, SindhAges 25–65 - NCT06465628Recruiting
Acupressure for dry mouth after head and neck cancer treatment
This trial tests if acupressure can help with dry mouth caused by radiation therapy for head and neck cancer. If you have dry mouth after treatment and can speak Cantonese or Mandarin, you may be able to join.
Hong Kong, Hong KongAges 18 years+ - NCT06472323Recruiting
Pulsed radiofrequency with platelet-rich plasma for trigeminal neuralgia
This trial tests a treatment that combines pulsed radiofrequency and platelet-rich plasma to see if it works better for trigeminal neuralgia pain that hasn't been helped by standard medicines like carbamazepine.
Beijing, Beijing MunicipalityAges 18–75 - NCT06472713RecruitingPhase 2
Liposomal mitoxantrone with immunotherapy for advanced nasopharyngeal cancer
This trial tests a combination of a chemotherapy drug (mitoxantrone liposome) with an immunotherapy (PD-1 blocker) for people whose nasopharyngeal cancer has come back or spread and hasn't responded to previous treatments. The goal is to see if this combination can shrink tumors or slow cancer growth.
Zhuhai, GuangdongAges 18–70 - NCT06472739RecruitingPhase 2
GM-CSF to prevent mouth sores during radiation for head and neck cancer
This study tests if a mouth rinse with GM-CSF (a protein that helps healing) can prevent mouth sores caused by radiation therapy for nasopharyngeal carcinoma. If you are about to start radiation, this may help reduce pain and trouble eating.
Guangzhou, GuangdongAges 18–65
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
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- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.