Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT06684769Recruiting
Chitosan brush and enamel proteins for gum treatment
This trial tests a new way to clean deep gum pockets at the base of molars using a chitosan brush and enamel proteins. It's for people who still have gum problems after standard treatment.
RigaAges 18 years+ - NCT06685016Recruiting
Study of dental health after IPR with clear aligners
This study looks at how the teeth and gums are doing after a common orthodontic step called IPR (a slight smoothing between teeth) in people wearing clear aligners. It will help understand if this procedure keeps your mouth healthy.
NaplesAges 17–100 - NCT06685523Recruiting
Peri-implantitis study for patients with gum disease around implants
This trial studies a substance called fractalkine and its receptor in the gum fluid around dental implants affected by peri-implantitis. It aims to understand the role of these markers in inflammation, which may help improve diagnosis or treatment.
KirikkaleAges 40–60 - NCT06685640Recruiting
Comparing metal and ceramic crowns for back baby teeth
This trial tests whether stainless steel or zirconia crowns work better for fixing cavities in children's back baby teeth after nerve treatment. It can help parents choose the best option for their child.
Aydin, AydınAges 4–5 - NCT06686979Recruiting
Drug sensitivity test for advanced salivary gland cancer
This trial tests whether a laboratory-grown mini-tumor (organoid) from your biopsy can predict which drugs will work best for your recurrent or metastatic salivary gland cancer. You would need to provide a tumor sample and have adequate organ function.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06688760Recruiting
Surgery vs surgery plus lower-dose radiation for early nasopharyngeal cancer
This trial compares two treatments for newly diagnosed Stage I nasopharyngeal cancer: surgery alone versus surgery followed by a lower dose of radiation. The goal is to see if adding a gentler radiation dose can prevent the cancer from coming back without too many side effects.
Guangzhou, GuangdongAges 18–70 - NCT06688851Recruiting
Custom implants for jaw cysts
This study tests custom-made implants to help treat jaw cysts that are near important structures. It may be an option for people whose cysts are in tricky locations where standard surgery might be risky.
Budapest, BudapestAges 18 years+ - NCT06692244Recruiting
Custom 3D-printed mesh for jawbone regrowth
This trial is testing a custom-made titanium mesh (built with a 3D printer) to help regrow bone in your jaw where teeth are missing. It may be an option if you have moderate to severe bone loss and need a strong foundation for dental implants.
Guangzhou, GuangdongAges 18–60 - NCT06692582Recruiting
Saltwater rinse for treating gum disease
This study tests whether rinsing your mouth with a special saltwater solution (electrolyzed water) can help treat gum disease. It's for people who have advanced gum disease and want to try a simple, gentle addition to regular care.
LjubljanaAges 18–80 - NCT06694168Recruiting
Gum surgery to repair bone loss, with or without your own healing proteins
This trial tests a gum surgery technique that preserves more of your gum tissue, with or without a special protein-rich material made from your own blood (L-PRF), to repair bone loss from gum disease.
Santiago, San BernardoAges 18 years+ - NCT06694532RecruitingPhase 1/Phase 2
Arthrocentesis with hyaluronic acid for TMJ disorders
This trial tests two types of hyaluronic acid (high vs low molecular weight) given during a jaw joint procedure (arthrocentesis) to see which better relieves pain and improves jaw function in people with TMJ disorders.
AsyutAges 18–100 - NCT06695845RecruitingPhase 2
Study of zanidatamab for HER2-positive solid tumors
This trial tests a drug called zanidatamab in people with advanced solid tumors that have high levels of HER2 protein (called HER2-positive). It aims to see if zanidatamab can shrink or slow the growth of these tumors.
Prescott, ArizonaAges 18 years+ - NCT06698718Recruiting
Gum color changes after treatment for gum disease
This study uses a special color-measuring tool to see how gum color changes after basic gum disease treatment. It may help find better ways to check if treatment is working.
Hangzhou, ZhejiangAges 18–65 - NCT06699199RecruitingPhase 4
Testing silver diamine fluoride on mouth bacteria in kids
This study tests if a liquid medicine (silver diamine fluoride) painted on baby teeth cavities can change the bacteria in a child's mouth. It is for healthy children ages 4–10 with an open cavity.
Jeddah, Mecca RegionAges 4–12 - NCT06700863Recruiting
Finding biomarkers for head and neck cancer radiation therapy
This study is looking for proteins or other substances in the blood (biomarkers) that can help predict how well head and neck cancer patients respond to radiation therapy. If you have head and neck cancer and are scheduled for radiation, possibly with chemo, immunotherapy, or targeted therapy, you may be able to join.
Nanjing, JiangsuAges 18–70 - NCT06702033RecruitingPhase 2
Surgery for HPV-related oropharyngeal cancer
This trial is testing a surgical approach for people with HPV-related oropharyngeal cancer that is stage I or II (but not the very smallest). The goal is to see if removing the tumor through the mouth and taking out neck lymph nodes is effective and safe. It may be an option if you are healthy enough for surgery.
St Louis, MissouriAges 18 years+ - NCT06706401RecruitingPhase 3
Lymphocyte-sparing radio-immunotherapy for head and neck cancer
This trial tests a new approach that combines radiation and immunotherapy, while trying to protect your immune cells. It is for people with head and neck cancer that has not spread across the midline of the body and has not been treated yet.
Lyon, FranceAges 18 years+ - NCT07687654Recruiting
Gum recession repair with tooth-colored fillings
This study tests whether placing a tooth-colored filling in a cavity near the gum line can help cover exposed roots when combined with a common gum graft procedure. It may be an option for people who need both a filling and gum recession surgery.
Adıyaman, MerkezAges 18–65 - NCT07460765RecruitingPhase 1
Nivolumab with a special dye for head and neck cancer surgery
This trial tests if a special dye attached to the drug nivolumab can help surgeons see cancer cells more clearly during surgery. If you have head and neck cancer and are scheduled for surgery, this study might be an option for you.
Nashville, TennesseeAges 18 years+ - NCT05688293Recruiting
Gum recession surgeries compared to improve gum coverage
This trial looks at different dental (gum) surgeries to help cover areas where the gum has receded. If you have mild gum recession and good oral care, it may offer options to improve gum health and appearance.
CairoAges 18–55 - NCT07688278Recruiting
Diabetes screening for people with advanced gum disease
This trial tests whether checking blood sugar (HbA1c) at the dentist can find undiagnosed diabetes. It is for adults with advanced periodontitis (severe gum disease) who have not already been told they have diabetes.
SkåneAges 18 years+ - NCT06819228RecruitingPhase 1
Lighted antibody imaging in head and neck cancer surgery
This trial tests a special fluorescent dye attached to panitumumab, a cancer-targeting antibody, to help surgeons see tumor tissue more clearly during head and neck cancer surgery. The goal is to improve removal of all cancer cells while sparing healthy tissue.
Nashville, TennesseeAges 18 years+ - NCT06063876Enrolling by invitation
Gum health study for treated dental implants
This study looks at how gums react to plaque buildup around dental implants that were previously treated for infection. It may help understand if one treatment method leads to healthier gums.
Pittsburgh, PennsylvaniaAges 18–80 - NCT07682883Enrolling by invitation
Mouth screening to prevent oral cancer
This study checks how well routine mouth exams can find early signs of oral cancer. It is for adults who do not already have a condition called OPMD (a mouth problem that can lead to cancer) and are not being treated for it.
Warsaw, Masovian VoivodeshipAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
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- Hormones & metabolism
- Mental health
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- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.