Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,053 recruiting studies in this area right now.
By phase
- Not applicable1,631
- Phase 2148
- Phase 183
- Phase 381
- Phase 458
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma79
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer35
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,053 total
- NCT06714760Recruiting
Flap surgery for mouth reconstruction
This trial tests a new surgical flap (using tissue from the scalp) to repair defects in the mouth after cancer surgery. It may be an option for patients with certain jawbone defects that haven't been operated on before in a specific area.
Bologna, Emilia-RomagnaAges 18 years+ - NCT06714929Recruiting
School water study for students in grades K-5
This study looks at how a new water program in schools might affect student health and hydration. It includes watching what kids drink at lunch, checking teeth and body weight for older students, and asking 4th and 5th graders and staff about their drinks.
Henrico, VirginiaAges 4 years+ - NCT06717230Recruiting
Comparing ways to restore a back tooth after root canal
This study tests three different methods (digital, conventional, and biomimetic) to restore a back tooth that had a root canal and needs a crown-like covering. It aims to find which approach works best over one year.
El-Sheikh Zayed City, Giza GovernorateAges 15 years+ - NCT06721104Recruiting
Balance and jaw health in autism
This study looks at balance, jaw joint function, and social skills in people with autism. It aims to understand how these areas are connected and could help improve care.
KirikkaleAges 4–21 - NCT06721234Recruiting
Vein thickness and inflammation in Behcet disease
This study looks at how the thickness of the femoral vein wall and certain markers of inflammation relate to Behcet disease. It may help doctors better understand and monitor the condition.
SohagAges 19–80 - NCT06723678Recruiting
Bone changes around implants with All-on-Four technique
This trial tests a special technique called 'All-on-Four' for people who need full-arch dental implants. It looks at how the bone around the implants changes over time. If you are in good general health and have a healthy jawbone, this study might help you understand if this approach works well for you.
Cairo, Nasr CityAges 50–65 - NCT06724029Recruiting
Neurosurgery outcomes research for multiple conditions
This study collects data from people having brain or spine surgery for many different conditions. It aims to understand how well different treatments work and how people recover. If you are scheduled for certain brain, spine, or nerve surgeries, you may be able to join.
Bergamo, BGAges 18 years+ - NCT06726876RecruitingPhase 3
Manuka honey rinse for gum disease in dialysis patients
This study tests whether a manuka honey mouth rinse can help treat gum disease in people who are on dialysis for kidney failure. If you have both kidney failure and gum disease, this study may offer a natural way to improve your oral health.
BanhāAges 18 years+ - NCT06727110Recruiting
New liquid treatment for tooth cavities
This study tests a new method to treat cavities that reach the middle layer of a tooth. It may help repair the tooth with a liquid that hardens into a filling. If you have a back tooth with a cavity that hasn't been filled yet, you might be eligible to join.
San Francisco, CaliforniaAges 18–64 - NCT06730360Recruiting
Light therapy for pulp treatment in young children's molars
This study tests whether a special light treatment (photobiomodulation) can help heal the nerve inside a child's first permanent molar when the tooth has deep decay and a painful nerve condition (irreversible pulpitis). The goal is to see if this approach can save the tooth and avoid more invasive treatments.
Al Mansurah, Dakahlia GovernorateAges 6–9 - NCT06732622Recruiting
Laser Acupuncture for Bell's Palsy
This trial tests laser acupuncture as a needle-free treatment for Bell's palsy (sudden facial weakness). It might help people with moderate to severe symptoms who start treatment within 8 weeks of onset.
Beijing, Beijing MunicipalityAges 18–65 - NCT06733948RecruitingPhase 2
Dental stent to protect taste during NPC radiation
This trial tests whether a custom-fitted dental stent (like a mouthguard) can help protect your sense of taste during radiation and chemotherapy for nasopharyngeal cancer. If you qualify, you'll receive either standard care or the stent, and your taste changes will be tracked.
SingaporeAges 21–100 - NCT06736379RecruitingPhase 1
RNA Therapy Injections for Head and Neck Cancer
This trial tests a new type of immunotherapy made of self-amplifying RNA (saRNA) that produces a protein called IL-12. It's injected directly into head and neck tumors to help your immune system fight the cancer. The study is for people whose cancer has not responded well to standard treatments or who are having surgery to remove their tumor.
Stanford, CaliforniaAges 18 years+ - NCT06737289Recruiting
Surgical guide effectiveness study
This trial tests whether using surgical guides in dental implant surgery leads to better outcomes. It may help if you are between 18 and 80 and are planning to get dental implants.
MadridAges Any age - NCT06737822RecruitingPhase 3
Surgery first vs chemo then surgery for oral cancer
This trial compares two approaches for treating oral cancer: having surgery right away or having chemotherapy first followed by surgery. It aims to find which sequence leads to better outcomes for patients.
Bhubaneswar, OdishaAges 18–75 - NCT06742580Recruiting
Sudden facial paralysis and homocysteine study
This study looks at a possible link between a substance in the blood called homocysteine and sudden facial paralysis (Bell's palsy). If you've recently been diagnosed with this condition, you may be able to join.
AfyonkarahisarAges 18–80 - NCT06745141Recruiting
Gum disease treatment after a heart attack
This trial tests whether treating severe gum disease can improve recovery after a heart attack (STEMI). If you recently had a heart attack and also have serious gum problems, you may be able to join and receive periodontal care.
Shanghai, Shanghai MunicipalityAges 30 years+ - NCT06747390RecruitingPhase 1
Lidocaine injection before throat cancer surgery
This early-phase trial tests whether injecting lidocaine (a numbing medicine) into the tumor before surgery can help with pain or other outcomes in people with oropharyngeal cancer. It's for patients who are already scheduled for a scope procedure and surgery at the University of Pennsylvania.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06747949RecruitingPhase 3
Long term extension study of dazodalibep for Sjogren's syndrome
This study gives continued access to the study drug dazodalibep for people with Sjogren's syndrome who completed a prior phase 3 study. The goal is to see how safe and effective the medication is over a longer period.
Avondale, ArizonaAges 18 years+ - NCT06749899RecruitingPhase 3
Immunotherapy with chemoradiation for advanced nasopharyngeal cancer
This trial tests a combination of a new immunotherapy (QL1706) plus standard chemoradiation for people with advanced nasopharyngeal cancer that hasn't spread to distant organs. The goal is to see if adding this drug helps control the cancer better than standard treatment alone.
Fuzhou, FujianAges 18–65 - NCT06751979Recruiting
Probiotics for people with braces
This trial tests if a probiotic can improve oral health for people with braces. It might help reduce plaque buildup around brackets and wires.
AarhusAges 10 years+ - NCT06752239RecruitingPhase 3
Optimizing radiation to protect thyroid in nasopharyngeal cancer
This trial tests a way to adjust radiation therapy to better protect the thyroid gland during treatment for nasopharyngeal carcinoma. It aims to reduce thyroid damage while still effectively treating the cancer.
Nanchang, JiangxiAges 18–70 - NCT06753305Recruiting
Ozone therapy for gum reshaping after inflammation
This study tests if ozone therapy helps heal gums after reshaping surgery for overgrown gum tissue caused by inflammation. It may reduce recovery time or improve results.
KütahyaAges 18 years+ - NCT06753682Recruiting
Healthy plant-based diet and gum disease treatment for Chinese adults
This study tests whether eating more fresh vegetables and fruits can improve treatment outcomes for gum disease. You may qualify if you have gum disease, are Chinese, and currently eat fewer than the recommended daily servings of vegetables and fruits.
Hong KongAges 18–64
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,053 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,969 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.