Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT06999005Recruiting
Dental cavity treatment study for children ages 6-12
This study tests two gentle cavity treatments for children's permanent molars. It aims to find which method works best over two years.
Santos, São PauloAges 6–12 - NCT06995859Enrolling by invitation
Dental filling teaching survey for pediatric dentists
This trial asks pediatric dentistry teachers in Egypt about how they teach amalgam fillings. It is a survey study to learn about current teaching practices.
CairoAges 20 years+ - NCT06991114RecruitingPhase 2
AlloNK and rituximab for relapsing rheumatologic diseases
This trial tests a new natural killer (NK) cell therapy called AlloNK given with rituximab for people with certain autoimmune diseases (rheumatoid arthritis, Sjögren's disease, inflammatory myopathies, or systemic sclerosis) that have not responded well to standard treatments. The goal is to see if this combination can better control the disease.
Tuscaloosa, AlabamaAges 18 years+ - NCT06984848Recruiting
Mouth spray for dry mouth in older adults
This trial tests an enzyme-containing mouth spray (Oral7®) to see if it helps with dry mouth, improves saliva flow, and boosts quality of life for older adults. If you often have a dry mouth, this spray might offer relief.
Kubang Kerian, KelantanAges 60 years+ - NCT06987253Recruiting
Test of OROXID® mouth rinse after oral surgery
This trial tests if a special mouth rinse, OROXID®, helps heal and prevent infection after a tooth extraction or root-tip surgery. It may be an option for people who are generally healthy and need this type of oral surgery.
Muljava, Municipality of Ivančna GoricaAges 18 years+ - NCT06984744Recruiting
Gum health study testing a new compound
This study tests a compound in gum to see how well it prevents plaque buildup over 4 days. You may be able to join if you are a healthy adult with at least 20 natural teeth and some existing plaque.
Indianapolis, IndianaAges 18–65 - NCT06988839Recruiting
Microneedling with gum flap for recession
This study tests whether using a tiny needle roller (microneedling) combined with a gum-advancement flap can help cover a receding gum on a front tooth, without needing a gum graft. It's for people with thin gums, and the goal is to reduce sensitivity and improve appearance.
Rohtak, HaryanaAges 20–50 - NCT06984861RecruitingPhase 2
Reduced radiation with chemo for HPV-related throat cancer
This trial tests if giving less radiation along with chemotherapy is safe and effective for people with HPV-positive throat cancer. It aims to reduce side effects while still controlling the cancer.
Basking Ridge, New JerseyAges 18 years+ - NCT06984666Enrolling by invitation
Study of facial profiles at 45 degrees
This study looks at facial features from a 45-degree angle to see what makes a beautiful profile. It includes orthodontists, patients who have had braces for over a year, and adults without braces experience. You will have photos taken and answer some questions.
Fuzhou, FujianAges 18–50 - NCT06991842Recruiting
Etching time for front tooth fillings
This study looks at how long to etch the tooth before placing a white filling on a front tooth. You may qualify if you need a standard filling on the side or corner of a front tooth.
Basel, Canton of Basel-CityAges 18 years+ - NCT06991998Enrolling by invitation
Comparing tooth graft vs. bone graft for gum disease bone defects
This trial tests whether a graft made from your own extracted tooth works as well as a traditional bone graft, both combined with a special enamel protein, to repair bone loss from gum disease.
Budapest, BudapestAges 18 years+ - NCT06980038RecruitingPhase 2
Testing two immunotherapy drugs before surgery for advanced head and neck cancer
This trial tests whether adding a second immunotherapy drug (CDX-1140) to the standard immunotherapy cemiplimab before surgery is better than cemiplimab alone for people with stage III-IV head and neck cancer that can be removed with surgery.
Irvine, CaliforniaAges 18 years+ - NCT06976190RecruitingPhase 3
MRG003 plus pucotenlimab vs chemo for advanced nasopharyngeal cancer
This trial tests whether combining an experimental antibody-drug conjugate (MRG003) with an immunotherapy (pucotenlimab) works better than standard chemotherapy for people with nasopharyngeal cancer that has come back or spread. If you have tried at least one prior treatment and are generally in good health, you may be able to join.
Guangzhou, GuangdongAges 18–75 - NCT06976411Enrolling by invitationPhase 4
Healing of root hole repair using different materials
This trial tests how well different materials help heal a small hole (perforation) in the root of a lower molar tooth. It may help if you have this type of tooth injury and are generally healthy.
CairoAges 15–50 - NCT06982300RecruitingPhase 1/Phase 2
PET scan for advanced nasopharyngeal cancer
This trial tests a special PET scan that can detect a receptor (SSTR2) on cancer cells to see if it can help guide treatment for people with nasopharyngeal cancer (a type of head and neck cancer). It may help doctors choose the best therapy for you.
GroningenAges 18 years+ - NCT06981767RecruitingPhase 2
Bromelain vs. Steroids for Oral Lichen Planus
This trial tests whether a pineapple enzyme (bromelain) works as well as a standard steroid treatment for painful mouth sores caused by oral lichen planus. If you have this condition and are not taking other medications, you may be eligible.
Cairo, Cairo GovernorateAges Any age - NCT06982105RecruitingPhase 4
Comparing two antibiotics for children with MRSA bone or head infections
This study compares two oral antibiotics, TMP-SMX and clindamycin, to see which works better for children with MRSA infections in bones, joints, or head/neck areas. It aims to find the best treatment after initial IV therapy.
Indianapolis, IndianaAges 2 months–18 years - NCT06977100Recruiting
Journaling study for jaw pain with other chronic pain conditions
This study tests if a journaling program can help people with jaw pain and at least one other chronic pain condition (like fibromyalgia, IBS, or migraines). You will write about your thoughts and feelings to see if it reduces pain and improves well-being.
Gainesville, FloridaAges 18–80 - NCT06980714Enrolling by invitation
Electric vs. manual toothbrush for advanced gum disease
This study compares electric and manual toothbrushes to see which one works better for people with advanced gum disease (stage 3 or 4 periodontitis). It might help you find a more effective way to care for your teeth and gums at home.
L’AquilaAges 18 years+ - NCT06980701Recruiting
Personalized oral hygiene advice for people with prediabetes
This trial tests whether personalized advice from a dentist or an AI can improve the oral and overall health of people with prediabetes. You may benefit if you have prediabetes and are willing to improve your daily oral care routine.
Hong Kong, Sai Ying PunAges 18 years+ - NCT06973057Enrolling by invitation
Comparing two treatments for deep cavities in baby molars
This trial tests two different ways to treat deep cavities in back baby teeth (molars) that are close to the nerve, to see which works better. It may help children who have cavities in both matching teeth on each side.
IrbidAges 4–10 - NCT06978712Recruiting
Gum inflammation and body stress link study
This study checks if gum inflammation (periodontitis) affects your body's stress system (allostatic load). It aims to find a link between severe gum disease and overall health stress.
Rohtak, HaryanaAges 30–50 - NCT06972797Enrolling by invitation
Comparing Computer Methods for Measuring Upper Canine Teeth
This study compares two computer methods for measuring an upper canine tooth that has not come in properly. It uses a 3D scanning tool to see which method gives more accurate results and could help dentists plan better treatments.
Cairo, Cairo GovernorateAges 8–70 - NCT06974591Recruiting
How your teeth affect your balance
This study looks at how small disturbances to your posture affect your jaw and balance. It compares people with all their natural teeth to those who wear full dentures, to see if the type of teeth you have changes how your body responds.
Boston, MassachusettsAges 30–65
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.