Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT05581680Recruiting
Facial movement study comparing people with and without facial weakness
This study uses special sensors (electrodes and small markers) to measure how facial muscles move. It compares people with peripheral facial palsy to people without facial problems to better understand facial movement changes.
Amiens, PicardieAges 18 years+ - NCT06465628Recruiting
Acupressure for dry mouth after head and neck cancer treatment
This trial tests if acupressure can help with dry mouth caused by radiation therapy for head and neck cancer. If you have dry mouth after treatment and can speak Cantonese or Mandarin, you may be able to join.
Hong Kong, Hong KongAges 18 years+ - NCT06956612Recruiting
Dietary nitrate supplements and your oral health
This trial tests whether taking dietary nitrate supplements can improve oral health in healthy adults. It may help you understand how simple diet changes could support your mouth's natural defenses.
NewcastleAges 18–65 - NCT06866431Recruiting
Ultrasound cavitation for faster healing after tooth extraction
This study tests if a special ultrasound tool (called cavitation) can help your gums heal better after having two teeth pulled. It is for people who need two teeth removed from the same jaw.
Trieste, TSAges 18–100 - NCT07041099RecruitingPhase 1
Study of CLN-978 for Sjögren's disease
This trial tests an experimental drug called CLN-978, given as a shot under the skin, that helps your immune system target and destroy disease-causing B cells. It's for people with moderate to severe Sjögren's disease who haven't had success with other treatments.
Orlando, FloridaAges 18 years+ - NCT07034079RecruitingPhase 2
Adding ridges to dentures for better fit and comfort
This study tests adding small ridges (called palatal rugae) to a complete upper denture to see if it makes patients more satisfied and improves their quality of life related to oral health. It may help dentures feel more natural and stable.
Islamabad, IslamabadAges 40–80 - NCT07035314Recruiting
Comparing medicines for pain after tonsil removal in children
This study compares two ways to manage pain after tonsil removal in children: a medication given by mouth or injection versus a medication applied directly to the surgical site. The goal is to find which approach works better for pain control.
CairoAges 4–10 - NCT07036237Enrolling by invitation
Comparing pain relief rinses after root canal
This trial tests whether rinsing the tooth with either tramadol (a pain reliever) or dexamethasone (a steroid) after a root canal reduces pain better. It is for people with a single-rooted tooth that has a very painful, inflamed nerve.
Karachi, SindhAges 18–50 - NCT07041905Recruiting
Comparing two ways to treat deep cavities in back teeth
This study compares two ways of removing deep tooth decay to see which keeps the tooth nerve healthy and causes less pain afterward. It's for people who have two deep cavities on opposite sides of their mouth and want to help find the best treatment.
AdanaAges 15–55 - NCT07041424Enrolling by invitation
Bonding methods for filling cavities to reduce tooth sensitivity
This trial tests two ways of bonding a tooth-colored filling to see which reduces tooth sensitivity after the procedure. It may help if you have a moderate cavity on a back tooth that causes brief pain or sensitivity.
Islamabad, FederalAges 18 years+ - NCT07043998Recruiting
Comparing two ways to set cement for full-coverage dental crowns
This study tests whether the way a special dental cement is hardened (using light or a chemical set) affects how well full-coverage metal-and-porcelain crowns stay attached. If you're getting a crown, this trial compares two curing methods to see which gives a stronger, longer-lasting bond.
CairoAges 21 years+ - NCT07039071Recruiting
Laceback study for orthodontic treatment outcomes
This trial tests whether a technique called laceback improves treatment results for people getting braces. It looks at tooth movement and patient comfort.
Kuantan, PahangAges 15 years+ - NCT07035236Recruiting
Titanium mesh for dental implant bone support
This trial tests a new method to help people who have lost bone in the upper jaw get dental implants. If your jawbone is too thin, they will use a small titanium mesh to support the sinus lining and make room for an implant.
IsmailiaAges 18–60 - NCT07041164Recruiting
Light vs X-ray for finding cavities in kids' back teeth
This trial tests a new light-based tool (near-infrared light) compared to traditional X-rays to find hidden cavities between baby molars. The goal is to see if the light method is better at spotting cavities and if kids like it more.
BangkokAges 4–10 - NCT07040176Recruiting
Moving upper back teeth back with aligners or mini-screws
This study compares two ways to move the upper back molars backward to fix an overbite where the upper teeth stick out too far. One method uses clear aligners, the other uses tiny temporary screws in the jawbone.
ThessalonikiAges Up to 30 years - NCT06277791RecruitingPhase 2
Adebrelimab plus chemo before surgery for advanced oral cancer
This trial is testing a new combination of an immunotherapy drug (adebrelimab) plus two chemotherapy drugs (paclitaxel and carboplatin) given before surgery for advanced oral cancer. The goal is to see if this treatment can shrink the tumor and improve outcomes.
Hubei, WuhanAges 18–75 - NCT06630819Recruiting
Comparing different volumes of numbing medicine for tooth removal
This study tests whether using a smaller amount of a numbing medicine (articaine) works as well as the usual amount for numbing the area before removing a lower back tooth. It aims to make the procedure more comfortable and efficient.
Buraidah, Al QassimAges 18 years+ - NCT07033091Recruiting
HPV screening study for healthy adults 40 and older
This study checks healthy adults aged 40+ for HPV in the mouth using a simple gargle rinse. It aims to see if this can help find early signs of oropharyngeal cancer.
BrnoAges 40 years+ - NCT07030088Recruiting
Testing a new two-sided toothbrush for healthier gums
This trial tests a special toothbrush that cleans both sides of your teeth at once. It compares this new brush to a regular one to see if it improves gum health in dentists.
RiyadhAges 25–40 - NCT07031856Recruiting
3D printed vs. CAD-CAM dental restorations comparison
This trial compares two modern ways to make partial dental restorations (like crowns or bridges): one using a 3D printer and the other using a computer-aided design and manufacturing (CAD-CAM) system. It aims to see which method works better for people who need a couple of teeth fixed.
Adana, SarıçamAges 18–65 - NCT07027709Recruiting
Hybrid ceramic veneers for better smiles
This trial tests how well hybrid ceramic laminate veneers work for fixing front teeth. It may help if you need cosmetic improvement and your teeth are healthy enough.
CairoAges 21 years+ - NCT07028151Enrolling by invitation
Massage versus standard care for teeth grinding
This study tests whether a classical massage can help relieve jaw tension and other symptoms of teeth grinding (bruxism) in college students, compared to standard treatments. If you grind or clench your teeth and are between 18 and 27, this might be a non-invasive option to explore.
Bartın, AnkaraAges 18–27 - NCT07029360Recruiting
Coenzyme Q10 and Probiotics for Gum Health in Pregnancy
This trial tests whether adding coenzyme Q10 and probiotics to standard gum treatment can improve gum health and reduce inflammation in pregnant women. If you are in your second or third trimester and have gum concerns, this treatment may help both you and your baby.
Pavia, LombardyAges 18 years+ - NCT07024251Recruiting
Collecting biological samples for oral and maxillofacial research
This study collects leftover samples (like tissue, saliva, or blood) from routine dental visits or oral surgeries. The samples are used to learn more about mouth and jaw diseases, with no extra procedures needed.
Milan, ItalyAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.