Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT06642324Recruiting
HPV and genetics in head and neck cancer study
This study looks at how HPV infection and genetic changes relate to head and neck squamous cell carcinoma. If you have this type of cancer, joining could help doctors learn more about the disease and improve future treatments.
Dhaka, Dhaka DivisionAges 18 years+ - NCT06642870Recruiting
Self-management programme for rare rheumatic conditions
This trial is developing a self-management programme for people with rare rheumatic conditions like lupus, vasculitis, myositis, or Sjogren syndrome. It aims to help participants better manage their condition and improve their quality of life.
BristolAges 18 years+ - NCT06643507RecruitingPhase 2/Phase 3
Testing a new gum repair technique for receding gums
This trial compares two ways to fix receding gums (a condition where your gums pull away from your teeth). It tests a newer technique using your own blood products versus a traditional graft to see which works better for moderate gum recession.
CairoAges 18–60 - NCT06643663Recruiting
Gum surgery for teeth with gum disease and failed root canal
This study tests a gum surgery technique (guided tissue regeneration) to help heal teeth that have both gum disease and a failed root canal. It looks at how well the tooth heals and how it affects your daily life.
HaryānaAges 16 years+ - NCT06646432Recruiting
Gum Recession Treatment: Tissue Graft vs. Blood Concentrate
This trial is testing two methods for fixing receding gums: using a small piece of tissue from the roof of your mouth (connective tissue graft) versus using a special concentrate of your own blood (injectable platelet-rich fibrin). Both are done through a tiny tunnel under the gum, and the goal is to cover the exposed root and make your gums look and feel healthier.
IsmailiaAges 21 years+ - NCT06651944Recruiting
Invisalign with jaw advancement aligners
This trial tests Invisalign clear aligners that also help move the lower jaw forward. It may be a good fit if you need both teeth straightening and jaw positioning help.
Richmond, British ColumbiaAges 10–16 - NCT06652230Recruiting
Comparing two ways to place braces for a better smile
This study compares two methods of placing braces to improve smile appearance. It tests if using the natural curve of your smile works better than a standard chart for bracket positioning.
Cairo, ManialAges 11–30 - NCT06653868Recruiting
Sticky bone grafts for front tooth implants
This trial tests two different types of sticky bone graft materials placed around a dental implant right after a tooth is removed. It aims to see which type helps the bone heal better around the implant in the front of your mouth.
CairoAges 20–50 - NCT06654141Recruiting
Healing time and tooth socket preservation after molar extraction
This study looks at how different healing times affect the success of preserving the bone where a molar is removed due to gum disease. It aims to find the best wait time before placing a dental implant.
ShanghaiAges 18 years+ - NCT06656325Recruiting
Laser treatment for gum disease study
This study tests a special low-level laser (Erchonia FX-405) as an extra treatment for gum disease (periodontitis). It aims to see if adding this laser to standard care helps improve gum health and reduce infection.
Thousand Oaks, CaliforniaAges 22–75 - NCT06657690RecruitingPhase 2
New drug combo for advanced nasopharyngeal cancer after immunotherapy
This trial tests a combination of two drugs, irinotecan liposome and S-1, for people with a type of nose and throat cancer that has spread or come back after treatment with immunotherapy (PD-1/L1 inhibitors). The goal is to see if this new combination can help when standard treatments have stopped working.
Zhuhai, GuangzhouAges 18–70 - NCT06659991RecruitingEarly Phase 1
Pain and daily tasks in jaw joint disorder
This study tests how pain from a jaw joint disorder (TMD) affects your ability to do daily tasks. You'll track your pain and activities on your smartphone to help researchers understand the link.
Minneapolis, MinnesotaAges 21–65 - NCT06660797Recruiting
Irrigation methods for root canal treatment
This trial tests different ways to flush and clean inside a tooth during root canal treatment. It aims to see which method best reaches deep into the tooth and reduces bacteria.
TantaAges 18–40 - NCT06662279Recruiting
Hyrax vs. Invisalign palatal expander study
This study compares a traditional metal palatal expander (Hyrax) to a new clear aligner-based expander (Invisalign) for widening the upper jaw in children aged 6-11. It aims to see which device works better and is more comfortable.
Laguna Hills, CaliforniaAges 6–11 - NCT06662929Recruiting
Arabic quality of life measure for head and neck cancer patients
This study will test a new Arabic questionnaire to measure how radiotherapy affects the quality of life of head and neck cancer patients. If you are receiving, have received, or will receive radiation treatment for head or neck cancer, you may be able to help by filling out surveys.
RiyadhAges 18 years+ - NCT06668194Recruiting
Teeth straightening: how much force is best?
This trial tests different force levels to move canine teeth after premolar extraction in teens. Results may help orthodontists choose the best force for faster, safer tooth movement.
Farmington, ConnecticutAges 11–16 - NCT06671106Recruiting
Mouthrinse for Teens with Early Gum Disease
This trial tests a special mouthrinse containing amine and zinc lactate to treat plaque-induced gingivitis (gum inflammation caused by plaque) in teenagers. If you or your teen have early gum disease and are eligible for free dental care through the Regional Health Service, this study may offer a home-based treatment option.
FerraraAges 12–14 - NCT06673329RecruitingPhase 1
Brodalumab for immune-related side effects from cancer treatment
This trial tests if brodalumab, an antibody that blocks a specific immune pathway (IL-17), can help control side effects caused by immunotherapy cancer treatment. It is for people with advanced solid organ cancers who have immune-related side effects that are suspected to involve IL-17.
New York, New YorkAges 18 years+ - NCT06675214RecruitingPhase 3
Immunotherapy with modified radiation for advanced NPC
This trial tests a new way to give radiation therapy after immunotherapy and chemotherapy for people with advanced nasopharyngeal cancer (NPC) that has partially shrunk. It aims to see if a different radiation schedule works better and has fewer side effects.
Zhuhai, GuangdongAges 18–65 - NCT06676826Recruiting
Comparing two gum-graft materials for bone defects
This study tests two types of gum-graft materials to see which works better for rebuilding bone next to deep pockets caused by gum disease. Both materials are used during a minor surgical procedure to help your gums and bone heal stronger.
BernAges 18 years+ - NCT06679283Recruiting
Surgery for implant gum infection with platelet-rich fibrin
This study tests whether adding a natural blood concentrate (platelet-rich fibrin) to standard surgery improves healing of gum infections around dental implants. It's for people with moderate to advanced implant problems who have good oral hygiene.
BernAges 18 years+ - NCT06682442Recruiting
Chemotherapy-guided radiation for EBV-related nasopharyngeal cancer
This trial tests whether the response to initial chemotherapy can guide the dose of radiation given to patients with Epstein-Barr virus (EBV)-associated nasopharyngeal cancer. The goal is to tailor treatment to reduce side effects while still being effective.
San Francisco, CaliforniaAges 18 years+ - NCT06682494Recruiting
Oral Cancer Awareness for African Americans
This study aims to raise awareness about oral cancer in the African American community. It will help researchers understand how to better communicate about prevention and early detection.
Richmond, VirginiaAges 18 years+ - NCT06684275Recruiting
Radiofrequency treatment comparison for trigeminal neuralgia pain
This trial compares two types of radiofrequency treatment (pulsed and thermal) to see which works better for people with trigeminal neuralgia, a condition that causes severe, stabbing facial pain. If you have had facial pain for at least six months that isn't controlled by medicine, this study may help you find relief.
Zagazig, Sharqia ProvinceAges 18–60
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.