Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,053 recruiting studies in this area right now.
By phase
- Not applicable1,631
- Phase 2148
- Phase 183
- Phase 381
- Phase 458
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma79
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer35
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,053 total
- NCT06588725Enrolling by invitation
Parent program to prevent cavities in young children
This study tests simple ways to help parents improve their child's dental health and prevent cavities. It focuses on changing behaviors to keep your child's teeth healthy.
Nashville, TennesseeAges 9 months–3 years - NCT06582238Enrolling by invitation
Dentist survey on managing tooth sensitivity
This study asks dentists about how they manage tooth sensitivity. If you are a dentist practicing in Egypt or Nigeria, your answers will help improve patient care.
CairoAges Any age - NCT06514664Enrolling by invitation
Do probiotic toothpastes help gums and teeth?
This trial tests whether using a probiotic toothpaste can improve gum health in people with gum disease (periodontitis). It may help reduce inflammation and slow bone loss.
KütahyaAges 18–99 - NCT06508723Enrolling by invitation
Comparing dental implants with different surfaces
This study tests two types of dental implant surfaces to see which works better. It may be a good fit if you need one or more missing teeth replaced and are generally healthy.
KütahyaAges 18–99 - NCT06430268Enrolling by invitation
Cleaning methods for infected dental implants
This study is testing different ways to clean a dental implant that is failing due to severe infection (peri-implantitis). If you need to have an implant removed because of advanced bone loss, the researchers will compare cleaning methods during the removal procedure.
Pittsburgh, PennsylvaniaAges 18–80 - NCT06410859Enrolling by invitationPhase 2
Botox injection for trigeminal neuralgia pain
This study tests a Botox injection (HengLi®) to see if it can reduce facial pain from trigeminal neuralgia. It is for people whose pain is not well controlled by standard medications.
Beijing, Beijing MunicipalityAges 18–75 - NCT06396988Enrolling by invitation
Novamin for weak enamel in children's teeth
This study tests a special toothpaste ingredient (Novamin) that may help repair weak enamel on permanent back teeth and front teeth in children and teens. The treatment is applied by a dentist and may strengthen the teeth and reduce sensitivity.
Pavia, LombardyAges 7–14 - NCT06373848Enrolling by invitation
Vitamin E and Coenzyme Q10 for early gum disease
This study tests whether adding vitamin E and coenzyme Q10 to standard gum treatment can help heal early-stage chronic gum disease. It is for otherwise healthy adults aged 28-35 with mild gum pockets on their lower molars.
TehranAges 28–40 - NCT06338319Enrolling by invitation
Book sharing study for toddlers with cleft palate
This study tests whether a book-sharing program can help toddlers (20-32 months) who had cleft palate repair improve their language and communication skills. Families will use a smartphone or tablet to record and send videos.
Seattle, WashingtonAges 1.7 years–2.7 years - NCT06330324Enrolling by invitation
Reproductive choices for genetic skin conditions
This study looks at the choices families have when they carry a genetic skin condition. It aims to learn more about how prenatal testing and IVF with genetic testing can help.
Maastricht, LimburgAges Any age - NCT06311253Enrolling by invitation
Gum treatment with lactoferrin toothpaste in pregnancy
This study tests whether special toothpaste and mouthwash with lactoferrin (a natural protein) can help treat gum problems in pregnant women. It may offer a safe way to care for your gums during pregnancy.
Pavia, LombardyAges 18–40 - NCT06308497Enrolling by invitation
Periodontal treatment with CoQ10 and probiotics for pregnant women
This study tests whether a combination of coenzyme Q10 and probiotics can improve gum health in pregnant women. It aims to find a safe, gentle treatment for gum problems during pregnancy.
Pavia, LombardyAges 18–40 - NCT06201377Enrolling by invitation
Early healing after periodontal surgery
This trial looks at how well gum surgery incisions heal in the first days and weeks after the procedure. It may help people with gum disease who need surgery to control their condition.
Leioa, BiscayAges 18 years+ - NCT06099431Enrolling by invitation
Bone plate for jaw reconstruction after benign tumor removal
This trial is testing a bone plate used to rebuild the lower jaw after removing a non-cancerous growth. It may help patients who need surgery to remove a benign lesion from the center of their jawbone.
Tanta, Gharbia GovernorateAges 12–50 - NCT06096220Enrolling by invitationPhase 4
Study of two treatments for jaw cysts
This trial tests if applying 5-fluorouracil or Carnoy's solution during surgery helps treat odontogenic keratocysts (a type of jaw cyst) and reduce the chance they come back.
BelgradeAges 18–70 - NCT06077513Enrolling by invitation
Comparing two mesh frames for jawbone grafting
This trial tests two different metal mesh frames used to rebuild bone in the jaw before placing a dental implant. If you need a bone graft for a missing tooth, this study may help find the best option for you.
Boston, MassachusettsAges 18–80 - NCT06050655Enrolling by invitation
Lingual aligners for adults: how well do they work?
This trial tests whether lingual aligners (braces placed on the inside of your teeth) are effective for straightening teeth in adults. If you are an adult planning to get orthodontic treatment, this study may be for you.
Geneva, Canton of GenevaAges 18 years+ - NCT05964933Enrolling by invitation
Pulpotomy vs root canal for painful nerve inflammation
This trial compares two treatments for a tooth nerve that is very inflamed and causing lingering pain: a pulpotomy versus a full root canal. It may help you choose the approach that best relieves symptoms and supports healing for the right kind of tooth.
SingaporeAges 12 years+ - NCT05947305Enrolling by invitation
Different ways to prepare gum tissue during periodontal surgery
This study compares different surgical techniques for removing and preparing gum (gingival) tissue to support healing after periodontal procedures. It may help improve how these common mouth surgeries are done and what tissue ends up for analysis.
Ann Arbor, MichiganAges 18 years+ - NCT05945225Enrolling by invitation
Oral care during pregnancy to reduce gum inflammation
This study looks at how a specific oral care approach during pregnancy may lower gum inflammation. It mainly enrolls pregnant people in mid-pregnancy and checks gum health over time.
NancyAges 18–40 - NCT05943782Enrolling by invitation
Digital onlay fillings made two ways for back teeth
This trial compares two digital manufacturing methods to make ceramic onlay fillings for back (molar) teeth—one method that removes material and one that builds it up. It may help you learn which approach makes more comfortable, effective onlays for teeth needing repair.
CairoAges 18–50 - NCT05932017Enrolling by invitation
Compare two ways to see during gum surgery
This trial compares two tools surgeons use to see during gum (periodontal) surgery: magnifying loupes versus a videoscope. It may help improve how the procedure is done for people with more severe gum disease.
Dallas, TexasAges 18 years+ - NCT05902026Enrolling by invitation
Questionnaire study for jaw-related headache and pain impact
This study tests a biopsychosocial questionnaire (a survey about thoughts, daily life, and pain) for people with jaw-related headaches from temporomandibular disorder (TMD). It may help researchers better understand what influences headache severity and how to support treatment planning.
Gaziantep, Hasan Kalyoncu UniversityAges 18–60 - NCT05876169Enrolling by invitation
Study how jaw surgery changes neck and jaw movement
This study looks at how orthognathic (jaw alignment) surgery affects how your jaw and neck muscles move. It may help doctors better understand recovery and movement changes after surgery.
UmeåAges 16–50
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,053 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,969 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.