Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,764 recruiting studies in this area right now.
By phase
- Not applicable3,111
- Phase 4251
- Phase 2144
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University97
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad26
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- Illinois38
- North Carolina38
Recruiting studies3,763 total
- NCT07153003Enrolling by invitationPhase 4
Tramadol and oxycodone vs oxycodone alone for joint pain
This trial tests if taking two pain relievers (tramadol and oxycodone) together works better than oxycodone alone to control pain after knee or hip replacement surgery. It aims to find a more effective way to manage pain with fewer side effects.
Rochester, MinnesotaAges 18 years+ - NCT07141992Enrolling by invitation
Nerve glide exercises for burning pain from diabetic neuropathy
This study compares two types of nerve gliding exercises to see which works better for reducing burning pain, improving muscle strength, and increasing movement in patients with diabetes-related nerve damage.
Karachi, SindhAges 40–65 - NCT07102121Enrolling by invitation
Comparing tooth sensitivity after cementing crowns with two dental materials
This study tests whether one type of dental cement causes less tooth sensitivity than another after placing a crown. The results could help your dentist choose the material that feels better for you.
Mingora, Khyber PakhtunkhwaAges 15–60 - NCT07101172Enrolling by invitation
Stress ball for anxiety and pain during prostate biopsy
This study tests whether using a stress ball during a prostate biopsy can help reduce anxiety and pain. It may be an option if you are having your first biopsy and can squeeze a ball.
Çorum, MerkezAges 18 years+ - NCT07096661Enrolling by invitation
Pain education for labor and postpartum pain
This study tests a way of teaching about pain (called pain science education) to help healthcare professionals better support women during labor and after birth. If you are a healthcare professional who works with pregnant or new mothers, this trial may be for you.
BournemouthAges Any age - NCT07090018Enrolling by invitation
A single session to help manage pain after C-section
This trial tests a one-time class (called Empowered Relief) for women who still have pain 6 weeks after a cesarean delivery. The goal is to see if this session helps reduce ongoing pain and improve recovery.
Palo Alto, CaliforniaAges 18 years+ - NCT07083219Enrolling by invitation
Exercise and pain processing in healthy adults
This study tests how aerobic exercise affects the way your body processes pain. If you are a healthy adult without chronic pain, you may be able to join.
El Paso, TexasAges 18–50 - NCT07072559Enrolling by invitation
Can a dental game reduce pain and anxiety during kids' pulp treatment?
This study tests whether playing a dental-themed game on a mobile device can help children aged 4 to 7 feel less pain and anxiety during a pulpotomy (a procedure to treat deep cavities in baby teeth). It aims to make the dental visit easier for kids who are cooperative but may be nervous.
Al MansurahAges 4–7 - NCT07062757Enrolling by invitation
Massage and melatonin for jaw surgery recovery
This study tests whether combining gentle lymphatic drainage massage with melatonin can reduce pain and swelling after jaw surgery. If you are scheduled for jaw surgery for the first time and are otherwise healthy, you may be able to join.
Istanbul, FatihAges 16–55 - NCT07055971Enrolling by invitation
Pain education and brain training for fibromyalgia
This trial tests whether a program that teaches you about pain and helps your brain control pain better can improve fibromyalgia symptoms. It also looks at how emotions play a role.
Granada, AndalusiaAges 18 years+ - NCT07051265Enrolling by invitation
Pain relief for head and neck cancer patients using TENS or acupressure
This study compares two non-drug methods—TENS (a mild electrical device) and acupressure (gentle finger pressure on specific points)—to help manage pain in people with head and neck cancer. If you have cancer-related pain and need medication, you may be able to join.
Kaohsiung CityAges 20–100 - NCT07046143Enrolling by invitation
Spinal cord stimulation for nerve pain in the lower back
This trial tests a non-invasive treatment that uses mild electrical stimulation on the skin over the spine to help relieve nerve-related pain in the lower back. It may be an option for people with chronic nerve pain, with or without pain spreading down the leg.
Nanchang, JiangxiAges 18–80 - NCT07028151Enrolling by invitation
Massage versus standard care for teeth grinding
This study tests whether a classical massage can help relieve jaw tension and other symptoms of teeth grinding (bruxism) in college students, compared to standard treatments. If you grind or clench your teeth and are between 18 and 27, this might be a non-invasive option to explore.
Bartın, AnkaraAges 18–27 - NCT07027631Enrolling by invitation
Comparing two treatments for chronic neck pain
This trial tests whether magnesium sulfate iontophoresis (a method that uses a mild electrical current to deliver medicine through the skin) or extracorporeal shockwave therapy (sound waves applied to the neck) works better for long-term neck pain caused by trigger points in the upper shoulder muscle.
GizaAges 18–40 - NCT07023991Enrolling by invitationPhase 1
Dexmedetomidine with bupivacaine for children's lower abdominal surgery
This trial tests whether adding dexmedetomidine (a sedative) to bupivacaine (a numbing medicine) improves pain relief from a nerve block in young children having lower belly surgery. The goal is to see if the combination provides better or longer-lasting pain control.
Cairo, EgyptAges 1–7 - NCT07023692Enrolling by invitation
Using visual and sound tricks to ease pain and worry during a bone marrow test
This trial tests whether watching a video or listening to sounds can help reduce pain and anxiety during a bone marrow aspiration or biopsy. It's for adults who are either healthy volunteers or patients without a blood cancer diagnosis, and who need this test at the clinic in Lund, Sweden.
Lund, Skåne CountyAges 18 years+ - NCT07011875Enrolling by invitation
Physical activity and period pain in women with MS
This study looks at how physical activity levels affect period pain, menstrual symptoms, and emotional well-being in women with multiple sclerosis. It aims to find out if being more active can help with these issues.
Karabük, Karabük ProvinceAges 18–55 - NCT07011537Enrolling by invitation
Digital health program and TENS for chronic low back pain
This trial tests a digital health program combined with a TENS device (a small device that sends gentle electrical pulses to help with pain) for people with ongoing low back pain. It compares this approach to standard care, and you would be randomly assigned to one of the two groups.
Eden Prairie, MinnesotaAges 18 years+ - NCT07006389Enrolling by invitation
Shock wave therapy for plantar fasciitis follow-up study
This study looks at how well shock wave therapy works for people with plantar fasciitis that hasn't improved with other treatments. If you've already had shock wave therapy 3 to 6 months ago, your experience could help doctors understand what makes the treatment effective.
IstanbulAges 18 years+ - NCT07005375Enrolling by invitation
Hot mineral water baths for rowers' pain and performance
This trial tests whether bathing in thermal mineral water can reduce pain and improve performance in rowers. It is open to competitive and recreational rowers who train regularly.
Budapest, BudapestAges 14–75 - NCT07003802Enrolling by invitation
Understanding back muscle control in disc injury
This study looks at how the brain controls back muscles in people with chronic disc injuries. It compares patients before surgery or physical therapy to healthy controls to better understand muscle function.
La Jolla, CaliforniaAges 18–60 - NCT06997016Enrolling by invitationPhase 4
Recovery program for living donor kidney transplant
This trial tests a special recovery program (ERAS) for people who get a kidney from a living donor. The program aims to help you heal faster and feel better after surgery.
Fort Worth, TexasAges 18 years+ - NCT06989866Enrolling by invitationPhase 3
Testing if numbing injections reduce pain pill use after nose surgery
This trial tests whether a numbing injection (regional anesthesia) during nose surgery can reduce the need for strong pain pills afterward. It's for people having their first nose surgery at specific military hospitals.
Portsmouth, VirginiaAges 18 years+ - NCT06986668Enrolling by invitation
Warm wax and mud therapy for carpal tunnel syndrome
This trial tests if paraffin wax baths and peloidotherapy (mud therapy) help reduce symptoms of mild to moderate carpal tunnel syndrome (a hand nerve condition). It may be a good fit if you haven't had prior wrist surgery, steroid injections, or other nerve problems.
KonyaAges 18–65
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,764 recruiting pain medicine studies from the U.S. registry right now, out of 6,842 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.