Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Mayo Clinic28
- Tanta University28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas51
- Ohio47
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT07754266Recruiting
Headache, ear, and dizziness registry
This study collects information from people who have headaches, ear problems, dizziness, or sinus issues to better understand these symptoms and how they relate to migraine. Your participation may help improve future treatments and diagnosis.
North Kingstown, Rhode IslandAges 18 years+ - NCT07251491RecruitingPhase 1/Phase 2
Psilocybin for depression after spinal cord injury
This trial tests whether psilocybin (a substance found in certain mushrooms) can help treat depression in people with a spinal cord injury. You would receive the study drug in a controlled setting, and your progress would be monitored closely.
The Bronx, New YorkAges 22 years+ - NCT07463170Recruiting
French translation of a pain assessment tool for newborns
This study is translating a pain assessment tool for newborns into French and testing it with healthcare workers in neonatal units. It aims to improve pain recognition in babies who cannot speak.
Paris, Île-de-France RegionAges Any age - NCT07540104Recruiting
Pain block vs morphine injection for chest surgery
This study compares two ways to manage pain after video-assisted chest surgery (VATS): a numbing injection near the shoulder blade (serratus posterior superior intercostal plane block) versus a small dose of pain medicine in the spine (intrathecal morphine). The goal is to find which approach works better and has fewer side effects.
Atakent, SamsunAges 18–75 - NCT07745972Recruiting
Pain relief block for gallbladder surgery
This trial tests a numbing injection near the ribs to reduce pain after laparoscopic gallbladder removal. It may help you recover with less discomfort.
IstanbulAges 18–80 - NCT06020508Recruiting
Light device to help place epidural needles
This trial tests a new device that uses light to help doctors place an epidural needle more accurately in your lower back. It may make the procedure safer and more comfortable.
New York, New YorkAges 18–99 - NCT06271707RecruitingPhase 4
Nerve block for surgery pain relief
This trial tests a nerve block (stellate ganglion block) to see if it helps reduce pain after surgery to remove part or all of the lung or esophagus. It may be an option for adults aged 18-85 having these procedures.
Minneapolis, MinnesotaAges 18–85 - NCT06831604Recruiting
Nerve blocks for clavicle surgery pain relief
This trial compares two types of nerve blocks to see which provides better pain control during and after clavicle fracture surgery. It may help patients have a smoother recovery with less pain.
Tanta, El-GharbiaAges 18–65 - NCT06815367Recruiting
Compression vs Blood Flow Restriction for Muscle Recovery
This study compares two methods to help muscles recover after exercise: pneumatic compression (like a gentle massage sleeve) versus blood flow restriction (using a cuff). It aims to find which works better for healthy, active young adults.
Los Angeles, CaliforniaAges 18–30 - NCT06681662RecruitingPhase 4
Ephedrine for faster muscle relaxant in elderly patients
This trial tests whether giving a small dose of ephedrine (a medicine that raises blood pressure) can make the muscle relaxant rocuronium work faster in older adults. It aims to help patients 80+ get a breathing tube placed more quickly during surgery.
CopenhagenAges 80 years+ - NCT06460155RecruitingPhase 4
CompuFlo device for epidural placement study
This study tests a device called CompuFlo that helps doctors place an epidural for surgery. If you need an epidural for an operation, you may be able to join.
Minneapolis, MinnesotaAges 18–99 - NCT05945719Recruiting
Study on harassment discrimination against pain staff
This study focuses on adult people living with chronic pain. It may be looking at how patient behavior and workplace discrimination or harassment affect pain care staff.
Surrey, British ColumbiaAges 20–99 - NCT07681648Enrolling by invitationPhase 4
Nerve blocks vs local numbing for lumbar spine surgery
This study compares two types of nerve blocks (a longissimus plane block and a multifidus plane block) to a local numbing injection for pain control during lumbar spine surgery. It aims to find which method works best for patients having back surgery.
Aswān, Aswan GovernorateAges 18–65 - NCT03415620Recruiting
Music listening during surgery to reduce anxiety and pain
This study tests whether listening to music around the time of surgery can lower anxiety and pain, reduce how much pain medicine you need, and improve satisfaction. You may be asked to fill out brief questionnaires before and after your procedure.
SingaporeAges 21–70 - NCT07254806RecruitingPhase 3
Cell therapy for low back pain from disc disease
This study tests if injecting a special cell therapy into a damaged spinal disc can reduce chronic low back pain. It is for people who have had low back pain for at least 6 months and haven't gotten enough relief from other treatments like physical therapy or pain medication.
Birmingham, AlabamaAges 18–75 - NCT06328062Recruiting
Comparing two pain medicines for knee replacement
This study compares two medicines, mirogabalin and pregabalin, to see which works better for pain after total knee replacement. It may help you find more effective pain relief after surgery.
Khlong Luang, Changwat Pathum ThaniAges 50–85 - NCT07739277Recruiting
Comparing two ways to give a chest wall pain block for breast surgery
This study compares two ways of giving a numbing injection (a nerve block) to the side of the chest wall for pain relief after breast surgery. The goal is to see which method works better for reducing pain and the need for pain medicine.
Ankara, Yenimahalle\AnkaraAges 18–65 - NCT07747649Recruiting
Multisensory stimulation for pain from newborn heel pricks
This study tests whether combining gentle touches, sounds, and other sensory input can reduce pain when newborns get a routine heel prick for blood tests. If you have a healthy newborn staying with you in the hospital's newborn care unit, this might make those pricks less uncomfortable.
Ankara, BeşevlerAges 1 day–4 weeks - NCT07333040Recruiting
Energy therapy vs. surgery for grade III hemorrhoids
This trial compares two less invasive energy-based treatments with standard surgery for people with grade III hemorrhoids. If you are between 18 and 75 and your hemorrhoids cause significant symptoms, this study may help find a gentler option.
TaoyuanAges 18–75 - NCT06626035RecruitingPhase 3
Pain Medicine Study for Children Having Heart Surgery
This study tests a pain medicine for children having heart surgery. It aims to see if the medicine works well and is safe for managing pain after the operation.
Oakland, CaliforniaAges 3–18 - NCT06657248Recruiting
Study of a new partial knee implant for inner knee arthritis
This study tests how well a new partial knee implant works and how safe it is for people with arthritis on the inner side of the knee who still have healthy knee ligaments and can bend their knee well.
Potsdam, BrandenburgAges 18–75 - NCT06655571Recruiting
Comparing two ways to give a caudal block to children
This trial compares two techniques for giving a caudal block (a numbing injection near the tailbone) to children having surgery. One method uses the usual way, and the other uses ultrasound imaging to guide the needle.
Tunis, Tunis GovernorateAges 6 months–6 years - NCT06606704Recruiting
Strength bands and creatine for healthy older adults
This study tests whether a simple home exercise program using resistance bands, combined with a creatine supplement, can help improve muscle strength and health in older adults who are not already doing regular strength training.
Regina, SaskatchewanAges 50 years+ - NCT06604455Recruiting
Acupuncture and integrative care for quality of life during war
This trial tests if acupuncture and integrative medicine can improve quality of life for cancer patients or hospitalized adults who are stressed by wartime conditions. It aims to help with emotional distress and other concerns related to national emergencies.
Haifa, IsraelAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,757 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.