Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Mayo Clinic28
- Tanta University28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas51
- Ohio47
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06512961Enrolling by invitation
Tissue flossing for arm blood flow: reliability study
This study tests whether a technique called tissue flossing (wrapping a band around your arm to temporarily restrict blood flow) is reliable and can improve arm performance. It is for healthy adults who have no major health conditions or recent injuries.
Presidente Prudente, São PauloAges 18–30 - NCT06479655RecruitingPhase 4
Comparing fentanyl and morphine for ICU sedation
This study compares two different pain and sedation medicines (fentanyl and morphine) given continuously through an IV to help patients who are on a breathing machine (ventilator) in the ICU. The goal is to see which medicine works better and is safer for keeping you comfortable and calm.
Kota Bharu, KelantanAges 18 years+ - NCT06476652Enrolling by invitation
Simulator Training for Beginners Learning a Leg Ultrasound Block
This trial tests whether using a simple simulator can help first-year anesthesiology residents learn how to perform an ultrasound-guided adductor canal block, a type of leg pain block. It is designed for residents who have never done this specific procedure before.
Hat Yai, Changwat SongkhlaAges 18 years+ - NCT06443437Recruiting
Bee-buzzy and Marionette doll for blood draw pain
This study tests two simple ways to help reduce pain and fear when children get a blood draw: a vibrating cold device called Bee-buzzy and a Marionette doll. It may help your child feel more comfortable during the procedure.
AsyutAges 3–6 - NCT06357715Recruiting
Nerve stretching in healthy adults: pain threshold study
This study tests a gentle nerve stretching technique (called 'slump neurodynamic mobilization') in healthy adults to see if it changes how they sense pain. Researchers want to learn how much pressure feels uncomfortable before and after the exercise.
RouenAges 30–65 - NCT06342570Recruiting
EEG changes during pain for laparoscopic surgery patients
This study measures brain wave changes in response to pain during laparoscopic surgery. It aims to improve how pain is monitored under anesthesia.
SeoulAges 19 years+ - NCT06304337Recruiting
New airway device for painless endoscopy
This trial is testing a new device to help keep your airway open during painless upper and lower endoscopy. It may be helpful for people who are already healthy enough for routine sedation.
JinanAges 18–95 - NCT06288438Recruiting
Tele-rehab program for veterans with multiple health issues
This trial tests a video-based rehabilitation program designed to help veterans manage multiple chronic conditions and improve physical function at home. It may be a good fit if you're a veteran aged 60+ with several health problems and trouble with daily activities like standing from a chair.
Aurora, ColoradoAges 60 years+ - NCT06271239Recruiting
Exercise Program for Older Adults
This study tests a gentle exercise program called VIVIFRAIL® to help older adults stay strong and active. You'll do simple movements in a group setting designed to improve balance and strength.
Porto Alegre, Rio Grande do SulAges 60 years+ - NCT06015711Recruiting
Does a pre-surgery painkiller reduce strong IV pain meds needed?
This trial tests if taking Maxigesic® (a combination of two pain relievers) before surgery can lower the amount of a strong IV pain medicine called remifentanil needed during anesthesia. It may help patients have a smoother recovery with fewer side effects.
Suwon, Gyeonggi-doAges 19–60 - NCT06014931Recruiting
Recovery support after ICU stay
This study uses telehealth to help older adults recover after a serious ICU illness, like being on a breathing machine or having sepsis. It tests whether virtual check-ins can improve your recovery at home.
Columbus, OhioAges 45 years+ - NCT05936671Recruiting
EEG and heart-signal guided anesthesia for recovery
This study tests whether using special brain-wave monitoring and heart-signal information during anesthesia can improve your comfort and recovery after certain laparoscopic gynecologic surgeries. If you qualify, your anesthesia plan may be guided by these monitors to help standardize care and track recovery.
Seoul, SeoulAges 19 years+ - NCT05898581Recruiting
Compare two pain block methods for hip replacement surgery
This trial studies whether one type of numbing injection (a PENG block) works better than another method (local anesthetic injected into the surgical area) to control pain during and after total hip replacement. It may help choose the best pain plan for people having a specific surgical approach.
London, OntarioAges 19 years+ - NCT05875571RecruitingPhase 4
Ketorolac IV to reduce pain after IUD placement
This trial tests whether giving ketorolac through an IV can lessen pain after a sedated IUD placement. If you’re scheduled for sedated IUD placement, this may help reduce post-procedure discomfort.
Little Rock, ArkansasAges 13–21 - NCT05874154Recruiting
Nerve surgery vs botox for spastic foot after stroke
This trial compares two treatments—tibial nerve selective surgery and botulinum toxin (botox) injections—to improve a stiff, turning-in foot after stroke. It aims to use goal-based care to see which option works better for walking and foot function.
BronAges 18–100 - NCT05846451RecruitingEarly Phase 1
Study of how kratom and oxycodone interact in healthy adults
This early study tests how kratom can change the body’s handling of oxycodone (a prescription opioid) and how safe and measurable the effects are. It may help researchers understand drug interactions, especially for people who have used kratom and opioids before.
Spokane, WashingtonAges 21–45 - NCT05367609Recruiting
Personalized pain plan for kids getting spine fusion surgery
This trial tests a personalized plan to manage pain around the time of pediatric posterior-lateral spinal fusion surgery. It aims to improve comfort and reduce the chance of pain or opioid problems after surgery by tailoring pain medicines to the child.
San Francisco, CaliforniaAges 10–21 - NCT05020158Recruiting
Family Talk support after a serious illness in the family
This trial tests a “Family Talk” support program for families dealing with a child’s life-threatening or life-limiting illness. It aims to help families talk and cope together during the early period after diagnosis or relapse.
StockholmAges 6 years+ - NCT05002439Recruiting
Exercise program to reduce frailty in older adults
This trial tests whether a Spanish health-clinic–guided exercise program can improve frailty in people who are starting to become frail (“pre-frail”). It may help you build strength and walking ability through supervised physical activity.
AlbaceteAges 70–100 - NCT04934683Enrolling by invitationPhase 4
Medication study during major surgery to protect blood pressure
This trial tests how well an “induction agent” medication works during major surgery to help keep blood pressure stable. It may help prevent complications in people at higher risk, especially those staying overnight in the hospital.
Omaha, NebraskaAges 45 years+ - NCT04428164Enrolling by invitation
Improving pain and sleep with non-drug hospital supports
This trial looks at non-medication ways to improve comfort (pain) and sleep for hospital patients. You may be asked to use study supports and complete short surveys.
Dallas, TexasAges 20 years+ - NCT03825809RecruitingPhase 2/Phase 3
Non-narcotic pain medicine after labral shoulder surgery
This trial studies whether a non-narcotic pain plan after labral (shoulder) surgery can control pain as well as or better than usual treatment. It may help patients avoid opioid (narcotic) pain medicines after surgery.
Detroit, MichiganAges 18 years+ - NCT03384563RecruitingPhase 4
Testing a sedative’s effect on anesthesia dose needs in toddlers
This study looks at whether dexmedetomidine changes the minimum amount of sevoflurane (an inhaled anesthesia medicine) needed during surgery in young children. It may help doctors choose safer, more accurate anesthesia dosing for kids undergoing surgery.
Houston, TexasAges 1 month–3 years - NCT03168958RecruitingPhase 4
Methadone to improve recovery after planned heart surgery
This trial looks at whether giving methadone during planned heart surgery can improve how patients feel and recover afterward. It will mainly compare recovery quality using a patient questionnaire.
Evanston, IllinoisAges 18–90
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,757 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.