Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Mayo Clinic28
- Tanta University28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas51
- Ohio47
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT07506044Recruiting
Dexmedetomidine in epidural for labor pain relief
This trial tests adding dexmedetomidine to the epidural medicine used for pain relief during labor. If you are in early labor with a healthy pregnancy, this could help manage pain more effectively.
Shebeen El KomAges 18–40 - NCT07659015Enrolling by invitation
Using a hand exercise tool during IV placement
This study tests if using a simple hand-extension rubber band during IV placement can help reduce pain or improve the procedure. It may be an option for right-handed adults getting an IV in specific arm veins.
Konya, MeramAges 18–65 - NCT07485517Recruiting
Deep vs Moderate Muscle Block for Hysterectomy
This study compares two levels of muscle relaxation (deep versus moderate) during hysterectomy surgery to see which may be better for recovery. If you are a woman scheduled for a planned hysterectomy and are in generally good health, you might be eligible.
Menoufia, Eg.mnAges 18–60 - NCT07324499Recruiting
Dexamethasone with nerve block for shoulder surgery
This trial tests if adding dexamethasone to a standard numbing medicine (bupivacaine) affects how much of the medicine stays in your blood. It may help improve pain relief after shoulder surgery.
SantiagoAges 18–90 - NCT05091242RecruitingPhase 2/Phase 3
Preventing agitation after anesthesia in babies up to 1 year old
This study tests a way to reduce post-surgery agitation (confusion or restlessness) in babies aged 3 to 12 months who need anesthesia for a procedure. The goal is to make recovery calmer and safer for your baby.
Perth, NedlandsAges 3 months–1 year - NCT06725550Recruiting
Acupuncture for pain in sickle cell disease
This trial tests whether adding acupuncture to standard pain treatments can help manage pain in people with sickle cell disease. It involves brain scans, questionnaires, and acupuncture sessions to see if this approach reduces pain and improves quality of life.
Cincinnati, OhioAges 14–80 - NCT06691269Recruiting
Light therapy for pain-free dental care in kids
This study tests a special light therapy called photobiomodulation to see if it can reduce pain during routine dental care in children. It may offer a safe, non-drug way to help kids feel more comfortable at the dentist.
Baltimore, MarylandAges 6–12 - NCT05102019Recruiting
Device implant for severe angina using a coronary sinus reducer
This trial tests whether implanting a small device in the heart’s coronary sinus can reduce symptoms in people with long-lasting “refractory” angina despite taking the usual heart medicines. It may help improve how much activity you can do and reduce angina-related limitations.
Phoenix, ArizonaAges 18 years+ - NCT06423716RecruitingPhase 4
Duloxetine to reduce opioid use after knee replacement
This study tests whether taking the pain medication duloxetine before and after knee replacement surgery can reduce the need for opioid painkillers. It may help patients manage pain with fewer side effects from strong narcotics.
Toronto, OntarioAges 50 years+ - NCT05072314RecruitingPhase 3
Lidocaine drip after breast surgery to improve long-term pain
This Phase 3 study tests whether a long-running lidocaine (a numbing medicine) drip given around the time of breast surgery can improve long-term post-surgery pain and recovery. It may help people who have pain after mastectomy or breast-conserving surgery.
Kingswood, New South WalesAges 18 years+ - NCT06371833Recruiting
Shoulder replacement study for arthritis or rotator cuff tears
This study is testing two types of shoulder replacement implants (one for arthritis and one for rotator cuff tears) to see how well they work over time. It may be a good option if you have severe shoulder pain from arthritis or a torn rotator cuff.
Cattolica, RiminiAges 18 years+ - NCT07756203Recruiting
Comparing two hand-held treatments for shoulder pain
This study tests two non-surgical treatments for shoulder pain caused by shoulder impingement. Both treatments use hand-held tools to ease pain and improve movement.
IstanbulAges 40–60 - NCT07743710Recruiting
Telehealth smoking study for chronic pain
This study tests a telehealth program to help people with chronic pain learn about smoking and pain management. It may help you understand how smoking affects your pain and explore ways to reduce smoking without quitting right away.
Binghamton, New YorkAges 18 years+ - NCT07730216Recruiting
Ultrasound-Guided Knee Block Study for Knee Replacement
This study looks at whether using ultrasound to guide a numbing injection around the knee can improve pain control after knee replacement surgery. It aims to make recovery more comfortable.
Konya, KonyaAges 18 years+ - NCT07300995Recruiting
Pain coping skills for older women with breast cancer
This study tests a behavioral program to help older women with breast cancer learn skills to cope with pain. The program is done through video or phone sessions.
Durham, North CarolinaAges 55 years+ - NCT07696260Recruiting
Emotions and tailbone pain study
This study looks at how people with chronic tailbone pain (coccydynia) understand and express their emotions—a trait called alexithymia. The goal is to see if there is a link between emotional awareness and the severity of tailbone pain.
IstanbulAges 18 years+ - NCT04556890Recruiting
Brain stimulation for treatment-resistant depression and chronic pain
This study tests a non-invasive brain stimulation treatment, called transcranial magnetic stimulation (TMS), to see if it can help people who have both major depression that hasn't improved with medication and chronic pain from fibromyalgia or chronic fatigue syndrome. It aims to reduce both depression and pain symptoms.
Los Angeles, CaliforniaAges 18–75 - NCT07756918Recruiting
Shockwave therapy versus dry needling for jumper's knee
This study compares two non-surgical treatments for jumper's knee (pain at the front of the knee from overuse): extracorporeal shockwave therapy (using sound waves to stimulate healing) and dry needling (using thin needles to release tension). The goal is to see which one works better for reducing pain. If you're eligible, you might get one of these treatments, and your progress will be followed to see how well it works.
Lahore, Punjab ProvinceAges 18–35 - NCT07758920RecruitingPhase 2
New tablet for long-term shingles pain
This trial tests a new tablet called HL-1186 for treating post-herpetic neuralgia (long-lasting pain after shingles). It compares the new drug to pregabalin, a standard treatment, to see if it's safer and more effective.
BeijingAges 18 years+ - NCT07756905Recruiting
Motor control exercises with and without tape for sciatica
This study tests whether adding kinesio tape (a flexible, supportive tape) to a motor control exercise program helps reduce sciatica pain more than exercises alone. It may help improve movement and reduce pain in your leg.
SialkotAges 35–50 - NCT07752693Recruiting
Partner-assisted rebozo technique for labor pain relief
This study tests a technique where your partner helps use a rebozo (a traditional Mexican shawl) to ease labor pain and improve your satisfaction during childbirth. It is for first-time mothers with a single baby in the head-down position.
TekirdağAges 18–49 - NCT06795126Enrolling by invitation
Virtual reality for pain and anxiety in kids getting IVs
This study tests if a virtual reality game called Little NIRVANA can help reduce pain and anxiety in children getting an IV. It's for kids ages 2 to 8 in the emergency department.
Columbus, OhioAges 2–8 - NCT07321483Recruiting
Reflex therapy for jaw pain
This trial tests if a special reflex therapy can help people with jaw muscle pain that isn't caused by joint damage. It might be a new way to reduce discomfort and improve function.
OlomoucAges 18 years+ - NCT07756541Recruiting
Online music and movement program for chronic pain
This study tests whether an online program combining music and gentle movement can help reduce chronic pain. It uses sessions you can do at home with your own device.
Cleveland, OhioAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,757 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.