Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,575 recruiting studies in this area right now.
By phase
- Not applicable2,950
- Phase 4240
- Phase 2131
- Phase 3102
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University20
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,575 total
- NCT07850167Recruiting
Pain during root canal treatment across menstrual stages
This study looks at how the menstrual cycle and menopause may affect pain during root canal treatment. It aims to help dentists better manage pain for women.
NiğdeAges 18 years+ - NCT07846722Recruiting
Comparing two medicines to reduce pain medicine use after laparoscopic hysterectomy
This study compares two drugs, esmolol and dexmedetomidine, to see which one better reduces the need for strong painkillers after laparoscopic hysterectomy. It may help you manage pain with fewer opioids.
AthensAges 20–70 - NCT07849140Recruiting
Hands-on therapy for painful periods
This study tests whether osteopathic manipulative treatment (a hands-on approach to relieve tension and improve blood flow) can reduce the pain and other symptoms of painful periods. It is only for people at Western University of Health Sciences.
Pomona, CaliforniaAges 20–51 - NCT07847788Recruiting
Using brain monitoring during gallbladder surgery
This study checks whether a special brain-monitoring device (entropy monitoring) can help anesthesiologists give just the right amount of anesthesia during gallbladder removal surgery. The goal is to see if this leads to using less anesthesia and a faster recovery after surgery.
IslamabadAges 18–60 - NCT07848126Recruiting
Foam rolling after knee replacement surgery
This study tests whether using a foam roller after knee replacement surgery helps reduce pain and improve movement. If you are having your first knee replacement, this may help you recover faster.
Izmir, BalçovaAges 40 years+ - NCT07842913Recruiting
Hybrid telerehabilitation for anterior knee pain
This study tests a hybrid telerehabilitation program for people with anterior knee pain. It combines at-home exercises with remote physiotherapy sessions using a smartphone app. The goal is to see if this approach is effective in routine clinical practice.
BrusselsAges 18 years+ - NCT07849374Recruiting
Hands-on therapy for recent ankle sprains
This trial tests a type of physical therapy called Mulligan mobilization for recent ankle sprains. It may help you recover faster and restore ankle movement without surgery.
Gistoux, Chaumont-GistouxAges 18 years+ - NCT07844395Recruiting
Stress ball for pain and anxiety during breast biopsy
This study tests whether squeezing a small ball (stress ball) during a breast biopsy can help reduce pain, anxiety, and changes in heart rate and blood pressure. If you are having your first breast biopsy, you may be able to participate and help learn if this simple technique improves comfort.
KayseriAges 18 years+ - NCT07845136Recruiting
Riddles to reduce pain and fear during child cast placement
This study tests whether solving riddles during cast placement helps children feel less pain, fear, and anxiety. It is a simple, non-drug approach that may make the experience more comfortable for your child.
Kilis, CentralAges 6–12 - NCT07850258Recruiting
Laser vs standard treatment for severe tooth pain
This study compares two ways to treat a severely inflamed tooth nerve (pulpitis) that causes ongoing pain. One method uses a laser, while the other uses standard tools, to see which is better at relieving pain and saving the tooth.
Kütahya, MerkezAges 12–40 - NCT07847502Recruiting
Pain relief after cesarean section
This study tests two pain-relieving methods (interferential current and TENS) for women after a cesarean section. These treatments use mild electrical pulses to help reduce pain without medication.
MuğlaAges 18–40 - NCT05768477Recruiting
Testing different treatments for chronic pain patients
This study looks at different ways to treat long-term (chronic) pain. You may be invited to participate if you’re an adult with chronic pain and can understand the study information.
GhentAges 18 years+ - NCT06393101RecruitingPhase 1
High-CBD cannabis extract for complex regional pain syndrome treatment
This study tests a high-CBD cannabis extract (BRC-002) to see if it can help reduce pain and improve health in people with Complex Regional Pain Syndrome (CRPS). Participants will not use opioids or other cannabis during the study.
La Jolla, CaliforniaAges 21–75 - NCT06189781RecruitingPhase 4
Pain shot vs epidural for hip surgery in kids with cerebral palsy
This study compares a pain injection to epidural anesthesia for children with cerebral palsy having hip surgery. The goal is to see which method provides better pain control during and after the procedure.
Los Angeles, CaliforniaAges Up to 18 years - NCT06353789Recruiting
Teen Period Pain and Future Health
This study at the University of Oxford is looking at whether painful periods in teenagers can lead to long-term pain. You will be asked about your period pain and may have an MRI scan of your brain (safe, no radiation). The goal is to find ways to prevent chronic pain later in life.
Oxford, OxfordshireAges 11–20 - NCT07841184RecruitingPhase 4
Comparing two spinal anesthetics for prostate surgery
This study compares two types of spinal anesthesia (numbing medicine injected near the spine) to see which one works better for patients having TURP, a common prostate surgery. You might benefit from joining because it could help improve your recovery and comfort during the procedure.
Islamabad, FederalAges 40–90 - NCT06460792Recruiting
Ultrasound-guided nerve blocks database study
This trial is building a database to study ultrasound-guided nerve blocks (injecting numbing medicine around nerves using ultrasound). It may help researchers learn how to better manage pain.
HillerødAges 2 years+ - NCT07834190Recruiting
Immediate effects of two types of back movement therapy for mid-back stiffness
This study compares two hands-on therapy techniques for people with stiffness and pain in the upper-to-mid back. It tests whether slow, consistent pressure or a gentle rhythmic movement works better right away to improve your back mobility and reduce pain.
Islamabad, Punjab ProvinceAges 25–44 - NCT07840183RecruitingPhase 4
Epidural versus other pain relief for open ventral hernia repair
This study compares two ways to manage pain after hernia repair surgery: using an epidural (a small tube in your back that delivers pain medicine) versus other pain medications that aim to reduce opioid use. The goal is to see which method provides better pain relief and helps you recover more comfortably.
Chicago, IllinoisAges 18–80 - NCT07838324Recruiting
Pain reprocessing therapy for functional dyspepsia
This study tests a type of talk therapy called Pain Reprocessing Therapy (PRT) to see if it helps reduce stomach pain and discomfort in people with functional dyspepsia. The therapy aims to retrain the brain's response to pain signals, potentially easing symptoms.
Rochester, MinnesotaAges 18 years+ - NCT07836439Enrolling by invitation
Comparing two manual therapies for low back pain relief
This study compares two hands-on treatments, the Graston Technique and diacutaneous fibrolysis, to see which works better for reducing low back pain, improving function, and enhancing quality of life. If you have non-specific low back pain (pain without a clear cause), this trial may help you find a new way to manage your symptoms.
Sialkot, Punjab ProvinceAges 20–40 - NCT07834489Recruiting
Anti-inflammatory diet and exercise for teen girls' reproductive health
This study tests whether a 16-week anti-inflammatory diet and physical activity plan can improve reproductive health in teenage girls. It may help by reducing inflammation and supporting hormonal balance.
Poznan, Greater Poland VoivodeshipAges 14–19 - NCT07834151Recruiting
Kinetic chain training plus standard exercises for shoulder pain
This study tests whether adding kinetic chain training (exercises that involve the whole body, like the legs and core) to standard shoulder exercises helps reduce shoulder pain and improve movement in people with subacromial pain syndrome, a common cause of shoulder pain.
Islamabad, Punjab ProvinceAges 35–60 - NCT07834177Recruiting
Comparing two neck and spine movement exercises for chronic neck pain
This study compares two types of gentle neck and spine movements (called 'glides') to see which one works better for people with chronic neck pain related to 'upper cross syndrome' (a pattern of tight and weak muscles in the neck and shoulders). The goal is to find a more effective way to reduce pain and improve posture.
Islamabad, Punjab ProvinceAges 20–40
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,575 recruiting pain medicine studies from the U.S. registry right now, out of 6,452 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.