Clinical trials
Acute Heart Failure clinical trials
Below are recruiting acute heart failure clinical trials, each written for real people, not researchers. We’re tracking 433 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04330287Recruiting
Study of heart health in adults aging with HIV
This study looks at how aging affects heart health in people who have HIV. It may help researchers find better ways to prevent or monitor heart problems over time.
Essen, NordrheinwestfalenAges 18 years+ - NCT06374277Recruiting
Pharmacy Coaching to Help After Hospital Stay
This study tests a program where a pharmacist helps you manage your medications after you leave the hospital. It is for people with long-term health conditions who want to stay on track with their medicines.
Knoxville, TennesseeAges 18 years+ - NCT06689111Recruiting
Heart resynchronization method study for patients with LBBB and heart failure
This study compares two ways to resynchronize the heart's pumping in people with heart failure and a specific heart block (LBBB). It uses special ultrasound imaging to see which method works better for improving heart function.
Pátrai, GreeceAges 18–90 - NCT06108076RecruitingEarly Phase 1
Oral ketones for heart failure and diabetes
This study tests whether taking a special oral ketone supplement can help people with both heart failure and diabetes. It looks at both short-term and long-term effects on heart function and blood sugar control.
San Antonio, TexasAges 18–80 - NCT07750873RecruitingPhase 2
Study of an investigational medicine for heart failure with reduced pumping function
This trial tests an investigational medicine called CRD-4730 (taken as a pill) to see if it can improve heart function and symptoms in people with heart failure and a reduced pumping ability. It may help you feel better and slow the progression of your condition.
Pasadena, CaliforniaAges 18–85 - NCT05700617RecruitingEarly Phase 1
Testing cardiac pumping strength in cardiogenic shock
This early study looks at how well the heart is pumping in people with cardiogenic shock, using measurements taken during a right-heart catheter (a small pressure-monitoring test). It may help doctors better assess heart function and guide next-step treatments like LVAD, heart transplant, or valve surgery.
Chicago, IllinoisAges 18 years+ - NCT06645535Enrolling by invitation
Gut Bacteria and Blood Substances in Stiff Heart Failure
This study looks at how bacteria in your gut and certain substances in your blood relate to a type of heart failure called HFpEF (where the heart is stiff and doesn't relax well). It may help doctors understand the condition better and find new ways to treat it.
Naning, JiangsuAges 18 years+ - NCT04913805RecruitingPhase 2
Study for HFpEF using heart pressure and energy signals
This Phase 2 study tests how matching heart “filling pressure” and heart muscle “energy use” may improve understanding or treatment of HFpEF, a type of heart failure with preserved pumping strength. You may be asked to have heart scans/tests and follow a study plan if your symptoms and test results fit.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05138575RecruitingPhase 2
Testing SGLT2 pill and potassium nitrate for heart failure with preserved EF
This trial studies whether two medicines—an SGLT2 inhibitor and potassium nitrate—can improve symptoms and heart function in people with heart failure with preserved ejection fraction (HFpEF). It focuses on people who still have signs of “stiff” or high filling pressure in the heart despite a normal-ish ejection fraction.
Philadelphia, PennsylvaniaAges 18 years+ - NCT03876223Recruiting
Testing imaging to study heart symptoms without blocked arteries
This trial studies people who have heart-related symptoms but do not have clear blocked heart arteries, using special heart imaging. It may help researchers better understand early forms of heart weakness (with preserved pumping function) and improve how these conditions are diagnosed.
Los Angeles, CaliforniaAges 18 years+ - NCT04592445Recruiting
Nerve ablation for right-sided symptoms in HFpEF heart failure
This trial tests a procedure to “turn off” the right greater splanchnic nerve to improve symptoms in people with HFpEF (heart failure with preserved pumping function). If successful, it may reduce shortness of breath and fluid congestion in daily life.
Birmingham, AlabamaAges 40 years+ - NCT06907017Recruiting
CorWave left heart pump first-in-human study
This trial tests a new left ventricular assist device (LVAD) for people with advanced heart failure who are not responding to standard treatments and are eligible for a heart transplant. The pump helps the heart circulate blood.
Sydney, New South WalesAges 18–75 - NCT07636343Recruiting
Eccentric Training for Heart Failure Recovery
This trial tests a special type of strength training (eccentric exercise, where muscles lengthen under load) for people with heart failure who have reduced pumping ability. The goal is to improve your exercise capacity and heart function safely.
EdegemAges Any age - NCT07207811RecruitingPhase 3
Study of coramitug for heart failure from ATTR amyloidosis
This study tests an investigational medicine called coramitug in people with heart failure caused by ATTR amyloidosis, a condition where abnormal protein builds up in the heart. The goal is to see if it can slow or improve heart function.
Phoenix, ArizonaAges 18 years+ - NCT06486649Recruiting
AI tool for diagnosing HFpEF heart failure
This trial is testing a new AI-powered tool to help doctors better diagnose a specific type of heart failure called HFpEF, where the heart pumps normally but doesn't relax properly. It may help you if you have symptoms like shortness of breath or swelling and your heart ultrasound shows normal pumping ability.
Beijing, Beijing MunicipalityAges 18–80 - NCT06770023RecruitingPhase 1
Bridge to lung transplant with ECMO for right heart failure
This study tests a special heart-lung support machine (ECMO) for people waiting for a lung transplant whose heart is failing due to high blood pressure in the lungs. The machine helps rest the heart and lungs until transplant surgery.
Jacksonville, FloridaAges 18–80 - NCT07492979Recruiting
Pacemaker placement study for heart failure
This trial compares two types of pacemaker placement to improve heart function in people with heart failure. One method paces the heart's natural conduction system, while the other paces the lower chambers of the heart. The goal is to find which approach works better for heart resynchronization therapy.
AarhusAges 18–99 - NCT07701369Recruiting
AI-assisted heart ultrasound for older adults with heart failure
This trial tests whether artificial intelligence can help interpret heart ultrasounds in older patients with acute heart failure. It aims to make echocardiograms more accurate and easier to obtain in geriatric care.
ParisAges 75 years+ - NCT03398369Recruiting
Imaging study to guide heart failure device treatment
This study uses advanced heart imaging to better understand heart function in people who may benefit from a cardiac resynchronization therapy (CRT) device. It aims to find ways to improve how doctors choose treatment and tailor care.
Charlottesville, VirginiaAges 20–90 - NCT03524222Recruiting
Home hospital care for adults after sudden illness
This trial tests whether certain adults can safely receive hospital-level care at home instead of staying in the hospital, using a home care team. It may help you recover in your own home if your condition fits their plan and you have support at home.
Boston, MassachusettsAges 18 years+ - NCT03854071Recruiting
Heart and health MRI testing in healthy people or patients
This study uses MRI (a scanning test) to develop new ways to measure heart function in both healthy volunteers and people with suspected or known heart disease. It may help researchers create better heart tests that could improve future diagnosis and monitoring.
Sheffield, EnglandAges 20–80 - NCT03895541Recruiting
Test MRI/ultrasound to measure heart stiffness in older heart failure
This study checks whether a noninvasive imaging test can measure how stiff (stiffness) your heart muscle is in older people with certain types of heart failure. It may help doctors better diagnose and sort out the type of heart failure using your scan results.
ParisAges 60–80 - NCT03994874RecruitingPhase 1/Phase 2
Testing fluid removal through the belly in heart-kidney failure
This trial studies a treatment that removes extra fluid through a catheter placed in the abdomen (peritoneal ultrafiltration) for people with “cardio-renal syndrome” (heart and kidney problems together). It may help those who stay congested despite high-dose water pills (diuretics) and have certain heart circulation and fluid signs.
ChietiAges 18 years+ - NCT04323371Recruiting
Study testing for heart-shock to reduce future events
This trial studies how to identify different types of “cardiogenic shock,” a serious drop in heart blood flow. It aims to use detailed patient information to guide care and possibly lower the chance of dangerous outcomes.
MilanAges 18–74
Hear when a new Acute Heart Failure trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for acute heart failure?
- Yes. Clin2 currently lists 433 recruiting acute heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.