Clinical trials
Atrial Fibrillation, Paroxysmal or Persistent clinical trials
Below are recruiting atrial fibrillation, paroxysmal or persistent clinical trials, each written for real people, not researchers. We’re tracking 469 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03546374Recruiting
Stop a common heart rhythm with surgery add-on therapy
This study looks at whether an added heart device approach around the time of planned open-heart surgery can help treat non-paroxysmal atrial fibrillation (AF), a long-lasting irregular heartbeat. It may help lower ongoing AF burden in people who also need non-emergency heart surgery.
Palo Alto, CaliforniaAges 18 years+ - NCT05776797Recruiting
Ablation vs best medicines for CRT patients with permanent atrial fibrillation
This trial compares two approaches—an AV junction ablation procedure versus continued best medical treatment—in people who already have a heart device for heart failure (CRT) but still have ongoing permanent atrial fibrillation. It aims to improve how well your heart rhythm is controlled and how effectively the device can pace your heart.
Liberec, Liberec RegionAges 18–85 - NCT06402617Recruiting
Ablation of active spots in atrial fibrillation
This trial is testing a new way to treat atrial fibrillation by using a catheter to target the specific areas in the heart that trigger the irregular heartbeat. If you have persistent atrial fibrillation and haven't had prior catheter ablation, you may be eligible to join.
LondonAges 18–85 - NCT06698159Recruiting
Wider pulmonary vein isolation in AFib ablation with single-shot cryoablation
This study tests a new approach to a common procedure for atrial fibrillation (AFib) called pulmonary vein isolation. It uses a single-shot cryoablation technique to treat people with paroxysmal or persistent AFib.
Pozzilli, IserniaAges 18 years+ - NCT06207383Recruiting
Comparing heart treatments for atrial fibrillation and heart failure
This study compares two treatments for people with atrial fibrillation and heart failure: one is a procedure to fix the irregular heartbeat (AF ablation), and the other involves a different type of pacing for the heart. It aims to find which approach helps you feel better and stay out of the hospital.
GrazAges 60 years+ - NCT07321964Recruiting
Digital yoga for quality of life with atrial fibrillation
This trial tests if a digital yoga program can improve quality of life, blood pressure, and heart rate in people with atrial fibrillation. It offers a convenient way to practice yoga from home using a smartphone or tablet.
HerlevAges Any age - NCT07857044Recruiting
Left atrial fibrosis in persistent atrial fibrillation study
This study looks at how scar tissue in the heart's upper chambers relates to other health issues in people with persistent atrial fibrillation. It aims to improve understanding and treatment for this condition.
Augsburg, BavariaAges 18 years+ - NCT07482020RecruitingPhase 2
SGLT2 inhibitor for atrial fibrillation, high blood pressure, and high blood sugar
This study tests whether a medication called an SGLT2 inhibitor (a type of diabetes drug) can improve the function of the upper left heart chamber in people who have paroxysmal atrial fibrillation, high blood pressure, and abnormal blood sugar levels. If you qualify, the trial may help your heart work better and reduce your risk of stroke.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07344961Recruiting
Micra AV2 study: tracking heart rhythm and AFib
This study looks at how well the Micra AV2 pacemaker tracks your heart’s natural rhythm and detects brief episodes of atrial fibrillation (a fast, irregular heartbeat). It is for people who already have or will get this pacemaker and have had AFib that comes and goes.
New Hyde Park, New YorkAges 18 years+ - NCT07118488Recruiting
New ablation approach for persistent atrial fibrillation with heart issues
This study tests a new way to treat long-lasting atrial fibrillation using focused energy (pulse field ablation) guided by special heart mapping. It may help people who have not improved with medications or have other heart problems like heart failure.
Madrid, MadridAges 18–80 - NCT06883864Recruiting
Ablation for leaky valve with constant atrial fibrillation
This study tests whether a catheter ablation procedure (a way to fix abnormal heart rhythms) can help people who have both constant atrial fibrillation and severe mitral regurgitation (a leaky heart valve). It is for people whose heart valve leak is caused by the rhythm problem, not by valve damage.
Hefei, AnhuiAges 18–80 - NCT06754176Recruiting
Alcohol and AFib: Avoiding vs. Allowing Drinking
This study tests whether avoiding alcohol completely for two weeks helps people with AFib have fewer episodes, compared to allowing regulated drinking. You will be randomly assigned to one of the two groups.
San Francisco, CaliforniaAges 21 years+ - NCT06212791Recruiting
Exercise MRI Study of Heart Function After Ablation
This study uses an exercise MRI to look at how the upper chambers of the heart (left atrium) work after ablation for atrial fibrillation. It may help doctors understand if the procedure improves heart function during exercise.
Richmond, VirginiaAges 18 years+ - NCT02932007RecruitingPhase 2
Chloroquine to treat ongoing atrial fibrillation symptoms
This trial tests whether chloroquine can reduce symptoms in people with persistent atrial fibrillation (AF), an irregular heartbeat that lasts longer than a week. It will also closely monitor heart rhythm and safety, since the medicine can affect the heart and other organs.
Tampa, FloridaAges 18 years+ - NCT02558699Recruiting
Virtual mapping guided catheter ablation for atrial fibrillation
This trial tests whether a “virtual” computer map created from your heart scans can help doctors do catheter ablation to treat atrial fibrillation (AF). It aims to improve the procedure for people whose AF symptoms were not controlled well with anti-arrhythmia medicines.
SeoulAges 19–80 - NCT06363604Recruiting
Alcohol injection with ablation for persistent atrial fibrillation
This trial is testing a new approach to treat persistent atrial fibrillation (a type of irregular heartbeat) by combining standard catheter ablation with a special injection of alcohol (ethanol) into certain heart veins. It may help people whose symptoms haven't improved with medication.
Shanghai, Shanghai MunicipalityAges 18–85 - NCT07792239RecruitingPhase 2
Study of budiodarone for atrial fibrillation
This study tests a new medicine, budiodarone, to help control atrial fibrillation (an irregular heartbeat) in people who haven't been helped by other treatments. It may reduce the time spent in AF and improve symptoms.
GdyniaAges 18–80 - NCT07783984Recruiting
Comparing two procedures for persistent atrial fibrillation with enlarged left atrium
This study compares two procedures to treat persistent atrial fibrillation in people whose upper left heart chamber is enlarged: catheter ablation (a minimally invasive procedure using a tube through a vein) versus thoracoscopic ablation (a surgical approach using small chest incisions). The goal is to see which method better restores a normal heart rhythm.
Seoul, SeoulAges 19 years+ - NCT07734194Recruiting
Studying a new sedation combo for afib treatment
This trial tests a mild sedation method using remimazolam and fentanyl during a procedure called pulsed-field ablation for atrial fibrillation (afib). It aims to find a safe and effective way to keep you comfortable without deep sedation.
PragueAges 18 years+ - NCT07726901Recruiting
Comparing Two Ablation Methods for Persistent Atrial Fibrillation
This study compares two techniques for treating persistent atrial fibrillation: one uses standard anatomy-based ablation, and the other uses a special mapping system to guide the procedure. It aims to find which method works better for people who have not had prior ablation.
Seoul, SeoulAges 19 years+ - NCT06023888Recruiting
Heart rhythm analysis for persistent atrial fibrillation
This study tests a new way to analyze heart signals in people with long-standing atrial fibrillation that hasn't gotten better with medication. It may help doctors understand your heart rhythm better and guide future treatments.
TaipeiAges 20–80 - NCT06654401Recruiting
Using electrical shock to restore normal heart rhythm after surgery
This study looks at whether giving an electrical shock (cardioversion) right after heart surgery can help people with long-lasting atrial fibrillation keep a normal heartbeat. It may help guide future treatment decisions for patients who have not gotten better with medication.
Saint Petersburg, Sankt-PeterburgAges 18 years+ - NCT07527299Recruiting
Varipulse catheter study for persistent atrial fibrillation
This study tests a new catheter to treat persistent atrial fibrillation (a type of irregular heartbeat lasting more than 7 days but less than a year). It aims to isolate the pulmonary veins and superior vena cava to restore normal rhythm. Some participants may also receive a left atrial appendage occlusion device if needed.
Birmingham, AlabamaAges 18–80 - NCT07523750Recruiting
Pulsed field ablation for persistent atrial fibrillation
This study tests two types of pulsed field ablation catheters to treat persistent atrial fibrillation, a heart rhythm problem lasting more than 7 days but less than a year. The goal is to see if these catheters can safely and effectively restore a normal heart rhythm.
Jonesboro, ArkansasAges 18–80
Hear when a new Atrial Fibrillation, Paroxysmal or Persistent trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for atrial fibrillation, paroxysmal or persistent?
- Yes. Clin2 currently lists 469 recruiting atrial fibrillation, paroxysmal or persistent studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a atrial fibrillation, paroxysmal or persistent trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a atrial fibrillation, paroxysmal or persistent trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.