Clinical trials
Atrial Fibrillation, Paroxysmal or Persistent clinical trials
Below are recruiting atrial fibrillation, paroxysmal or persistent clinical trials, each written for real people, not researchers. We’re tracking 471 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05725187Enrolling by invitation
AI tool to predict episodes of atrial fibrillation
This study checks whether an AI prediction tool can spot people at risk for recurring episodes of atrial fibrillation (an irregular heartbeat that comes and goes). It may help doctors identify who is more likely to have paroxysmal episodes and plan care earlier.
GwangjuAges 20 years+ - NCT04148625Enrolling by invitation
Sub-xiphoid hybrid maze for persistent atrial fibrillation after failed ablation
This trial studies a hybrid heart procedure to treat persistent atrial fibrillation in people whose previous catheter ablation did not work. It aims to improve heart rhythm and reduce ongoing symptoms by using a planned combination of techniques and careful follow-up.
Ages 18–80 - NCT05776797Recruiting
Ablation vs best medicines for CRT patients with permanent atrial fibrillation
This trial compares two approaches—an AV junction ablation procedure versus continued best medical treatment—in people who already have a heart device for heart failure (CRT) but still have ongoing permanent atrial fibrillation. It aims to improve how well your heart rhythm is controlled and how effectively the device can pace your heart.
Liberec, Liberec RegionAges 18–85 - NCT06207383Recruiting
Comparing heart treatments for atrial fibrillation and heart failure
This study compares two treatments for people with atrial fibrillation and heart failure: one is a procedure to fix the irregular heartbeat (AF ablation), and the other involves a different type of pacing for the heart. It aims to find which approach helps you feel better and stay out of the hospital.
GrazAges 60 years+ - NCT06402617Recruiting
Ablation of active spots in atrial fibrillation
This trial is testing a new way to treat atrial fibrillation by using a catheter to target the specific areas in the heart that trigger the irregular heartbeat. If you have persistent atrial fibrillation and haven't had prior catheter ablation, you may be eligible to join.
LondonAges 18–85 - NCT06698159Recruiting
Wider pulmonary vein isolation in AFib ablation with single-shot cryoablation
This study tests a new approach to a common procedure for atrial fibrillation (AFib) called pulmonary vein isolation. It uses a single-shot cryoablation technique to treat people with paroxysmal or persistent AFib.
Pozzilli, IserniaAges 18 years+ - NCT07321964Recruiting
Digital yoga for quality of life with atrial fibrillation
This trial tests if a digital yoga program can improve quality of life, blood pressure, and heart rate in people with atrial fibrillation. It offers a convenient way to practice yoga from home using a smartphone or tablet.
HerlevAges Any age - NCT06523738Recruiting
Studying heart size changes after shock and ablation for AF
This trial looks at how the size of your heart's upper-left chamber (left atrium) changes after a procedure to restore a normal rhythm (cardioversion). It aims to see if these changes can predict whether atrial fibrillation (AF) will come back after a later procedure called radiofrequency ablation.
Chongqing, Chongqing MunicipalityAges 18 years+ - NCT06542770Recruiting
Predicting hidden atrial fibrillation after cryptogenic stroke
This trial uses a small heart monitor to see if certain heart changes can predict hidden atrial fibrillation in people who had a stroke or mini-stroke with no clear cause. It aims to find those who might benefit from blood thinners to prevent another stroke.
BarcelonaAges 50–89 - NCT05872776Recruiting
Home ECG monitoring to reduce atrial fibrillation episodes
This trial uses a home heart monitor (a chest patch with an ECG) to study how atrial fibrillation (an irregular heartbeat) changes over time and how this may help manage symptoms. You may be included if you have a documented, short-lasting type of atrial fibrillation and a moderate amount of AF seen on a 14-day heart recording.
Tel AvivAges 18–85 - NCT06212791Recruiting
Exercise MRI Study of Heart Function After Ablation
This study uses an exercise MRI to look at how the upper chambers of the heart (left atrium) work after ablation for atrial fibrillation. It may help doctors understand if the procedure improves heart function during exercise.
Richmond, VirginiaAges 18 years+ - NCT06754176Recruiting
Alcohol and AFib: Avoiding vs. Allowing Drinking
This study tests whether avoiding alcohol completely for two weeks helps people with AFib have fewer episodes, compared to allowing regulated drinking. You will be randomly assigned to one of the two groups.
San Francisco, CaliforniaAges 21 years+ - NCT06883864Recruiting
Ablation for leaky valve with constant atrial fibrillation
This study tests whether a catheter ablation procedure (a way to fix abnormal heart rhythms) can help people who have both constant atrial fibrillation and severe mitral regurgitation (a leaky heart valve). It is for people whose heart valve leak is caused by the rhythm problem, not by valve damage.
Hefei, AnhuiAges 18–80 - NCT07118488Recruiting
New ablation approach for persistent atrial fibrillation with heart issues
This study tests a new way to treat long-lasting atrial fibrillation using focused energy (pulse field ablation) guided by special heart mapping. It may help people who have not improved with medications or have other heart problems like heart failure.
Madrid, MadridAges 18–80 - NCT07344961Recruiting
Micra AV2 study: tracking heart rhythm and AFib
This study looks at how well the Micra AV2 pacemaker tracks your heart’s natural rhythm and detects brief episodes of atrial fibrillation (a fast, irregular heartbeat). It is for people who already have or will get this pacemaker and have had AFib that comes and goes.
New Hyde Park, New YorkAges 18 years+ - NCT07482020RecruitingPhase 2
SGLT2 inhibitor for atrial fibrillation, high blood pressure, and high blood sugar
This study tests whether a medication called an SGLT2 inhibitor (a type of diabetes drug) can improve the function of the upper left heart chamber in people who have paroxysmal atrial fibrillation, high blood pressure, and abnormal blood sugar levels. If you qualify, the trial may help your heart work better and reduce your risk of stroke.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07523750Recruiting
Comparing two catheter treatments for persistent atrial fibrillation
This study compares two different catheters that use pulsed field ablation to treat a type of irregular heartbeat called persistent atrial fibrillation. The goal is to see which one works better and is safer.
Phoenix, ArizonaAges 18–80 - NCT07527299Recruiting
Varipulse catheter study for persistent atrial fibrillation
This study tests a new catheter to treat persistent atrial fibrillation (a type of irregular heartbeat lasting more than 7 days but less than a year). It aims to isolate the pulmonary veins and superior vena cava to restore normal rhythm. Some participants may also receive a left atrial appendage occlusion device if needed.
Birmingham, AlabamaAges 18–80 - NCT07734194Recruiting
Studying a new sedation combo for afib treatment
This trial tests a mild sedation method using remimazolam and fentanyl during a procedure called pulsed-field ablation for atrial fibrillation (afib). It aims to find a safe and effective way to keep you comfortable without deep sedation.
PragueAges 18 years+ - NCT07726901Recruiting
Comparing Two Ablation Methods for Persistent Atrial Fibrillation
This study compares two techniques for treating persistent atrial fibrillation: one uses standard anatomy-based ablation, and the other uses a special mapping system to guide the procedure. It aims to find which method works better for people who have not had prior ablation.
Seoul, SeoulAges 19 years+ - NCT03397602Recruiting
Exercise program for long-term atrial fibrillation
This trial studies how an exercise training program affects people with persistent or permanent atrial fibrillation (an irregular heart rhythm). It may help improve how you feel and how well your heart and body handle activity.
London, OntarioAges 40 years+ - NCT04823299Recruiting
Atrial fibrillation ablation using two different energy types
This trial tests whether one ablation approach works better than another for paroxysmal (intermittent) atrial fibrillation by targeting the heart’s “triggers” and “substrate” (where the rhythm problem is). If you qualify, you’ll be randomly assigned to one of two ablation energy methods during a pulmonary vein isolation procedure.
Ottawa, OntarioAges 18 years+ - NCT05115214Recruiting
Device test for treating irregular heartbeat with AF ablation
This trial studies a heart procedure using the Affera SpherePVI system to treat paroxysmal (comes and goes) or persistent atrial fibrillation. It’s for people who still have symptoms despite at least one anti-arrhythmia medicine, and who are good candidates for catheter ablation.
PragueAges 18–75 - NCT05144503Recruiting
Test of a new catheter procedure for irregular heart rhythm
This study checks how safe and effective a special catheter procedure (SpherePVI) is for treating paroxysmal (comes and goes) or persistent atrial fibrillation. You may be considered if your atrial fibrillation keeps returning and you’ve already tried at least one medication but it didn’t work or you couldn’t tolerate it.
VilniusAges 18–75
Hear when a new Atrial Fibrillation, Paroxysmal or Persistent trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for atrial fibrillation, paroxysmal or persistent?
- Yes. Clin2 currently lists 471 recruiting atrial fibrillation, paroxysmal or persistent studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a atrial fibrillation, paroxysmal or persistent trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a atrial fibrillation, paroxysmal or persistent trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.