Clinical trials
Atrial Fibrillation, Paroxysmal or Persistent clinical trials
Below are recruiting atrial fibrillation, paroxysmal or persistent clinical trials, each written for real people, not researchers. We’re tracking 474 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06578793Recruiting
Catheter plus vein ablation for atrial fibrillation with heart failure
This trial tests whether adding a vein ablation to standard catheter ablation helps people with persistent atrial fibrillation and heart failure. It aims to find the best treatment to improve heart function and reduce symptoms.
Changsha, HunanAges 18–80 - NCT06801392Recruiting
Pulsed-field ablation for non-paroxysmal atrial fibrillation
This trial tests a new way to treat non-paroxysmal atrial fibrillation (AF) using a focused type of ablation (pulsed-field energy) on specific areas of the heart. It aims to see if targeting the left atrial wall and mitral isthmus can improve outcomes for people who have not had this procedure before.
PragueAges 18 years+ - NCT07236619Recruiting
A new heart procedure for atrial fibrillation
This study tests a new catheter that uses pulsed field energy to isolate the veins in your heart that trigger atrial fibrillation. The goal is to see how long the effects last, and you would need to have a repeat procedure about 2–3 months after the first one.
Rotterdam, South HollandAges 18–80 - NCT07776054RecruitingPhase 4
Clinical Impact of SGLT2 Inhibitor After DC Cardioversion in Persistent AF With HFpEF
Seoul, SeoulAges 19 years+ - NCT06199180Recruiting
Comparing two ablation methods for repeat atrial fibrillation treatment
This trial tests a newer type of energy (pulsed field ablation) against the standard heat-based method (radiofrequency) for people who have already had one ablation and now have atrial fibrillation again. The goal is to see which works better for keeping your heart in a normal rhythm.
GroningenAges 18–80 - NCT06828939Recruiting
Balloon treatment for atrial fibrillation
This trial tests a new balloon device that uses gentle energy pulses to treat atrial fibrillation (AF), a type of irregular heartbeat. It may help people whose AF has not improved with medication.
Prague, Czech RepublicAges 18–75 - NCT06529978Recruiting
CoreMap heart mapping for atrial fibrillation ablation
This study tests a new mapping system that helps doctors see the electrical signals in your heart more clearly during a standard ablation for persistent atrial fibrillation. It may improve the accuracy of the treatment.
Naples, FloridaAges 18–80 - NCT07405359Recruiting
Comparing ablation methods for persistent atrial fibrillation
This trial tests a newer, possibly safer way to treat persistent atrial fibrillation using pulsed field ablation. It compares standard vein isolation alone to adding extra ablation spots to improve success.
San Francisco, CaliforniaAges 18 years+ - NCT05116384Recruiting
Renal nerve ablation plus AF ablation for persistent AF
This study tests whether treating kidney-related nerves along with the usual AF (irregular heartbeat) catheter procedure works better than the usual procedure alone. It may help some people with persistent AF, but you must meet specific heart and kidney safety requirements.
Short Hills, New JerseyAges 18 years+ - NCT05227053Recruiting
Cryoablation study for paroxysmal atrial fibrillation after approval
This study looks at outcomes after a specific heart procedure called pulmonary vein isolation done with a cryoablation catheter. It is for adults with symptomatic “paroxysmal” atrial fibrillation who are planning this exact procedure.
Anchorage, AlaskaAges 18 years+ - NCT05264831Recruiting
Ablation treatment after failed electric heart shock
This trial tests whether blocking faulty heart signals from the pulmonary veins (with or without additional “substrate” modification) works better when electric cardioversion doesn’t stop persistent atrial fibrillation. It may help people who remain in atrial fibrillation after cardioversion by reducing symptoms and abnormal rhythm over time.
Caluire-et-CuireAges 18–80 - NCT06392932Recruiting
Esophageal temperature monitoring during heart ablation
This study tests a new way to monitor the temperature in your esophagus during a standard heart ablation procedure for atrial fibrillation. The goal is to see if the new catheter (Q-DOT Micro) safely heats the heart tissue without harming the esophagus.
Los Angeles, CaliforniaAges 18 years+ - NCT06445439Recruiting
Finding the Best Pacemaker Rate for Heart Failure
This study tests whether adjusting the pacing rate on a special pacemaker (CRT or conduction system pacing) can improve heart function and daily symptoms in people with atrial fibrillation and heart failure.
Washington D.C., District of ColumbiaAges 18–90 - NCT06747091Recruiting
Ablation study for people with persistent atrial fibrillation
This trial tests a catheter ablation procedure for people with persistent atrial fibrillation (a type of irregular heartbeat that lasts more than 7 days but less than a year). It aims to see if the procedure is safe and effective for restoring a normal heart rhythm.
Manhasset, New YorkAges 18–80 - NCT05136131Recruiting
Quality-of-life support after cardioversion for persistent AF
This study looks at how a heart rhythm procedure (cardioversion) affects quality of life in people with persistent atrial fibrillation (AF). It may help you understand whether a specific approach can improve day-to-day symptoms and well-being after treatment.
Newmarket, OntarioAges 18 years+ - NCT07421076Recruiting
Grid mapping study for atrial fibrillation ablation
This trial tests a new mapping tool to help doctors find and treat the source of atrial fibrillation (AF) during a standard ablation procedure. It may offer a more precise way to guide treatment for people with AF that comes and goes.
Jinan, ShandongAges 18 years+ - NCT07439016Recruiting
LA function after pulse field ablation for paroxysmal AF
This trial tests how pulse field ablation (a treatment that uses short electrical pulses to correct irregular heartbeats) affects the left atrium's function in people with paroxysmal atrial fibrillation (AFib that comes and goes). It may help if you have paroxysmal AFib and are in normal rhythm at the start of the procedure.
PragueAges 18 years+ - NCT07441382Recruiting
Comparing treatments for frail older adults with atrial fibrillation
This study tests whether combining a heart procedure (catheter ablation) with a device to close the left atrial appendage (LAAO) is safer or better than blood thinners alone for frail patients 75 years or older with atrial fibrillation and high stroke risk. It aims to find a treatment that reduces stroke while lowering bleeding risks.
Guangzhou, GuangdongAges 75 years+ - NCT07621003Recruiting
PULSed Field Ablation for New-Onset Atrial Fibrillation
This study tests a newer ablation technique using pulsed electrical energy to treat atrial fibrillation (an irregular heartbeat). You may qualify if you were recently diagnosed with AF and haven't had ablation before.
Bad OeynhausenAges 18 years+ - NCT07728539Recruiting
Comparing a faster ablation method for atrial fibrillation
This study compares a newer, faster type of ablation (high-power short-duration) with the standard approach for treating atrial fibrillation. The goal is to see which method is safer and more effective at restoring a normal heart rhythm.
MoscowAges 18–70 - NCT04696081Recruiting
Atrial fibrillation treatment in people with active cancer
This trial studies atrial fibrillation (an irregular heartbeat) in adults who have active cancer. It looks at people whose atrial fibrillation started after their cancer diagnosis or returned after cancer diagnosis.
Caen, NormandyAges 18 years+ - NCT05266144Recruiting
Catheter ablation for non-valvular atrial fibrillation
This trial studies catheter ablation, a procedure that targets heart rhythm triggers, for people with atrial fibrillation (an irregular heartbeat). It may help improve rhythm control, but you must meet specific heart and testing requirements and avoid certain conditions.
Beijing, Beijing MunicipalityAges 18–80 - NCT07100483Enrolling by invitation
Comparing surgery methods for atrial fibrillation
This trial studies different surgical techniques for treating atrial fibrillation during heart surgery. It may help people with a history of AFib who are already scheduled for open-heart surgery.
Grand Rapids, MichiganAges 18–85 - NCT05976685Recruiting
Close the left atrial appendage after stroke despite blood thinners
This study tests whether closing a heart pouch called the left atrial appendage can prevent future strokes in people with atrial fibrillation who had an ischemic stroke even while taking blood thinners. It may help reduce stroke risk by blocking a common place where clotting can start.
BrugesAges 18 years+
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Common questions
- Are there clinical trials for atrial fibrillation, paroxysmal or persistent?
- Yes. Clin2 currently lists 474 recruiting atrial fibrillation, paroxysmal or persistent studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a atrial fibrillation, paroxysmal or persistent trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a atrial fibrillation, paroxysmal or persistent trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.