Clinical trials
Heart Failure NYHA Class II clinical trials
Below are recruiting heart failure nyha class ii clinical trials, each written for real people, not researchers. We’re tracking 159 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07567001RecruitingPhase 3
Testing NNC0487-0111 for Heart Failure and Obesity
This study tests whether a new medication called NNC0487-0111 can help people with heart failure who also have obesity. Researchers will compare it to a placebo (inactive pill) to see if it improves heart function and overall health.
Alexander City, AlabamaAges 18 years+ - NCT06427343RecruitingPhase 4
IV iron: low dose vs high dose for heart failure with low iron
This study compares two different doses of IV iron (low vs high) to see which works better for people with heart failure and low iron levels. It may help you feel less tired and breathe easier.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06992089Recruiting
Pacemaker study for heart failure with low heart rate
This trial tests a special pacemaker setting to help your heart beat faster during exercise. It may improve your ability to be active if you have heart failure with preserved ejection fraction (HFpEF) and a low resting heart rate.
ValenciaAges 18 years+ - NCT06061627Recruiting
LOT-CRT vs standard CRT for heart failure with NICD
This study compares a newer pacing therapy (LOT-CRT) to standard cardiac resynchronization therapy (BiVP) for people with heart failure who have a specific type of electrical delay in the heart (NICD). The goal is to see if the newer method works better.
Nanjing, JiangsuAges 18–80 - NCT05562167RecruitingPhase 2
Inorganic nitrate plus exercise for heart failure performance
This Phase 2 study tests whether taking inorganic nitrate can improve exercise ability and heart-function symptoms in people with heart failure with reduced pumping. It also checks whether the treatment is safe when combined with an exercise program.
St Louis, MissouriAges 19–79 - NCT06935370RecruitingPhase 3
Testing vicadrostat with empagliflozin for heart failure with weak pump
This trial tests a new drug called vicadrostat combined with another drug, empagliflozin, for people with heart failure and a weak heart pump. It aims to see if this combination helps improve symptoms and outcomes.
Beverly Hills, CaliforniaAges 18 years+ - NCT03197350Recruiting
Study of heart failure with preserved pumping function
This study looks at people who have heart failure symptoms but whose heart pumping strength is not reduced. Researchers aim to better understand this type of heart failure and compare it with people who have no history of heart disease or heart failure.
BrusselsAges 18–99 - NCT02901184RecruitingPhase 3
Spironolactone start study for heart failure with preserved pumping
This trial tests whether starting spironolactone helps people with heart failure symptoms when the heart pumps “preserved” (not severely reduced). Participants are assigned to start spironolactone or usual care so researchers can see if it improves outcomes.
Alexander City, AlabamaAges 50–99 - NCT07650474Recruiting
Mobile app for heart failure management and quality of life
This study tests whether using a mobile phone app to monitor and manage chronic heart failure improves how you feel and function day-to-day. Researchers will check in with you regularly through your phone to track your symptoms and health.
Addis AbabaAges 18–65 - NCT07560436RecruitingPhase 2
Stents for Heart Failure With Normal Pumping
This trial tests whether placing stents in coronary arteries helps patients with heart failure who still have a strong-pumping heart. The study aims to see if improving blood flow to the heart reduces symptoms and improves quality of life.
LondonAges 18 years+ - NCT07379840Recruiting
Finerenone for chronic heart failure in South Korea
This trial tests how safe and effective finerenone is for adults with chronic heart failure. It includes people whose heart pumps blood with at least 40% efficiency.
Multiple LocationsAges 19 years+ - NCT07326605Enrolling by invitation
Heart MRI study for heart failure with preserved pumping function
This trial uses a special heart MRI to create pressure-volume loops in people with heart failure who have a normal pumping strength (ejection fraction of 50% or higher). It aims to better understand heart function and could help guide future treatments. You may qualify if you have heart failure symptoms and specific heart structure or function changes.
Ages 18 years+ - NCT06307652RecruitingPhase 3
Testing a new heart failure and kidney treatment combo
This study tests a new combination of two medicines (balcinrenone and dapagliflozin) for people with heart failure and reduced kidney function. The goal is to see if this combination helps improve heart and kidney health better than current treatments.
Alexander City, AlabamaAges 18–130 - NCT05174351Recruiting
Stopping beta-blockers in heart failure with preserved pumping
This study checks whether safely stopping beta-blocker medicine is possible in some people with heart failure with preserved pumping (EF ≥50%). It may help by testing whether reducing the medication is safe and workable for certain patients.
Farmington, ConnecticutAges 50–80 - NCT07761117RecruitingPhase 3
Heart failure treatment study for people with preserved pumping function
This study tests an investigational medication called elecoglipron to see if it can improve heart and blood vessel outcomes in people with heart failure with preserved or mildly reduced ejection fraction. If you join, you will receive either the study drug or a placebo, and your heart health will be monitored over time.
Fairhope, AlabamaAges 18 years+ - NCT07693049Recruiting
Exercise training for heart failure with preserved pumping ability
This trial tests whether high-intensity interval training can improve heart function and fitness in people with a type of heart failure where the heart pumps normally but doesn't fill properly. You will do supervised exercise sessions to see if it helps you feel better and be more active.
BeijingAges 35–70 - NCT07592494Recruiting
Arm Exercise Training for Heart Failure With Device
This study compares different types of arm exercises for people with heart failure who have a pacemaker or defibrillator implanted. The goal is to see which exercise approach best improves how well your arms function and help you stay active.
ÇorumAges 18 years+ - NCT07465653RecruitingPhase 1
Study of HJB647 for heart failure with reduced pumping ability
This trial tests a new medicine, HJB647, in people with heart failure who have a weak heart pump. It aims to see if the drug is safe and well-tolerated. You may qualify if your heart's pumping ability is reduced and you are on a specific standard therapy.
Bradenton, FloridaAges 18–100 - NCT07420088Recruiting
Seasonal activity in heart failure with a heart device
This trial studies how physical activity changes with the seasons in people with heart failure who have a pacemaker or defibrillator. It aims to help doctors understand how to better support your activity levels throughout the year.
ÇorumAges 18 years+ - NCT06560762RecruitingPhase 1
Study of a new drug for heart failure with preserved pumping ability
This trial tests an investigational drug for people with a type of heart failure where the heart pumps normally but is stiff. The goal is to see if the drug can improve symptoms and quality of life.
Chicago, IllinoisAges 18 years+ - NCT05265520Recruiting
Pacing strategy study for certain heart failure patients
This trial tests a pacing approach designed to improve how the heart beats in some people with heart failure and a specific heart rhythm pattern on ECG. If you already need a device (CRT-D) based on your results, the study may help see whether this pacing correction improves outcomes.
Phoenix, ArizonaAges 18 years+ - NCT05508035RecruitingPhase 3
Testing sacubitril/valsartan vs ramipril for heart failure
This trial compares two blood-pressure and heart-failure medicines: sacubitril/valsartan versus ramipril, to see which improves heart pumping and heart structure over time. It’s aimed at people with ischemic (blocked-artery) heart failure with mid-range ejection fraction and ongoing symptoms.
Krakow, Lesser Poland VoivodeshipAges 18 years+ - NCT07123779RecruitingPhase 1/Phase 2
Study of a new drug for heart failure with pulmonary hypertension
This study tests an investigational drug (HS235) for people who have both heart failure with preserved ejection fraction and a type of pulmonary hypertension that can happen with it. The goal is to see if the drug can improve symptoms and quality of life.
Kansas City, MissouriAges 18 years+ - NCT06518694RecruitingPhase 3
Can you stop beta-blockers after heart failure recovery?
This trial tests whether people whose heart function has returned to normal after heart failure can safely stop taking beta-blockers. It aims to see if staying on the medication is still needed or if stopping is just as safe.
Paris, IDFAges 18 years+
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Common questions
- Are there clinical trials for heart failure nyha class ii?
- Yes. Clin2 currently lists 159 recruiting heart failure nyha class ii studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure nyha class ii trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure nyha class ii trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.