Clinical trials
Heart Failure With Preserved Ejection Fraction clinical trials
Below are recruiting heart failure with preserved ejection fraction clinical trials, each written for real people, not researchers. We’re tracking 160 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05723679Recruiting
Breathing-targeted program to improve function in HFpEF
This trial studies a breathing-focused treatment to help people with HFpEF (a type of heart failure) feel and function better. It may help improve daily activity by addressing breathing limits that commonly come with this condition.
Dallas, TexasAges 55–90 - NCT05839067Recruiting
Support program for U.S. veterans living with heart failure
This trial supports U.S. Veterans who have heart failure, to see whether the added support improves health and well-being. You may be able to join if you meet the age, diagnosis, and communication requirements.
Gainesville, FloridaAges 18 years+ - NCT05873634Recruiting
Using health records and testing to study heart failure types
This study combines electronic health record data and detailed heart testing to better understand different heart failure types and what treatments may work best for each. It mainly enrolls people with known heart failure, and also some people without heart failure for comparison.
Sacramento, CaliforniaAges 30 years+ - NCT05878912Recruiting
Obesity and weight loss in certain heart failure patients
This study looks at how higher body weight and weight loss affect people who have heart failure with preserved pumping strength. It uses heart scans to measure how the heart and body change, which may help guide future treatment plans.
OxfordAges 18–85 - NCT05888688Recruiting
Studying muscle loss in people with heart failure or diabetes
This study looks at sarcopenia, which is age-related loss of muscle, in people with certain types of heart failure or in people with stable type 2 diabetes but no symptoms. The goal is to better understand muscle changes and what might help people stay stronger.
Leicester, LeicestershireAges 18 years+ - NCT06015776Recruiting
Heart cell signals after menopause
This trial studies how heart cells communicate after menopause. Researchers are looking at a chemical signal called purinergic signaling during heart surgery.
Boston, MassachusettsAges 30–88 - NCT06061549RecruitingPhase 1
Gene therapy for stiff heart failure (preserved EF)
This trial tests a one-time gene therapy for people with heart failure who still have normal pumping strength (preserved ejection fraction). It aims to improve how heart cells handle calcium, which may help the heart relax better and ease symptoms.
Durham, North CarolinaAges 50 years+ - NCT06065124Recruiting
Study on weight loss surgery for heart failure with irregular heartbeat
This trial tests if weight loss surgery can help people with heart failure and atrial fibrillation (an irregular heartbeat) improve their heart condition. You may join if you are between 45 and 70, have a BMI of 32 to 40, and have mild to moderate heart failure with preserved pumping function.
Arnhem, GelderlandAges 45–70 - NCT06081049RecruitingPhase 2
Colchicine for heart failure with preserved pumping function
This trial is testing whether colchicine, a medication used for gout, can help people with a specific type of heart failure where the heart pumps normally but is stiff. If you have heart failure with preserved pumping and certain signs of inflammation, this study might be a good fit.
HellerupAges 40 years+ - NCT06081543Recruiting
Ketogenic vs. Mixed Diet for Heart Failure
This study compares a ketogenic (low-carb, high-fat) diet to a standard mixed diet in people with heart failure. It aims to see if the ketogenic diet can improve heart function and symptoms.
Columbus, OhioAges 18–80 - NCT06101693Recruiting
Biomarker study for suspected heart failure
This study looks at certain proteins in your blood to help doctors better understand and diagnose a type of heart failure called HFpEF. You might be able to join if your doctor recently ordered a blood test for NT-proBNP because they thought you might have heart failure.
GlasgowAges 18 years+ - NCT06125925Recruiting
Ablation for AFib in patients with heart failure and preserved ejection fraction
This study tests whether a catheter ablation procedure can help people with atrial fibrillation and a kind of heart failure where the heart pumps normally but doesn't relax properly (HFpEF). It looks at whether the procedure can improve symptoms and heart function.
NanjingAges 18–80 - NCT06249945RecruitingPhase 4
Empagliflozin for heart failure with preserved ejection fraction and dialysis
This trial tests whether a medicine called empagliflozin (used for diabetes and heart failure) can help people with both heart failure (with preserved pumping ability) and end-stage kidney disease who are on dialysis. The study looks at how the drug affects heart function and overall well-being.
HsinchuAges 20 years+ - NCT06278844Recruiting
Pacing method to improve exercise in heart failure
This study tests a new way to pace the heart in people with heart failure who need a pacemaker. It aims to see if this pacing method helps them exercise more easily.
Edegem, AntwerpAges 18 years+ - NCT06409585Recruiting
Heart muscle disease imaging study for scarring
This study uses advanced imaging (PET/MR or PET/CT) to look at scarring (fibrosis) in the heart muscle. It is for people with various heart muscle diseases, including heart failure with preserved pumping, thickened heart muscle, high blood pressure-related heart damage, heart inflammation, and others.
Edinburgh, ScotlandAges 30–90 - NCT06465043Recruiting
Understanding Heart Failure When the Heart Stiffens
This study is for people with a type of heart failure called HFpEF, where the heart pumps normally but doesn't relax well. It aims to better understand heart failure through advanced testing, and it includes people who are newly diagnosed or have had a recent hospitalization.
HelsinkiAges 18–85 - NCT06479876Recruiting
Home-based heart rehab for heart failure
This study tests a home-based cardiac rehabilitation program for people with heart failure. It aims to help you become more active and manage your condition safely at home.
Nashville, TennesseeAges 18 years+ - NCT06517186Recruiting
Heart failure study with preserved pumping function
This study looks at how the heart muscle works in people with a type of heart failure where the heart pumps normally but doesn't fill properly. It aims to understand the cause better, which could lead to new treatments.
Chicago, IllinoisAges 30 years+ - NCT06650995Recruiting
Ablation and Exercise for Heart Failure with Normal Pumping
This study tests whether a combination of catheter ablation (a procedure to correct irregular heartbeats) and a structured exercise program can improve symptoms and quality of life in people with diastolic heart failure and a recent onset of persistent atrial fibrillation.
MunichAges 18–99 - NCT06652087Recruiting
Testing rifaximin for heart failure with preserved pumping
This trial tests whether the antibiotic rifaximin (taken by mouth) can improve heart function in people with a type of heart failure where the heart pumps well but is still weak (HFpEF). Rifaximin might help by changing the bacteria in your gut.
MoscowAges 18–80 - NCT06652763Recruiting
MRI scan for heart failure with normal pumping strength
This study uses a special MRI scan with a natural contrast agent (manganese) to look at how well the heart muscle works in people with heart failure who still have normal pumping strength. The goal is to learn more about why this type of heart failure happens.
LeicesterAges 18 years+ - NCT06699056Recruiting
AI heart monitor study for ejection fraction
This study uses an AI-powered wearable monitor to check how well your heart pumps blood (ejection fraction) from a simple EKG recording. It may help doctors quickly assess heart function without extra tests.
Orange, CaliforniaAges 18 years+ - NCT06008197RecruitingPhase 3
A study of finerenone for hospitalized heart failure patients
This trial tests a medication called finerenone to see if it helps people hospitalized for heart failure live longer and have fewer heart-related problems. It may be an option for those with a certain type of heart failure where the heart's pumping strength is mildly reduced or normal.
Birmingham, AlabamaAges 18 years+ - NCT07447908Recruiting
Understanding worsening heart failure after leaving the hospital
This study monitors heart failure patients after a hospital stay or urgent clinic visit to better understand the signs of worsening heart failure. It may help researchers find ways to predict and prevent future exacerbations.
Newmarket, OntarioAges 18 years+
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Common questions
- Are there clinical trials for heart failure with preserved ejection fraction?
- Yes. Clin2 currently lists 160 recruiting heart failure with preserved ejection fraction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure with preserved ejection fraction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure with preserved ejection fraction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Heart Failure With Reduced Ejection Fraction
- Heart Failure With Mildly Reduced Ejection Fraction
- Heart Failure With Mid Range Ejection Fraction
- Heart Failure With Normal Ejection Fraction
- Chronic Heart Failure With Reduced Ejection Fraction
- Preserved Ejection Fraction
- Acute Heart Failure
- Chronic Heart Failure
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.