Clinical trials · North Carolina
High blood pressure clinical trials in North Carolina
We’re tracking 53 recruiting high blood pressure studies with a site in North Carolina — including Phase 2, Phase 2/Phase 3 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT07136623Recruiting
Can a smart stethoscope detect pulmonary hypertension?
This study is testing if a special digital stethoscope (CORE 500) can help detect a heart condition called pulmonary hypertension. You may join if you are 18 or older, not currently hospitalized, and will have a heart ultrasound or right heart catheterization around the time of your visit.
Durham, North CarolinaAges 18 years+ - NCT07356518Recruiting
Telehealth and Remote Blood Pressure for Pregnancy
This study tests if using telehealth and remote blood pressure monitoring can help manage high blood pressure during pregnancy. It may be a good fit if you already had high blood pressure before pregnancy and want to monitor it from home.
Winston-Salem, North CarolinaAges 18–45 - NCT07142356RecruitingPhase 2
Modified release RTN-001 for uncontrolled high blood pressure
This trial tests a new modified-release drug, RTN-001, to see if it can help people whose blood pressure remains high despite taking at least two standard blood pressure medicines. You will take either RTN-001 or a placebo, and researchers will monitor your blood pressure closely.
Asheboro, North CarolinaAges 18–70 - NCT07583940Recruiting
Energy Intake and Blood Pressure in College Athletes
This study looks at whether not eating enough calories affects blood pressure in Division I college athletes. Researchers want to understand if improving nutrition can help prevent high blood pressure in young athletes.
Greensboro, North CarolinaAges 18–26 - NCT06052072Enrolling by invitation
Heart failure trial testing nerve treatment for lung pressure
This trial tests a new treatment that uses a device to calm overactive nerves in the lung's blood vessels. It is for heart failure patients who also have high blood pressure in their lungs, to see if it can help them breathe easier and feel better.
Durham, North CarolinaAges 22–85 - NCT06002165Enrolling by invitation
Testing Ways to Improve Care for High Blood Pressure in Pregnancy
This study tests ways to help clinics follow a set of best practices for managing severe high blood pressure during and after pregnancy. It wants to see if the new approach helps clinics treat high blood pressure faster and more effectively.
Chapel Hill, North CarolinaAges birth–99 years - NCT07064473RecruitingPhase 3
Testing vicadrostat plus empagliflozin for diabetes, high blood pressure, and heart disease
This study tests a new pill called vicadrostat taken with another medicine (empagliflozin) to see if it helps people with type 2 diabetes, high blood pressure, and heart disease. It may reduce the risk of heart problems, but you must not have had heart failure or use certain other heart medications.
Cary, North CarolinaAges 18 years+ - NCT07288398RecruitingPhase 3
Levosimendan for exercise limitation in PH-HFpEF
This trial tests if the drug levosimendan can help people with a specific type of pulmonary hypertension (PH-HFpEF) feel less tired and breathless during daily activities, and improve their exercise ability.
Durham, North CarolinaAges 18–85 - NCT06297291Recruiting
Long-term safety study for a kidney nerve treatment
This study tests a device that uses ultrasound to calm overactive kidney nerves, which may help lower blood pressure. It is for people with high blood pressure that is hard to control with medication.
Chapel Hill, North CarolinaAges 18 years+ - NCT06975111RecruitingPhase 2/Phase 3
Improving health during menopause
This trial studies ways to help women during the late menopausal transition. It uses a smartphone app and telehealth visits to track your health and help you feel better.
Chapel Hill, North CarolinaAges 45–55 - NCT07610278RecruitingPhase 2
Blood Pressure and Cholesterol Treatment Study
This study tests a combination of two new medications (QCZ484 and inclisiran) designed to lower both blood pressure and cholesterol levels. You may be a good fit if you have high blood pressure and high cholesterol that isn't fully controlled by current treatments.
Monroe, North CarolinaAges 18–75 - NCT06274801RecruitingPhase 3
Long-term study of seralutinib for pulmonary arterial hypertension
This trial is for people with pulmonary arterial hypertension (PAH) who have already completed a previous study of the drug seralutinib. It offers continued access to the treatment so doctors can watch its safety and effects over a longer time.
Chapel Hill, North CarolinaAges 18–75 - NCT06742723RecruitingPhase 3
Study of baxdrostat and dapagliflozin for kidney disease and high blood pressure
This trial tests if combining baxdrostat with dapagliflozin helps protect kidney function and reduce heart risks in people with chronic kidney disease and high blood pressure. It's for adults who are already taking standard blood pressure medications.
Greenville, North CarolinaAges 18 years+ - NCT04669548Recruiting
Accuryn monitoring study for people having heart surgery
This registry collects information from patients who are monitored with the Accuryn system during heart surgery and their ICU stay. It helps researchers learn from the system’s signals to better understand patient care around cardiac procedures.
Asheville, North CarolinaAges 18 years+ - NCT05129345Recruiting
HIV care program for heart health goals in the Southeast US
This trial tests an approach to help people living with HIV reach heart- and metabolism-related health goals, such as blood pressure, cholesterol, and blood sugar. It involves clinics and community partners and may offer education, support, and care coordination to remove barriers to treatment.
Charlotte, North CarolinaAges 18 years+ - NCT06038630RecruitingPhase 2
Xenon gas MRI study for lung and heart health
This study uses a special MRI scan (Xenon gas imaging) to look at how well your lungs and heart are working. It is for people with certain lung conditions, those getting blood transfusions or phlebotomy, or healthy volunteers.
Durham, North CarolinaAges 18 years+ - NCT06129240Recruiting
Study of a new inhaled treprostinil powder for PH-ILD
This study tests a new dry powder inhaled medicine called LIQ861 for people with pulmonary hypertension related to lung scarring (PH-ILD). If you are already taking an inhaled treprostinil treatment but need better control, this trial may help you switch to a potentially easier-to-use version.
Chapel Hill, North CarolinaAges 18–80 - NCT06375694Recruiting
Probiotic and nitrate: a blood flow study
This study tests if a probiotic supplement can help your body turn nitrates from food into a substance that may improve blood flow. Healthy adults who are comfortable with blood and saliva samples can take part.
Winston-Salem, North CarolinaAges 18–70 - NCT06526195Recruiting
A study of CardioMEMS and HeartMate 3 for advanced heart failure
This trial tests if a combination of a tiny lung-artery pressure sensor (CardioMEMS) and a mechanical heart pump (HeartMate 3) is safe and effective for people with advanced heart failure. If you qualify, you'll either get the heart pump plus standard medical therapy, or continue with standard therapy alone and have your pressure monitored remotely.
Charlotte, North CarolinaAges 18 years+ - NCT06876896Recruiting
Pressure inside belly during pulse field ablation for A-fib
This study looks at how pulse field ablation (a heart procedure for irregular heartbeats) affects pressure inside the belly. If you have atrial fibrillation or atrial flutter and are planning to have this procedure, your participation may help doctors understand how to make it safer.
Winston-Salem, North CarolinaAges 18 years+ - NCT06907147Recruiting
Renal denervation for uncontrolled high blood pressure
This trial tests a procedure called renal denervation to lower blood pressure in people whose medication isn't enough. It uses a special catheter to calm nerves near the kidneys that may be overactive.
Chapel Hill, North CarolinaAges 18–80 - NCT07031739Recruiting
Managing high blood pressure and food insecurity
This study tests different ways to help people with high blood pressure who also struggle to get enough food. It aims to improve blood pressure control and reduce food insecurity.
Winston-Salem, North CarolinaAges 18 years+ - NCT07126587Recruiting
Healthy Living in Anson County Study
This study offers healthy meals and group classes to help people in Anson County manage or prevent chronic diseases like diabetes and high blood pressure. You'll learn about and try a Mediterranean diet, which is known to be good for heart health.
Chapel Hill, North CarolinaAges 18–99 - NCT07222917RecruitingPhase 2
Dapagliflozin with baxdrostat for kidney disease and high blood pressure
This trial tests if adding dapagliflozin to baxdrostat (a new blood pressure drug) reduces protein in urine better than baxdrostat alone in people with chronic kidney disease and high blood pressure. It aims to find a more effective way to protect kidney health.
Jacksonville, North CarolinaAges 18 years+
High blood pressure trials by city in North Carolina
Where these studies are running in North Carolina
Institutions with a site for the recruiting high blood pressure studies listed above.
- University of North Carolina at Chapel Hill · 6 studies
- Wake Forest University Health Sciences · 5 studies
- Duke University · 3 studies
- Duke University Medical Center · 3 studies
- Research Site · 2 studies
- UNC School of Medicine · 2 studies
- Accellacare
- Atrium Health Wake Forest Baptist Medical Center (Wake Forest Baptist)
What taking part in a high blood pressure study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
High blood pressure trials in other states
Common questions
- Are there high blood pressure clinical trials in North Carolina?
- Yes. We're currently tracking 53 recruiting high blood pressure studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a high blood pressure study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a high blood pressure trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New high blood pressure studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.