Clinical trials
Thyroid clinical trials
Below are recruiting thyroid clinical trials, each written for real people, not researchers. We’re tracking 338 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05766098Recruiting
Genetic testing of papillary thyroid tumor samples
This trial studies the genetic “mutations” in papillary thyroid cancer tumors using tumor tissue. The goal is to better describe tumor genetic patterns, which may help researchers understand the disease.
Milan, MIAges Any age - NCT05768178RecruitingPhase 2/Phase 3
Vemurafenib plus cobimetinib for BRAF-mutant cancers
This trial tests whether combining two targeted cancer medicines—vemurafenib and cobimetinib—can treat adults whose tumors have a specific “BRAF V600” mutation. You may be screened with blood tests and a tissue biopsy before starting treatment.
BelfastAges 18 years+ - NCT05786924RecruitingPhase 1/Phase 2
Targeted cancer drug study for RAS/RAF mutation-positive tumors
This Phase 1/2 study tests S241656 (a targeted cancer medicine) in people whose cancers have certain “RAS/RAF” gene changes. It may help shrink tumors or control cancer growth, and also finds the safest dose and best way to use the drug.
Gilbert, ArizonaAges 18 years+ - NCT05830500RecruitingPhase 4
Anlotinib for advanced medullary thyroid cancer
This trial studies anlotinib in people with advanced or metastatic medullary thyroid cancer that has been getting worse. It aims to see how well the treatment controls the cancer and how safe it is for patients who can’t have curative surgery.
Hefei, AnhuiAges 18–75 - NCT05837260Recruiting
Tracking tumor DNA changes in advanced thyroid cancers
This study looks at a small blood test (called ctDNA) and tumor tissue to understand how advanced thyroid cancers change over time. It may help doctors better monitor cancer growth and guide treatment choices.
LondonAges 18 years+ - NCT05962892Recruiting
Study of thyroid cancer return risk after heat ablation
This study looks at what makes papillary thyroid cancer come back after a heat-based treatment called thermal ablation. It may help doctors better predict recurrence risk and guide follow-up after treatment.
BeijingAges 18 years+ - NCT05994365Recruiting
Testing anlotinib for advanced thyroid cancer that resists radioactive iodine
This trial tests a targeted therapy pill (anlotinib) for people with advanced thyroid cancer that stopped responding to radioactive iodine. It may slow tumor growth or shrink tumors.
Beijing, Beijing MunicipalityAges 18–75 - NCT05999630RecruitingPhase 3
Artificial tears to prevent tear duct blockage during RAI therapy
This study tests if using artificial tears (eye drops that keep your eyes moist) can prevent tear duct blockage in people receiving high-dose radioactive iodine for thyroid cancer. If you qualify, you will use artificial tears during your treatment to see if they help keep your tear ducts open.
Nashville, TennesseeAges 18 years+ - NCT06007924RecruitingPhase 2
Study of avutometinib and defactinib for thyroid cancer
This trial tests two oral drugs (avutometinib and defactinib) for people with certain types of advanced thyroid cancer that have specific genetic changes. The goal is to see if this combination can shrink tumors or slow their growth.
Basking Ridge, New JerseyAges 18 years+ - NCT06079333RecruitingPhase 2
Targeted therapy before and after surgery for BRAF-mutant anaplastic thyroid cancer
This trial tests whether giving a targeted therapy pill (which attacks cancer cells with a BRAF mutation) before and after surgery can help treat anaplastic thyroid cancer that hasn't spread to other organs. It's for people whose cancer has a specific gene change (BRAF V600E or V600K) and who are healthy enough for surgery.
Leiden, South HollandAges 18 years+ - NCT06082180RecruitingPhase 3
Preventive neck lymph node removal in low-risk thyroid cancer
This trial is for people with low-risk papillary thyroid cancer. It compares two surgical approaches: one that removes just the thyroid gland, and another that also removes some lymph nodes in the center of the neck as a preventive measure. The goal is to see if removing these lymph nodes helps prevent the cancer from coming back.
Beijing, Beijing MunicipalityAges 18–70 - NCT06087068RecruitingPhase 2
Thyroid hormone therapy after lobectomy for low-risk thyroid cancer
This trial is testing whether thyroid hormone replacement after surgery is safe for people with low-risk papillary thyroid cancer. It may help maintain normal hormone levels after part of the thyroid is removed.
Beijing, Beijing MunicipalityAges 1.5 years–70 years - NCT06149637Recruiting
Lateral neck lymph node surgery for thyroid cancer
This trial tests a surgical procedure to remove cancer-affected lymph nodes on the side of the neck in patients with differentiated thyroid cancer. It aims to improve outcomes for those with confirmed or suspected spread to these nodes.
Medellín, AntioquiaAges 18–99 - NCT06207188Recruiting
Using sound waves to tell thyroid lumps apart
This study uses a special ultrasound technique to look at thyroid nodules and lumps in the neck. The goal is to tell the difference between harmless lumps and cancer, so you may get a clearer answer without extra procedures.
Scottsdale, ArizonaAges 8 years+ - NCT06222606Recruiting
Surgery for Thyroid Cancer With or Without Special Light to Protect Calcium Glands
This study tests whether using a special light (called autofluorescence) during thyroid cancer surgery helps lower the risk of a common side effect—hypoparathyroidism, which can cause low calcium levels. You may be able to join if you are scheduled for a complete thyroid removal and have normal calcium before surgery.
Aarhus, DenmarkAges 18 years+ - NCT06225765Recruiting
Scarless thyroid surgery through the mouth vs open surgery
This trial compares a new scarless thyroid surgery (through the mouth) with traditional open thyroid surgery for treating thyroid nodules. It may be an option if you have a benign nodule under 4 cm or a suspicious nodule under 2 cm.
Hong KongAges 18 years+ - NCT06286631Recruiting
Predicting lymph node spread in thyroid cancer with a new scale
This trial is testing a new scale to predict if thyroid cancer has spread to nearby lymph nodes. It may help doctors decide on the best treatment for you.
Xi'an, ShaanxiAges 16–80 - NCT06307990Recruiting
Understanding thyroid hormone response problems
This trial is for people who may have a problem with how their body responds to thyroid hormone. It aims to better understand, diagnose, and monitor these conditions to improve care.
MilanAges Any age - NCT06340945Recruiting
Treating benign thyroid nodules with heat
This study uses heat (thermal ablation) guided by ultrasound to shrink benign thyroid nodules that are causing symptoms or cosmetic concerns. It's an option if you can't have surgery or prefer not to.
BeijingAges 18 years+ - NCT06345339RecruitingPhase 2/Phase 3
Comparing Armour Thyroid to synthetic T4 for hypothyroidism
This study is testing whether Armour Thyroid (a natural pig-derived thyroid hormone) works as well as synthetic T4 (levothyroxine) for people with hypothyroidism. If you are already on a stable dose of levothyroxine, you may be able to switch to Armour Thyroid and see how it compares.
Birmingham, AlabamaAges 18–75 - NCT06359795Recruiting
PET Scan for Thyroid Eye Disease Activity
This study uses a special PET/CT scan (with a tracer called 18F-AlF-FAPI) to see how active your thyroid eye disease is. It may help doctors better understand and manage the condition.
Beijing, Beijing MunicipalityAges 18–80 - NCT06362694RecruitingPhase 2
Re-treating anaplastic thyroid cancer that progressed on BRAF therapy
This trial tests if a second course of targeted therapy (dabrafenib and trametinib) combined with chemotherapy can help people with a specific type of aggressive thyroid cancer (BRAF-positive anaplastic thyroid cancer) whose tumors stopped responding to initial targeted therapy.
Saint PetersburgAges 18 years+ - NCT06374602RecruitingPhase 2
Pembrolizumab and lenvatinib for anaplastic thyroid cancer
This trial tests a combination of two drugs, pembrolizumab and lenvatinib, for people with a rare and aggressive thyroid cancer that cannot be removed by surgery. The goal is to see if this treatment can shrink the tumor or slow its growth.
Saint PetersburgAges 18 years+ - NCT06423235RecruitingPhase 4
Prunella oral liquid for thyroid nodules
This trial tests if an herbal liquid made from prunella can shrink benign thyroid nodules. It may be an option for people with solid, non-cancerous nodules who want to avoid surgery.
Chongqing, Chongqing MunicipalityAges 18–65
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Common questions
- Are there clinical trials for thyroid?
- Yes. Clin2 currently lists 338 recruiting thyroid studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a thyroid trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a thyroid trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.