Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT07011979Recruiting
IBD study for those at higher risk
This study watches people who might be more likely to get Inflammatory Bowel Disease (IBD). It looks at close family members of IBD patients, people with autoimmune diseases, and those with certain digestive issues who also have a specific blood marker (ASCA). The goal is to find early signs and possibly prevent the disease.
SeoulAges 10 years+ - NCT07007663Recruiting
Directional preference in lumbar spinal stenosis
This study looks at whether people with lumbar spinal stenosis (a narrowing in the lower spine) have a 'directional preference'—a specific movement or position that eases their symptoms. If you have leg or buttock pain when walking, this trial may help find better ways to treat your condition.
Lake Success, New YorkAges 48 years+ - NCT07004218Enrolling by invitation
Ultrasound follow-up after massive rotator cuff tear surgery
This trial uses ultrasound imaging to check how the shoulder heals over the first year after surgery for a large tear in the rotator cuff (the group of tendons that helps lift and rotate your arm). The goal is to better understand recovery and improve care for people with this injury.
Çankaya, AnkaraAges 18–80 - NCT07003932Recruiting
Remote monitoring after knee replacement surgery
This trial tests a remote monitoring program for people having knee replacement surgery. It uses a smartphone app to track your recovery, so you can stay in touch with your care team without needing extra clinic visits.
Oslo, Please SelectAges 50 years+ - NCT07006389Enrolling by invitation
Shock wave therapy for plantar fasciitis follow-up study
This study looks at how well shock wave therapy works for people with plantar fasciitis that hasn't improved with other treatments. If you've already had shock wave therapy 3 to 6 months ago, your experience could help doctors understand what makes the treatment effective.
IstanbulAges 18 years+ - NCT07006545Enrolling by invitation
Getting back to activity after knee replacement
This study looks at how well people can return to daily activities and exercise after total knee replacement surgery. It may help find better ways to guide recovery.
Munich, BavariaAges 18 years+ - NCT07006883Recruiting
Yoga program for knee osteoarthritis
This trial tests whether a yoga program can improve daily function in people with knee osteoarthritis. It may help reduce pain and stiffness while improving mobility.
São PauloAges 40–80 - NCT07004166Recruiting
New injection techniques to reduce pain and leakage
This study tests two different injection methods (TPR and Z-track) to see if they cause less pain and less medication leakage when giving the painkiller diclofenac sodium into the hip muscle.
SivasAges 18–40 - NCT07009717Recruiting
Big toe strength and chemo nerve damage
This study looks at whether the strength of your big toe is related to nerve damage from chemotherapy. It involves a one-time test of your toe strength and some questionnaires. It may help researchers better understand how chemo affects your nerves.
Gainesville, FloridaAges 18–90 - NCT07008365RecruitingPhase 3
Measuring belly pressure and ultrasound to guide fluid removal in heart failure
This trial tests whether using belly pressure and bedside ultrasound can help doctors better manage fluid removal (decongestion) in people hospitalized with heart failure. The goal is to see if this approach leads to better outcomes.
ZaragozaAges 18–100 - NCT07010484Recruiting
New imaging tests for polymyalgia rheumatica
This trial tests if new imaging methods can help diagnose and treat polymyalgia rheumatica (PMR). It may be for you if you're over 50, have pain in your shoulders or hips, and haven't taken steroids for PMR in the last 2 months.
AarhusAges 50 years+ - NCT07010146RecruitingPhase 2
Estrogen's Effect on Bone Health in FHA
This study tests how estrogen treatment affects bone strength in young women with Functional Hypothalamic Amenorrhea (FHA), a condition where periods stop due to stress, low weight, or over-exercise. Participants who have had very few periods will receive estrogen to see if it improves bone density.
Charlottesville, VirginiaAges 14–30 - NCT07013110RecruitingPhase 2
AI-guided precision therapy for active rheumatoid arthritis
This study tests a new, AI-powered treatment approach for rheumatoid arthritis. It's for people with active disease who haven't used certain biologic or targeted therapies in the last 6 months.
SingaporeAges 21 years+ - NCT07007338Recruiting
Calcium bone balance in children on dialysis starting cinacalcet
This study looks at how a medicine called cinacalcet affects calcium in the bones of children on dialysis. It may help doctors better understand bone health for kids like yours.
BordeauxAges 3–17 - NCT06054633Recruiting
L-arginine for knee osteoarthritis pain
This study tests whether L-arginine, a natural amino acid, can help with knee pain from osteoarthritis. You might be eligible if you are 40–80 years old, have moderate osteoarthritis on X-ray, and have had knee pain for at least 3 months.
Changsha, HunanAges 40–80 - NCT06806514Recruiting
Exercise and muscle strength in chronic low back pain
This trial measures how well you can use your arms and how strong your breathing and other muscles are if you have chronic low back pain. It aims to understand the links between these factors to improve future treatments.
KırşehirAges 18–65 - NCT06587399Recruiting
Manual Therapy vs. Shock Waves for Shoulder Pain
This study compares two non-surgical treatments—manual therapy (hands-on techniques) and radial shock wave therapy (sound wave pulses)—to see which works better for long-lasting shoulder pain. It may be a good fit if your pain is from a common cause called impingement syndrome.
Alcalá de Henares, MadridAges 18–80 - NCT06998134Recruiting
Exoskeleton walking training for children and young adults
This trial tests whether a robotic leg exoskeleton can help improve walking in children and young adults with certain conditions (like cerebral palsy, muscular dystrophy, spina bifida, or spinal cord injury) or those with no walking issues. The goal is to find out if the exoskeleton is safe and effective for everyday use, especially in younger people who might lose the ability to walk as they get older.
Bethesda, MarylandAges 5–25 - NCT06999460Recruiting
Shoulder block for pain relief during shoulder surgery
This trial tests if a nerve block near the shoulder blade can reduce pain before, during, and after shoulder surgery. It may help patients need less pain medicine and feel more comfortable.
Zagazig, EgyptAges 21–65 - NCT06995534Recruiting
Splint or Exercise for De Quervain's Wrist Pain
This trial compares wearing a splint versus doing specific exercises to treat De Quervain's tenosynovitis, a condition that causes wrist pain and swelling. It may help if you have new or worsening wrist pain without other injuries or diseases.
KonyaAges 18–65 - NCT07002762Recruiting
Burdock root extract for high uric acid without symptoms
This trial tests whether burdock root extract can lower uric acid levels in people who have high uric acid but no symptoms of gout. It may help prevent future health problems related to high uric acid.
KyivAges 35–65 - NCT06994754Recruiting
Expanding the upper jaw with clear aligners in cleft lip and palate patients
This trial tests whether clear aligners can safely widen the upper jaw in children with cleft lip and palate who still have some baby teeth. It may be an option for those needing jaw expansion without braces.
Cairo, SelectAges 6–12 - NCT07001761Recruiting
Ultrasound study for knee osteoarthritis
This study uses ultrasound imaging to evaluate knee osteoarthritis in people over 30 with painful knees. It aims to better understand how the condition appears on imaging.
SohagAges 30 years+ - NCT07000916Recruiting
Follow-up study for new arthritis in kids and young adults
This study follows children and young adults newly diagnosed with certain types of arthritis or related conditions to learn more about their health over time. It may help doctors better understand how these diseases progress and how treatments work.
BrusselsAges 2–50
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.