Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06999057RecruitingEarly Phase 1
Knee injury study for healthy active adults
This trial studies how your thigh muscle adapts after a simulated knee injury. It uses mild electrical stimulation and a small needle to measure muscle signals, and may help improve recovery after knee injuries.
Orlando, FloridaAges 18–30 - NCT06995690Recruiting
Ketamine to prevent low blood pressure during orthopedic surgery
This study tests if a low dose of ketamine (a pain medicine) given before spinal anesthesia can prevent dangerously low blood pressure during orthopedic surgery. It might help keep your blood pressure steady, making the procedure safer.
CairoAges 18 years+ - NCT06994754Recruiting
Expanding the upper jaw with clear aligners in cleft lip and palate patients
This trial tests whether clear aligners can safely widen the upper jaw in children with cleft lip and palate who still have some baby teeth. It may be an option for those needing jaw expansion without braces.
Cairo, SelectAges 6–12 - NCT07002944Recruiting
Testing nerve treatment for shoulder pain after mastectomy
This study compares two types of pulsed radiofrequency (a minimally invasive treatment using radio waves) to see which better relieves shoulder pain in women who have had a mastectomy. It's for women who still have pain despite taking a high dose of tramadol.
CairoAges 18–65 - NCT07000916Recruiting
Follow-up study for new arthritis in kids and young adults
This study follows children and young adults newly diagnosed with certain types of arthritis or related conditions to learn more about their health over time. It may help doctors better understand how these diseases progress and how treatments work.
BrusselsAges 2–50 - NCT06998628RecruitingPhase 2
Pentoxifylline for rheumatoid arthritis inflammation
This study tests if pentoxifylline, a medicine typically used for circulation, can help reduce joint inflammation in people with rheumatoid arthritis who still have active symptoms despite taking standard DMARDs.
Damietta, Damietta GovernorateAges 18–70 - NCT06999915Recruiting
Bone grafting with immediate provisional dentures for dental implants
This trial tests whether placing a temporary tooth (immediate provisional denture) right after implant surgery helps improve bone growth around the implant. It is for people who need a front tooth replaced in the upper jaw and have good overall health.
LondonAges 18 years+ - NCT07000838Recruiting
Corrective insoles for foot overpronation in healthcare workers
This study tests whether special rubber insoles can help healthcare workers with flat feet (overpronation) reduce foot strain while standing and walking for long shifts. If you work in a hospital or clinic and spend most of your shift on your feet, this may help you understand if the insoles improve comfort and foot alignment.
Milan, ItalyAges 18–65 - NCT06995352Enrolling by invitationPhase 4
Better pain relief after ankle surgery
This trial compares two methods of pain management after ankle surgery: a one-time injection of long-lasting numbing medicine (liposomal bupivacaine) versus a continuous nerve block via a small tube (catheter) placed near the nerve. The goal is to find which approach provides better pain relief with fewer side effects.
La Jolla, CaliforniaAges 18 years+ - NCT07003113Recruiting
Blood flow therapy for knee and back pain
This study tests a treatment called ischemic preconditioning, which uses a blood pressure cuff to temporarily restrict blood flow to your leg. It may help reduce pain from osteoarthritis in the knee or chronic back pain.
Chicago, IllinoisAges 50 years+ - NCT07003087Enrolling by invitation
AI gait analysis for shoe sole adjustments
This study uses a 2D video and AI to analyze how you walk. The goal is to adjust your shoe soles to help with discomfort in your legs or feet.
TaichungAges 20–70 - NCT07001969Enrolling by invitation
Percutaneous facet spine fixation for instability
This study tests a minimally invasive procedure to fix unstable vertebrae in the neck or lower back using a small incision. It may help people with spinal instability causing nerve symptoms or pressure on the spinal cord.
Cairo, ShoroukAges Any age - NCT06752551Recruiting
Apprehension training vs standard physical therapy for shoulder dislocation in military
This study compares a new type of training focused on controlling shoulder 'apprehension' (the feeling that your shoulder might pop out) with standard physical therapy. It is for military personnel who have had a shoulder dislocation and may help you regain trust in your shoulder without surgery.
Be’er Ya‘aqovAges 18–39 - NCT05860673Recruiting
Minimally invasive vs standard surgery for adolescent scoliosis
This study compares a less invasive surgical approach with the usual back surgery for adolescent idiopathic scoliosis (a sideways spine curve that starts in the teen years). It aims to see which approach works better and is easier to recover from.
BolognaAges 12–25 - NCT05179473Recruiting
Predict and diagnose stiffness after a recent stroke
This study looks at how to predict and measure spasticity (muscle stiffness and tightness) in people after a recent stroke. It may help clinicians better diagnose and understand what to expect as you recover.
Montreal, QuebecAges 18–85 - NCT06239649Recruiting
Nerve block before knee replacement for faster recovery
This trial tests whether a numbing injection (nerve block) around the knee before surgery can help you recover faster and feel less pain after a total knee replacement. It is for people with knee osteoarthritis who are ready for their first knee replacement surgery.
Denizli, PamukkaleAges 40–85 - NCT06367413Recruiting
Protein and NAC for muscle recovery after exercise
This study tests whether taking a protein supplement and NAC (a type of amino acid) together helps your muscles recover better after an intense workout. It's for healthy adults who don't smoke, don't use certain medications, and don't have specific health conditions.
Trikala, KariesAges 18–27 - NCT06987019Recruiting
Measuring balance in people with below-knee amputation
This study tests a new way to measure how well people with a below-knee amputation keep their balance while wearing their prosthesis. It aims to see if this measurement is reliable and accurate, which could help improve future care.
New York, New YorkAges 18 years+ - NCT06991114RecruitingPhase 2
AlloNK and rituximab for relapsing rheumatologic diseases
This trial tests a new natural killer (NK) cell therapy called AlloNK given with rituximab for people with certain autoimmune diseases (rheumatoid arthritis, Sjögren's disease, inflammatory myopathies, or systemic sclerosis) that have not responded well to standard treatments. The goal is to see if this combination can better control the disease.
Tuscaloosa, AlabamaAges 18 years+ - NCT06989138Recruiting
Brace and exercise for spondylolisthesis
This trial tests if wearing a back brace combined with exercise helps people with a specific type of low back problem called spondylolisthesis (where a spine bone slips forward). It may reduce pain and improve function.
Istanbul, IstanbulAges 18–65 - NCT06989229Recruiting
Nutritional care before and after joint replacement surgery
This trial tests if special nutritional support before and after hip or knee replacement helps you recover faster. It is for people having planned (not emergency) surgery.
Brno, CzechiaAges 18 years+ - NCT06987370Recruiting
Radiation study for bone metastases with soft tissue mass
This trial tests a new way of giving radiation (SFRT and SCART) to bone metastases that have a soft tissue mass. It may be an option if you have limited spread and your organs are working well.
Jinan, ShandongAges 18–75 - NCT06990893Recruiting
Oliceridine vs morphine for pain after lumbar surgery
This study compares a new pain medicine called oliceridine with morphine or sufentanil to see which works better after lumbar spine surgery. It aims to find a safer and more effective way to manage pain after your operation.
Anqing, AnhuiAges 18–65 - NCT06991192Recruiting
ACL surgery rehab with exercise and mental support
This study tests a rehab program that combines physical exercises with psychological support to help young athletes recover from ACL surgery and return to sports safely.
Bloomington, MinnesotaAges 15–25
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.