Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,834 recruiting studies in this area right now.
By phase
- Not applicable3,966
- Phase 2225
- Phase 4197
- Phase 1189
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida81
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,834 total
- NCT06323018Recruiting
Remote preconditioning for cemented hip replacement recovery
This trial tests whether a simple, safe treatment called remote ischemic preconditioning (using a blood pressure cuff on your arm just before surgery) can help people recover better after cemented hip replacement. It is for patients aged 66 and older who are scheduled for this surgery.
Tartu, TartuAges 65–90 - NCT06323538Recruiting
Plant-based diets and health (COPLANT)
This study looks at how different plant-based diets affect your health. Researchers will collect information through questionnaires and blood samples to understand the benefits of eating more plants.
ViennaAges 18–69 - NCT04821154Recruiting
Testing outcomes after revision knee replacement with a Persona system
This study looks at how well a specific revision knee replacement system (the Persona system) works after earlier knee problems or surgeries. You may be eligible if you need a revision knee and can follow follow-up care instructions; the trial also checks for certain infection, bone, and health-safety factors.
Fayetteville, ArkansasAges 18 years+ - NCT05169229RecruitingPhase 2
Antibiotic bone graft to prevent infection in hip replacement
This trial tests whether adding antibiotics to the bone graft used during hip replacement surgery can lower the risk of infection. It may help people who need a bone graft as part of their hip replacement.
Linköping, Region ÖstergotlandAges 18 years+ - NCT06438471RecruitingPhase 1
Study of a new drug for nerve pain after spinal cord injury
This trial tests an experimental pill for people with spinal cord injury who have long-term nerve pain. It aims to see if the drug can reduce pain and be safe.
Augusta, GeorgiaAges 18 years+ - NCT07481461Recruiting
Knee alignment and biology in osteoarthritis
This study looks at how changes in knee alignment affect symptoms and joint biology in people with early knee osteoarthritis. It may help doctors understand how to better treat knee OA.
Leuven, Vlaams-BrabantAges 18 years+ - NCT05214924Enrolling by invitationPhase 2/Phase 3
PRF injections for mild to moderate jaw joint wear
This study tests whether injecting iPRF (a therapy made from your blood growth factors) into the jaw joint can reduce symptoms from mild to moderate jaw joint degeneration. It’s being compared against standard care for people who currently are not on other jaw-joint treatments.
WroclawAges 18–80 - NCT07520669Recruiting
Shoulder Surgery to Prevent Too Much Rotation
This study tests whether a surgical technique called capsuloplasty can prevent excessive external rotation (outward twisting) of the shoulder after surgery for recurrent shoulder dislocation. The goal is to help contact sport athletes return to activity safely.
MérignacAges 18–50 - NCT06972446RecruitingPhase 2
Study of targeted therapies for rheumatoid arthritis
This trial tests different targeted treatments for people with rheumatoid arthritis who have tried one or two biologic or targeted synthetic drugs but still have symptoms. You need to be taking a stable dose of methotrexate.
Peoria, ArizonaAges 18 years+ - NCT07553273Recruiting
Vibration to reduce pain from steroid hand and arm injections
This study tests whether applying gentle vibration during steroid injections into the hands, wrists, or elbows can reduce injection pain. If vibration works, it could make these commonly prescribed treatments more comfortable for patients.
Galveston, TexasAges 18 years+ - NCT06326229Recruiting
Validating a tool for muscle and joint care in physiotherapy
This study checks how well a tool (the ICF Core Set) helps physiotherapists evaluate people with muscle, bone, or joint problems in primary care. If you have a muscle or joint issue and speak Spanish, you may be able to help improve care for others.
Ólvega, SoriaAges 18–99 - NCT06330350Recruiting
Talking about family planning for genetic skin conditions
This study interviews people with inherited skin conditions (genodermatoses) who want to have children, and the doctors who care for them. The goal is to learn how to better support family planning decisions, like counseling about genetics and pregnancy risks.
Maastricht, LimburgAges Any age - NCT06330545Recruiting
Radiation for Dupuytren's after non-surgical release
This study tests if a short course of radiation therapy can help prevent Dupuytren's contracture from coming back after a non-surgical release (like an injection). It may be an option for people whose finger is already bent and cannot touch the table.
Lebanon, New HampshireAges 45 years+ - NCT06330922Recruiting
Muscle and tendon health study in cerebral palsy
This study looks at muscle and tendon health in people with spastic cerebral palsy who are mildly to severely affected. It involves using a special running frame to see how it affects the body.
GrazAges 14–30 - NCT06334159Recruiting
Comparing two collagen membranes for bone grafting before dental implants
This study compares two types of collagen membranes used in guided bone regeneration to rebuild jawbone so dental implants can be placed. If you need a bone graft for missing back teeth and are generally healthy, this trial may be a good fit.
Barcelona, Sant Cugat Del VallèsAges 18 years+ - NCT06335251Recruiting
Radiation therapy for limb cancers
This study looks at how radiation therapy works for cancers in the arms or legs, including primary tumors and cancers that have spread there. It aims to understand the best ways to use radiation for treatment or pain relief.
MilanAges 18 years+ - NCT06335095Recruiting
Spine disease and walking analysis study for adults 50–85
This study looks at how spine conditions affect the way people walk. Researchers will analyze your walking patterns to better understand spine disease and help guide future treatments.
LisbonAges 50–85 - NCT06337786Recruiting
RheumaBuddy app study for rheumatoid arthritis
This study tests if a digital app called RheumaBuddy4.1 can help manage rheumatoid arthritis symptoms. You would use the app at home and report how you feel.
Frederiksberg, Copenhagen FAges 18–65 - NCT06338735Recruiting
High-frequency ultrasound for Sjögren's diagnosis
This study uses a special, very high-frequency ultrasound to take detailed images of the small glands that can be affected in Sjögren's syndrome. The goal is to see if this new ultrasound technique can help doctors diagnose Sjögren's more accurately.
PisaAges 18 years+ - NCT06339177Recruiting
HLH study looking at immune system and genes
This study is for people with hemophagocytic lymphohistiocytosis (HLH), a condition where the immune system becomes overactive. Researchers want to collect medical data and blood samples to better understand HLH and find better ways to diagnose and treat it.
Bethesda, MarylandAges 18–120 - NCT06339489Recruiting
Bone Health in Early Menopause Study
This study looks at how bone health changes in women with premature ovarian insufficiency (early menopause). It aims to understand the body's bone metabolism to help manage long-term health.
BeijingAges 18–39 - NCT06339957Recruiting
Rheumatology diet study for arthritis and related conditions
This study looks at how diet affects people with different types of arthritis and related autoimmune conditions. If you are a UCF Health patient between 18 and 65, you may be able to help researchers learn more about which foods help or worsen symptoms.
Orlando, FloridaAges 18–65 - NCT06341920Recruiting
BoneFit: exercise before hip or knee replacement
This trial tests a pre-surgery exercise program called BoneFit for people waiting at least 6 months for a hip or knee replacement. The goal is to see if getting stronger before surgery helps recovery.
HullAges 18–75 - NCT06342765Recruiting
Safety of SpineVision posterior fixation systems in thoracolumbar spine
This trial checks how well the SpineVision Lumis, Plus, or Ulis spine fixation systems work and stay safe in the lower back and mid-back area. It is for people who already have one of these systems implanted.
BayonneAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,834 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,975 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.