Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT07020312RecruitingPhase 2
Brain training to improve muscle recovery after joint surgery
This trial tests whether brain-computer interface training can help you regain muscle control more effectively after knee or hip surgery. It focuses on four common procedures and uses neurofeedback to optimize muscle activation during recovery.
Chicago, IllinoisAges 18 years+ - NCT07022197RecruitingPhase 1/Phase 2
BAFF-R CAR T cells for severe nerve and immune diseases
This trial tests a new treatment using your own immune cells (called BAFF-R CAR T cells) for people with severe nerve and immune diseases that have not improved with standard medicines. These cells are designed to target and destroy certain immune cells that may be causing your illness.
Tianjin, Tianjin MunicipalityAges 18–60 - NCT07017686Recruiting
Reboot Study: Nerve stimulation for rheumatoid arthritis
This study tests a device that sends mild electrical pulses to the vagus nerve in the abdomen to treat rheumatoid arthritis. It is for people whose arthritis has not improved after trying multiple medications.
Fitzroy, VictoriaAges 18–75 - NCT07023523Recruiting
Controlling brain activity for chronic pain
This study tests if people with fibromyalgia can learn to control their own brain activity using real-time feedback from an MRI machine to reduce pain. It is designed to help those with long-term chronic pain find new ways to manage it.
Boston, MassachusettsAges 18–65 - NCT07023094RecruitingPhase 4
Comparing two nerve blocks for kids' hip surgery
This trial tests two types of pain-relieving nerve blocks for children having hip surgery. One uses a PENG block with LFCB, the other an ESP block; the goal is to see which provides better pain control.
PoznanAges 2–16 - NCT07015476Recruiting
Bone density in young women with amenorrhea
This study looks back at medical records of young women who had no menstrual period for at least 6 months. The goal is to understand how their bone density changed and what factors might have affected it.
BolognaAges 15–39 - NCT07017101Enrolling by invitation
Exercise for better breathing, less fatigue in fibromyalgia
This trial combines Pilates with special breathing techniques to see if it helps people with fibromyalgia breathe easier, feel less tired, and have a better quality of life. It compares this combined approach to Pilates alone.
Istanbul, TuzlaAges 18–65 - NCT07015632Recruiting
Fall risk screening with sensors in Duchenne MD
This study uses a machine-learning tool (like a smart computer program) to help predict fall risk in people with Duchenne Muscular Dystrophy. It involves wearing sensors to track your movement and balance, which could help doctors create safer care plans.
Seoul, JongnoAges 10–30 - NCT07014787Recruiting
Balance and knee cartilage study
This study looks at how different stages of knee cartilage damage (chondromalacia) affect your balance. You will be tested on a special balance machine to help doctors understand how your knee problem might affect your stability.
GizaAges 18–40 - NCT07021820Recruiting
New light-based imaging for centronuclear myopathy
This study tests a new type of imaging that uses light and sound to look at muscles in people with centronuclear myopathy. It may help doctors see muscle changes more clearly. It does not involve any treatment or medicine.
Erlangen, BavariaAges 2 years+ - NCT07018791RecruitingPhase 3
Art-based pain test for jaw joint disorder patients
This trial tests if using art can help measure pain in people with temporomandibular joint disorders (TMD). It may offer a new way to understand and manage your pain without surgery.
Jeddah, Mecca RegionAges 18 years+ - NCT07021287Recruiting
Cold therapy after knee replacement surgery
This study compares different cold therapy programs to see which works best for pain and swelling after total knee replacement. Everyone in the study receives cold therapy, and the researchers will track recovery outcomes.
Yiwu, ZhejiangAges 18 years+ - NCT07019727Recruiting
ACL injury prevention program for Czech athletes
This study tests a special training program designed to prevent ACL injuries in young athletes (ages 17-20) who play high-risk sports like soccer, basketball, or skiing. It aims to see if the program can reduce the chances of getting an ACL injury.
BrnoAges 17–20 - NCT07016672Recruiting
PRP vs. hyaluronic acid for advanced knee arthritis
This study compares two treatments—platelet-rich plasma (PRP) and hyaluronic acid (a lubricating injection)—for people with severe knee arthritis seen on MRI. The goal is to see which better reduces pain.
Toulon, VarAges 18 years+ - NCT06996028Recruiting
Lift and pedals for balance and movement in children with CP
This study tests if doing lifting and pedaling exercises helps children with cerebral palsy improve their balance and ability to move around. It may be a good fit if your child can walk without much help and follow simple instructions.
Lahore, Punjab ProvinceAges 6–12 - NCT06736457Recruiting
Safety and performance of AdvanCore bone void filler
This study tests a new bone filler called AdvanCore for people with a single bone fracture or defect that needs a graft. It aims to see if the filler is safe and works well to help the bone heal.
Guimarães, Braga DistrictAges 18 years+ - NCT04875052Recruiting
Study vibration after ACL injury and future arthritis risk
This study looks at whether using vibration after an ACL injury helps predict or reduce the risk of developing post-traumatic osteoarthritis (wear-and-tear arthritis) later. It may help researchers learn which patients are more likely to develop arthritis after ACL reconstruction.
Chapel Hill, North CarolinaAges 16–35 - NCT04802707RecruitingPhase 2
Study drug for mitochondrial depletion disorder due to gene changes
This Phase 2 trial tests a treatment made from deoxynucleosides to help people with mitochondrial depletion disorder caused by certain gene changes. If you match the genetic diagnosis, the study may see whether the treatment improves symptoms or disease markers.
Montreal, QuebecAges 1 month–60 years - NCT06003283RecruitingPhase 4
Reducing rituximab doses in rheumatoid arthritis
This trial compares two ways to reduce the amount of rituximab you take: one that gradually gives it less often based on time, and another that only gives it when your disease flares up. The goal is to see which approach keeps your arthritis under control while using less medication.
Merksem, AntwerpenAges 18 years+ - NCT07008469Enrolling by invitationPhase 3
Long-term safety study of del-desiran for DM1
This study tests whether the drug del-desiran continues to be safe and effective for people with DM1 (myotonic dystrophy type 1) after they complete an earlier study. You'll receive the drug and have regular check-ups to see how you're doing.
Los Angeles, CaliforniaAges 16 years+ - NCT07011537Enrolling by invitation
Digital health program and TENS for chronic low back pain
This trial tests a digital health program combined with a TENS device (a small device that sends gentle electrical pulses to help with pain) for people with ongoing low back pain. It compares this approach to standard care, and you would be randomly assigned to one of the two groups.
Eden Prairie, MinnesotaAges 18 years+ - NCT07006883Recruiting
Yoga program for knee osteoarthritis
This trial tests whether a yoga program can improve daily function in people with knee osteoarthritis. It may help reduce pain and stiffness while improving mobility.
São PauloAges 40–80 - NCT07004166Recruiting
New injection techniques to reduce pain and leakage
This study tests two different injection methods (TPR and Z-track) to see if they cause less pain and less medication leakage when giving the painkiller diclofenac sodium into the hip muscle.
SivasAges 18–40 - NCT07004218Enrolling by invitation
Ultrasound follow-up after massive rotator cuff tear surgery
This trial uses ultrasound imaging to check how the shoulder heals over the first year after surgery for a large tear in the rotator cuff (the group of tendons that helps lift and rotate your arm). The goal is to better understand recovery and improve care for people with this injury.
Çankaya, AnkaraAges 18–80
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.