Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,838 recruiting studies in this area right now.
By phase
- Not applicable3,969
- Phase 2224
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 276
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis87
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,838 total
- NCT06261645Recruiting
Exercise program for non-traumatic shoulder instability
This study tests a new exercise program for people with non-traumatic shoulder instability (looseness without injury). It focuses on improving how well your rotator cuff muscles control shoulder rotation.
Gothenburg, MölndalAges 16–35 - NCT06263075Recruiting
Monitoring during craniosynostosis surgery: comparing newer vs. traditional monitors
This study compares two types of monitors that track your baby's heart and blood flow during surgery to fix craniosynostosis. The goal is to see if a newer monitor works as well as the traditional one.
Bologna, BOAges 3 months–8 months - NCT06264076Recruiting
Ligament balancing in knee replacement
This trial tests a new method of balancing the ligaments during total knee replacement. If you are generally healthy and need a first-time knee replacement due to arthritis, you may be eligible.
Bærums verk, AkershusAges 40 years+ - NCT06265038Recruiting
Study of a new implant for lower back fusion surgery
This study tests a new implant called ReSpace TiCell Cage for TLIF surgery, which is a procedure to stabilize the lower back by fusing two vertebrae. It may be a good option if you have a degenerative spine condition causing pain or instability and are a candidate for this type of surgery.
Budapest, Pest CountyAges 18–80 - NCT06265246Recruiting
Milk and yogurt for stronger bones in young adults
This study tests whether adding milk and yogurt to your diet can improve bone health and body composition. If you're a young adult with low calcium intake, you may qualify to join.
Saskatoon, SaskatchewanAges 19–30 - NCT06265636Recruiting
Nerve stimulation for jaw pain and function in TMD
This trial tests whether gentle electrical stimulation of a nerve in your jaw can reduce pain and improve chewing, talking, and mouth opening for people with temporomandibular joint disorder (TMD).
Alcorcón, MadridAges 18–65 - NCT06267482RecruitingPhase 4
Using a robot for knee replacement surgery
This trial tests if a robot-assisted device (ROSA) helps with challenging knee replacements. It compares it to the standard surgery for people with mild knee bowing who need a first-time knee replacement.
London, OntarioAges 21–80 - NCT06270758Recruiting
Bone health check for women after menopause (BBCT-hip)
This study is testing a new way to check bone health in women who have gone through menopause and live in the Emilia-Romagna region of Italy. It aims to help predict and prevent hip fractures.
BolognaAges 65–85 - NCT06271915Recruiting
Neck stretches for tennis elbow pain
This study tests if gentle neck movements can reduce elbow pain in people with tennis elbow. It is for those whose elbow pain may be linked to a stiff neck.
GizaAges 30–50 - NCT06272292Recruiting
Hip impingement study: comparing men with and without symptoms
This trial looks at how a CAM-type hip impingement (a bump on the ball of the hip joint) affects hip movement and stress. It compares men with and without symptoms to understand what causes pain and how to prevent future hip problems.
Leuven, Vlaams-BrabantAges 21–35 - NCT06272422Recruiting
Comparing hip replacement surgeries with 3D planning
This study compares three types of hip replacement surgery (total hip, Minihip, and RSA) using 3D imaging to see which one best restores normal hip function. It might be a good fit if you are planning one of these surgeries and have a healthy other hip.
LilleAges 18 years+ - NCT06274021RecruitingEarly Phase 1
Brain stimulation to reduce leg stiffness after spinal cord injury
This study tests a non-invasive brain stimulation technique (like a gentle magnetic pulse) to see if it can reduce muscle stiffness and spasms in the legs after a spinal cord injury. It may be a good option if you have ongoing leg stiffness and want a drug-free approach.
Jackson, MississippiAges 18 years+ - NCT06277401Recruiting
Exercise for people with loose joints and knee pain
This study tests whether a specific exercise program can help people with loose joints (hypermobility) who have knee pain. If you have had knee pain for at least 3 months and your knees are very flexible, this could be a way to strengthen your knees and reduce pain.
Odense, FynAges 18–45 - NCT06280352Recruiting
Robotic vs custom knee replacement trial
This study compares two modern ways of doing knee replacement: robot-assisted surgery versus a custom-made implant tailored to your knee shape. It aims to see which approach leads to better recovery and function for people with osteoarthritis.
Graz, StyriaAges 40–90 - NCT06281223Recruiting
Brain and spinal cord connection study in spasticity
This study looks at how the brain and spinal cord connect in children with spasticity (muscle stiffness). It will help doctors understand more about this condition by studying patients who are already scheduled for surgery to reduce stiffness.
NiceAges 3–17 - NCT06283199Recruiting
Tracking pain reports with a smartphone app
This trial compares pain reports recorded in real time using a smartphone app to those collected during monthly clinic visits. It aims to understand if daily tracking gives a more accurate picture of symptoms for people with musculoskeletal conditions.
BolognaAges 18 years+ - NCT06283979RecruitingPhase 2
Antibiotic bone filler vs standard care for infected pressure ulcers
This trial tests a special antibiotic bone filler (STIMULAN VG) compared to standard care for people with a serious pressure ulcer that has infected the bone. You need to be able to have surgery to clean and close the wound.
Phoenix, ArizonaAges 18 years+ - NCT06284434RecruitingPhase 3
EXPAREL for pain after cleft gum repair
This trial tests if a long-lasting numbing medicine (EXPAREL) can help control pain after surgery to repair the gum in children and adults with cleft lip or palate. It may mean less discomfort after the procedure.
Chicago, IllinoisAges 6 years+ - NCT06284993Recruiting
Acupuncture for chronic heel pain: testing different schedules
This study tests whether acupuncture given at different frequencies (how often you get it) can help relieve chronic heel pain from plantar fasciitis. It may help you if you've had persistent pain for at least 6 months and have not tried certain recent treatments.
BeijingAges 18–75 - NCT06285539RecruitingPhase 2
Testing a drug for rare inflammatory diseases
This trial is testing a new drug (a JAK inhibitor) for people with rare inflammatory diseases like Behçet's, myositis, or IgG4-related disease that hasn't improved with standard treatments. The goal is to see if it can help control symptoms and reduce inflammation.
AmsterdamAges 18–65 - NCT06286553Recruiting
Ab muscle repair after childbirth: breathing and core training
This study tests if a program of trunk and breathing exercises can help close the gap in abdominal muscles (diastasis recti) that sometimes happens after pregnancy. It is for women who are at least 6 months postpartum and have a muscle separation larger than 2.8 cm.
PátraiAges 18–50 - NCT06287762Recruiting
Natural history study of RYR1-related disorders
This study follows people with RYR1-related disorders over time to learn how the condition progresses. It may help researchers plan future treatments.
Bethesda, MarylandAges 7–100 - NCT06289114Recruiting
Can physical activity predict treatment success in rheumatoid arthritis?
This study tests if measuring your physical activity over a short time can help predict how well a new biologic medication will work for your rheumatoid arthritis. The goal is to find a simple way to see if the treatment is helping.
EsbjergAges 18 years+ - NCT06290713RecruitingPhase 2
Blood flow and exercise study for Duchenne muscular dystrophy
This trial tests if a medicine that improves blood flow, combined with exercise, can help muscles in boys with Duchenne muscular dystrophy. It is for boys who can still walk and are on a stable steroid medication.
Gainesville, FloridaAges 6 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,838 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,965 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.